Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P0C6U5 (R1A_CVHN5) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Replicase polyprotein 1a

Short name=pp1a
Alternative name(s):
ORF1a polyprotein

Cleaved into the following 11 chains:

  1. Non-structural protein 1
    Short name=nsp1
    Alternative name(s):
    p28
  2. Non-structural protein 2
    Short name=nsp2
    Alternative name(s):
    p65
  3. Non-structural protein 3
    Short name=nsp3
    EC=3.4.19.12
    EC=3.4.22.69
    Alternative name(s):
    PL1-PRO/PL2-PRO
    PL1/PL2
    Papain-like proteinases 1/2
    p210
  4. Non-structural protein 4
    Short name=nsp4
    Alternative name(s):
    Peptide HD2
    p44
  5. 3C-like proteinase
    Short name=3CL-PRO
    Short name=3CLp
    EC=3.4.22.-
    Alternative name(s):
    M-PRO
    nsp5
    p27
  6. Non-structural protein 6
    Short name=nsp6
  7. Non-structural protein 7
    Short name=nsp7
    Alternative name(s):
    p10
  8. Non-structural protein 8
    Short name=nsp8
    Alternative name(s):
    p22
  9. Non-structural protein 9
    Short name=nsp9
    Alternative name(s):
    p12
  10. Non-structural protein 10
    Short name=nsp10
    Alternative name(s):
    Growth factor-like peptide
    Short name=GFL
    p15
  11. Non-structural protein 11
    Short name=nsp11
Gene names
ORF Names:1a
OrganismHuman coronavirus HKU1 (isolate N5) (HCoV-HKU1) [Complete proteome]
Taxonomic identifier443241 [NCBI]
Taxonomic lineageVirusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeBetacoronavirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length4421 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

The papain-like proteinase 1 (PL1-PRO) and papain-like proteinase 2 (PL2-PRO) are responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PLP2 possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF-3 By similarity.

The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK. Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function By similarity.

Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter By similarity.

Nsp9 is a ssRNA-binding protein By similarity.

Non-structural protein 1: binds to the 40S ribosomal subunit and inhibits host translation. The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response By similarity.

Catalytic activity

TSAVLQ-|-SGFRK-NH2 and SGVTFQ-|-GKFKK the two peptides corresponding to the two self-cleavage sites of the SARS 3C-like proteinase are the two most reactive peptide substrates. The enzyme exhibits a strong preference for substrates containing Gln at P1 position and Leu at P2 position.

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subunit structure

3CL-PRO exists as monomer and homodimer. Eight copies of nsp7 and eight copies of nsp8 assemble to form a heterohexadecamer. Nsp9 is a dimer. Nsp10 forms a dodecamer By similarity.

Subcellular location

Non-structural protein 3: Host membrane; Multi-pass membrane protein Potential.

Non-structural protein 4: Host membrane; Multi-pass membrane protein Potential.

Non-structural protein 6: Host membrane; Multi-pass membrane protein Potential.

Non-structural protein 7: Host cytoplasmhost perinuclear region By similarity. Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes.

Non-structural protein 8: Host cytoplasmhost perinuclear region By similarity. Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes.

Non-structural protein 9: Host cytoplasmhost perinuclear region By similarity. Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes.

Non-structural protein 10: Host cytoplasmhost perinuclear region By similarity. Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes.

Domain

The hydrophobic domains (HD) could mediate the membrane association of the replication complex and thereby alter the architecture of the host cell membrane.

Post-translational modification

Specific enzymatic cleavages in vivo by its own proteases yield mature proteins. 3CL-PRO and PL-PRO proteinases are autocatalytically processed By similarity.

Miscellaneous

Isolate N5 belongs to genotype C. Genotype C probably arose from recombination between genotypes A and B.

Sequence similarities

Belongs to the coronaviruses polyprotein 1ab family.

Contains 1 Macro domain.

Contains 2 peptidase C16 domains.

