##gff-version 3 P0C6V6 UniProtKB Chain 1 4117 . . . ID=PRO_0000338347;Note=Replicase polyprotein 1a P0C6V6 UniProtKB Chain 1 110 . . . ID=PRO_0000338348;Note=Non-structural protein 1;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6V6 UniProtKB Chain 111 895 . . . ID=PRO_0000338349;Note=Non-structural protein 2;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6V6 UniProtKB Chain 896 2516 . . . ID=PRO_0000338350;Note=Papain-like protease nsp3;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6V6 UniProtKB Chain 2517 2997 . . . ID=PRO_0000338351;Note=Non-structural protein 4;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6V6 UniProtKB Chain 2998 3299 . . . ID=PRO_0000338352;Note=3C-like proteinase nsp5;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6V6 UniProtKB Chain 3300 3579 . . . ID=PRO_0000338353;Note=Non-structural protein 6;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6V6 UniProtKB Chain 3580 3662 . . . ID=PRO_0000338354;Note=Non-structural protein 7;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6V6 UniProtKB Chain 3663 3857 . . . ID=PRO_0000338355;Note=Non-structural protein 8;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6V6 UniProtKB Chain 3858 3965 . . . ID=PRO_0000338356;Note=RNA-capping enzyme subunit nsp9;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6V6 UniProtKB Chain 3966 4100 . . . ID=PRO_0000338357;Note=Non-structural protein 10;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6V6 UniProtKB Chain 4111 4117 . . . ID=PRO_0000338358;Note=Non-structural protein 11;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6V6 UniProtKB Transmembrane 1959 1979 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6V6 UniProtKB Transmembrane 2022 2042 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6V6 UniProtKB Transmembrane 2105 2125 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6V6 UniProtKB Transmembrane 2127 2147 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6V6 UniProtKB Transmembrane 2150 2170 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6V6 UniProtKB Transmembrane 2528 2548 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6V6 UniProtKB Transmembrane 2619 2639 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6V6 UniProtKB Transmembrane 2654 2674 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6V6 UniProtKB Transmembrane 2754 2774 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6V6 UniProtKB Transmembrane 2787 2807 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6V6 UniProtKB Transmembrane 2814 2834 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6V6 UniProtKB Transmembrane 2863 2883 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6V6 UniProtKB Transmembrane 3336 3356 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6V6 UniProtKB Transmembrane 3361 3381 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6V6 UniProtKB Transmembrane 3399 3419 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6V6 UniProtKB Transmembrane 3431 3451 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6V6 UniProtKB Transmembrane 3454 3474 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6V6 UniProtKB Transmembrane 3476 3496 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6V6 UniProtKB Transmembrane 3500 3520 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6V6 UniProtKB Domain 2 109 . . . Note=CoV Nsp1 globular;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01307 P0C6V6 UniProtKB Domain 112 364 . . . Note=CoV Nsp2 N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01333 P0C6V6 UniProtKB Domain 383 776 . . . Note=CoV Nsp2 middle;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01334 P0C6V6 UniProtKB Domain 778 895 . . . Note=CoV Nsp2 C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01335 P0C6V6 UniProtKB Domain 896 991 . . . Note=Ubiquitin-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00214 P0C6V6 UniProtKB Domain 1057 1296 . . . Note=Peptidase C16 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6V6 UniProtKB Domain 1297 1465 . . . Note=Macro;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00490 P0C6V6 UniProtKB Domain 1630 1685 . . . Note=Ubiquitin-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00214 P0C6V6 UniProtKB Domain 1691 1951 . . . Note=Peptidase C16 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6V6 UniProtKB Domain 2038 2102 . . . Note=3Ecto;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01337 P0C6V6 UniProtKB Domain 2176 2516 . . . Note=CoV Nsp3 Y;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6V6 UniProtKB Domain 2902 2997 . . . Note=Nsp4C;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01291 P0C6V6 UniProtKB Domain 2998 3299 . . . Note=Peptidase C30;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00772 P0C6V6 UniProtKB Domain 3580 3662 . . . Note=RdRp Nsp7 cofactor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01294 P0C6V6 UniProtKB Domain 3663 3857 . . . Note=RdRp Nsp8 cofactor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01295 P0C6V6 UniProtKB Domain 3858 3965 . . . Note=Nsp9 ssRNA-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01296 P0C6V6 UniProtKB Domain 3966 4103 . . . Note=ExoN/MTase coactivator;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6V6 UniProtKB Zinc finger 1162 1193 . . . Note=C4-type 1%3B degenerate;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6V6 UniProtKB Zinc finger 1808 1838 . . . Note=C4-type 2%3B degenerate;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6V6 UniProtKB Zinc finger 4039 4055 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6V6 UniProtKB Zinc finger 4081 4094 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6V6 UniProtKB Region 1009 1040 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P0C6V6 UniProtKB Region 1959 2170 . . . Note=HD1 P0C6V6 UniProtKB Region 2176 2266 . . . Note=Y1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6V6 UniProtKB Region 2180 2193 . . . Note=ZF1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6V6 UniProtKB Region 2226 2236 . . . Note=ZF2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6V6 UniProtKB Region 2267 2516 . . . Note=CoV-Y;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6V6 UniProtKB Region 2267 2356 . . . Note=Y2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6V6 UniProtKB Region 2357 2414 . . . Note=Y3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6V6 UniProtKB Region 2415 2516 . . . Note=Y4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6V6 