P0C6K6 (HBEAG_HBVB8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Truncated HBeAg protein

Gene names

Name:

C

Organism

Hepatitis B virus genotype B1 (isolate Japan/Ry30/2002) (HBV-B) [Complete proteome]

Taxonomic identifier

489465 [NCBI]

Taxonomic lineage

Viruses › Retro-transcribing viruses › Hepadnaviridae › Orthohepadnavirus

Virus host

Pan troglodytes (Chimpanzee) [TaxID: 9598]
Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	27 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Miscellaneous

A genomic mutation in 1896 creates a stop codon at position 28 of HBeAg, without affecting capsid open reading frame. The HBeAg negative variants of HBV are associated with fulminant hepatitis, but can also be found in patients with persistent infection and chronic hepatitis.

Ontologies

Keywords
Coding sequence diversity	Alternative initiation
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pathogenesis Inferred from electronic annotation. Source: InterPro
Molecular function	structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative initiation. [Align] [Select]

Isoform External core antigen (identifier: P0C6K6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Capsid protein (identifier: P0C677-1)

The sequence of this isoform can be found in the external entry P0C677.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 27	27	Truncated HBeAg protein		PRO_0000324711

Sequences

	Sequence		Length	Mass (Da)
	Isoform External core antigen [UniParc]. Last modified March 18, 2008. Version 1. Checksum: B42B9C13CC7B689D	FASTA	27	2,995
	10 20 MQLFHLCLVI SCSCPTVQAS KLCLGWL
	Isoform Capsid protein [UniParc]. See P0C677.		–	–

References

[1]

"Hepatitis B virus of genotype B with or without recombination with genotype C over the precore region plus the core gene." Sugauchi F., Orito E., Ichida T., Kato H., Sakugawa H., Kakumu S., Ishida T., Chutaputti A., Lai C.L., Ueda R., Miyakawa Y., Mizokami M. J. Virol. 76:5985-5992(2002) [PubMed: 12021331] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB073854 Genomic DNA. No translation available.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR013195. Hepatitis_B_virus_capsid_N. [Graphical view]
Pfam	PF08290. Hep_core_N. 1 hit. [Graphical view]
ProDom	PD000874. Vir_capsid_Znf-put_N_Hepatitis. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

HBEAG_HBVB8

Accession

Primary (citable) accession number: P0C6K6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	March 18, 2008
Last modified:	January 25, 2012
This is version 7 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program