##gff-version 3 P0C6F7 UniProtKB Chain 1 4441 . . . ID=PRO_0000338062;Note=Replicase polyprotein 1a P0C6F7 UniProtKB Chain 1 195 . . . ID=PRO_0000338063;Note=Non-structural protein 1;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F7 UniProtKB Chain 196 847 . . . ID=PRO_0000338064;Note=Non-structural protein 2;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F7 UniProtKB Chain 848 2791 . . . ID=PRO_0000338065;Note=Papain-like protease nsp3;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F7 UniProtKB Chain 2792 3298 . . . ID=PRO_0000338066;Note=Non-structural protein 4;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F7 UniProtKB Chain 3299 3604 . . . ID=PRO_0000338067;Note=3C-like proteinase nsp5;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F7 UniProtKB Chain 3605 3896 . . . ID=PRO_0000338068;Note=Non-structural protein 6;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F7 UniProtKB Chain 3897 3979 . . . ID=PRO_0000338069;Note=Non-structural protein 7;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F7 UniProtKB Chain 3980 4178 . . . ID=PRO_0000338070;Note=Non-structural protein 8;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F7 UniProtKB Chain 4179 4288 . . . ID=PRO_0000338071;Note=RNA-capping enzyme subunit nsp9;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F7 UniProtKB Chain 4288 4441 . . . ID=PRO_0000338073;Note=Non-structural protein 11;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F7 UniProtKB Chain 4289 4427 . . . ID=PRO_0000338072;Note=Non-structural protein 10;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F7 UniProtKB Transmembrane 2152 2172 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F7 UniProtKB Transmembrane 2229 2249 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F7 UniProtKB Transmembrane 2333 2353 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F7 UniProtKB Transmembrane 2357 2377 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F7 UniProtKB Transmembrane 2382 2402 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F7 UniProtKB Transmembrane 2807 2827 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F7 UniProtKB Transmembrane 3079 3099 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F7 UniProtKB Transmembrane 3112 3132 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F7 UniProtKB Transmembrane 3156 3176 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F7 UniProtKB Transmembrane 3610 3630 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F7 UniProtKB Transmembrane 3644 3664 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F7 UniProtKB Transmembrane 3669 3689 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F7 UniProtKB Transmembrane 3714 3734 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F7 UniProtKB Transmembrane 3742 3762 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F7 UniProtKB Transmembrane 3791 3811 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F7 UniProtKB Transmembrane 3815 3835 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F7 UniProtKB Domain 25 151 . . . Note=CoV Nsp1 globular;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01307 P0C6F7 UniProtKB Domain 167 195 . . . Note=BetaCoV Nsp1 C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01308 P0C6F7 UniProtKB Domain 197 472 . . . Note=CoV Nsp2 N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01333 P0C6F7 UniProtKB Domain 478 712 . . . Note=CoV Nsp2 middle;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01334 P0C6F7 UniProtKB Domain 714 847 . . . Note=CoV Nsp2 C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01335 P0C6F7 UniProtKB Domain 851 960 . . . Note=Ubiquitin-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00214 P0C6F7 UniProtKB Domain 1159 1328 . . . Note=Macro 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00490 P0C6F7 UniProtKB Domain 1329 1453 . . . Note=Macro 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00490 P0C6F7 UniProtKB Domain 1453 1526 . . . Note=DPUP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01289 P0C6F7 UniProtKB Domain 1531 1586 . . . Note=Ubiquitin-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00214 P0C6F7 UniProtKB Domain 1600 1871 . . . Note=Peptidase C16;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6F7 UniProtKB Domain 1885 2002 . . . Note=Nucleic acid-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01290 P0C6F7 UniProtKB Domain 2019 2140 . . . Note=G2M;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01338 P0C6F7 UniProtKB Domain 2266 2332 . . . Note=3Ecto;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01337 P0C6F7 UniProtKB Domain 2416 2789 . . . Note=CoV Nsp3 Y;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6F7 UniProtKB Domain 3202 3298 . . . Note=Nsp4C;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01291 P0C6F7 UniProtKB Domain 3299 3604 . . . Note=Peptidase C30;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00772 P0C6F7 UniProtKB Domain 3897 3979 . . . Note=RdRp Nsp7 cofactor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01294 P0C6F7 UniProtKB Domain 3980 4178 . . . Note=RdRp Nsp8 cofactor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01295 P0C6F7 UniProtKB Domain 4179 4288 . . . Note=Nsp9 ssRNA-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01296 P0C6F7 UniProtKB Domain 4289 4427 . . . Note=ExoN/MTase coactivator;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6F7 