Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P0C6Q8

- DMA_VIBCH

UniProt

P0C6Q8 - DMA_VIBCH

Protein

DNA adenine methylase

Gene

dam

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (18 Mar 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Methylates DNA within the sequence GATC. Directly involved in methyl-directed DNA mismatch repair By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei10 – 101S-adenosyl-L-methionineBy similarity
    Binding sitei14 – 141S-adenosyl-L-methionine; via amide nitrogenBy similarity
    Binding sitei54 – 541S-adenosyl-L-methionineBy similarity
    Binding sitei181 – 1811S-adenosyl-L-methionineBy similarity

    GO - Molecular functioni

    1. nucleic acid binding Source: InterPro
    2. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciVCHO:VC2626-MONOMER.

    Protein family/group databases

    REBASEi4762. M.VchADamP.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA adenine methylase (EC:2.1.1.72)
    Alternative name(s):
    DNA adenine methyltransferase
    Deoxyadenosyl-methyltransferase
    M.VchADam
    Gene namesi
    Name:dam
    Ordered Locus Names:VC_2626
    OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
    Taxonomic identifieri243277 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000000584: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 277277DNA adenine methylasePRO_0000087999Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243277.VC2626.

    Structurei

    3D structure databases

    ProteinModelPortaliP0C6Q8.
    SMRiP0C6Q8. Positions 3-271.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the N(4)/N(6)-methyltransferase family.Curated

    Phylogenomic databases

    eggNOGiCOG0338.
    KOiK06223.
    OMAiKFTREIY.
    OrthoDBiEOG6CS08V.

    Family and domain databases

    Gene3Di1.10.1020.10. 1 hit.
    3.40.50.150. 2 hits.
    InterProiIPR023095. Ade_MeTrfase_dom_2.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR012263. M_m6A_EcoRV.
    IPR012327. MeTrfase_D12.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF02086. MethyltransfD12. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000398. M_m6A_EcoRV. 1 hit.
    PRINTSiPR00505. D12N6MTFRASE.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00571. dam. 1 hit.
    PROSITEiPS00092. N6_MTASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0C6Q8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKQRAFLKW AGGKYSLVED IQRHLPEARE LVEPFVGAGS VFLNTDFERY    50
    LLADINPDLI NFYNLLKTEP QAYIHEAKRW FVPENNRKEV YLDIRKQFNQ 100
    SDDAMFRSLA FLYMNRFGFN GLCRYNKKGG FNVPFGSYKK PYFPEQELEF 150
    FAEKAQRATF ICASYGETFA RAQSDSVIYC DPPYAPLSTT ANFTSYAGNG 200
    FTLDDQAALA DIAEKTAKER GISVLISNHD TTHTRRLYRG AQLNVVKANR 250
    TISRNGAGRN KVDELLALFT PHLSSQA 277
    Length:277
    Mass (Da):31,624
    Last modified:March 18, 2008 - v1
    Checksum:i48D831240F9E7C60
    GO

    Sequence cautioni

    The sequence CAA48031.1 differs from that shown. Reason: Frameshift at several positions.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X67820 Genomic DNA. Translation: CAA48031.1. Frameshift.
    AE003852 Genomic DNA. Translation: AAF95767.1.
    PIRiH82052.
    S29558.
    RefSeqiNP_232254.1. NC_002505.1.

    Genome annotation databases

    EnsemblBacteriaiAAF95767; AAF95767; VC_2626.
    GeneIDi2615643.
    KEGGivch:VC2626.
    PATRICi20084276. VBIVibCho83274_2504.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X67820 Genomic DNA. Translation: CAA48031.1 . Frameshift.
    AE003852 Genomic DNA. Translation: AAF95767.1 .
    PIRi H82052.
    S29558.
    RefSeqi NP_232254.1. NC_002505.1.

    3D structure databases

    ProteinModelPortali P0C6Q8.
    SMRi P0C6Q8. Positions 3-271.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243277.VC2626.

    Protein family/group databases

    REBASEi 4762. M.VchADamP.

    Protocols and materials databases

    DNASUi 2615643.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF95767 ; AAF95767 ; VC_2626 .
    GeneIDi 2615643.
    KEGGi vch:VC2626.
    PATRICi 20084276. VBIVibCho83274_2504.

    Phylogenomic databases

    eggNOGi COG0338.
    KOi K06223.
    OMAi KFTREIY.
    OrthoDBi EOG6CS08V.

    Enzyme and pathway databases

    BioCyci VCHO:VC2626-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1020.10. 1 hit.
    3.40.50.150. 2 hits.
    InterProi IPR023095. Ade_MeTrfase_dom_2.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR012263. M_m6A_EcoRV.
    IPR012327. MeTrfase_D12.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF02086. MethyltransfD12. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000398. M_m6A_EcoRV. 1 hit.
    PRINTSi PR00505. D12N6MTFRASE.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00571. dam. 1 hit.
    PROSITEi PS00092. N6_MTASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA adenine methyltransferase-encoding gene (dam) of Vibrio cholerae."
      Bandyopadhyay R., Das J.
      Gene 140:67-71(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 39315 / El Tor Inaba N16961.

    Entry informationi

    Entry nameiDMA_VIBCH
    AccessioniPrimary (citable) accession number: P0C6Q8
    Secondary accession number(s): Q08318, Q9KNV4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: March 18, 2008
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Restriction enzymes and methylases
      Classification of restriction enzymes and methylases and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3