Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3

Gene

LINGO3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3
Alternative name(s):
Leucine-rich repeat neuronal protein 2
Leucine-rich repeat neuronal protein 6B
Gene namesi
Name:LINGO3
Synonyms:LERN2, LRRN6B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:21206. LINGO3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 531507ExtracellularSequence analysisAdd
BLAST
Transmembranei532 – 55221HelicalSequence analysisAdd
BLAST
Topological domaini553 – 59240CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162394097.

Polymorphism and mutation databases

BioMutaiLINGO3.
DMDMi182662399.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 592568Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3PRO_0000326529Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence analysis
Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence analysis
Glycosylationi247 – 2471N-linked (GlcNAc...)Sequence analysis
Glycosylationi257 – 2571N-linked (GlcNAc...)Sequence analysis
Glycosylationi276 – 2761N-linked (GlcNAc...)Sequence analysis
Glycosylationi324 – 3241N-linked (GlcNAc...)Sequence analysis
Disulfide bondi429 ↔ 480PROSITE-ProRule annotation
Glycosylationi488 – 4881N-linked (GlcNAc...)Sequence analysis
Glycosylationi512 – 5121N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP0C6S8.
PRIDEiP0C6S8.

PTM databases

PhosphoSiteiP0C6S8.

Expressioni

Gene expression databases

BgeeiP0C6S8.
CleanExiHS_LINGO3.
GenevisibleiP0C6S8. HS.

Organism-specific databases

HPAiHPA055932.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000384979.

Structurei

3D structure databases

ProteinModelPortaliP0C6S8.
SMRiP0C6S8. Positions 25-522.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 5430LRRNTAdd
BLAST
Repeati55 – 7622LRR 1Add
BLAST
Repeati79 – 10022LRR 2Add
BLAST
Repeati103 – 12422LRR 3Add
BLAST
Repeati127 – 14822LRR 4Add
BLAST
Repeati151 – 17222LRR 5Add
BLAST
Repeati175 – 19622LRR 6Add
BLAST
Repeati207 – 22822LRR 7Add
BLAST
Repeati247 – 26822LRR 8Add
BLAST
Repeati271 – 29222LRR 9Add
BLAST
Repeati295 – 31622LRR 10Add
BLAST
Repeati319 – 34022LRR 11Add
BLAST
Domaini352 – 40655LRRCTAdd
BLAST
Domaini407 – 49690Ig-like C2-typeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi576 – 5794Poly-Ala

Sequence similaritiesi

Contains 11 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118831.
HOGENOMiHOG000246971.
HOVERGENiHBG057546.
InParanoidiP0C6S8.
OMAiGDLAPYP.
PhylomeDBiP0C6S8.
TreeFamiTF334360.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 9 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C6S8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTCWLCVLSL PLLLLPAAPP PAGGCPARCE CTVQTRAVAC TRRRLTAVPD
60 70 80 90 100
GIPAETRLLE LSRNRIRCLN PGDLAALPAL EELDLSENAI AHVEPGAFAN
110 120 130 140 150
LPRLRVLRLR GNQLKLIPPG VFTRLDNLTL LDLSENKLVI LLDYTFQDLH
160 170 180 190 200
SLRRLEVGDN DLVFVSRRAF AGLLALEELT LERCNLTALS GESLGHLRSL
210 220 230 240 250
GALRLRHLAI ASLEDQNFRR LPGLLHLEID NWPLLEEVAA GSLRGLNLTS
260 270 280 290 300
LSVTHTNITA VPAAALRHQA HLTCLNLSHN PISTVPRGSF RDLVRLRELH
310 320 330 340 350
LAGALLAVVE PQAFLGLRQI RLLNLSNNLL STLEESTFHS VNTLETLRVD
360 370 380 390 400
GNPLACDCRL LWIVQRRKTL NFDGRLPACA TPAEVRGDAL RNLPDSVLFE
410 420 430 440 450
YFVCRKPKIR ERRLQRVTAT AGEDVRFLCR AEGEPAPTVA WVTPQHRPVT
460 470 480 490 500
ATSAGRARVL PGGTLEIQDA RPQDSGTYTC VASNAGGNDT YFATLTVRPE
510 520 530 540 550
PAANRTPGEA HNETLAALRA PLDLTTILVS TAMGCITFLG VVLFCFVLLF
560 570 580 590
VWSRGRGQHK NNFSVEYSFR KVDGPAAAAG QGGARKFNMK MI
Length:592
Mass (Da):64,881
Last modified:April 8, 2008 - v1
Checksum:i54C12AD313CE1414
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti426 – 4261R → H.
Corresponds to variant rs7258841 [ dbSNP | Ensembl ].
VAR_059395

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004152 Genomic DNA. No translation available.
CCDSiCCDS45905.1.
RefSeqiNP_001094861.1. NM_001101391.1.
UniGeneiHs.371587.

Genome annotation databases

EnsembliENST00000585527; ENSP00000467753; ENSG00000220008.
GeneIDi645191.
KEGGihsa:645191.
UCSCiuc060rka.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004152 Genomic DNA. No translation available.
CCDSiCCDS45905.1.
RefSeqiNP_001094861.1. NM_001101391.1.
UniGeneiHs.371587.

3D structure databases

ProteinModelPortaliP0C6S8.
SMRiP0C6S8. Positions 25-522.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000384979.

PTM databases

PhosphoSiteiP0C6S8.

Polymorphism and mutation databases

BioMutaiLINGO3.
DMDMi182662399.

Proteomic databases

PaxDbiP0C6S8.
PRIDEiP0C6S8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000585527; ENSP00000467753; ENSG00000220008.
GeneIDi645191.
KEGGihsa:645191.
UCSCiuc060rka.1. human.

Organism-specific databases

CTDi645191.
GeneCardsiLINGO3.
H-InvDBHIX0202769.
HGNCiHGNC:21206. LINGO3.
HPAiHPA055932.
MIMi609792. gene.
neXtProtiNX_P0C6S8.
PharmGKBiPA162394097.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118831.
HOGENOMiHOG000246971.
HOVERGENiHBG057546.
InParanoidiP0C6S8.
OMAiGDLAPYP.
PhylomeDBiP0C6S8.
TreeFamiTF334360.

Miscellaneous databases

GenomeRNAii645191.
PROiP0C6S8.
SOURCEiSearch...

Gene expression databases

BgeeiP0C6S8.
CleanExiHS_LINGO3.
GenevisibleiP0C6S8. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 9 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "LRRN6A/LERN1 (leucine-rich repeat neuronal protein 1), a novel gene with enriched expression in limbic system and neocortex."
    Carim-Todd L., Escarceller M., Estivill X., Sumoy L.
    Eur. J. Neurosci. 18:3167-3182(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiLIGO3_HUMAN
AccessioniPrimary (citable) accession number: P0C6S8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: June 8, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.