UniProtKB Zinc finger 1721 1758 . . . Note=C4-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6F7 UniProtKB Zinc finger 4362 4378 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6F7 UniProtKB Zinc finger 4404 4417 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6F7 UniProtKB Region 339 360 . . . Note=C4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01333 P0C6F7 UniProtKB Region 1039 1061 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P0C6F7 UniProtKB Region 2119 2402 . . . Note=HD1;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6F7 UniProtKB Region 2416 2506 . . . Note=Y1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6F7 UniProtKB Region 2420 2433 . . . Note=ZF1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6F7 UniProtKB Region 2466 2476 . . . Note=ZF2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6F7 UniProtKB Region 2507 2789 . . . Note=CoV-Y;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6F7 UniProtKB Region 2507 2605 . . . Note=Y2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6F7 UniProtKB Region 2606 2688 . . . Note=Y3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6F7 UniProtKB Region 2689 2789 . . . Note=Y4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6F7 UniProtKB Region 2807 3176 . . . Note=HD2;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6F7 UniProtKB Region 3610 3835 . . . Note=HD3;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6F7 UniProtKB Compositional bias 1040 1061 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P0C6F7 UniProtKB Active site 1641 1641 . . . Note=For PL-PRO activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6F7 UniProtKB Active site 1807 1807 . . . Note=For PL-PRO activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6F7 UniProtKB Active site 1822 1822 . . . Note=For PL-PRO activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6F7 UniProtKB Active site 3339 3339 . . . Note=For 3CL-PRO activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00772 P0C6F7 UniProtKB Active site 3446 3446 . . . Note=For 3CL-PRO activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00772 P0C6F7 UniProtKB Binding site 339 339 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01333 P0C6F7 UniProtKB Binding site 342 342 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01333 P0C6F7 UniProtKB Binding site 358 358 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01333 P0C6F7 UniProtKB Binding site 360 360 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01333 P0C6F7 UniProtKB Binding site 1721 1721 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6F7 UniProtKB Binding site 1724 1724 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6F7 UniProtKB Binding site 1756 1756 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6F7 UniProtKB Binding site 1758 1758 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6F7 UniProtKB Binding site 2420 2420 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6F7 UniProtKB Binding site 2425 2425 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6F7 UniProtKB Binding site 2430 2430 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6F7 UniProtKB Binding site 2433 2433 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6F7 UniProtKB Binding site 2466 2466 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6F7 UniProtKB Binding site 2469 2469 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6F7 UniProtKB Binding site 2473 2473 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6F7 UniProtKB Binding site 2476 2476 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6F7 UniProtKB Binding site 4362 4362 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6F7 UniProtKB Binding site 4365 4365 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6F7 UniProtKB Binding site 4371 4371 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6F7 UniProtKB Binding site 4378 4378 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6F7 UniProtKB Binding site 4404 4404 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6F7 UniProtKB Binding site 4407 4407 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6F7 UniProtKB Binding site 4415 4415 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6F7 UniProtKB Binding site 4417 4417 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6F7 UniProtKB Site 195 196 . . . Note=Cleavage;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F7 UniProtKB Site 847 848 . . . Note=Cleavage%3B by PL-PRO;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F7 UniProtKB Site 2791 2792 . . . Note=Cleavage%3B by PL-PRO;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F7 UniProtKB Site 3298 3299 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F7 UniProtKB Site 3604 3605 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F7 UniProtKB Site 3896 3897 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F7 UniProtKB Site 3979 3980 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F7 UniProtKB Site 4178 4179 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F7 UniProtKB Site 4288 4289 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F7 UniProtKB Site 4427 4428 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6F7 UniProtKB Disulfide bond 2282 2310 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01337 P0C6F7 UniProtKB Disulfide bond 2300 2307 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01337