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Protein

Replicase polyprotein 1a

Gene

1a

Organism
Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The papain-like proteinase (PL-PRO) is responsible for the cleavages located at the N-terminus of replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF-3.
The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK (By similarity). Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function.PROSITE-ProRule annotation5 Publications
Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.
Nsp9 is a ssRNA-binding protein.
Non-structural protein 1: binds to the 40S ribosomal subunit and inhibits host translation. The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. Viral mRNAs are not susceptible to nsp1-mediated endonucleolytic RNA cleavage thanks to the presence of a 5'-end leader sequence and are therefore protected from degradation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
TSAVLQ-|-SGFRK-NH2 and SGVTFQ-|-GKFKK the two peptides corresponding to the two self-cleavage sites of the SARS 3C-like proteinase are the two most reactive peptide substrates. The enzyme exhibits a strong preference for substrates containing Gln at P1 position and Leu at P2 position.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1651For PL-PRO activityPROSITE-ProRule annotation1
Active sitei1812For PL-PRO activityPROSITE-ProRule annotation1
Active sitei3281For 3CL-PRO activityPROSITE-ProRule annotation1
Active sitei3385For 3CL-PRO activityPROSITE-ProRule annotation1
Metal bindingi4304Zinc1
Metal bindingi4307Zinc1
Metal bindingi4313Zinc1
Metal bindingi4320Zinc1
Metal bindingi4347Zinc1
Metal bindingi4350Zinc1
Metal bindingi4358Zinc1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1729 – 1766C4-typePROSITE-ProRule annotationAdd BLAST38
Zinc fingeri4304 – 4320Add BLAST17
Zinc fingeri4347 – 4360Add BLAST14

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease, Protease, Thiol protease

Keywords - Biological processi

Activation of host autophagy by virus, Decay of host mRNAs by virus, Eukaryotic host gene expression shutoff by virus, Eukaryotic host translation shutoff by virus, Host gene expression shutoff by virus, Host mRNA suppression by virus, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host IRF3 by virus, Inhibition of host ISG15 by virus, Inhibition of host RLR pathway by virus, Modulation of host ubiquitin pathway by viral deubiquitinase, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathway, Viral immunoevasion

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Enzyme and pathway databases

BRENDAi3.4.22.69. 7599.

Protein family/group databases

MEROPSiC16.009.

Names & Taxonomyi

Protein namesi
Recommended name:
Replicase polyprotein 1a
Short name:
pp1a
Alternative name(s):
ORF1a polyprotein
Cleaved into the following 11 chains:
Non-structural protein 1
Short name:
nsp1
Alternative name(s):
Leader protein
Non-structural protein 2
Short name:
nsp2
Alternative name(s):
p65 homolog
Alternative name(s):
PL2-PRO
Papain-like proteinase
Short name:
PL-PRO
SARS coronavirus main proteinase
Non-structural protein 4
Short name:
nsp4
3C-like proteinase (EC:3.4.22.-)
Short name:
3CL-PRO
Short name:
3CLp
Alternative name(s):
nsp5
Non-structural protein 6
Short name:
nsp6
Non-structural protein 7
Short name:
nsp7
Non-structural protein 8
Short name:
nsp8
Non-structural protein 9
Short name:
nsp9
Non-structural protein 10
Short name:
nsp10
Alternative name(s):
Growth factor-like peptide
Short name:
GFL
Non-structural protein 11
Short name:
nsp11
Gene namesi
ORF Names:1a
OrganismiHuman SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus)
Taxonomic identifieri227859 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeBetacoronavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Paguma larvata (Masked palm civet) [TaxID: 9675]
Proteomesi
  • UP000000354 Componenti: Genome

Subcellular locationi

Non-structural protein 7 :
  • Host cytoplasmhost perinuclear region By similarity

  • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
Non-structural protein 8 :
  • Host cytoplasmhost perinuclear region By similarity

  • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
Non-structural protein 9 :
  • Host cytoplasmhost perinuclear region By similarity

  • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
Non-structural protein 10 :
  • Host cytoplasmhost perinuclear region By similarity

  • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei2092 – 2112HelicalSequence analysisAdd BLAST21
Transmembranei2203 – 2223HelicalSequence analysisAdd BLAST21
Transmembranei2304 – 2324HelicalSequence analysisAdd BLAST21
Transmembranei2326 – 2346HelicalSequence analysisAdd BLAST21
Transmembranei2351 – 2371HelicalSequence analysisAdd BLAST21
Transmembranei2755 – 2775HelicalSequence analysisAdd BLAST21
Transmembranei2830 – 2850HelicalSequence analysisAdd BLAST21
Transmembranei2879 – 2899HelicalSequence analysisAdd BLAST21
Transmembranei2992 – 3012HelicalSequence analysisAdd BLAST21
Transmembranei3022 – 3042HelicalSequence analysisAdd BLAST21
Transmembranei3054 – 3074HelicalSequence analysisAdd BLAST21
Transmembranei3077 – 3097HelicalSequence analysisAdd BLAST21
Transmembranei3105 – 3125HelicalSequence analysisAdd BLAST21
Transmembranei3142 – 3162HelicalSequence analysisAdd BLAST21
Transmembranei3564 – 3584HelicalSequence analysisAdd BLAST21
Transmembranei3586 – 3606HelicalSequence analysisAdd BLAST21
Transmembranei3612 – 3632HelicalSequence analysisAdd BLAST21
Transmembranei3658 – 3678HelicalSequence analysisAdd BLAST21
Transmembranei3707 – 3727HelicalSequence analysisAdd BLAST21
Transmembranei3728 – 3748HelicalSequence analysisAdd BLAST21
Transmembranei3756 – 3776HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Host membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3927.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003382541 – 4382Replicase polyprotein 1aAdd BLAST4382
ChainiPRO_00003382551 – 180Non-structural protein 1By similarityAdd BLAST180
ChainiPRO_0000338256181 – 818Non-structural protein 2By similarityAdd BLAST638
ChainiPRO_0000338257819 – 2740Non-structural protein 3By similarityAdd BLAST1922
ChainiPRO_00003382582741 – 3240Non-structural protein 4Sequence analysisAdd BLAST500
ChainiPRO_00003382593241 – 35463C-like proteinaseBy similarityAdd BLAST306
ChainiPRO_00003382603547 – 3836Non-structural protein 6By similarityAdd BLAST290
ChainiPRO_00003382613837 – 3919Non-structural protein 7By similarityAdd BLAST83
ChainiPRO_00003382623920 – 4117Non-structural protein 8By similarityAdd BLAST198
ChainiPRO_00003382634118 – 4230Non-structural protein 9By similarityAdd BLAST113
ChainiPRO_00003382644231 – 4369Non-structural protein 10By similarityAdd BLAST139
ChainiPRO_00003382654370 – 4382Non-structural protein 11Sequence analysisAdd BLAST13

Post-translational modificationi

Specific enzymatic cleavages in vivo by its own proteases yield mature proteins. 3CL-PRO and PL-PRO proteinases are autocatalytically processed (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei180 – 181CleavageBy similarity2
Sitei818 – 819Cleavage; by PL-PROBy similarity2
Sitei2740 – 2741Cleavage; by PL-PROBy similarity2
Sitei3240 – 3241Cleavage; by 3CL-PROBy similarity2
Sitei3546 – 3547Cleavage; by 3CL-PROBy similarity2
Sitei3836 – 3837Cleavage; by 3CL-PROBy similarity2
Sitei3919 – 3920Cleavage; by 3CL-PROBy similarity2
Sitei4117 – 4118Cleavage; by 3CL-PROBy similarity2
Sitei4230 – 4231Cleavage; by 3CL-PROBy similarity2
Sitei4369 – 4370Cleavage; by 3CL-PROBy similarity2

Proteomic databases

PRIDEiP0C6U8.

