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Protein

Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3

Gene

LINGO3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3
Alternative name(s):
Leucine-rich repeat neuronal protein 2
Leucine-rich repeat neuronal protein 6B
Gene namesi
Name:LINGO3
Synonyms:LERN2, LRRN6B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:21206. LINGO3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 531ExtracellularSequence analysisAdd BLAST507
Transmembranei532 – 552HelicalSequence analysisAdd BLAST21
Topological domaini553 – 592CytoplasmicSequence analysisAdd BLAST40

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000220008.
PharmGKBiPA162394097.

Polymorphism and mutation databases

BioMutaiLINGO3.
DMDMi182662399.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000032652925 – 592Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3Add BLAST568

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi127N-linked (GlcNAc...)Sequence analysis1
Glycosylationi185N-linked (GlcNAc...)Sequence analysis1
Glycosylationi247N-linked (GlcNAc...)Sequence analysis1
Glycosylationi257N-linked (GlcNAc...)Sequence analysis1
Glycosylationi276N-linked (GlcNAc...)Sequence analysis1
Glycosylationi324N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi429 ↔ 480PROSITE-ProRule annotation
Glycosylationi488N-linked (GlcNAc...)Sequence analysis1
Glycosylationi512N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP0C6S8.
PeptideAtlasiP0C6S8.
PRIDEiP0C6S8.

PTM databases

PhosphoSitePlusiP0C6S8.

Expressioni

Gene expression databases

BgeeiENSG00000220008.
CleanExiHS_LINGO3.
GenevisibleiP0C6S8. HS.

Organism-specific databases

HPAiHPA055932.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000384979.

Structurei

3D structure databases

ProteinModelPortaliP0C6S8.
SMRiP0C6S8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 54LRRNTAdd BLAST30
Repeati55 – 76LRR 1Add BLAST22
Repeati79 – 100LRR 2Add BLAST22
Repeati103 – 124LRR 3Add BLAST22
Repeati127 – 148LRR 4Add BLAST22
Repeati151 – 172LRR 5Add BLAST22
Repeati175 – 196LRR 6Add BLAST22
Repeati207 – 228LRR 7Add BLAST22
Repeati247 – 268LRR 8Add BLAST22
Repeati271 – 292LRR 9Add BLAST22
Repeati295 – 316LRR 10Add BLAST22
Repeati319 – 340LRR 11Add BLAST22
Domaini352 – 406LRRCTAdd BLAST55
Domaini407 – 496Ig-like C2-typeAdd BLAST90

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi576 – 579Poly-Ala4

Sequence similaritiesi

Contains 11 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118831.
HOGENOMiHOG000246971.
HOVERGENiHBG057546.
InParanoidiP0C6S8.
OMAiGDLAPYP.
OrthoDBiEOG091G047N.
PhylomeDBiP0C6S8.
TreeFamiTF334360.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 9 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C6S8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTCWLCVLSL PLLLLPAAPP PAGGCPARCE CTVQTRAVAC TRRRLTAVPD
60 70 80 90 100
GIPAETRLLE LSRNRIRCLN PGDLAALPAL EELDLSENAI AHVEPGAFAN
110 120 130 140 150
LPRLRVLRLR GNQLKLIPPG VFTRLDNLTL LDLSENKLVI LLDYTFQDLH
160 170 180 190 200
SLRRLEVGDN DLVFVSRRAF AGLLALEELT LERCNLTALS GESLGHLRSL
210 220 230 240 250
GALRLRHLAI ASLEDQNFRR LPGLLHLEID NWPLLEEVAA GSLRGLNLTS
260 270 280 290 300
LSVTHTNITA VPAAALRHQA HLTCLNLSHN PISTVPRGSF RDLVRLRELH
310 320 330 340 350
LAGALLAVVE PQAFLGLRQI RLLNLSNNLL STLEESTFHS VNTLETLRVD
360 370 380 390 400
GNPLACDCRL LWIVQRRKTL NFDGRLPACA TPAEVRGDAL RNLPDSVLFE
410 420 430 440 450
YFVCRKPKIR ERRLQRVTAT AGEDVRFLCR AEGEPAPTVA WVTPQHRPVT
460 470 480 490 500
ATSAGRARVL PGGTLEIQDA RPQDSGTYTC VASNAGGNDT YFATLTVRPE
510 520 530 540 550
PAANRTPGEA HNETLAALRA PLDLTTILVS TAMGCITFLG VVLFCFVLLF
560 570 580 590
VWSRGRGQHK NNFSVEYSFR KVDGPAAAAG QGGARKFNMK MI
Length:592
Mass (Da):64,881
Last modified:April 8, 2008 - v1
Checksum:i54C12AD313CE1414
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059395426R → H.Corresponds to variant rs7258841dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004152 Genomic DNA. No translation available.
CCDSiCCDS45905.1.
RefSeqiNP_001094861.1. NM_001101391.1.
UniGeneiHs.371587.

Genome annotation databases

EnsembliENST00000585527; ENSP00000467753; ENSG00000220008.
GeneIDi645191.
KEGGihsa:645191.
UCSCiuc060rka.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004152 Genomic DNA. No translation available.
CCDSiCCDS45905.1.
RefSeqiNP_001094861.1. NM_001101391.1.
UniGeneiHs.371587.

3D structure databases

ProteinModelPortaliP0C6S8.
SMRiP0C6S8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000384979.

PTM databases

PhosphoSitePlusiP0C6S8.

Polymorphism and mutation databases

BioMutaiLINGO3.
DMDMi182662399.

Proteomic databases

PaxDbiP0C6S8.
PeptideAtlasiP0C6S8.
PRIDEiP0C6S8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000585527; ENSP00000467753; ENSG00000220008.
GeneIDi645191.
KEGGihsa:645191.
UCSCiuc060rka.1. human.

Organism-specific databases

CTDi645191.
GeneCardsiLINGO3.
H-InvDBHIX0202769.
HGNCiHGNC:21206. LINGO3.
HPAiHPA055932.
MIMi609792. gene.
neXtProtiNX_P0C6S8.
OpenTargetsiENSG00000220008.
PharmGKBiPA162394097.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118831.
HOGENOMiHOG000246971.
HOVERGENiHBG057546.
InParanoidiP0C6S8.
OMAiGDLAPYP.
OrthoDBiEOG091G047N.
PhylomeDBiP0C6S8.
TreeFamiTF334360.

Miscellaneous databases

GenomeRNAii645191.
PROiP0C6S8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000220008.
CleanExiHS_LINGO3.
GenevisibleiP0C6S8. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 9 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLIGO3_HUMAN
AccessioniPrimary (citable) accession number: P0C6S8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: November 2, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.