Contains 1 peptidase C30 domain.

Ontologies

Keywords
   Biological processActivation of host autophagy by virus
Decay of host mRNAs by virus
Eukaryotic host gene expression shutoff by virus
Eukaryotic host translation shutoff by virus
Host gene expression shutoff by virus
Host mRNA suppression by virus
Host-virus interaction
Inhibition of host innate immune response by virus
Inhibition of host interferon signaling pathway by virus
Inhibition of host IRF3 by virus
Inhibition of host ISG15 by virus
Inhibition of host RLR pathway by virus
Modulation of host ubiquitin pathway by viral deubiquitinase
Modulation of host ubiquitin pathway by virus
Ubl conjugation pathway
Viral immunoevasion
   Cellular componentHost cytoplasm
Host membrane
Membrane
   Coding sequence diversityRibosomal frameshifting
   DomainRepeat
Transmembrane
Transmembrane helix
Zinc-finger
   LigandMetal-binding
RNA-binding
Zinc
   Molecular functionHydrolase
Protease
Thiol protease
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processinduction by virus of catabolism of host mRNA

Inferred from electronic annotation. Source: UniProtKB-KW

induction by virus of host autophagy

Inferred from electronic annotation. Source: UniProtKB-KW

modulation by virus of host protein ubiquitination

Inferred from electronic annotation. Source: UniProtKB-KW

suppression by virus of host IRF3 activity

Inferred from electronic annotation. Source: UniProtKB-KW

suppression by virus of host ISG15 activity

Inferred from electronic annotation. Source: UniProtKB-KW

suppression by virus of host translation

Inferred from electronic annotation. Source: UniProtKB-KW

suppression by virus of host type I interferon-mediated signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

viral genome replication

Inferred from electronic annotation. Source: InterPro

viral protein processing

Inferred from electronic annotation. Source: InterPro

   Cellular_componenthost cell membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

host cell perinuclear region of cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

RNA-directed RNA polymerase activity

Inferred from electronic annotation. Source: InterPro

cysteine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

omega peptidase activity

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by ribosomal frameshifting. [Align] [Select]
Isoform Replicase polyprotein 1a (identifier: P0C6U5-1)

Also known as: pp1a; ORF1a polyprotein;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: Produced by conventional translation.
Isoform Replicase polyprotein 1ab (identifier: P0C6X4-1)

Also known as: pp1ab;

The sequence of this isoform can be found in the external entry P0C6X4.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Produced by -1 ribosomal frameshifting at the 1a-1b genes boundary.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 44214421Replicase polyprotein 1a
PRO_0000338218
Chain1 – 222222Non-structural protein 1 By similarity
PRO_0000338219
Chain223 – 809587Non-structural protein 2 By similarity
PRO_0000338220
Chain810 – 27881979Non-structural protein 3 By similarity
PRO_0000338221
Chain2789 – 3284496Non-structural protein 4 By similarity
PRO_0000338222
Chain3285 – 35873033C-like proteinase By similarity
PRO_0000338223
Chain3588 – 3874287Non-structural protein 6 By similarity
PRO_0000338224
Chain3875 – 396692Non-structural protein 7 By similarity
PRO_0000338225
Chain3967 – 4160194Non-structural protein 8 By similarity
PRO_0000338226
Chain4161 – 4270110Non-structural protein 9 By similarity
PRO_0000338227
Chain4271 – 4407137Non-structural protein 10 By similarity
PRO_0000338228
Chain4408 – 442114Non-structural protein 11 Potential
PRO_0000338229