Interactioni

Subunit structurei

Eight copies of nsp7 and eight copies of nsp8 assemble to form a heterohexadecamer. Nsp9 is a dimer. Nsp10 forms a dodecamer.

Protein-protein interaction databases

DIPiDIP-48580N.

Chemistry databases

BindingDBiP0C6U8.

Structurei

Secondary structure

14382
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1208 – 1211Combined sources4
Beta strandi1214 – 1216Combined sources3
Helixi1219 – 1222Combined sources4
Turni1223 – 1225Combined sources3
Beta strandi1229 – 1233Combined sources5
Beta strandi1235 – 1237Combined sources3
Helixi1241 – 1244Combined sources4
Helixi1253 – 1255Combined sources3
Turni1256 – 1258Combined sources3
Beta strandi1266 – 1269Combined sources4
Beta strandi1272 – 1276Combined sources5
Helixi1280 – 1282Combined sources3
Helixi1286 – 1293Combined sources8
Beta strandi1298 – 1303Combined sources6
Beta strandi1309 – 1312Combined sources4
Helixi1315 – 1324Combined sources10
Beta strandi1325 – 1331Combined sources7
Helixi1343 – 1345Combined sources3
Helixi1351 – 1361Combined sources11
Beta strandi1364 – 1368Combined sources5
Helixi1372 – 1381Combined sources10
Turni1382 – 1384Combined sources3
Beta strandi1389 – 1401Combined sources13
Beta strandi1403 – 1405Combined sources3
Helixi1407 – 1417Combined sources11
Beta strandi1421 – 1423Combined sources3
Turni1429 – 1431Combined sources3
Helixi1435 – 1442Combined sources8
Beta strandi1449 – 1452Combined sources4
Helixi1456 – 1467Combined sources12
Helixi1473 – 1484Combined sources12
Beta strandi1485 – 1487Combined sources3
Beta strandi1500 – 1506Combined sources7
Beta strandi1509 – 1513Combined sources5
Beta strandi1515 – 1518Combined sources4
Beta strandi1521 – 1523Combined sources3
Beta strandi1526 – 1528Combined sources3
Helixi1530 – 1537Combined sources8
Beta strandi1544 – 1555Combined sources12
Beta strandi1557 – 1562Combined sources6
Beta strandi1563 – 1565Combined sources3
Helixi1567 – 1570Combined sources4
Beta strandi1571 – 1576Combined sources6
Helixi1581 – 1583Combined sources3
Helixi1588 – 1590Combined sources3
Beta strandi1594 – 1597Combined sources4
Helixi1602 – 1612Combined sources11
Helixi1619 – 1630Combined sources12
Turni1648 – 1650Combined sources3
Helixi1651 – 1660Combined sources10
Beta strandi1667 – 1669Combined sources3
Helixi1670 – 1680Combined sources11
Helixi1685 – 1695Combined sources11
Helixi1705 – 1713Combined sources9
Beta strandi1722 – 1729Combined sources8
Turni1730 – 1732Combined sources3
Beta strandi1733 – 1740Combined sources8
Helixi1741 – 1744Combined sources4
Beta strandi1746 – 1749Combined sources4
Helixi1753 – 1758Combined sources6
Beta strandi1760 – 1763Combined sources4
Beta strandi1767 – 1794Combined sources28
Beta strandi1799 – 1806Combined sources8
Helixi1808 – 1810Combined sources3
Beta strandi1811 – 1826Combined sources16
Beta strandi1829 – 1846Combined sources18
Beta strandi1848 – 1851Combined sources4
Helixi3251 – 3254Combined sources4
Beta strandi3257 – 3262Combined sources6
Beta strandi3265 – 3272Combined sources8
Beta strandi3275 – 3279Combined sources5
Helixi3280 – 3283Combined sources4
Helixi3286 – 3288Combined sources3
Beta strandi3289 – 3291Combined sources3
Helixi3294 – 3299Combined sources6
Helixi3303 – 3305Combined sources3
Beta strandi3306 – 3310Combined sources5
Beta strandi3313 – 3315Combined sources3
Beta strandi3317 – 3323Combined sources7
Beta strandi3326 – 3333Combined sources8
Beta strandi3340 – 3343Combined sources4
Beta strandi3351 – 3358Combined sources8
Beta strandi3361 – 3369Combined sources9
Turni3380 – 3383Combined sources4
Beta strandi3388 – 3393Combined sources6
Beta strandi3396 – 3406Combined sources11
Turni3408 – 3410Combined sources3
Beta strandi3412 – 3415Combined sources4
Beta strandi3417 – 3419Combined sources3
Beta strandi3421 – 3424Combined sources4
Beta strandi3427 – 3430Combined sources4
Helixi3441 – 3453Combined sources13
Turni3458 – 3460Combined sources3
Helixi3467 – 3476Combined sources10
Helixi3484 – 3489Combined sources6
Helixi3491 – 3497Combined sources7
Helixi3501 – 3514Combined sources14
Beta strandi3521 – 3523Combined sources3
Beta strandi3524 – 3526Combined sources3
Helixi3533 – 3539Combined sources7
Beta strandi3541 – 3543Combined sources3
Helixi3838 – 3855Combined sources18
Helixi3858 – 3860Combined sources3
Helixi3862 – 3877Combined sources16
Helixi3881 – 3896Combined sources16
Helixi3904 – 3913Combined sources10
Helixi3997 – 4017Combined sources21
Helixi4020 – 4030Combined sources11
Beta strandi4035 – 4037Combined sources3
Beta strandi4046 – 4051Combined sources6
Helixi4054 – 4060Combined sources7
Beta strandi4065 – 4068Combined sources4
Beta strandi4071 – 4079Combined sources9
Helixi4088 – 4090Combined sources3
Turni4093 – 4095Combined sources3
Helixi4096 – 4098Combined sources3
Beta strandi4103 – 4109Combined sources7
Beta strandi4127 – 4136Combined sources10
Turni4137 – 4139Combined sources3
Beta strandi4142 – 4150Combined sources9
Turni4152 – 4154Combined sources3
Beta strandi4157 – 4164Combined sources8
Beta strandi4170 – 4173Combined sources4
Beta strandi4176 – 4179Combined sources4
Beta strandi4180 – 4186Combined sources7
Beta strandi4190 – 4194Combined sources5
Beta strandi4201 – 4208Combined sources8
Helixi4213 – 4224Combined sources12
Helixi4240 – 4248Combined sources9
Beta strandi4250 – 4252Combined sources3
Helixi4253 – 4262Combined sources10
Beta strandi4273 – 4275Combined sources3
Beta strandi4284 – 4288Combined sources5
Beta strandi4295 – 4299Combined sources5
Helixi4301 – 4303Combined sources3
Helixi4305 – 4309Combined sources5
Beta strandi4316 – 4318Combined sources3
Turni4321 – 4324Combined sources4
Beta strandi4325 – 4330Combined sources6
Helixi4331 – 4333Combined sources3
Helixi4337 – 4343Combined sources7
Turni4348 – 4350Combined sources3
Turni4354 – 4356Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1P76model-A3241-3541[»]
B4225-4231[»]
1P9Tmodel-A3241-3544[»]
1PA5model-A3241-3546[»]
1PUKmodel-A3241-3550[»]
1Q1Xmodel-A3241-3542[»]
1Q2WX-ray1.86A/B3241-3544[»]
1QZ8X-ray2.70A/B4118-4230[»]
1UJ1X-ray1.90A/B3241-3546[»]
1UK2X-ray2.20A/B3241-3546[»]
1UK3X-ray2.40A/B3241-3546[»]
1UK4X-ray2.50A/B3241-3546[»]
1UW7X-ray2.80A4118-4230[»]
1WOFX-ray2.00A/B3241-3546[»]
1YSYNMR-A3837-3919[»]
1Z1IX-ray2.80A3241-3546[»]
1Z1JX-ray2.80A/B3241-3546[»]
2A5AX-ray2.08A3241-3546[»]
2A5IX-ray1.88A3241-3546[»]
2A5KX-ray2.30A/B3241-3546[»]
2ACFX-ray1.40A/B/C/D1002-1176[»]
2AHMX-ray2.40A/B/C/D3837-3919[»]
E/F/G/H3920-4117[»]
2AJ5model-A3241-3546[»]
2ALVX-ray1.90A3241-3543[»]
2AMDX-ray1.85A/B3241-3546[»]
2AMQX-ray2.30A/B3241-3546[»]
2BX3X-ray2.00A3241-3546[»]
2BX4X-ray2.79A3241-3546[»]
2C3SX-ray1.90A3241-3546[»]
2D2DX-ray2.70A/B3241-3546[»]
2DUCX-ray1.70A/B3241-3546[»]
2FAVX-ray1.80A/B/C1000-1173[»]
2FE8X-ray1.85A/B/C1541-1854[»]
2FYGX-ray1.80A4240-4362[»]
2G9TX-ray2.10A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X4231-4382[»]
2GA6X-ray2.70A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X4231-4382[»]
2GDTNMR-A13-127[»]
2GRINMR-A819-930[»]
2GT7X-ray1.82A/B3241-3546[»]
2GT8X-ray2.00A3241-3546[»]
2GTBX-ray2.00A3241-3546[»]
2GX4X-ray1.93A3241-3546[»]
2GZ7X-ray1.86A3241-3546[»]
2GZ8X-ray1.97A3241-3546[»]
2GZ9X-ray2.17A3241-3546[»]
2H2ZX-ray1.60A3241-3546[»]
2HOBX-ray1.95A3241-3546[»]
2HSXNMR-A13-127[»]
2IDYNMR-A819-930[»]
2KAFNMR-A1473-1538[»]
2KQVNMR-A1345-1538[»]
2KQWNMR-A1345-1538[»]
2KYSNMR-A3837-3919[»]
2LIZNMR-A3427-3546[»]
2OP9X-ray1.80A/B3241-3541[»]
2PWXX-ray2.50A3241-3546[»]
2W2GX-ray2.22A/B1207-1470[»]
2WCTX-ray2.79A/B/C/D1207-1470[»]
2Z3CX-ray1.79A3241-3546[»]
2Z3DX-ray2.10A3241-3546[»]
2Z3EX-ray2.32A3241-3546[»]
2ZU4X-ray1.93A3241-3546[»]
2ZU5X-ray1.65A3241-3546[»]
3ATWX-ray2.36A/B3241-3546[»]
3AVZX-ray2.46A3241-3546[»]
3AW0X-ray2.30A3241-3546[»]
3AW1X-ray2.00A/B3241-3546[»]
3E91X-ray2.55A/B3241-3546[»]
3EA7X-ray2.65A/B3241-3546[»]
3EA8X-ray2.25A3241-3546[»]
3EA9X-ray2.40A3241-3546[»]
3EAJX-ray2.70A/B3241-3546[»]
3EE7X-ray2.60A/B/C/D4118-4230[»]
3F9EX-ray2.50A3241-3546[»]
3F9FX-ray2.30A/B3241-3546[»]
3F9GX-ray2.60A/B3241-3541[»]
3F9HX-ray2.90A/B3241-3546[»]
3FZDX-ray2.35A3241-3541[»]
3IWMX-ray3.20A/B/C/D3241-3546[»]
3M3SX-ray2.30A/B3241-3546[»]
3M3TX-ray2.90A3241-3546[»]
3M3VX-ray2.70A/B3241-3546[»]
3MJ5X-ray2.63A/B1541-1855[»]
3R24X-ray2.00B4240-4382[»]
3SN8X-ray1.99A3241-3546[»]
3SNAX-ray3.05A3241-3541[»]
3SNBX-ray2.40A3241-3546[»]
3SNCX-ray2.58A3241-3546[»]
3SNDX-ray1.89A/B3241-3546[»]
3SNEX-ray2.60A3241-3546[»]
3SZNX-ray1.69A3241-3546[»]
3TITX-ray1.99A3241-3546[»]
3TIUX-ray2.08A3241-3546[»]
3TNSX-ray1.99A3241-3546[»]
3TNTX-ray1.59A3241-3546[»]
3V3MX-ray1.96A3241-3546[»]
3VB3X-ray2.20A/B3241-3546[»]
3VB4X-ray2.20A/B3241-3546[»]
3VB5X-ray1.95A/B3241-3546[»]
3VB6X-ray2.50A/B3241-3546[»]
3VB7X-ray1.95A/B3241-3546[»]
4HI3X-ray2.09A/B3241-3546[»]
4M0WX-ray1.40A1541-1858[»]
4MDSX-ray1.60A3241-3542[»]
4MM3X-ray2.75B1541-1855[»]
4OVZX-ray2.50A/B1541-1855[»]
4OW0X-ray2.10A/B1541-1855[»]
5F22X-ray2.15A3837-3919[»]
ProteinModelPortaliP0C6U8.
SMRiP0C6U8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0C6U8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1003 – 1169MacroPROSITE-ProRule annotationAdd BLAST167
Domaini1611 – 1875Peptidase C16PROSITE-ProRule annotationAdd BLAST265
Domaini3241 – 3546Peptidase C30PROSITE-ProRule annotationAdd BLAST306

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2092 – 2371HD1Add BLAST280
Regioni2755 – 3162HD2Add BLAST408
Regioni3564 – 3776HD3Add BLAST213

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi930 – 1001Glu-richAdd BLAST72
Compositional biasi2210 – 2213Poly-Leu4
Compositional biasi3766 – 3769Poly-Cys4

Domaini

The hydrophobic domains (HD) could mediate the membrane association of the replication complex and thereby alter the architecture of the host cell membrane.

