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P0C6M9

- LHDAG_HDVWO

UniProt

P0C6M9 - LHDAG_HDVWO

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Protein

Large delta antigen

Gene
N/A
Organism
Hepatitis delta virus genotype I (isolate Woodchuck) (HDV)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Following virus entry into host cell, provides nuclear import of HDV RNPs thanks to its nuclear localization signal. Needs co-infection with hepatitis B virus to provide surface proteins, otherwise there is no packaging or budding. Packages the HDV ribonucleoprotein in hepatitis B virus empty particles. Interacts with both HDV genomic RNA and cytoplasmic tail of HBsAg. May inhibit viral RNA replication (By similarity).By similarity

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. viral entry into host cell Source: UniProtKB-KW
  2. viral penetration into host nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Viral penetration into host nucleus, Virus entry into host cell

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Large delta antigen
Short name:
L-HDAg
Alternative name(s):
p27
OrganismiHepatitis delta virus genotype I (isolate Woodchuck) (HDV)
Taxonomic identifieri31764 [NCBI]
Taxonomic lineageiVirusesDeltavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000008686: Genome

Subcellular locationi

Virion. Host nucleushost nucleolus
Note: isoprenylated in the cytoplasm, and translocates in the nucleus possibly after phosphorylation. Translocates after to nuclear speckle, then to the ER membrane where interaction with Hepatitis B virus antigene takes place (By similarity).By similarity

GO - Cellular componenti

  1. host cell nucleus Source: UniProtKB-KW
  2. intracellular Source: GOC
  3. virion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 211211Large delta antigenPRO_0000038158Add
BLAST
Propeptidei212 – 2143Removed in mature formBy similarityPRO_0000396678

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21Phosphoserine; by hostBy similarity
Modified residuei13 – 131Omega-N-methylated arginine; by hostBy similarity
Modified residuei72 – 721N6-acetyllysine; by hostBy similarity
Modified residuei123 – 1231Phosphoserine; by hostBy similarity
Modified residuei177 – 1771Phosphoserine; by hostBy similarity
Modified residuei211 – 2111Cysteine methyl ester; by hostBy similarity
Lipidationi211 – 2111S-farnesyl cysteine; by hostBy similarity

Post-translational modificationi

Prenylated by host farnesyl-transferase in the cytoplasm prior to nucleus translocation.By similarity
Phosphorylated at serines by host CK2 and other kinases. phosphorylation does not seem to be important for its function (By similarity).By similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Interactioni

Subunit structurei

Homodimer. Homooctamer. Interacts with HBV HBsAg. May interact with clathrin to induce virion budding (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP0C6M9.
SMRiP0C6M9. Positions 12-60.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni12 – 6049DimerizationSequence AnalysisAdd
BLAST
Regioni97 – 10711RNA-bindingSequence AnalysisAdd
BLAST
Regioni136 – 14611RNA-bindingSequence AnalysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi66 – 7510Nuclear localization signalBy similarity

Sequence similaritiesi

Belongs to the hepatitis delta antigen family.Curated

Family and domain databases

Gene3Di4.10.220.40. 1 hit.
InterProiIPR027403. Delta_antigen_N.
IPR002506. HDV_ag.
[Graphical view]
PfamiPF01517. HDV_ag. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C6M9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRSESRKNR GGREEILEQW VAGRKKLEEL ERDLRKTKKK LKKIEDENPW
60 70 80 90 100
LGNIKGILGK KDKDGEGAPP AKRARTDQME VDSGPRKRPL RGGFTDKERQ
110 120 130 140 150
DHRRRKALEN KKKQLSAGGK NLSKEEEEEL RRLTEEDERR ERRVAGPPVG
160 170 180 190 200
GVNPLEGGSR GAPGGGFVPN LQGVPESPFS RTGEGLDIRG NQGFPWDILF
210
PADPPFSPQS CRPQ
Length:214
Mass (Da):24,078
Last modified:April 14, 2009 - v1
Checksum:i44360B6EF6870B5C
GO

RNA editingi

Partially edited. RNA editing at this position occurs on the antigenomic strand and consists of a conversion of A to G catalyzed by the cellular enzyme ADAR1. The unedited RNA version gives rise to the small delta antigen (AC P29997), which ends with a nonsense codon at position 196. In the edited version, this amber codon is modified to a tryptophan codon and gives rise to the large delta antigen protein. S-HDAg suppresses editing of non-replicating antigenomic RNA, thereby regulating the extent of editing (By similarity).By similarity

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti11 – 111G → R in strain: Isolate Woodchuck5.
Natural varianti86 – 861R → G in strain: Isolate Woodchuck5.
Natural varianti96 – 961D → E in strain: Isolate Woodchuck5.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21012 Genomic RNA. Translation: AAA45723.1. Different termination.
AJ307077 Genomic RNA. Translation: CAC32838.1.
PIRiA30054. SAVLWC.

Keywords - Coding sequence diversityi

RNA editing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21012 Genomic RNA. Translation: AAA45723.1 . Different termination.
AJ307077 Genomic RNA. Translation: CAC32838.1 .
PIRi A30054. SAVLWC.

3D structure databases

ProteinModelPortali P0C6M9.
SMRi P0C6M9. Positions 12-60.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 4.10.220.40. 1 hit.
InterProi IPR027403. Delta_antigen_N.
IPR002506. HDV_ag.
[Graphical view ]
Pfami PF01517. HDV_ag. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of hepatitis delta virus RNA from an infected woodchuck liver: sequence, structure, and applications."
    Kuo M.Y.P., Goldberg J., Coates L., Mason W., Gerin J., Taylor J.
    J. Virol. 62:1855-1861(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Nucleotide sequence analysis of three different hepatitis delta viruses isolated from a woodchuck and humans."
    Deny P., Zignego A.L., Rascalou N., Ponzetto A., Tiollais P., Brechot C.
    J. Gen. Virol. 72:735-739(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA], RNA EDITING.
    Strain: Isolate Woodchuck5.
  3. "Hepatitis D."
    Husa P., Linhartova A., Nemecek V., Husova L.
    Acta Virol. 49:219-225(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  4. "Post-translational modification of delta antigen of hepatitis D virus."
    Huang W.H., Chen C.W., Wu H.L., Chen P.J.
    Curr. Top. Microbiol. Immunol. 307:91-112(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiLHDAG_HDVWO
AccessioniPrimary (citable) accession number: P0C6M9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 14, 2009
Last modified: October 29, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

This strain belongs to the genotype I found in North America, Europe, Africa, East and West Asia and the South Pacific.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3