##gff-version 3 P0C6F8 UniProtKB Chain 1 4376 . . . ID=PRO_0000338074;Note=Replicase polyprotein 1a P0C6F8 UniProtKB Chain 1 179 . . . ID=PRO_0000338075;Note=Non-structural protein 1;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6F8 UniProtKB Chain 180 818 . . . ID=PRO_0000338076;Note=Non-structural protein 2;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6F8 UniProtKB Chain 819 2734 . . . ID=PRO_0000338077;Note=Papain-like protease nsp3;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6F8 UniProtKB Chain 2735 3234 . . . ID=PRO_0000338078;Note=Non-structural protein 4;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6F8 UniProtKB Chain 3235 3540 . . . ID=PRO_0000338079;Note=3C-like proteinase nsp5;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6F8 UniProtKB Chain 3541 3830 . . . ID=PRO_0000338080;Note=Non-structural protein 6;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6F8 UniProtKB Chain 3831 3913 . . . ID=PRO_0000338081;Note=Non-structural protein 7;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6F8 UniProtKB Chain 3914 4111 . . . ID=PRO_0000338082;Note=Non-structural protein 8;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6F8 UniProtKB Chain 4112 4224 . . . ID=PRO_0000338083;Note=RNA-capping enzyme subunit nsp9;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6F8 UniProtKB Chain 4225 4363 . . . ID=PRO_0000338084;Note=Non-structural protein 10;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6F8 UniProtKB Chain 4364 4376 . . . ID=PRO_0000338085;Note=Non-structural protein 11;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F8 UniProtKB Transmembrane 2197 2217 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F8 UniProtKB Transmembrane 2298 2318 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F8 UniProtKB Transmembrane 2345 2365 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F8 UniProtKB Transmembrane 2744 2764 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F8 UniProtKB Transmembrane 2986 3006 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F8 UniProtKB Transmembrane 3016 3036 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F8 UniProtKB Transmembrane 3048 3068 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F8 UniProtKB Transmembrane 3071 3091 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F8 UniProtKB Transmembrane 3099 3119 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F8 UniProtKB Transmembrane 3136 3156 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F8 UniProtKB Transmembrane 3558 3578 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F8 UniProtKB Transmembrane 3580 3600 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F8 UniProtKB Transmembrane 3606 3626 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F8 UniProtKB Transmembrane 3652 3672 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F8 UniProtKB Transmembrane 3679 3698 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F8 UniProtKB Transmembrane 3722 3742 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F8 UniProtKB Transmembrane 3750 3770 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F8 UniProtKB Domain 12 127 . . . Note=CoV Nsp1 globular;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01307 P0C6F8 UniProtKB Domain 148 179 . . . Note=BetaCoV Nsp1 C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01308 P0C6F8 UniProtKB Domain 183 456 . . . Note=CoV Nsp2 N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01333 P0C6F8 UniProtKB Domain 458 688 . . . Note=CoV Nsp2 middle;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01334 P0C6F8 UniProtKB Domain 690 818 . . . Note=CoV Nsp2 C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01335 P0C6F8 UniProtKB Domain 822 930 . . . Note=Ubiquitin-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00214 P0C6F8 UniProtKB Domain 998 1164 . . . Note=Macro 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00490 P0C6F8 UniProtKB Domain 1201 1329 . . . Note=Macro 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00490 P0C6F8 UniProtKB Domain 1337 1464 . . . Note=Macro 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00490 P0C6F8 UniProtKB Domain 1466 1532 . . . Note=DPUP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01289 P0C6F8 UniProtKB Domain 1536 1591 . . . Note=Ubiquitin-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00214 P0C6F8 UniProtKB Domain 1605 1869 . . . Note=Peptidase C16;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6F8 UniProtKB Domain 1882 1992 . . . Note=Nucleic acid-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01290 P0C6F8 UniProtKB Domain 2017 2126 . . . Note=G2M;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01338 P0C6F8 UniProtKB Domain 2218 2288 . . . Note=3Ecto;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01337 P0C6F8 UniProtKB Domain 2366 2734 . . . Note=CoV Nsp3 Y;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6F8 UniProtKB Domain 3136 3234 . . . Note=Nsp4C;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01291 P0C6F8 UniProtKB Domain 3235 3540 . . . Note=Peptidase C30;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00772 P0C6F8 UniProtKB Domain 3831 3913 . . . Note=RdRp Nsp7 cofactor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01294 P0C6F8 UniProtKB Domain 3914 4111 . . . Note=RdRp Nsp8 cofactor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01295 P0C6F8 UniProtKB Domain 4112 4224 . . . Note=Nsp9 ssRNA-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01296 P0C6F8 UniProtKB Domain 4225 4363 . . . Note=ExoN/MTase coactivator;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6F8 UniProtKB Zinc finger 1723 1760 . . . Note=C4-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6F8 UniProtKB Zinc finger 4298 4314 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6F8 UniProtKB Zinc finger 4341 4354 