UniProtKB Region 2528 2883 . . . Note=HD2 P0C6V6 UniProtKB Region 3336 3520 . . . Note=HD3 P0C6V6 UniProtKB Active site 1091 1091 . . . Note=For PL1-PRO activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6V6 UniProtKB Active site 1239 1239 . . . Note=For PL1-PRO activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6V6 UniProtKB Active site 1252 1252 . . . Note=For PL1-PRO activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6V6 UniProtKB Active site 1729 1729 . . . Note=For PL2-PRO activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6V6 UniProtKB Active site 1888 1888 . . . Note=For PL2-PRO activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6V6 UniProtKB Active site 1901 1901 . . . Note=For PL2-PRO activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6V6 UniProtKB Active site 3038 3038 . . . Note=For 3CL-PRO activity;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00772,ECO:0000269|PubMed:27173881;Dbxref=PMID:27173881 P0C6V6 UniProtKB Active site 3141 3141 . . . Note=For 3CL-PRO activity;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00772,ECO:0000269|PubMed:27173881;Dbxref=PMID:27173881 P0C6V6 UniProtKB Binding site 2180 2180 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6V6 UniProtKB Binding site 2185 2185 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6V6 UniProtKB Binding site 2190 2190 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6V6 UniProtKB Binding site 2193 2193 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6V6 UniProtKB Binding site 2226 2226 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6V6 UniProtKB Binding site 2229 2229 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6V6 UniProtKB Binding site 2233 2233 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6V6 UniProtKB Binding site 2236 2236 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6V6 UniProtKB Binding site 4039 4039 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6V6 UniProtKB Binding site 4042 4042 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6V6 UniProtKB Binding site 4048 4048 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6V6 UniProtKB Binding site 4055 4055 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6V6 UniProtKB Binding site 4081 4081 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6V6 UniProtKB Binding site 4084 4084 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6V6 UniProtKB Binding site 4092 4092 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6V6 UniProtKB Binding site 4094 4094 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6V6 UniProtKB Site 110 111 . . . Note=Cleavage%3B by PL1-PRO;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6V6 UniProtKB Site 895 896 . . . Note=Cleavage%3B by PL1-PRO;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6V6 UniProtKB Site 2516 2517 . . . Note=Cleavage%3B by PL2-PRO;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6V6 UniProtKB Site 2997 2998 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6V6 UniProtKB Site 3299 3300 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6V6 UniProtKB Site 3579 3580 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6V6 UniProtKB Site 3662 3663 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6V6 UniProtKB Site 3857 3858 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6V6 UniProtKB Site 3965 3966 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6V6 UniProtKB Site 4100 4101 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6V6 UniProtKB Disulfide bond 2054 2080 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01337 P0C6V6 UniProtKB Disulfide bond 2072 2077 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01337 P0C6V6 UniProtKB Disulfide bond 3916 3916 . . . Note=Interchain;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0C6Y4 P0C6V6 UniProtKB Helix 3008 3011 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5GWZ P0C6V6 UniProtKB Beta strand 3014 3019 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5GWZ P0C6V6 UniProtKB Beta strand 3022 3029 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5GWZ P0C6V6 UniProtKB Beta strand 3032 3036 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5GWZ P0C6V6 UniProtKB Helix 3037 3040 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5GWZ P0C6V6 UniProtKB Beta strand 3044 3046 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5GWZ P0C6V6 UniProtKB Helix 3050 3056 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5GWZ P0C6V6 UniProtKB Helix 3059 3061 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5GWZ P0C6V6 UniProtKB Beta strand 3062 3066 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5GWZ P0C6V6 UniProtKB Beta strand 3069 3071 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5GWZ P0C6V6 UniProtKB Beta strand 3073 3079 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5GWZ P0C6V6 UniProtKB Beta strand 3082 3089 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5GWZ P0C6V6 UniProtKB Beta strand 3096 3099 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5GWZ P0C6V6 UniProtKB Beta strand 3107 3114 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5GWZ P0C6V6 UniProtKB Beta strand 3117 3125 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5GWZ P0C6V6 UniProtKB Beta strand 3144 3149 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5GWZ P0C6V6 UniProtKB Beta strand 3152 3162 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5GWZ P0C6V6 UniProtKB Beta strand 3168 3171 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5GWZ P0C6V6 UniProtKB Helix 3178 3180 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5GWZ P0C6V6 UniProtKB Beta strand 3183 3186 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5GWZ P0C6V6 UniProtKB Helix 3197 3209 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5GWZ P0C6V6 UniProtKB Helix 3223 3230 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5GWZ P0C6V6 UniProtKB Turn 3231 3234 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5GWZ P0C6V6 UniProtKB Helix 3242 3244 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5GWZ P0C6V6 UniProtKB Helix 3245 3251 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5GWZ P0C6V6 UniProtKB Helix 3255 3265 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5GWZ P0C6V6 UniProtKB Beta strand 3277 3279 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5GWZ P0C6V6 UniProtKB Helix 3286 3294 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5GWZ