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P0C6M9

- LHDAG_HDVWO

UniProt

P0C6M9 - LHDAG_HDVWO

Protein

Large delta antigen

Gene
N/A
Organism
Hepatitis delta virus genotype I (isolate Woodchuck) (HDV)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 19 (01 Oct 2014)
      Sequence version 1 (14 Apr 2009)
      Previous versions | rss
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    Functioni

    Following virus entry into host cell, provides nuclear import of HDV RNPs thanks to its nuclear localization signal. Needs co-infection with hepatitis B virus to provide surface proteins, otherwise there is no packaging or budding. Packages the HDV ribonucleoprotein in hepatitis B virus empty particles. Interacts with both HDV genomic RNA and cytoplasmic tail of HBsAg. May inhibit viral RNA replication By similarity.By similarity

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. viral entry into host cell Source: UniProtKB-KW
    2. viral penetration into host nucleus Source: UniProtKB-KW

    Keywords - Biological processi

    Viral penetration into host nucleus, Virus entry into host cell

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Large delta antigen
    Short name:
    L-HDAg
    Alternative name(s):
    p27
    OrganismiHepatitis delta virus genotype I (isolate Woodchuck) (HDV)
    Taxonomic identifieri31764 [NCBI]
    Taxonomic lineageiVirusesDeltavirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000008686: Genome

    Subcellular locationi

    Virion. Host nucleushost nucleolus
    Note: isoprenylated in the cytoplasm, and translocates in the nucleus possibly after phosphorylation. Translocates after to nuclear speckle, then to the ER membrane where interaction with Hepatitis B virus antigene takes place By similarity.By similarity

    GO - Cellular componenti

    1. host cell nucleolus Source: UniProtKB-SubCell
    2. intracellular Source: GOC
    3. virion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host nucleus, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 211211Large delta antigenPRO_0000038158Add
    BLAST
    Propeptidei212 – 2143Removed in mature formBy similarityPRO_0000396678

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21Phosphoserine; by hostBy similarity
    Modified residuei13 – 131Omega-N-methylated arginine; by hostBy similarity
    Modified residuei72 – 721N6-acetyllysine; by hostBy similarity
    Modified residuei123 – 1231Phosphoserine; by hostBy similarity
    Modified residuei177 – 1771Phosphoserine; by hostBy similarity
    Modified residuei211 – 2111Cysteine methyl ester; by hostBy similarity
    Lipidationi211 – 2111S-farnesyl cysteine; by hostBy similarity

    Post-translational modificationi

    Prenylated by host farnesyl-transferase in the cytoplasm prior to nucleus translocation.By similarity
    Phosphorylated at serines by host CK2 and other kinases. phosphorylation does not seem to be important for its function By similarity.By similarity

    Keywords - PTMi

    Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

    Interactioni

    Subunit structurei

    Homodimer. Homooctamer. Interacts with HBV HBsAg. May interact with clathrin to induce virion budding By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP0C6M9.
    SMRiP0C6M9. Positions 12-60.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni12 – 6049DimerizationSequence AnalysisAdd
    BLAST
    Regioni97 – 10711RNA-bindingSequence AnalysisAdd
    BLAST
    Regioni136 – 14611RNA-bindingSequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi66 – 7510Nuclear localization signalBy similarity

    Sequence similaritiesi

    Belongs to the hepatitis delta antigen family.Curated

    Family and domain databases

    Gene3Di4.10.220.40. 1 hit.
    InterProiIPR027403. Delta_antigen_N.
    IPR002506. HDV_ag.
    [Graphical view]
    PfamiPF01517. HDV_ag. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0C6M9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRSESRKNR GGREEILEQW VAGRKKLEEL ERDLRKTKKK LKKIEDENPW    50
    LGNIKGILGK KDKDGEGAPP AKRARTDQME VDSGPRKRPL RGGFTDKERQ 100
    DHRRRKALEN KKKQLSAGGK NLSKEEEEEL RRLTEEDERR ERRVAGPPVG 150
    GVNPLEGGSR GAPGGGFVPN LQGVPESPFS RTGEGLDIRG NQGFPWDILF 200
    PADPPFSPQS CRPQ 214
    Length:214
    Mass (Da):24,078
    Last modified:April 14, 2009 - v1
    Checksum:i44360B6EF6870B5C
    GO

    RNA editingi

    Partially edited. RNA editing at this position occurs on the antigenomic strand and consists of a conversion of A to G catalyzed by the cellular enzyme ADAR1. The unedited RNA version gives rise to the small delta antigen (AC P29997), which ends with a nonsense codon at position 196. In the edited version, this amber codon is modified to a tryptophan codon and gives rise to the large delta antigen protein. S-HDAg suppresses editing of non-replicating antigenomic RNA, thereby regulating the extent of editing By similarity.By similarity

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti11 – 111G → R in strain: Isolate Woodchuck5.
    Natural varianti86 – 861R → G in strain: Isolate Woodchuck5.
    Natural varianti96 – 961D → E in strain: Isolate Woodchuck5.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M21012 Genomic RNA. Translation: AAA45723.1. Different termination.
    AJ307077 Genomic RNA. Translation: CAC32838.1.
    PIRiA30054. SAVLWC.

    Keywords - Coding sequence diversityi

    RNA editing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M21012 Genomic RNA. Translation: AAA45723.1 . Different termination.
    AJ307077 Genomic RNA. Translation: CAC32838.1 .
    PIRi A30054. SAVLWC.

    3D structure databases

    ProteinModelPortali P0C6M9.
    SMRi P0C6M9. Positions 12-60.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 4.10.220.40. 1 hit.
    InterProi IPR027403. Delta_antigen_N.
    IPR002506. HDV_ag.
    [Graphical view ]
    Pfami PF01517. HDV_ag. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of hepatitis delta virus RNA from an infected woodchuck liver: sequence, structure, and applications."
      Kuo M.Y.P., Goldberg J., Coates L., Mason W., Gerin J., Taylor J.
      J. Virol. 62:1855-1861(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Nucleotide sequence analysis of three different hepatitis delta viruses isolated from a woodchuck and humans."
      Deny P., Zignego A.L., Rascalou N., Ponzetto A., Tiollais P., Brechot C.
      J. Gen. Virol. 72:735-739(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA], RNA EDITING.
      Strain: Isolate Woodchuck5.
    3. "Hepatitis D."
      Husa P., Linhartova A., Nemecek V., Husova L.
      Acta Virol. 49:219-225(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    4. "Post-translational modification of delta antigen of hepatitis D virus."
      Huang W.H., Chen C.W., Wu H.L., Chen P.J.
      Curr. Top. Microbiol. Immunol. 307:91-112(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiLHDAG_HDVWO
    AccessioniPrimary (citable) accession number: P0C6M9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: April 14, 2009
    Last modified: October 1, 2014
    This is version 19 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    This strain belongs to the genotype I found in North America, Europe, Africa, East and West Asia and the South Pacific.

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3