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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathway:iglycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI)
  4. Enolase (eno)
  5. Pyruvate kinase (VC_0485), Pyruvate kinase (VC_2008), Pyruvate kinase (VC_A0708)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361SubstrateBy similarity
Binding sitei113 – 1131SubstrateBy similarity
Binding sitei146 – 1461SubstrateBy similarity
Binding sitei197 – 1971ATPBy similarity
Binding sitei314 – 3141ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi340 – 3434ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:pgk
Ordered Locus Names:VC_0477
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000584 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 387387Phosphoglycerate kinasePRO_0000146034Add
BLAST

Proteomic databases

PRIDEiP0C6Q3.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi243277.VC0477.

Structurei

3D structure databases

ProteinModelPortaliP0C6Q3.
SMRiP0C6Q3. Positions 2-386.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 233Substrate bindingBy similarity
Regioni59 – 624Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Phylogenomic databases

eggNOGiCOG0126.
KOiK00927.
OMAiAGHPVGK.
OrthoDBiEOG64N9Z0.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C6Q3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVIKMIDLD LAGKRVFIRA DLNVPVKDGK VTSDARILAS LPTIKHCLEA
60 70 80 90 100
GAKVMVTSHL GRPTEGEYAE EFSLLPVVNY LNDALDCEVR LVKDYLDGVE
110 120 130 140 150
LNAGELVVLE NVRFNKGEKK NEEALSKKYA ALCDVFVMDA FGTAHRAQAS
160 170 180 190 200
THGVGMFAPI ACAGPLLADE LEALGKAMDK PARPMVAIVG GSKVSTKLTV
210 220 230 240 250
LESLSKIADQ LVVGGGIANT FIAAAGHNVG KSLYEADLVE TAKKLMEECA
260 270 280 290 300
IPVATDVACA KAFDENAEAE IKHVSEVQDD DMIFDLGPNS TAELAEILKN
310 320 330 340 350
AKTILWNGPV GVFEFKNFEA GTRGIAEAIA QSEGFSVAGG GDTLAAIDKF
360 370 380
GIKADVSYIS TGGGAFLEFV EGKKLPAVEM LEARAKA
Length:387
Mass (Da):40,979
Last modified:March 18, 2008 - v1
Checksum:i0D7EBFBF5C93F719
GO

Sequence cautioni

The sequence AAF93650.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF93650.1. Different initiation.
PIRiF82317.
RefSeqiNP_230131.1. NC_002505.1.
WP_001883298.1. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF93650; AAF93650; VC_0477.
GeneIDi2615271.
KEGGivch:VC0477.
PATRICi20080051. VBIVibCho83274_0451.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF93650.1. Different initiation.
PIRiF82317.
RefSeqiNP_230131.1. NC_002505.1.
WP_001883298.1. NC_002505.1.

3D structure databases

ProteinModelPortaliP0C6Q3.
SMRiP0C6Q3. Positions 2-386.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243277.VC0477.

Proteomic databases

PRIDEiP0C6Q3.

Protocols and materials databases

DNASUi2615271.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF93650; AAF93650; VC_0477.
GeneIDi2615271.
KEGGivch:VC0477.
PATRICi20080051. VBIVibCho83274_0451.

Phylogenomic databases

eggNOGiCOG0126.
KOiK00927.
OMAiAGHPVGK.
OrthoDBiEOG64N9Z0.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39315 / El Tor Inaba N16961.

Entry informationi

Entry nameiPGK_VIBCH
AccessioniPrimary (citable) accession number: P0C6Q3
Secondary accession number(s): P96154, Q9KUN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: July 22, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.