Regions

Transmembrane2176 – 219621Helical; Potential
Transmembrane2237 – 225721Helical; Potential
Transmembrane2268 – 228821Helical; Potential
Transmembrane2351 – 237121Helical; Potential
Transmembrane2393 – 241321Helical; Potential
Transmembrane2794 – 281421Helical; Potential
Transmembrane3069 – 308921Helical; Potential
Transmembrane3101 – 312121Helical; Potential
Transmembrane3128 – 314821Helical; Potential
Transmembrane3153 – 317321Helical; Potential
Transmembrane3601 – 362121Helical; Potential
Transmembrane3626 – 364621Helical; Potential
Transmembrane3651 – 367121Helical; Potential
Transmembrane3694 – 371421Helical; Potential
Transmembrane3722 – 374221Helical; Potential
Transmembrane3750 – 377021Helical; Potential
Transmembrane3793 – 381321Helical; Potential
Repeat945 – 954101
Repeat955 – 964102
Repeat965 – 974103
Repeat975 – 984104
Repeat985 – 994105
Repeat995 – 1004106
Repeat1005 – 1014107
Repeat1015 – 1024108
Repeat1025 – 1034109
Domain1073 – 1323251Peptidase C16 1
Domain1301 – 1472172Macro
Domain1668 – 1928261Peptidase C16 2
Domain3285 – 3587303Peptidase C30
Zinc finger1188 – 121629C4-type 1 By similarity
Zinc finger1785 – 182137C4-type 2 By similarity
Zinc finger4344 – 436017 By similarity
Zinc finger4386 – 439914 By similarity
Region945 – 1034909 X 10 AA tandem repeat of N-[DN]-D-E-D-V-V-T-G-D
Region2176 – 2413238HD1 By similarity
Region2794 – 3173380HD2 By similarity
Region3601 – 3813213HD3 By similarity
Compositional bias934 – 1066133Asp-rich
Compositional bias2179 – 227193Phe-rich
Compositional bias2566 – 25694Poly-Val

Sites

Active site11111For PL1-PRO activity By similarity
Active site12621For PL1-PRO activity By similarity
Active site17071For PL2-PRO activity By similarity
Active site18641For PL2-PRO activity By similarity
Active site33251For 3CL-PRO activity By similarity
Active site34291For 3CL-PRO activity By similarity
Site222 – 2232Cleavage; by PL1-PRO By similarity
Site809 – 8102Cleavage; by PL1-PRO By similarity
Site2788 – 27892Cleavage; by PL2-PRO By similarity
Site3284 – 32852Cleavage; by 3CL-PRO By similarity
Site3587 – 35882Cleavage; by 3CL-PRO By similarity
Site3874 – 38752Cleavage; by 3CL-PRO By similarity
Site3966 – 39672Cleavage; by 3CL-PRO By similarity
Site4160 – 41612Cleavage; by 3CL-PRO By similarity
Site4270 – 42712Cleavage; by 3CL-PRO By similarity
Site4407 – 44082Cleavage; by 3CL-PRO By similarity

Sequences

Sequence LengthMass (Da)Tools
Isoform Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: 19FFC89AAA1E43AB

FASTA4,421497,400
        10         20         30         40         50         60 
MIKTSKYGLG FKWAPEFRWL LPDAAEELAS PMKSDEGGLC PSTGQAMESV GFVYDNHVKI 

        70         80         90        100        110        120 
DCRCILGQEW HVQSNLIRDI FVHEDLHVVE VLTKTAVKSG TAILIKSPLH SLGGFPKGYV 

       130        140        150        160        170        180 
MGLFRSYKTK RYVVHHLSMT TSTTNFGEDF FGWIVPFGFM PSYVHKWFQF CRLYIEESDL 

       190        200        210        220        230        240 
IISNFKFDDY DFSVEAAYAE VHAEPKGKYS QKAYALLRQY RGIKPVLFVD QYGCDYSGKL 

       250        260        270        280        290        300 
ADCLQAYGHY SLQDMRQKQS VWLANCDFDI VVAWHVVRDS RFVMRLQTIA TICGIKYVAQ 

       310        320        330        340        350        360 
PTEDVVDGDV VIREPVHLLS ADAIVLKLPS LMKVMTHMDD FSIKSIYNVD LCDCGFVMQY 

