ID   OST4_HUMAN              Reviewed;          37 AA.
AC   P0C6T2;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   15-JUN-2010, entry version 14.
DE   RecName: Full=Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4;
GN   Name=OST4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in N-glycosylation through its
CC       association with N-oligosaccharyl transferase (By similarity).
CC   -!- SUBUNIT: Component of the oligosaccharyl transferase (OST) complex
CC       (By similarity). OST seems to exist in different forms which
CC       contain at least RPN1/ribophorin-1, RPN2/ribophorin-2, OST48,
CC       DAD1, and either STT3A or STT3B (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein
CC       (Potential).
CC   -!- SIMILARITY: Belongs to the OST4 family.
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DR   EMBL; AC013403; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC015653; -; NOT_ANNOTATED_CDS; mRNA.
DR   IPI; IPI00913953; -.
DR   RefSeq; NP_001128165.1; -.
DR   UniGene; Hs.502948; -.
DR   GeneID; 100128731; -.
DR   KEGG; hsa:100128731; -.
DR   CTD; 100128731; -.
DR   eggNOG; maNOG05485; -.
DR   HOVERGEN; HBG073488; -.
DR   OrthoDB; EOG9MD0M7; -.
DR   Genevestigator; P0C6T2; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR018943; Oligosaccaryltransferase.
DR   Pfam; PF10215; Ost4; 1.
DR   SUPFAM; SSF103464; Oligosaccaryltransferase; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Membrane; Transmembrane.
FT   CHAIN         1     37       Dolichyl-diphosphooligosaccharide--
FT                                protein glycosyltransferase subunit 4.
FT                                /FTId=PRO_0000328638.
FT   TRANSMEM      5     25       Helical; (Potential).
SQ   SEQUENCE   37 AA;  4193 MW;  AADA830EA2A3952C CRC64;
     MITDVQLAIF ANMLGVSLFL LVVLYHYVAV NNPKKQE
//