Sequence similaritiesi

Contains 1 Macro domain.PROSITE-ProRule annotation
Contains 1 peptidase C16 domain.PROSITE-ProRule annotation
Contains 1 peptidase C30 domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1729 – 1766C4-typePROSITE-ProRule annotationAdd BLAST38
Zinc fingeri4304 – 4320Add BLAST17
Zinc fingeri4347 – 4360Add BLAST14

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix, Zinc-finger

Family and domain databases

InterProiIPR032505. Corona_NSP4_C.
IPR002589. Macro_dom.
IPR032592. NAR_dom.
IPR021590. NSP1.
IPR024375. Nsp3_coronavir.
IPR014828. NSP7.
IPR014829. NSP8.
IPR014822. NSP9.
IPR008740. Peptidase_C30.
IPR013016. Peptidase_C30/C16.
IPR009003. Peptidase_S1_PA.
IPR018995. RNA_synth_NSP10_coronavirus.
IPR024358. SARS-CoV_Nsp3_N.
IPR022733. SARS_polyprot_cleavage.
IPR014827. Viral_protease.
[Graphical view]
PfamiPF16348. Corona_NSP4_C. 1 hit.
PF12379. DUF3655. 1 hit.
PF01661. Macro. 1 hit.
PF16251. NAR. 1 hit.
PF11501. Nsp1. 1 hit.
PF09401. NSP10. 1 hit.
PF12124. Nsp3_PL2pro. 1 hit.
PF08716. nsp7. 1 hit.
PF08717. nsp8. 1 hit.
PF08710. nsp9. 1 hit.
PF05409. Peptidase_C30. 1 hit.
PF11633. SUD-M. 1 hit.
PF08715. Viral_protease. 1 hit.
[Graphical view]
SMARTiSM00506. A1pp. 1 hit.
[Graphical view]
SUPFAMiSSF101816. SSF101816. 1 hit.
SSF144246. SSF144246. 1 hit.
SSF50494. SSF50494. 1 hit.
PROSITEiPS51442. M_PRO. 1 hit.
PS51154. MACRO. 1 hit.
PS51124. PEPTIDASE_C16. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by ribosomal frameshifting. AlignAdd to basket

Isoform Replicase polyprotein 1a (identifier: P0C6U8-1) [UniParc]FASTAAdd to basket
Also known as: pp1a, ORF1a polyprotein