       370        380        390        400        410        420 
GYVDCFNDNC DFYGWVSGNM MDGFSCPLCC TVYDSSEVKA QSSGVIPENP VLFTNSTDTV 

       430        440        450        460        470        480 
NPDSFNLYGY SVTPFGSCIY WSPRPGLWIP IIKSSVKSYD DLVYSGVVGC KSIVKETALI 

       490        500        510        520        530        540 
THALYLDYVQ CKCGNLEQNH ILGVNNSWCR QLLLNRGDYN MLLKNIDLFV KRRADFACKF 

       550        560        570        580        590        600 
AVCGDGFVPF LLDGLIPRSY YLIQSGIFFT SLMSQFSQEV SDMCLKMCIL FMDRVSVATF 

       610        620        630        640        650        660 
YIEHYVNRLV TQFKLLGTTL VNKMVNWFNT MLDASAPATG WLLYQLLNGF FVVSQANLNF 

       670        680        690        700        710        720 
VALIPDYAKI LVNKFYTFFK LLLECVTVDV LKDMPVLKTI NGLVCIVGNK FYNVSTGLIP 

       730        740        750        760        770        780 
GFVLPCNAQE QQIYFFEGVA ESVIVEDDVI ENVKSSLSSY EYCQPPKSVE KICIIDNMYM 

       790        800        810        820        830        840 
GKCGDKFFPI VMNDKNICLL DHAWRFPCAG RKVNFNEKPV VMEIPSLMTV KVMFDLDSTF 

       850        860        870        880        890        900 
DDILGKVCSE FEVEKGVTVD DFVAVVCDAI ENALNSCKEH PVVGYQVRAF LNKLNENVVY 

       910        920        930        940        950        960 
LFDEAGDEAM ASRMYCTFAI EDVEDVISSE AVEDTIDGVV EDTINDDEDV VTGDNDDEDV 

       970        980        990       1000       1010       1020 
VTGDNDDEDV VTGDNDDEDV VTGDNDDEDV VTGDNDDEDV VTGDNDDEDV VTGDNDDEDV 

      1030       1040       1050       1060       1070       1080 
VTGDNNDEDV VTGDNNDEES VTGDNDDQIV VTGDDVDDIE SIYDFDTYKA LLVFNDVYND 

      1090       1100       1110       1120       1130       1140 
ALFVSYGSSV ETETYFKVNG LWSPTITHTN CWLRSVLLVM QKLPFKFKDL AIENMWLSYK 

      1150       1160       1170       1180       1190       1200 
VGYNQSFVDY LLTTIPKAIV LPQGGYVADF AYWFLNQFDI NAYANWCCLK CGFSFDLNGL 

      1210       1220       1230       1240       1250       1260 
DAVFFYGDIV SHVCKCGHNM TLIAADLPCT LHFSLFDDNF CAFCTPKKIF IAACAVDVNV 

      1270       1280       1290       1300       1310       1320 
CHSVAVIGDE QIDGKFVTKF SGDKFDFIVG YGMSFSMSSF ELAQLYGLCI TPNVCFVKGD 

      1330       1340       1350       1360       1370       1380 
IINVARLVKA DVIVNPANGH MLHGGGVAKA IAVAAGKKFS KETAAMVKSK GVCQVGDCYV 

      1390       1400       1410       1420       1430       1440 
STGGKLCKTI LNIVGPDARQ DGRQSYVLLA RAYKHLNNYD CCLSTLISAG IFSVPADVSL 

      1450       1460       1470       1480       1490       1500 
TYLLGVVDKQ VILVSNNKED FDIIQKCQIT SVVGTKALAV RLTANVGRVI KFETDAYKLF 

      1510       1520       1530       1540       1550       1560 
LSGDDCFVSN SSVIQEVLLL RHDIQLNNDV RDYLLSKMTS LPKDWRLINK FDVINGVKTV 

