##gff-version 3 P0C6U5 UniProtKB Chain 1 4421 . . . ID=PRO_0000338218;Note=Replicase polyprotein 1a P0C6U5 UniProtKB Chain 1 222 . . . ID=PRO_0000338219;Note=Non-structural protein 1;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U5 UniProtKB Chain 223 809 . . . ID=PRO_0000338220;Note=Non-structural protein 2;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U5 UniProtKB Chain 810 2788 . . . ID=PRO_0000338221;Note=Papain-like protease nsp3;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U5 UniProtKB Chain 2789 3284 . . . ID=PRO_0000338222;Note=Non-structural protein 4;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U5 UniProtKB Chain 3285 3587 . . . ID=PRO_0000338223;Note=3C-like proteinase nsp5;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U5 UniProtKB Chain 3588 3874 . . . ID=PRO_0000338224;Note=Non-structural protein 6;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U5 UniProtKB Chain 3875 3966 . . . ID=PRO_0000338225;Note=Non-structural protein 7;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U5 UniProtKB Chain 3967 4160 . . . ID=PRO_0000338226;Note=Non-structural protein 8;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U5 UniProtKB Chain 4161 4270 . . . ID=PRO_0000338227;Note=RNA-capping enzyme subunit nsp9;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U5 UniProtKB Chain 4271 4407 . . . ID=PRO_0000338228;Note=Non-structural protein 10;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U5 UniProtKB Chain 4408 4421 . . . ID=PRO_0000338229;Note=Non-structural protein 11;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6U5 UniProtKB Transmembrane 2176 2196 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6U5 UniProtKB Transmembrane 2237 2257 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6U5 UniProtKB Transmembrane 2268 2288 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6U5 UniProtKB Transmembrane 2351 2371 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6U5 UniProtKB Transmembrane 2393 2413 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6U5 UniProtKB Transmembrane 2794 2814 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6U5 UniProtKB Transmembrane 3069 3089 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6U5 UniProtKB Transmembrane 3101 3121 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6U5 UniProtKB Transmembrane 3128 3148 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6U5 UniProtKB Transmembrane 3153 3173 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6U5 UniProtKB Transmembrane 3601 3621 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6U5 UniProtKB Transmembrane 3626 3646 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6U5 UniProtKB Transmembrane 3651 3671 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6U5 UniProtKB Transmembrane 3694 3714 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6U5 UniProtKB Transmembrane 3722 3742 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6U5 UniProtKB Transmembrane 3750 3770 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6U5 UniProtKB Transmembrane 3793 3813 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6U5 UniProtKB Domain 54 174 . . . Note=CoV Nsp1 globular;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01307 P0C6U5 UniProtKB Domain 192 222 . . . Note=BetaCoV Nsp1 C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01308 P0C6U5 UniProtKB Domain 226 488 . . . Note=CoV Nsp2 N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01333 P0C6U5 UniProtKB Domain 493 681 . . . Note=CoV Nsp2 middle;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01334 P0C6U5 UniProtKB Domain 697 809 . . . Note=CoV Nsp2 C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01335 P0C6U5 UniProtKB Domain 811 923 . . . Note=Ubiquitin-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00214 P0C6U5 UniProtKB Repeat 945 954 . . . Note=1 P0C6U5 UniProtKB Repeat 955 964 . . . Note=2 P0C6U5 UniProtKB Repeat 965 974 . . . Note=3 P0C6U5 UniProtKB Repeat 975 984 . . . Note=4 P0C6U5 UniProtKB Repeat 985 994 . . . Note=5 P0C6U5 UniProtKB Repeat 995 1004 . . . Note=6 P0C6U5 UniProtKB Repeat 1005 1014 . . . Note=7 P0C6U5 UniProtKB Repeat 1015 1024 . . . Note=8 P0C6U5 UniProtKB Repeat 1025 1034 . . . Note=9 P0C6U5 UniProtKB Domain 1073 1323 . . . Note=Peptidase C16 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6U5 UniProtKB Domain 1301 1472 . . . Note=Macro;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00490 P0C6U5 UniProtKB Domain 1528 1599 . . . Note=DPUP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01289 P0C6U5 UniProtKB Domain 1599 1654 . . . Note=Ubiquitin-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00214 P0C6U5 UniProtKB Domain 1668 1928 . . . Note=Peptidase C16 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6U5 UniProtKB Domain 1942 2043 . . . Note=Nucleic acid-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01290 P0C6U5 UniProtKB Domain 2058 2207 . . . Note=G2M;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01338 P0C6U5 UniProtKB Domain 2273 2334 . . . Note=3Ecto;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01337 P0C6U5 UniProtKB Domain 2421 2788 . . . Note=CoV Nsp3 Y;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6U5 UniProtKB Domain 3187 3284 . . . Note=Nsp4C;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01291 P0C6U5 UniProtKB Domain 3285 3587 . . . Note=Peptidase C30;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00772 P0C6U5 UniProtKB Domain 3875 3963 . . . Note=RdRp Nsp7 cofactor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01294 P0C6U5 UniProtKB Domain 3964 4160 . . . Note=RdRp Nsp8 cofactor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01295 P0C6U5 UniProtKB Domain 4161 4270 . . . Note=Nsp9 ssRNA-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01296 P0C6U5 UniProtKB Domain 4271 4408 . . . Note=ExoN/MTase coactivator;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6U5 UniProtKB Zinc finger 1188 1216 . . . Note=C4-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6U5 UniProtKB Zinc finger 1785 1821 . . . Note=C4-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6U5 UniProtKB Zinc finger 4344 4360 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U5 UniProtKB Zinc finger 4386 4399 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U5 UniProtKB Region 365 389 . . . Note=C4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01333 P0C6U5 UniProtKB Region 945 1034 . . . Note=9 X 10 AA tandem repeat of N-[DN]-D-E-D-V-V-T-G-D P0C6U5 UniProtKB Region 947 1042 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P0C6U5 UniProtKB Region 2176 2413 . . . Note=HD1;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U5 UniProtKB Region 2421 2511 . . . Note=Y1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6U5 UniProtKB Region 2425 2438 . . . Note=ZF1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6U5 UniProtKB Region 2471 2481 . . . Note=ZF2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6U5 UniProtKB Region 2512 2788 . . . Note=CoV-Y;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6U5 UniProtKB Region 2512 2604 . . . Note=Y2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6U5 UniProtKB Region 2605 2687 . . . Note=Y3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6U5 UniProtKB Region 2688 2788 . . . Note=Y4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6U5 UniProtKB Region 2794 3173 . . . Note=HD2;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U5 UniProtKB Region 3601 3813 . . . Note=HD3;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U5 UniProtKB Active site 1111 1111 . . . Note=For PL1-PRO activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6U5 UniProtKB Active site 1262 1262 . . . Note=For PL1-PRO activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6U5 UniProtKB Active site 1273 1273 . . . Note=For PL1-PRO activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6U5 UniProtKB Active site 1707 1707 . . . Note=For PL2-PRO activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6U5 UniProtKB Active site 1864 1864 . . . Note=For PL2-PRO activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6U5 UniProtKB Active site 1878 1878 . . . Note=For PL2-PRO activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6U5 UniProtKB Active site 3325 3325 . . . Note=For 3CL-PRO activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00772 P0C6U5 UniProtKB Active site 3429 3429 . . . Note=For 3CL-PRO activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00772 P0C6U5 UniProtKB Binding site 365 365 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01333 P0C6U5 UniProtKB Binding site 370 370 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01333 P0C6U5 UniProtKB Binding site 386 386 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01333 P0C6U5 UniProtKB Binding site 389 389 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01333 P0C6U5 UniProtKB Binding site 1188 1188 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6U5 UniProtKB Binding site 1191 1191 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6U5 UniProtKB Binding site 1214 1214 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6U5 UniProtKB Binding site 1216 1216 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6U5 UniProtKB Binding site 1785 1785 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6U5 UniProtKB Binding site 1787 1787 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6U5 UniProtKB Binding site 1819 1819 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6U5 UniProtKB Binding site 1821 1821 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6U5 UniProtKB Binding site 2425 2425 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6U5 UniProtKB Binding site 2430 2430 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6U5 UniProtKB Binding site 2435 2435 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6U5 UniProtKB Binding site 2438 2438 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6U5 UniProtKB Binding site 2471 2471 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6U5 UniProtKB Binding site 2474 2474 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6U5 UniProtKB Binding site 2478 2478 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6U5 UniProtKB Binding site 2481 2481 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6U5 UniProtKB Binding site 4344 4344 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6U5 UniProtKB Binding site 4347 4347 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6U5 UniProtKB Binding site 4353 4353 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6U5 UniProtKB Binding site 4360 4360 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6U5 UniProtKB Binding site 4386 4386 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6U5 UniProtKB Binding site 4389 4389 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6U5 UniProtKB Binding site 4397 4397 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6U5 UniProtKB Binding site 4399 4399 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6U5 UniProtKB Site 222 223 . . . Note=Cleavage%3B by PL1-PRO;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U5 UniProtKB Site 809 810 . . . Note=Cleavage%3B by PL1-PRO;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U5 UniProtKB Site 2788 2789 . . . Note=Cleavage%3B by PL2-PRO;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U5 UniProtKB Site 3284 3285 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U5 UniProtKB Site 3587 3588 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U5 UniProtKB Site 3874 3875 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U5 UniProtKB Site 3966 3967 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U5 UniProtKB Site 4160 4161 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U5 UniProtKB Site 4270 4271 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U5 UniProtKB Site 4407 4408 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U5 UniProtKB Disulfide bond 2289 2313 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01337 P0C6U5 UniProtKB Disulfide bond 2304 2310 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01337