##gff-version 3 P0C6U0 UniProtKB Chain 1 4383 . . . ID=PRO_0000338158;Note=Replicase polyprotein 1a P0C6U0 UniProtKB Chain 1 246 . . . ID=PRO_0000338159;Note=Non-structural protein 1;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U0 UniProtKB Chain 247 851 . . . ID=PRO_0000338160;Note=Non-structural protein 2;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U0 UniProtKB Chain 852 2750 . . . ID=PRO_0000338161;Note=Papain-like protease nsp3;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U0 UniProtKB Chain 2751 3246 . . . ID=PRO_0000338162;Note=Non-structural protein 4;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U0 UniProtKB Chain 3247 3549 . . . ID=PRO_0000338163;Note=3C-like proteinase nsp5;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U0 UniProtKB Chain 3550 3836 . . . ID=PRO_0000338164;Note=Non-structural protein 6;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U0 UniProtKB Chain 3837 3925 . . . ID=PRO_0000338165;Note=Non-structural protein 7;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U0 UniProtKB Chain 3926 4122 . . . ID=PRO_0000338166;Note=Non-structural protein 8;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U0 UniProtKB Chain 4123 4232 . . . ID=PRO_0000338167;Note=RNA-capping enzyme subunit nsp9;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U0 UniProtKB Chain 4233 4369 . . . ID=PRO_0000338168;Note=Non-structural protein 10;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U0 UniProtKB Chain 4370 4383 . . . ID=PRO_0000338169;Note=Non-structural protein 11;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6U0 UniProtKB Transmembrane 2138 2158 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6U0 UniProtKB Transmembrane 2199 2219 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6U0 UniProtKB Transmembrane 2221 2241 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6U0 UniProtKB Transmembrane 2313 2333 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6U0 UniProtKB Transmembrane 2343 2363 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6U0 UniProtKB Transmembrane 2365 2385 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6U0 UniProtKB Transmembrane 2752 2772 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6U0 UniProtKB Transmembrane 3031 3051 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6U0 UniProtKB Transmembrane 3063 3083 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6U0 UniProtKB Transmembrane 3090 3110 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6U0 UniProtKB Transmembrane 3115 3135 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6U0 UniProtKB Transmembrane 3558 3578 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6U0 UniProtKB Transmembrane 3588 3608 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6U0 UniProtKB Transmembrane 3615 3635 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6U0 UniProtKB Transmembrane 3657 3677 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6U0 UniProtKB Transmembrane 3684 3704 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6U0 UniProtKB Transmembrane 3711 3731 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6U0 UniProtKB Transmembrane 3755 3775 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6U0 UniProtKB Domain 54 196 . . . Note=CoV Nsp1 globular;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01307 P0C6U0 UniProtKB Domain 216 246 . . . Note=BetaCoV Nsp1 C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01308 P0C6U0 UniProtKB Domain 250 519 . . . Note=CoV Nsp2 N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01333 P0C6U0 UniProtKB Domain 524 713 . . . Note=CoV Nsp2 middle;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01334 P0C6U0 UniProtKB Domain 733 851 . . . Note=CoV Nsp2 C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01335 P0C6U0 UniProtKB Domain 853 966 . . . Note=Ubiquitin-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00214 P0C6U0 UniProtKB Domain 1036 1274 . . . Note=Peptidase C16 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6U0 UniProtKB Domain 1275 1435 . . . Note=Macro;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00490 P0C6U0 UniProtKB Domain 1491 1563 . . . Note=DPUP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01289 P0C6U0 UniProtKB Domain 1562 1617 . . . Note=Ubiquitin-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00214 P0C6U0 UniProtKB Domain 1631 1892 . . . Note=Peptidase C16 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6U0 UniProtKB Domain 1906 2007 . . . Note=Nucleic acid-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01290 P0C6U0 UniProtKB Domain 2020 2169 . . . Note=G2M;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01338 P0C6U0 UniProtKB Domain 2235 2296 . . . Note=3Ecto;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01337 P0C6U0 UniProtKB Domain 2383 2750 . . . Note=CoV Nsp3 Y;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6U0 UniProtKB Domain 3149 3246 . . . Note=Nsp4C;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01291 P0C6U0 UniProtKB Domain 3247 3549 . . . Note=Peptidase C30;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00772 P0C6U0 UniProtKB Domain 3837 3925 . . . Note=RdRp Nsp7 cofactor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01294 P0C6U0 UniProtKB Domain 3926 4122 . . . Note=RdRp Nsp8 cofactor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01295 P0C6U0 UniProtKB Domain 4123 4232 . . . Note=Nsp9 ssRNA-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01296 P0C6U0 UniProtKB Domain 4233 4370 . . . Note=ExoN/MTase coactivator;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6U0 UniProtKB Zinc finger 1151 1179 . . . Note=C4-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6U0 UniProtKB Zinc finger 1749 1785 . . . Note=C4-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6U0 