      1570       1580       1590       1600       1610       1620 
KYFECPNSIY ICSQGKDFGY VCDGSFYKAT VNQVCVLLAK KIDVLLTVDG VNFKSISLTV 

      1630       1640       1650       1660       1670       1680 
GEVFGKILGN VFCDGIDVTK LKCSDFYADK ILYQYENLSL ADISAVQSSF GFDQQQLLAY 

      1690       1700       1710       1720       1730       1740 
YNFLTVCKWS VVVNGPFFSF EQSHNNCYVN VACLMLQHIN LKFNKWQWQE AWYEFRAGRP 

      1750       1760       1770       1780       1790       1800 
HRLVALVLAK GHFKFDEPSD ATDFIRVVLK QADLSGAICE LELICDCGIK QESRVGVDAV 

      1810       1820       1830       1840       1850       1860 
MHFGTLAKTD LFNGYKIGCN CAGRIVHCTK LNVPFLICSN TPLSKDLPDD VVAANMFMGV 

      1870       1880       1890       1900       1910       1920 
GVGHYTHLKC GSPYQHYDAC SVKKYTGVSG CLTDCLYLKN LTQTFTSMLT NYFLDDVEMV 

      1930       1940       1950       1960       1970       1980 
AYNPDLSQYY CDNGKYYTKP IIKAQFKPFA KVDGVYTNFK LVGHDICAQL NDKLGFNVDL 

      1990       2000       2010       2020       2030       2040 
PFVEYKVTVW PVATGDVVLA SDDLYVKRYF KGCETFGKPV IWFCHDEASL NSLTYFNKPS 

      2050       2060       2070       2080       2090       2100 
FKSENRYSVL SVDSVSEESQ GNVVTSVMES QISTKEVKLK GVRKTVKIED AIIVNDENSS 

      2110       2120       2130       2140       2150       2160 
IKVVKSLSLV DVWDMYLTGC DYVVWVANEL SRLVKSPTVR EYIRYGIKPI TIPIDLLCLR 

      2170       2180       2190       2200       2210       2220 
DDNQTLLVPK IFKARAIEFY GFLKWLFIYV FSLLHFTNDK TIFYTTEIAS KFTFNLFCLA 

      2230       2240       2250       2260       2270       2280 
LKNAFQTFRW SIFIKGFLVV ATVFLFWFNF LYINVIFSDF YLPNISVFPI FVGRIVMWIK 

      2290       2300       2310       2320       2330       2340 
ATFGLVTICD FYSKLGVGFT SHFCNGSFIC ELCHSGFDML DTYAAIDFVQ YEVDRRVLFD 

      2350       2360       2370       2380       2390       2400 
YVSLVKLIVE LVIGYSLYTV WFYPLFCLIG LQLFTTWLPD LFMLETMHWL IRFIVFVANM 

      2410       2420       2430       2440       2450       2460 
LPAFVLLRFY IVVTAMYKVV GFIRHIVYGC NKAGCLFCYK RNCSVRVKCS TIVGGVIRYY 

      2470       2480       2490       2500       2510       2520 
DITANGGTGF CVKHQWNCFN CHSFKPGNTF ITVEAAIELS KELKRPVNPT DASHYVVTDI 

      2530       2540       2550       2560       2570       2580 
KQVGCMMRLF YDRDGQRVYD DVDASLFVDI NNLLHSKVKV VPNLYVVVVE SDADRANFLN 

      2590       2600       2610       2620       2630       2640 
AVVFYAQSLY RPILLVDKKL ITTACNGISV TQIMFDVYVD TFMSHFDVDR KSFNNFVNIA 

      2650       2660       2670       2680       2690       2700 
HASLREGVQL EKVLDTFVGC VRKCCSIDSD VETRFITKSM ISAVAAGLEF TDENYNNLVP 