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6F8 UniProtKB Region 200 236 . . . Note=C2H2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01333 P0C6F8 UniProtKB Region 323 344 . . . Note=C4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01333 P0C6F8 UniProtKB Region 370 416 . . . Note=C2HC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01333 P0C6F8 UniProtKB Region 2086 2365 . . . Note=HD1;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6F8 UniProtKB Region 2366 2456 . . . Note=Y1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6F8 UniProtKB Region 2370 2383 . . . Note=ZF1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6F8 UniProtKB Region 2416 2426 . . . Note=ZF2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6F8 UniProtKB Region 2457 2734 . . . Note=CoV-Y;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6F8 UniProtKB Region 2457 2551 . . . Note=Y2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6F8 UniProtKB Region 2552 2633 . . . Note=Y3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6F8 UniProtKB Region 2634 2734 . . . Note=Y4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6F8 UniProtKB Region 2749 3156 . . . Note=HD2;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6F8 UniProtKB Region 3558 3770 . . . Note=HD3;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6F8 UniProtKB Active site 1645 1645 . . . Note=For PL-PRO activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6F8 UniProtKB Active site 1806 1806 . . . Note=For PL-PRO activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6F8 UniProtKB Active site 1820 1820 . . . Note=For PL-PRO activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6F8 UniProtKB Active site 3275 3275 . . . Note=For 3CL-PRO activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00772 P0C6F8 UniProtKB Active site 3379 3379 . . . Note=For 3CL-PRO activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00772 P0C6F8 UniProtKB Binding site 200 200 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01333 P0C6F8 UniProtKB Binding site 231 231 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01333 P0C6F8 UniProtKB Binding site 234 234 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01333 P0C6F8 UniProtKB Binding site 236 236 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01333 P0C6F8 UniProtKB Binding site 323 323 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01333 P0C6F8 UniProtKB Binding site 326 326 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01333 P0C6F8 UniProtKB Binding site 341 341 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01333 P0C6F8 UniProtKB Binding site 344 344 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01333 P0C6F8 UniProtKB Binding site 370 370 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01333 P0C6F8 UniProtKB Binding site 373 373 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01333 P0C6F8 UniProtKB Binding site 382 382 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01333 P0C6F8 UniProtKB Binding site 416 416 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01333 P0C6F8 UniProtKB Binding site 1723 1723 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6F8 UniProtKB Binding site 1726 1726 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6F8 UniProtKB Binding site 1758 1758 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6F8 UniProtKB Binding site 1760 1760 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6F8 UniProtKB Binding site 2370 2370 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6F8 UniProtKB Binding site 2375 2375 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6F8 UniProtKB Binding site 2380 2380 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6F8 UniProtKB Binding site 2383 2383 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6F8 UniProtKB Binding site 2416 2416 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6F8 UniProtKB Binding site 2419 2419 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6F8 UniProtKB Binding site 2423 2423 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6F8 UniProtKB Binding site 2426 2426 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6F8 UniProtKB Binding site 4298 4298 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6F8 UniProtKB Binding site 4301 4301 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6F8 UniProtKB Binding site 4307 4307 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6F8 UniProtKB Binding site 4314 4314 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6F8 UniProtKB Binding site 4341 4341 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6F8 UniProtKB Binding site 4344 4344 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6F8 UniProtKB Binding site 4352 4352 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6F8 UniProtKB Binding site 4354 4354 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6F8 UniProtKB Site 179 180 . . . Note=Cleavage%3B by PL-PRO;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6F8 UniProtKB Site 818 819 . . . Note=Cleavage%3B by PL-PRO;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6F8 UniProtKB Site 3234 3235 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6F8 UniProtKB Site 3540 3541 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6F8 UniProtKB Site 3830 3831 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6F8 UniProtKB Site 3913 3914 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6F8 UniProtKB Site 4111 4112 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6F8 UniProtKB Site 4224 4225 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6F8 UniProtKB Site 4363 4364 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6F8 UniProtKB Disulfide bond 2234 2262 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01337 P0C6F8 UniProtKB Disulfide bond 2253 2259 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01337