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESLVLGVNE KTHVQLSLPV LQVRDVLVRG FGDSVEEALS EAREHLKNGT
60 70 80 90 100
CGLVELEKGV LPQLEQPYVF IKRSDALSTN HGHKVVELVA EMDGIQYGRS
110 120 130 140 150
GITLGVLVPH VGETPIAYRN VLLRKNGNKG AGGHSYGIDL KSYDLGDELG
160 170 180 190 200
TDPIEDYEQN WNTKHGSGAL RELTRELNGG AVTRYVDNNF CGPDGYPLDC
210 220 230 240 250
IKDFLARAGK SMCTLSEQLD YIESKRGVYC CRDHEHEIAW FTERSDKSYE
260 270 280 290 300
HQTPFEIKSA KKFDTFKGEC PKFVFPLNSK VKVIQPRVEK KKTEGFMGRI
310 320 330 340 350
RSVYPVASPQ ECNNMHLSTL MKCNHCDEVS WQTCDFLKAT CEHCGTENLV
360 370 380 390 400
IEGPTTCGYL PTNAVVKMPC PACQDPEIGP EHSVADYHNH SNIETRLRKG
410 420 430 440 450
GRTRCFGGCV FAYVGCYNKR AYWVPRASAD IGSGHTGITG DNVETLNEDL
460 470 480 490 500
LEILSRERVN INIVGDFHLN EEVAIILASF SASTSAFIDT IKSLDYKSFK
510 520 530 540 550
TIVESCGNYK VTKGKPVKGA WNIGQQRSVL TPLCGFPSQA AGVIRSIFAR
560 570 580 590 600
TLDAANHSIP DLQRAAVTIL DGISEQSLRL VDAMVYTSDL LTNSVIIMAY
610 620 630 640 650
VTGGLVQQTS QWLSNLLGTT VEKLRPIFEW IEAKLSAGVE FLKDAWEILK
660 670 680 690 700
FLITGVFDIV KGQIQVASDN IKDCVKCFID VVNKALEMCI DQVTIAGAKL
710 720 730 740 750
RSLNLGEVFI AQSKGLYRQC IRGKEQLQLL MPLKAPKEVT FLEGDSHDTV
760 770 780 790 800
LTSEEVVLKN GELEALETPV DSFTNGAIVG TPVCVNGLML LEIKDKEQYC
810 820 830 840 850
ALSPGLLATN NVFRLKGGAP IKGVTFGEDT VWEVQGYKNV RITFELDERV
860 870 880 890 900
DKVLNEKCSV YTVESGTEVT EFACVVAEAV VKTLQPVSDL LTNMGIDLDE
910 920 930 940 950
WSVATFYLFD DAGEENFSSR MYCSFYPPDE EEEDDAECEE EEIDETCEHE
960 970 980 990 1000
YGTEDDYQGL PLEFGASAET VRVEEEEEED WLDDTTEQSE IEPEPEPTPE
1010 1020 1030 1040 1050
EPVNQFTGYL KLTDNVAIKC VDIVKEAQSA NPMVIVNAAN IHLKHGGGVA
1060 1070 1080 1090 1100
GALNKATNGA MQKESDDYIK LNGPLTVGGS CLLSGHNLAK KCLHVVGPNL
1110 1120 1130 1140 1150
NAGEDIQLLK AAYENFNSQD ILLAPLLSAG IFGAKPLQSL QVCVQTVRTQ
1160 1170 1180 1190 1200
VYIAVNDKAL YEQVVMDYLD NLKPRVEAPK QEEPPNTEDS KTEEKSVVQK
1210 1220 1230 1240 1250
PVDVKPKIKA CIDEVTTTLE ETKFLTNKLL LFADINGKLY HDSQNMLRGE
1260 1270 1280 1290 1300
DMSFLEKDAP YMVGDVITSG DITCVVIPSK KAGGTTEMLS RALKKVPVDE
1310 1320 1330 1340 1350
YITTYPGQGC AGYTLEEAKT ALKKCKSAFY VLPSEAPNAK EEILGTVSWN
1360 1370 1380 1390 1400
LREMLAHAEE TRKLMPICMD VRAIMATIQR KYKGIKIQEG IVDYGVRFFF
1410 1420 1430 1440 1450
YTSKEPVASI ITKLNSLNEP LVTMPIGYVT HGFNLEEAAR CMRSLKAPAV
1460 1470 1480 1490 1500
VSVSSPDAVT TYNGYLTSSS KTSEEHFVET VSLAGSYRDW SYSGQRTELG
1510 1520 1530 1540 1550
VEFLKRGDKI VYHTLESPVE FHLDGEVLSL DKLKSLLSLR EVKTIKVFTT
1560 1570 1580 1590 1600
VDNTNLHTQL VDMSMTYGQQ FGPTYLDGAD VTKIKPHVNH EGKTFFVLPS
1610 1620 1630 1640 1650
DDTLRSEAFE YYHTLDESFL GRYMSALNHT KKWKFPQVGG LTSIKWADNN
1660 1670 1680 1690 1700
CYLSSVLLAL QQLEVKFNAP ALQEAYYRAR AGDAANFCAL ILAYSNKTVG
1710 1720 1730 1740 1750
ELGDVRETMT HLLQHANLES AKRVLNVVCK HCGQKTTTLT GVEAVMYMGT
1760 1770 1780 1790 1800
LSYDNLKTGV SIPCVCGRDA TQYLVQQESS FVMMSAPPAE YKLQQGTFLC
1810 1820 1830 1840 1850
ANEYTGNYQC GHYTHITAKE TLYRIDGAHL TKMSEYKGPV TDVFYKETSY
1860 1870 1880 1890 1900
TTTIKPVSYK LDGVTYTEIE PKLDGYYKKD NAYYTEQPID LVPTQPLPNA
1910 1920 1930 1940 1950
SFDNFKLTCS NTKFADDLNQ MTGFTKPASR ELSVTFFPDL NGDVVAIDYR
1960 1970 1980 1990 2000
HYSASFKKGA KLLHKPIVWH INQATTKTTF KPNTWCLRCL WSTKPVDTSN
2010 2020 2030 2040 2050
SFEVLAVEDT QGMDNLACES QQPTSEEVVE NPTIQKEVIE CDVKTTEVVG
2060 2070 2080 2090 2100
NVILKPSDEG VKVTQELGHE DLMAAYVENT SITIKKPNEL SLALGLKTIA
2110 2120 2130 2140 2150
THGIAAINSV PWSKILAYVK PFLGQAAITT SNCAKRLAQR VFNNYMPYVF
2160 2170 2180 2190 2200
TLLFQLCTFT KSTNSRIRAS LPTTIAKNSV KSVAKLCLDA GINYVKSPKF
2210 2220 2230 2240 2250
SKLFTIAMWL LLLSICLGSL ICVTAAFGVL LSNFGAPSYC NGVRELYLNS
2260 2270 2280 2290 2300
SNVTTMDFCE GSFPCSICLS GLDSLDSYPA LETIQVTISS YKLDLTILGL
2310 2320 2330 2340 2350
AAEWVLAYML FTKFFYLLGL SAIMQVFFGY FASHFISNSW LMWFIISIVQ
2360 2370 2380 2390 2400
MAPVSAMVRM YIFFASFYYI WKSYVHIMDG CTSSTCMMCY KRNRATRVEC
2410 2420 2430 2440 2450
TTIVNGMKRS FYVYANGGRG FCKTHNWNCL NCDTFCTGST FISDEVARDL
2460 2470 2480 2490 2500
SLQFKRPINP TDQSSYIVDS VAVKNGALHL YFDKAGQKTY ERHPLSHFVN
2510 2520 2530 2540 2550
LDNLRANNTK GSLPINVIVF DGKSKCDESA SKSASVYYSQ LMCQPILLLD
2560 2570 2580 2590 2600
QALVSDVGDS TEVSVKMFDA YVDTFSATFS VPMEKLKALV ATAHSELAKG
2610 2620 2630 2640 2650
VALDGVLSTF VSAARQGVVD TDVDTKDVIE CLKLSHHSDL EVTGDSCNNF
2660 2670 2680 2690 2700
MLTYNKVENM TPRDLGACID CNARHINAQV AKSHNVSLIW NVKDYMSLSE
2710 2720 2730 2740 2750
QLRKQIRSAA KKNNIPFRLT CATTRQVVNV ITTKISLKGG KIVSTCFKLM
2760 2770 2780 2790 2800
LKATLLCVLA ALVCYIVMPV HTLSIHDGYT NEIIGYKAIQ DGVTRDIIST