      2710       2720       2730       2740       2750       2760 
TYLKSDNIVA ADLGVLIQNG AKHVQGNVAK VANISCIWFI DAFNQLTADL QHKLKKACVK 

      2770       2780       2790       2800       2810       2820 
TGLKLKLTFN KQEASVPILT TPFSLKGGVV LSNLLYILFF ISLICFILLW ALLPTYSVYK 

      2830       2840       2850       2860       2870       2880 
SDIHLPAYAS FKVIDNGVVR DISVNDLCFA NKFFQFDQWY ESTFGSVYYH NSMDCPIVVA 

      2890       2900       2910       2920       2930       2940 
VMDEDIGSTM FNVPTKVLRY GFHVLHFLTY AFASDSVQCY TPHIQISYND FYASGCVLSS 

      2950       2960       2970       2980       2990       3000 
LCTMFKRGDG TPHPYCYTDG VMKNASLYTS LVPHTRYSLA NSNGFIRFPD VISEGIVRIV 

      3010       3020       3030       3040       3050       3060 
RTRSMTYCRV GACEYAEEGI CFNFNSSWVL NNDYYRSMPG TFCGRDFFDL FYQFFSSLIR 

      3070       3080       3090       3100       3110       3120 
PIDFFSLTAS SIFGAILAIV VVLVFYYLIK LKRAFGDYTS VVVINVIVWC INFLMLFVFQ 

      3130       3140       3150       3160       3170       3180 
VYPICACVYA CFYFYVTLYF PSEISVIMHL QWIVMYGAIM PFWFCVTYVA MVIANHVLWL 

      3190       3200       3210       3220       3230       3240 
FSYCRKIGVN VCSDSTFEET SLTTFMITKD SYCRLKNSVS DVAYNRYLSL YNKYRYYSGK 

      3250       3260       3270       3280       3290       3300 
MDTAAYREAA CSQLAKAMET FNHNNGNDVL YQPPTASVST SFLQSGIVKM VSPTSKIEPC 

      3310       3320       3330       3340       3350       3360 
LVSVTYGSMT LNGLWLDDKV YCPRHVICLS SNMNEPDYSA LLCRVTLGDF TIMSGRMSLT 

      3370       3380       3390       3400       3410       3420 
VVSYQMQGCQ LVLTVSLQNP YTPKYTFGVV KPGETFTVLA AYNGRPQGAF HVTMRSSYTI 

      3430       3440       3450       3460       3470       3480 
KGSFLCGSCG SVGYVLTGDS VKFVYMHQLE LSTGCHTGTD FNGNFYGPYR DAQVVQLPVK 

      3490       3500       3510       3520       3530       3540 
DYVQTVNVIA WLYAAILNNC AWFVQNDVCS IEDFNVWAMT NGFSQVKADL VLDALASMTG 

      3550       3560       3570       3580       3590       3600 
VSIETLLAAI KRLYMGFQGR QILGSCTFED ELAPSDVYQQ LAGVKLQSKT KRFIKETIYW 

      3610       3620       3630       3640       3650       3660 
ILISTFLFSC IISAFVKWTI FMYINTHMIG VTLCVLCFVS FMMLLVKHKH FYLTMYIIPV 

      3670       3680       3690       3700       3710       3720 
LCTLFYVNYL VVYKEGFRGF TYVWLSHFVP AVNFTYVYEV FYGCILCVFA IFITMHSINH 

      3730       3740       3750       3760       3770       3780 
DIFSLMFLVG RIVTLISMWY FGSNLEEDVL LFITAFLGTY TWTTILSLAI AKIVANWLSV 

      3790       3800       3810       3820       3830       3840 
NIFYFTDVPY IKLILLSYLF IGYILSCYWG FFSLLNSVFR MPMGVYNYKI SVQELRYMNA 

      3850       3860       3870       3880       3890       3900 
NGLRPPRNSF EAILLNLKLL GIGGVPVIEV SQIQSKLTDV KCANVVLLNC LQHLHVASNS 

