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P0C6Q8 (DMA_VIBCH) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA adenine methylase

EC=2.1.1.72
Alternative name(s):
DNA adenine methyltransferase
Deoxyadenosyl-methyltransferase
M.VchADam
Gene names
Name:dam
Ordered Locus Names:VC_2626
OrganismVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) [Reference proteome] [HAMAP]
Taxonomic identifier243277 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length277 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Methylates DNA within the sequence GATC. Directly involved in methyl-directed DNA mismatch repair By similarity.

Catalytic activity

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

Sequence similarities

Belongs to the N(4)/N(6)-methyltransferase family.

Sequence caution

The sequence CAA48031.1 differs from that shown. Reason: Frameshift at several positions.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 277277DNA adenine methylase
PRO_0000087999

Sites

Binding site101S-adenosyl-L-methionine By similarity
Binding site141S-adenosyl-L-methionine; via amide nitrogen By similarity
Binding site541S-adenosyl-L-methionine By similarity
Binding site1811S-adenosyl-L-methionine By similarity

Sequences

Sequence LengthMass (Da)Tools
P0C6Q8 [UniParc].

Last modified March 18, 2008. Version 1.
Checksum: 48D831240F9E7C60

FASTA27731,624
        10         20         30         40         50         60 
MKKQRAFLKW AGGKYSLVED IQRHLPEARE LVEPFVGAGS VFLNTDFERY LLADINPDLI 

        70         80         90        100        110        120 
NFYNLLKTEP QAYIHEAKRW FVPENNRKEV YLDIRKQFNQ SDDAMFRSLA FLYMNRFGFN 

       130        140        150        160        170        180 
GLCRYNKKGG FNVPFGSYKK PYFPEQELEF FAEKAQRATF ICASYGETFA RAQSDSVIYC 

       190        200        210        220        230        240 
DPPYAPLSTT ANFTSYAGNG FTLDDQAALA DIAEKTAKER GISVLISNHD TTHTRRLYRG 

       250        260        270 
AQLNVVKANR TISRNGAGRN KVDELLALFT PHLSSQA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X67820 Genomic DNA. Translation: CAA48031.1. Frameshift.
AE003852 Genomic DNA. Translation: AAF95767.1.
PIRH82052.
S29558.
RefSeqNP_232254.1. NC_002505.1.

3D structure databases

ProteinModelPortalP0C6Q8.
SMRP0C6Q8. Positions 3-271.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243277.VC2626.

Protein family/group databases

REBASE4762. M.VchADamP.

Protocols and materials databases

DNASU2615643.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF95767; AAF95767; VC_2626.
GeneID2615643.
KEGGvch:VC2626.
PATRIC20084276. VBIVibCho83274_2504.

Phylogenomic databases

eggNOGCOG0338.
KOK06223.
OMALYMNRHG.
OrthoDBEOG6CS08V.
ProtClustDBCLSK874863.

Enzyme and pathway databases

BioCycVCHO:VC2626-MONOMER.

Family and domain databases

Gene3D1.10.1020.10. 1 hit.
InterProIPR023095. Ade_MeTrfase_dom_2.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR012263. M_m6A_EcoRV.
IPR012327. MeTrfase_D12.
[Graphical view]
PfamPF02086. MethyltransfD12. 1 hit.
[Graphical view]
PIRSFPIRSF000398. M_m6A_EcoRV. 1 hit.
PRINTSPR00505. D12N6MTFRASE.
TIGRFAMsTIGR00571. dam. 1 hit.
PROSITEPS00092. N6_MTASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDMA_VIBCH
AccessionPrimary (citable) accession number: P0C6Q8
Secondary accession number(s): Q08318, Q9KNV4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: December 11, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Restriction enzymes and methylases

Classification of restriction enzymes and methylases and list of entries