2810 2820 2830 2840 2850
DDCFANKHAG FDAWFSQRGG SYKNDKSCPV VAAIITREIG FIVPGLPGTV
2860 2870 2880 2890 2900
LRAINGDFLH FLPRVFSAVG NICYTPSKLI EYSDFATSAC VLAAECTIFK
2910 2920 2930 2940 2950
DAMGKPVPYC YDTNLLEGSI SYSELRPDTR YVLMDGSIIQ FPNTYLEGSV
2960 2970 2980 2990 3000
RVVTTFDAEY CRHGTCERSE VGICLSTSGR WVLNNEHYRA LSGVFCGVDA
3010 3020 3030 3040 3050
MNLIANIFTP LVQPVGALDV SASVVAGGII AILVTCAAYY FMKFRRVFGE
3060 3070 3080 3090 3100
YNHVVAANAL LFLMSFTILC LVPAYSFLPG VYSVFYLYLT FYFTNDVSFL
3110 3120 3130 3140 3150
AHLQWFAMFS PIVPFWITAI YVFCISLKHC HWFFNNYLRK RVMFNGVTFS
3160 3170 3180 3190 3200
TFEEAALCTF LLNKEMYLKL RSETLLPLTQ YNRYLALYNK YKYFSGALDT
3210 3220 3230 3240 3250
TSYREAACCH LAKALNDFSN SGADVLYQPP QTSITSAVLQ SGFRKMAFPS
3260 3270 3280 3290 3300
GKVEGCMVQV TCGTTTLNGL WLDDTVYCPR HVICTAEDML NPNYEDLLIR
3310 3320 3330 3340 3350
KSNHSFLVQA GNVQLRVIGH SMQNCLLRLK VDTSNPKTPK YKFVRIQPGQ
3360 3370 3380 3390 3400
TFSVLACYNG SPSGVYQCAM RPNHTIKGSF LNGSCGSVGF NIDYDCVSFC
3410 3420 3430 3440 3450
YMHHMELPTG VHAGTDLEGK FYGPFVDRQT AQAAGTDTTI TLNVLAWLYA
3460 3470 3480 3490 3500
AVINGDRWFL NRFTTTLNDF NLVAMKYNYE PLTQDHVDIL GPLSAQTGIA
3510 3520 3530 3540 3550
VLDMCAALKE LLQNGMNGRT ILGSTILEDE FTPFDVVRQC SGVTFQGKFK
3560 3570 3580 3590 3600
KIVKGTHHWM LLTFLTSLLI LVQSTQWSLF FFVYENAFLP FTLGIMAIAA
3610 3620 3630 3640 3650
CAMLLVKHKH AFLCLFLLPS LATVAYFNMV YMPASWVMRI MTWLELADTS
3660 3670 3680 3690 3700
LSGYRLKDCV MYASALVLLI LMTARTVYDD AARRVWTLMN VITLVYKVYY
3710 3720 3730 3740 3750
GNALDQAISM WALVISVTSN YSGVVTTIMF LARAIVFVCV EYYPLLFITG
3760 3770 3780 3790 3800
NTLQCIMLVY CFLGYCCCCY FGLFCLLNRY FRLTLGVYDY LVSTQEFRYM
3810 3820 3830 3840 3850
NSQGLLPPKS SIDAFKLNIK LLGIGGKPCI KVATVQSKMS DVKCTSVVLL
3860 3870 3880 3890 3900
SVLQQLRVES SSKLWAQCVQ LHNDILLAKD TTEAFEKMVS LLSVLLSMQG
3910 3920 3930 3940 3950
AVDINRLCEE MLDNRATLQA IASEFSSLPS YAAYATAQEA YEQAVANGDS
3960 3970 3980 3990 4000
EVVLKKLKKS LNVAKSEFDR DAAMQRKLEK MADQAMTQMY KQARSEDKRA
4010 4020 4030 4040 4050
KVTSAMQTML FTMLRKLDND ALNNIINNAR DGCVPLNIIP LTTAAKLMVV
4060 4070 4080 4090 4100
VPDYGTYKNT CDGNTFTYAS ALWEIQQVVD ADSKIVQLSE INMDNSPNLA
4110 4120 4130 4140 4150
WPLIVTALRA NSAVKLQNNE LSPVALRQMS CAAGTTQTAC TDDNALAYYN
4160 4170 4180 4190 4200
NSKGGRFVLA LLSDHQDLKW ARFPKSDGTG TIYTELEPPC RFVTDTPKGP
4210 4220 4230 4240 4250
KVKYLYFIKG LNNLNRGMVL GSLAATVRLQ AGNATEVPAN STVLSFCAFA
4260 4270 4280 4290 4300
VDPAKAYKDY LASGGQPITN CVKMLCTHTG TGQAITVTPE ANMDQESFGG
4310 4320 4330 4340 4350
ASCCLYCRCH IDHPNPKGFC DLKGKYVQIP TTCANDPVGF TLRNTVCTVC
4360 4370 4380
GMWKGYGCSC DQLREPLMQS ADASTFLNGF AV
Note: Produced by conventional translation.
Length:4,382
Mass (Da):486,373
Last modified:June 10, 2008 - v1
Checksum:iE1F65D5FD5DFF828
GO
Isoform Replicase polyprotein 1ab (identifier: P0C6X7-1) [UniParc]FASTAAdd to basket
Also known as: pp1ab
The sequence of this isoform can be found in the external entry P0C6X7.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Produced by -1 ribosomal frameshifting at the 1a-1b genes boundary.
Length:7,073
Mass (Da):790,248
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti82G → C in strain: Isolate GD01. 1
Natural varianti130G → R in strain: Isolate GD01. 1
Natural varianti138I → T in strain: Isolate SZ16. 1
Natural varianti181A → V in strain: Isolate Shanghai LY. 1
Natural varianti225K → Q in strain: Isolate GD01. 1
Natural varianti249Y → C in strain: Isolate Shanghai LY. 1
Natural varianti306V → F in strain: Isolate BJ04. 1
Natural varianti549A → S in strain: Isolate SZ3. 1
Natural varianti765A → T in strain: Isolate FRA and Isolate Frankfurt-1. 1
Natural varianti852K → R in strain: Isolate SZ16. 1
Natural varianti1004N → H in strain: Isolate BJ03. 1
Natural varianti1021V → A in strain: Isolate SZ3 and Isolate SZ16. 1
Natural varianti1023I → T in strain: Isolate Shanghai QXC1. 1
Natural varianti1121I → T in strain: Isolate GD01, Isolate SZ3 and Isolate SZ16. 1
Natural varianti1136P → L in strain: Isolate SZ3 and Isolate SZ16. 1
Natural varianti1257K → E in strain: Isolate Shanghai QXC1. 1
Natural varianti1319K → R in strain: Isolate GD01. 1
Natural varianti1329F → S in strain: Isolate GD01. 1
Natural varianti1361T → A in strain: Isolate Shanghai QXC1. 1
Natural varianti1385I → V in strain: Isolate Shanghai QXC1. 1
Natural varianti1538S → T in strain: Isolate GD01. 1
Natural varianti1563M → K in strain: Isolate BJ02. 1
Natural varianti1663L → I in strain: Isolate SZ3 and Isolate SZ16. 1
Natural varianti1762I → L in strain: Isolate BJ03. 1
Natural varianti1776 – 1777QQ → PP in strain: Isolate BJ03. 2
Natural varianti1790E → G in strain: Isolate Shanghai QXC1. 1
Natural varianti1806G → V in strain: Isolate BJ02. 1
Natural varianti1962L → I in strain: Isolate BJ04. 1
Natural varianti2116L → F in strain: Isolate GD01, Isolate SZ3 and Isolate SZ16. 1
Natural varianti2222C → Y in strain: Isolate GD01, Isolate SZ3 and Isolate SZ16. 1
Natural varianti2269L → S in strain: Isolate SZ3 and Isolate SZ16. 1
Natural varianti2326V → A in strain: Isolate Shanghai QXC1. 1
Natural varianti2392 – 2394RNR → CNH in strain: Isolate Shanghai QXC1. 3
Natural varianti2480L → P in strain: Isolate Shanghai QXC1. 1
Natural varianti2552A → V in strain: Isolate Urbani and Isolate Taiwan TC2. 1
Natural varianti2556D → N in strain: Isolate HKU-39849. 1
Natural varianti2564S → P in strain: Isolate GD01. 1
Natural varianti2648N → Y in strain: Isolate Shanghai QXC1. 1
Natural varianti2708S → T in strain: Isolate HKU-39849. 1
Natural varianti2718R → T in strain: Isolate HKU-39849. 1
Natural varianti2746C → W in strain: Isolate SZ3 and Isolate SZ16. 1
Natural varianti2770V → L in strain: Isolate BJ01 and Isolate BJ02. 1
Natural varianti2944T → I in strain: Isolate SIN2500, Isolate GD01 and Isolate GZ50. 1
Natural varianti2971V → A in strain: Isolate GD01 and Isolate SZ16. 1
Natural varianti3020V → A in strain: Isolate Shanghai QXC1. 1
Natural varianti3047V → A in strain: Isolate CUHK-W1, Isolate GD01, Isolate SZ3, Isolate SZ16, Isolate BJ01, Isolate BJ02, Isolate BJ03 and Isolate Shanghai QXC1. 1
Natural varianti3072V → A in strain: Isolate CUHK-W1, Isolate SZ3, Isolate SZ16 and Isolate GD01. 1
Natural varianti3197A → V in strain: Isolate BJ01, Isolate BJ02, Isolate BJ03, Isolate BJ04 and Isolate Shanghai QXC1. 1
Natural varianti3429Q → P in strain: Isolate BJ02. 1
Natural varianti3488D → E in strain: Isolate BJ04. 1
Natural varianti3717V → A in strain: Isolate Shanghai QXC1. 1
Natural varianti3818N → T in strain: Isolate BJ04. 1
Natural varianti3903D → N in strain: Isolate BJ03. 1
Natural varianti3904I → F in strain: Isolate BJ02. 1
Natural varianti3911M → V in strain: Isolate Shanghai QXC1. 1
Natural varianti4001K → Q in strain: Isolate Shanghai LY. 1
Natural varianti4003T → A in strain: Isolate Shanghai LY. 1
Natural varianti4085I → H in strain: Isolate ZJ01. 1
Natural varianti4114V → A in strain: Isolate Shanghai QXC1. 1
Natural varianti4202V → M in strain: Isolate Shanghai QXC1. 1
Natural varianti4240N → H in strain: Isolate ZJ01. 1
Natural varianti4296E → G in strain: Isolate Shanghai QXC1. 1
Natural varianti4377 – 4378LN → FK in strain: Isolate Shanghai QXC1. 2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY278741 Genomic RNA. Translation: AAP13439.1.
AY274119 Genomic RNA. No translation available.
AY278554 Genomic RNA. Translation: AAP13575.1.
AY282752 Genomic RNA. Translation: AAP30712.1.
AY304495 Genomic RNA. No translation available.
AY304486 Genomic RNA. No translation available.
AY304488 Genomic RNA. No translation available.
AY278491 Genomic RNA. No translation available.
AY283794 Genomic RNA. No translation available.
AY283795 Genomic RNA. No translation available.
AY283796 Genomic RNA. No translation available.
AY283797 Genomic RNA. No translation available.
AY283798 Genomic RNA. No translation available.
AY286320 Genomic RNA. Translation: AAR16181.1.
AY278488 Genomic RNA. Translation: AAP30029.1.
AY278490 Genomic RNA. No translation available.
AY279354 Genomic RNA. No translation available.
AY278489 Genomic RNA. Translation: AAP51226.1.
AY291451 Genomic RNA. Translation: AAP37016.1.
AY310120 Genomic RNA. Translation: AAP50484.1.
AY291315 Genomic RNA. Translation: AAP33695.1.
AY323977 Genomic RNA. Translation: AAP72974.2.
AY321118 Genomic RNA. No translation available.
AY338174 Genomic RNA. Translation: AAQ01595.1.
AY338175 Genomic RNA. Translation: AAQ01607.1.
AY348314 Genomic RNA. Translation: AAP97880.1.
AP006557 Genomic RNA. Translation: BAC81347.1.
AP006558 Genomic RNA. Translation: BAC81361.1.
AP006559 Genomic RNA. Translation: BAC81375.1.
AP006560 Genomic RNA. Translation: BAC81389.1.
AP006561 Genomic RNA. Translation: BAC81403.1.
AY427439 Genomic RNA. Translation: AAQ94059.1.
AY322205 Genomic RNA. Translation: AAP82966.1.
AY322206 Genomic RNA. Translation: AAP82976.1.
AY463059 Genomic RNA. No translation available.
RefSeqiNP_828850.1. NC_004718.3. [P0C6U8-1]