      3910       3920       3930       3940       3950       3960 
KLWQYCSVLH NEILSTSDLS VAFDKLAQLL IVLFSNPAAV DTKCLASIDE VSDDYVQDST 

      3970       3980       3990       4000       4010       4020 
VLQALQSEFV NMASFVEYEV AKKNLADAKN SGSVNQQQIK QLEKACNIAK SVYERDKAVA 

      4030       4040       4050       4060       4070       4080 
RKLERMADLA LTNMYKEARI NDKKSKVVSA LQTMLFSMVR KLDNQALNSI LDNAVKGCVP 

      4090       4100       4110       4120       4130       4140 
LSAIPALAAN TLTIIIPDKQ VFDKVVDNVY VTYAGSVWHI QTVQDADGIN KQLTDISVDS 

      4150       4160       4170       4180       4190       4200 
NWPLVIIANR YNEVANAVMQ NNELMPHKLK IQVVNSGSDI NCNIPTQCYY NNVSSGRIVY 

      4210       4220       4230       4240       4250       4260 
AVLSDVDGLK YTKIMKDDGN CVVLELDPPC KFSIQDVKGL KIKYLYFIKG CNTLARGWVV 

      4270       4280       4290       4300       4310       4320 
GTLSSTIRLQ AGVATEYAAN SSILSLCAFS VDPKKTYLDY IQQGGVPIIN CVKMLCDHAG 

      4330       4340       4350       4360       4370       4380 
TGMAITIKPE ATINQDSYGG ASVCIYCRAR VEHPDVDGIC KLRGKFVQVP LGIKDPILYV 

      4390       4400       4410       4420 
LTHDVCQVCG FWRDGSCSCV GSSVAVQSKD LNFLNGLGVL V 

« Hide

Isoform Replicase polyprotein 1ab (pp1ab) [UniParc].

See P0C6X4.

References

[1]"Comparative analysis of 22 coronavirus HKU1 genomes reveals a novel genotype and evidence of natural recombination in coronavirus HKU1."
Woo P.C.Y., Lau S.K.P., Yip C.C.Y., Huang Y., Tsoi H.-W., Chan K.-H., Yuen K.-Y.
J. Virol. 80:7136-7145(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ339101 Genomic RNA. No translation available.

3D structure databases

ProteinModelPortalP0C6U5.
SMRP0C6U5. Positions 4002-4152, 4276-4400.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR022570. Coronavirus_NSP1.
IPR002589. Macro_dom.
IPR014828. NSP7.
IPR014829. NSP8.
IPR014822. NSP9.
IPR002705. Pept_C30/C16_sub.
IPR008740. Peptidase_C30.
IPR013016. Peptidase_C30/C16.
IPR018995. RNA_synth_NSP10_coronavirus.
IPR009003. Trypsin-like_Pept_dom.
IPR014827. Viral_protease.
[Graphical view]
PfamPF11963. DUF3477. 1 hit.
PF01661. Macro. 1 hit.
PF09401. NSP10. 1 hit.
PF08716. nsp7. 1 hit.
PF08717. nsp8. 1 hit.
PF08710. nsp9. 1 hit.
PF01831. Peptidase_C16. 1 hit.
PF05409. Peptidase_C30. 1 hit.
PF08715. Viral_protease. 1 hit.
[Graphical view]
SMARTSM00506. A1pp. 1 hit.
[Graphical view]
SUPFAMSSF101816. SSF101816. 1 hit.
SSF144246. SSF144246. 1 hit.
SSF50494. SSF50494. 1 hit.
PROSITEPS51442. M_PRO. 1 hit.
PS51154. MACRO. 1 hit.
PS51124. PEPTIDASE_C16. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameR1A_CVHN5
AccessionPrimary (citable) accession number: P0C6U5
Secondary accession number(s): Q0ZME9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: July 9, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries