ID   OST4_HUMAN              Reviewed;          37 AA.
AC   P0C6T2;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   14-OCT-2015, entry version 50.
DE   RecName: Full=Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4;
GN   Name=OST4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   STRUCTURE BY NMR, AND TRANSMEMBRANE DOMAIN.
RX   PubMed=21609714; DOI=10.1016/j.bbrc.2011.05.050;
RA   Gayen S., Kang C.;
RT   "Solution structure of a human minimembrane protein Ost4, a subunit of
RT   the oligosaccharyltransferase complex.";
RL   Biochem. Biophys. Res. Commun. 409:572-576(2011).
CC   -!- FUNCTION: May be involved in N-glycosylation through its
CC       association with N-oligosaccharyl transferase. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the oligosaccharyltransferase (OST) complex.
CC       OST seems to exist in different forms which contain at least
CC       RPN1/ribophorin-1, RPN2/ribophorin-2, OST48, DAD1, and either
CC       STT3A or STT3B. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass
CC       type III membrane protein. Note=The single transmembrane helix has
CC       a kink in the middle of the transmembrane span.
CC   -!- SIMILARITY: Belongs to the OST4 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC013403; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC015653; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS58703.1; -.
DR   RefSeq; NP_001128165.1; NM_001134693.1.
DR   UniGene; Hs.502948; -.
DR   PDB; 2LAT; NMR; -; A=1-37.
DR   PDBsum; 2LAT; -.
DR   ProteinModelPortal; P0C6T2; -.
DR   SMR; P0C6T2; 1-37.
DR   BioGrid; 933663; 4.
DR   STRING; 9606.ENSP00000454411; -.
DR   PhosphoSite; P0C6T2; -.
DR   BioMuta; OST4; -.
DR   DMDM; 182894143; -.
DR   Ensembl; ENST00000429985; ENSP00000455716; ENSG00000228474.
DR   Ensembl; ENST00000447619; ENSP00000454411; ENSG00000228474.
DR   Ensembl; ENST00000456793; ENSP00000457935; ENSG00000228474.
DR   GeneID; 100128731; -.
DR   KEGG; hsa:100128731; -.
DR   UCSC; uc002rig.3; human.
DR   CTD; 100128731; -.
DR   GeneCards; OST4; -.
DR   HGNC; HGNC:32483; OST4.
DR   neXtProt; NX_P0C6T2; -.
DR   PharmGKB; PA165697090; -.
DR   GeneTree; ENSGT00390000016516; -.
DR   HOVERGEN; HBG073488; -.
DR   InParanoid; P0C6T2; -.
DR   OrthoDB; EOG7TXKM7; -.
DR   PhylomeDB; P0C6T2; -.
DR   ChiTaRS; OST4; human.
DR   GenomeRNAi; 100128731; -.
DR   NextBio; 20771742; -.
DR   PRO; PR:P0C6T2; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; P0C6T2; -.
DR   Genevisible; P0C6T2; HS.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR018943; Oligosaccaryltransferase.
DR   Pfam; PF10215; Ost4; 1.
DR   SUPFAM; SSF103464; SSF103464; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Complete proteome; Endoplasmic reticulum; Membrane;
KW   Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
FT   CHAIN         1     37       Dolichyl-diphosphooligosaccharide--
FT                                protein glycosyltransferase subunit 4.
FT                                /FTId=PRO_0000328638.
FT   TOPO_DOM      1      4       Lumenal. {ECO:0000255}.
FT   TRANSMEM      5     25       Helical. {ECO:0000255}.
FT   TOPO_DOM     26     37       Cytoplasmic. {ECO:0000255}.
FT   HELIX         5     31       {ECO:0000244|PDB:2LAT}.
SQ   SEQUENCE   37 AA;  4193 MW;  AADA830EA2A3952C CRC64;
     MITDVQLAIF ANMLGVSLFL LVVLYHYVAV NNPKKQE
//