Genome annotation databases

GeneIDi1489680.

Keywords - Coding sequence diversityi

Ribosomal frameshifting

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY278741 Genomic RNA. Translation: AAP13439.1.
AY274119 Genomic RNA. No translation available.
AY278554 Genomic RNA. Translation: AAP13575.1.
AY282752 Genomic RNA. Translation: AAP30712.1.
AY304495 Genomic RNA. No translation available.
AY304486 Genomic RNA. No translation available.
AY304488 Genomic RNA. No translation available.
AY278491 Genomic RNA. No translation available.
AY283794 Genomic RNA. No translation available.
AY283795 Genomic RNA. No translation available.
AY283796 Genomic RNA. No translation available.
AY283797 Genomic RNA. No translation available.
AY283798 Genomic RNA. No translation available.
AY286320 Genomic RNA. Translation: AAR16181.1.
AY278488 Genomic RNA. Translation: AAP30029.1.
AY278490 Genomic RNA. No translation available.
AY279354 Genomic RNA. No translation available.
AY278489 Genomic RNA. Translation: AAP51226.1.
AY291451 Genomic RNA. Translation: AAP37016.1.
AY310120 Genomic RNA. Translation: AAP50484.1.
AY291315 Genomic RNA. Translation: AAP33695.1.
AY323977 Genomic RNA. Translation: AAP72974.2.
AY321118 Genomic RNA. No translation available.
AY338174 Genomic RNA. Translation: AAQ01595.1.
AY338175 Genomic RNA. Translation: AAQ01607.1.
AY348314 Genomic RNA. Translation: AAP97880.1.
AP006557 Genomic RNA. Translation: BAC81347.1.
AP006558 Genomic RNA. Translation: BAC81361.1.
AP006559 Genomic RNA. Translation: BAC81375.1.
AP006560 Genomic RNA. Translation: BAC81389.1.
AP006561 Genomic RNA. Translation: BAC81403.1.
AY427439 Genomic RNA. Translation: AAQ94059.1.
AY322205 Genomic RNA. Translation: AAP82966.1.
AY322206 Genomic RNA. Translation: AAP82976.1.
AY463059 Genomic RNA. No translation available.
RefSeqiNP_828850.1. NC_004718.3. [P0C6U8-1]