UniProtKB Zinc finger 4306 4322 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U0 UniProtKB Zinc finger 4348 4361 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U0 UniProtKB Region 392 416 . . . Note=C4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01333 P0C6U0 UniProtKB Region 972 992 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P0C6U0 UniProtKB Region 2138 2385 . . . Note=HD1 P0C6U0 UniProtKB Region 2383 2473 . . . Note=Y1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6U0 UniProtKB Region 2387 2400 . . . Note=ZF1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6U0 UniProtKB Region 2433 2443 . . . Note=ZF2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6U0 UniProtKB Region 2474 2750 . . . Note=CoV-Y;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6U0 UniProtKB Region 2474 2566 . . . Note=Y2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6U0 UniProtKB Region 2567 2649 . . . Note=Y3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6U0 UniProtKB Region 2650 2750 . . . Note=Y4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6U0 UniProtKB Region 2752 3135 . . . Note=HD2 P0C6U0 UniProtKB Region 3558 3775 . . . Note=HD3 P0C6U0 UniProtKB Active site 1074 1074 . . . Note=For PL1-PRO activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6U0 UniProtKB Active site 1225 1225 . . . Note=For PL1-PRO activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6U0 UniProtKB Active site 1236 1236 . . . Note=For PL1-PRO activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6U0 UniProtKB Active site 1671 1671 . . . Note=For PL2-PRO activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6U0 UniProtKB Active site 1828 1828 . . . Note=For PL2-PRO activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6U0 UniProtKB Active site 1842 1842 . . . Note=For PL2-PRO activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6U0 UniProtKB Active site 3287 3287 . . . Note=For 3CL-PRO activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00772 P0C6U0 UniProtKB Active site 3391 3391 . . . Note=For 3CL-PRO activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00772 P0C6U0 UniProtKB Binding site 392 392 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01333 P0C6U0 UniProtKB Binding site 397 397 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01333 P0C6U0 UniProtKB Binding site 413 413 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01333 P0C6U0 UniProtKB Binding site 416 416 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01333 P0C6U0 UniProtKB Binding site 1151 1151 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6U0 UniProtKB Binding site 1154 1154 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6U0 UniProtKB Binding site 1177 1177 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6U0 UniProtKB Binding site 1179 1179 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6U0 UniProtKB Binding site 1749 1749 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6U0 UniProtKB Binding site 1751 1751 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6U0 UniProtKB Binding site 1783 1783 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6U0 UniProtKB Binding site 1785 1785 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6U0 UniProtKB Binding site 2387 2387 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6U0 UniProtKB Binding site 2392 2392 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6U0 UniProtKB Binding site 2397 2397 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6U0 UniProtKB Binding site 2400 2400 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6U0 UniProtKB Binding site 2433 2433 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6U0 UniProtKB Binding site 2436 2436 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6U0 UniProtKB Binding site 2440 2440 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6U0 UniProtKB Binding site 2443 2443 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6U0 UniProtKB Binding site 4306 4306 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6U0 UniProtKB Binding site 4309 4309 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6U0 UniProtKB Binding site 4315 4315 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6U0 UniProtKB Binding site 4322 4322 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6U0 UniProtKB Binding site 4348 4348 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6U0 UniProtKB Binding site 4351 4351 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6U0 UniProtKB Binding site 4359 4359 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6U0 UniProtKB Binding site 4361 4361 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6U0 UniProtKB Site 246 247 . . . Note=Cleavage%3B by PL1-PRO;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U0 UniProtKB Site 851 852 . . . Note=Cleavage%3B by PL1-PRO;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U0 UniProtKB Site 2750 2751 . . . Note=Cleavage%3B by PL2-PRO;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U0 UniProtKB Site 3246 3247 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U0 UniProtKB Site 3549 3550 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U0 UniProtKB Site 3836 3837 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U0 UniProtKB Site 3925 3926 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U0 UniProtKB Site 4122 4123 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U0 UniProtKB Site 4232 4233 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U0 UniProtKB Site 4369 4370 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6U0 UniProtKB Disulfide bond 2251 2275 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01337 P0C6U0 UniProtKB Disulfide bond 2266 2272 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01337