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1P76model-A3241-3541[»]
B4225-4231[»]
1P9Tmodel-A3241-3544[»]
1PA5model-A3241-3546[»]
1PUKmodel-A3241-3550[»]
1Q1Xmodel-A3241-3542[»]
1Q2WX-ray1.86A/B3241-3544[»]
1QZ8X-ray2.70A/B4118-4230[»]
1UJ1X-ray1.90A/B3241-3546[»]
1UK2X-ray2.20A/B3241-3546[»]
1UK3X-ray2.40A/B3241-3546[»]
1UK4X-ray2.50A/B3241-3546[»]
1UW7X-ray2.80A4118-4230[»]
1WOFX-ray2.00A/B3241-3546[»]
1YSYNMR-A3837-3919[»]
1Z1IX-ray2.80A3241-3546[»]
1Z1JX-ray2.80A/B3241-3546[»]
2A5AX-ray2.08A3241-3546[»]
2A5IX-ray1.88A3241-3546[»]
2A5KX-ray2.30A/B3241-3546[»]
2ACFX-ray1.40A/B/C/D1002-1176[»]
2AHMX-ray2.40A/B/C/D3837-3919[»]
E/F/G/H3920-4117[»]
2AJ5model-A3241-3546[»]
2ALVX-ray1.90A3241-3543[»]
2AMDX-ray1.85A/B3241-3546[»]
2AMQX-ray2.30A/B3241-3546[»]
2BX3X-ray2.00A3241-3546[»]
2BX4X-ray2.79A3241-3546[»]
2C3SX-ray1.90A3241-3546[»]
2D2DX-ray2.70A/B3241-3546[»]
2DUCX-ray1.70A/B3241-3546[»]
2FAVX-ray1.80A/B/C1000-1173[»]
2FE8X-ray1.85A/B/C1541-1854[»]
2FYGX-ray1.80A4240-4362[»]
2G9TX-ray2.10A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X4231-4382[»]
2GA6X-ray2.70A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X4231-4382[»]
2GDTNMR-A13-127[»]
2GRINMR-A819-930[»]
2GT7X-ray1.82A/B3241-3546[»]
2GT8X-ray2.00A3241-3546[»]
2GTBX-ray2.00A3241-3546[»]
2GX4X-ray1.93A3241-3546[»]
2GZ7X-ray1.86A3241-3546[»]
2GZ8X-ray1.97A3241-3546[»]
2GZ9X-ray2.17A3241-3546[»]
2H2ZX-ray1.60A3241-3546[»]
2HOBX-ray1.95A3241-3546[»]
2HSXNMR-A13-127[»]
2IDYNMR-A819-930[»]
2KAFNMR-A1473-1538[»]
2KQVNMR-A1345-1538[»]
2KQWNMR-A1345-1538[»]
2KYSNMR-A3837-3919[»]
2LIZNMR-A3427-3546[»]
2OP9X-ray1.80A/B3241-3541[»]
2PWXX-ray2.50A3241-3546[»]
2W2GX-ray2.22A/B1207-1470[»]
2WCTX-ray2.79A/B/C/D1207-1470[»]
2Z3CX-ray1.79A3241-3546[»]
2Z3DX-ray2.10A3241-3546[»]
2Z3EX-ray2.32A3241-3546[»]
2ZU4X-ray1.93A3241-3546[»]
2ZU5X-ray1.65A3241-3546[»]
3ATWX-ray2.36A/B3241-3546[»]
3AVZX-ray2.46A3241-3546[»]
3AW0X-ray2.30A3241-3546[»]
3AW1X-ray2.00A/B3241-3546[»]
3E91X-ray2.55A/B3241-3546[»]
3EA7X-ray2.65A/B3241-3546[»]
3EA8X-ray2.25A3241-3546[»]
3EA9X-ray2.40A3241-3546[»]
3EAJX-ray2.70A/B3241-3546[»]
3EE7X-ray2.60A/B/C/D4118-4230[»]
3F9EX-ray2.50A3241-3546[»]
3F9FX-ray2.30A/B3241-3546[»]
3F9GX-ray2.60A/B3241-3541[»]
3F9HX-ray2.90A/B3241-3546[»]
3FZDX-ray2.35A3241-3541[»]
3IWMX-ray3.20A/B/C/D3241-3546[»]
3M3SX-ray2.30A/B3241-3546[»]
3M3TX-ray2.90A3241-3546[»]
3M3VX-ray2.70A/B3241-3546[»]
3MJ5X-ray2.63A/B1541-1855[»]
3R24X-ray2.00B4240-4382[»]
3SN8X-ray1.99A3241-3546[»]
3SNAX-ray3.05A3241-3541[»]
3SNBX-ray2.40A3241-3546[»]
3SNCX-ray2.58A3241-3546[»]
3SNDX-ray1.89A/B3241-3546[»]
3SNEX-ray2.60A3241-3546[»]
3SZNX-ray1.69A3241-3546[»]
3TITX-ray1.99A3241-3546[»]
3TIUX-ray2.08A3241-3546[»]
3TNSX-ray1.99A3241-3546[»]
3TNTX-ray1.59A3241-3546[»]
3V3MX-ray1.96A3241-3546[»]
3VB3X-ray2.20A/B3241-3546[»]
3VB4X-ray2.20A/B3241-3546[»]
3VB5X-ray1.95A/B3241-3546[»]
3VB6X-ray2.50A/B3241-3546[»]
3VB7X-ray1.95A/B3241-3546[»]
4HI3X-ray2.09A/B3241-3546[»]
4M0WX-ray1.40A1541-1858[»]
4MDSX-ray1.60A3241-3542[»]
4MM3X-ray2.75B1541-1855[»]
4OVZX-ray2.50A/B1541-1855[»]
4OW0X-ray2.10A/B1541-1855[»]
5F22X-ray2.15A3837-3919[»]
ProteinModelPortaliP0C6U8.
SMRiP0C6U8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-48580N.

Chemistry databases

BindingDBiP0C6U8.
ChEMBLiCHEMBL3927.

Protein family/group databases

MEROPSiC16.009.

Proteomic databases

PRIDEiP0C6U8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1489680.

Enzyme and pathway databases

BRENDAi3.4.22.69. 7599.

Miscellaneous databases

EvolutionaryTraceiP0C6U8.

Family and domain databases

InterProiIPR032505. Corona_NSP4_C.
IPR002589. Macro_dom.
IPR032592. NAR_dom.
IPR021590. NSP1.
IPR024375. Nsp3_coronavir.
IPR014828. NSP7.
IPR014829. NSP8.
IPR014822. NSP9.
IPR008740. Peptidase_C30.
IPR013016. Peptidase_C30/C16.
IPR009003. Peptidase_S1_PA.
IPR018995. RNA_synth_NSP10_coronavirus.
IPR024358. SARS-CoV_Nsp3_N.
IPR022733. SARS_polyprot_cleavage.
IPR014827. Viral_protease.
[Graphical view]
PfamiPF16348. Corona_NSP4_C. 1 hit.
PF12379. DUF3655. 1 hit.
PF01661. Macro. 1 hit.
PF16251. NAR. 1 hit.
PF11501. Nsp1. 1 hit.
PF09401. NSP10. 1 hit.
PF12124. Nsp3_PL2pro. 1 hit.
PF08716. nsp7. 1 hit.
PF08717. nsp8. 1 hit.
PF08710. nsp9. 1 hit.
PF05409. Peptidase_C30. 1 hit.
PF11633. SUD-M. 1 hit.
PF08715. Viral_protease. 1 hit.
[Graphical view]
SMARTiSM00506. A1pp. 1 hit.
[Graphical view]
SUPFAMiSSF101816. SSF101816. 1 hit.
SSF144246. SSF144246. 1 hit.
SSF50494. SSF50494. 1 hit.
PROSITEiPS51442. M_PRO. 1 hit.
PS51154. MACRO. 1 hit.
PS51124. PEPTIDASE_C16. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiR1A_CVHSA
AccessioniPrimary (citable) accession number: P0C6U8
Secondary accession number(s): P59641
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: November 2, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Caution

Isolates SZ3 and SZ16 have been isolated from Paguma larvata and are described as SARS-like in literature.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.