SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P0C6F6

- R1A_BC512

UniProt

P0C6F6 - R1A_BC512

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Replicase polyprotein 1a
Gene
1a
Organism
Bat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005)
Status
Reviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

The papain-like proteinase 1 (PLP1) and papain-like proteinase 2 (PLP2) are responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PLP2 possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. PLP2 also antagonizes innate immune induction of type I interferon by blocking the nuclear translocation of host IRF-3 By similarity.
The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK. Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function By similarity.
Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter By similarity.
Nsp9 is a ssRNA-binding protein By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei110 – 1112Cleavage; by PL1-PRO By similarity
Sitei897 – 8982Cleavage; by PL1-PRO By similarity
Active sitei1103 – 11031For PL1-PRO activity By similarity
Active sitei1252 – 12521For PL1-PRO activity By similarity
Active sitei1737 – 17371For PL2-PRO activity By similarity
Active sitei1902 – 19021For PL2-PRO activity By similarity
Sitei2530 – 25312Cleavage; by PL2-PRO By similarity
Sitei3012 – 30132Cleavage; by 3CL-PRO By similarity
Active sitei3053 – 30531For 3CL-PRO activity By similarity
Active sitei3156 – 31561For 3CL-PRO activity By similarity
Sitei3314 – 33152Cleavage; by 3CL-PRO By similarity
Sitei3590 – 35912Cleavage; by 3CL-PRO By similarity
Sitei3673 – 36742Cleavage; by 3CL-PRO By similarity
Sitei3868 – 38692Cleavage; by 3CL-PRO By similarity
Sitei3976 – 39772Cleavage; by 3CL-PRO By similarity
Sitei4111 – 41122Cleavage; by 3CL-PRO By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1174 – 120532C4-type By similarity
Add
BLAST
Zinc fingeri4050 – 406617 By similarity
Add
BLAST
Zinc fingeri4092 – 410514 By similarity
Add
BLAST

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
  2. RNA-directed RNA polymerase activity Source: InterPro
  3. cysteine-type endopeptidase activity Source: InterPro
  4. omega peptidase activity Source: InterPro
  5. zinc ion binding Source: InterPro

GO - Biological processi

  1. induction by virus of host autophagy Source: UniProtKB-KW
  2. modulation by virus of host protein ubiquitination Source: UniProtKB-KW
  3. suppression by virus of host IRF3 activity Source: UniProtKB-KW
  4. viral genome replication Source: InterPro
  5. viral protein processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Activation of host autophagy by virus, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host IRF3 by virus, Inhibition of host RLR pathway by virus, Modulation of host ubiquitin pathway by viral deubiquitinase, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathway, Viral immunoevasion

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Replicase polyprotein 1a
Short name:
pp1a
Alternative name(s):
ORF1a polyprotein
Cleaved into the following 11 chains:
Non-structural protein 1
Short name:
nsp1
Alternative name(s):
p9
Non-structural protein 2
Short name:
nsp2
Alternative name(s):
p87
Alternative name(s):
PL1-PRO/PL2-PRO
PLP1/PLP2
Papain-like proteinases 1/2
p195
Non-structural protein 4
Short name:
nsp4
Alternative name(s):
Peptide HD2
3C-like proteinase (EC:3.4.22.-)
Short name:
3CL-PRO
Short name:
3CLp
Alternative name(s):
M-PRO
nsp5
p34
Non-structural protein 6
Short name:
nsp6
Non-structural protein 7
Short name:
nsp7
Alternative name(s):
p5
Non-structural protein 8
Short name:
nsp8
Alternative name(s):
p23
Non-structural protein 9
Short name:
nsp9
Alternative name(s):
p12
Non-structural protein 10
Short name:
nsp10
Alternative name(s):
Growth factor-like peptide
Short name:
GFL
p14
Non-structural protein 11
Short name:
nsp11
Gene namesi
ORF Names:1a
OrganismiBat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005)
Taxonomic identifieri693999 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeAlphacoronavirus
Virus hostiScotophilus kuhlii (Lesser asiatic yellow bat) [TaxID: 153297]

Subcellular locationi

Chain Non-structural protein 7 : Host cytoplasmhost perinuclear region By similarity
Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes By similarity.
Chain Non-structural protein 8 : Host cytoplasmhost perinuclear region By similarity
Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes By similarity.
Chain Non-structural protein 9 : Host cytoplasmhost perinuclear region By similarity
Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes By similarity.
Chain Non-structural protein 10 : Host cytoplasmhost perinuclear region By similarity
Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1973 – 199321Helical; Reviewed prediction
Add
BLAST
Transmembranei2036 – 205621Helical; Reviewed prediction
Add
BLAST
Transmembranei2119 – 213921Helical; Reviewed prediction
Add
BLAST
Transmembranei2141 – 216121Helical; Reviewed prediction
Add
BLAST
Transmembranei2164 – 218421Helical; Reviewed prediction
Add
BLAST
Transmembranei2543 – 256321Helical; Reviewed prediction
Add
BLAST
Transmembranei2634 – 265421Helical; Reviewed prediction
Add
BLAST
Transmembranei2669 – 268921Helical; Reviewed prediction
Add
BLAST
Transmembranei2769 – 278921Helical; Reviewed prediction
Add
BLAST
Transmembranei2802 – 282221Helical; Reviewed prediction
Add
BLAST
Transmembranei2829 – 284921Helical; Reviewed prediction
Add
BLAST
Transmembranei2878 – 289821Helical; Reviewed prediction
Add
BLAST
Transmembranei3351 – 337121Helical; Reviewed prediction
Add
BLAST
Transmembranei3376 – 339621Helical; Reviewed prediction
Add
BLAST
Transmembranei3414 – 343421Helical; Reviewed prediction
Add
BLAST
Transmembranei3443 – 346321Helical; Reviewed prediction
Add
BLAST
Transmembranei3466 – 348621Helical; Reviewed prediction
Add
BLAST
Transmembranei3488 – 350720Helical; Reviewed prediction
Add
BLAST
Transmembranei3511 – 353121Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. host cell membrane Source: UniProtKB-SubCell
  2. host cell perinuclear region of cytoplasm Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Host membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 41284128Replicase polyprotein 1a
PRO_0000338050Add
BLAST
Chaini1 – 110110Non-structural protein 1 By similarity
PRO_0000338051Add
BLAST
Chaini111 – 897787Non-structural protein 2 By similarity
PRO_0000338052Add
BLAST
Chaini898 – 25301633Non-structural protein 3 By similarity
PRO_0000338053Add
BLAST
Chaini2531 – 3012482Non-structural protein 4 By similarity
PRO_0000338054Add
BLAST
Chaini3013 – 33143023C-like proteinase By similarity
PRO_0000338055Add
BLAST
Chaini3315 – 3590276Non-structural protein 6 By similarity
PRO_0000338056Add
BLAST
Chaini3591 – 367383Non-structural protein 7 By similarity
PRO_0000338057Add
BLAST
Chaini3674 – 3868195Non-structural protein 8 By similarity
PRO_0000338058Add
BLAST
Chaini3869 – 3976108Non-structural protein 9 By similarity
PRO_0000338059Add
BLAST
Chaini3977 – 4111135Non-structural protein 10 By similarity
PRO_0000338060Add
BLAST
Chaini4112 – 412817Non-structural protein 11 Reviewed prediction
PRO_0000338061Add
BLAST

Post-translational modificationi

Specific enzymatic cleavages in vivo by its own proteases yield mature proteins. 3CL-PRO and PL-PRO proteinases are autocatalytically processed By similarity.

Interactioni

Subunit structurei

3CL-PRO exists as monomer and homodimer. Eight copies of nsp7 and eight copies of nsp8 assemble to form a heterohexadecamer. Nsp9 is a dimer. Nsp10 forms a dodecamer By similarity.

Structurei

3D structure databases

ProteinModelPortaliP0C6F6.
SMRiP0C6F6. Positions 3013-3311, 3871-3975, 3982-4107.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1069 – 1302234Peptidase C16 1
Add
BLAST
Domaini1303 – 1467165Macro
Add
BLAST
Domaini1699 – 1965267Peptidase C16 2
Add
BLAST
Domaini3013 – 3314302Peptidase C30
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1973 – 2184212HD1 By similarity
Add
BLAST
Regioni2543 – 2898356HD2 By similarity
Add
BLAST
Regioni3351 – 3531181HD3 By similarity
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1827 – 1946120Val-rich
Add
BLAST

Domaini

The hydrophobic domains (HD) could mediate the membrane association of the replication complex and thereby alter the architecture of the host cell membrane By similarity.

Sequence similaritiesi

Contains 1 Macro domain.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix, Zinc-finger

Family and domain databases

InterProiIPR002589. Macro_dom.
IPR014828. NSP7.
IPR014829. NSP8.
IPR014822. NSP9.
IPR008740. Peptidase_C30.
IPR013016. Peptidase_C30/C16.
IPR018995. RNA_synth_NSP10_coronavirus.
IPR009003. Trypsin-like_Pept_dom.
IPR014827. Viral_protease.
[Graphical view]
PfamiPF01661. Macro. 1 hit.
PF09401. NSP10. 1 hit.
PF08716. nsp7. 1 hit.
PF08717. nsp8. 1 hit.
PF08710. nsp9. 1 hit.
PF05409. Peptidase_C30. 1 hit.
PF08715. Viral_protease. 2 hits.
[Graphical view]
SUPFAMiSSF101816. SSF101816. 1 hit.
SSF144246. SSF144246. 1 hit.
SSF50494. SSF50494. 1 hit.
PROSITEiPS51442. M_PRO. 1 hit.
PS51154. MACRO. 1 hit.
PS51124. PEPTIDASE_C16. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by ribosomal frameshifting. Align

Isoform Replicase polyprotein 1a (identifier: P0C6F6-1) [UniParc]FASTAAdd to Basket

Also known as: pp1a, ORF1a polyprotein

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MASNHISLAF ANDEEISAIG FGSVEEAVSY YSDAAVNGFD QCRFVSLGLQ     50
DAVVGVEDDD VVMLITGVTQ LRAYLGTFGD RPLNLRGWLL FSNCNYFLEE 100
LDLVFGRCGG TTIPVDQFMC GADGAPVIQE GDWTFMDYFQ DSNQFTLNGI 150
TYVKAWDVDR KPNDYAKQNV TCIRRITYIT DHRHVLADGT TMKTARHPKV 200
NKSVVLDSPF DQIYKEVGSP FMGNGSTFVE MLKDPAFFHA LITCECGRSE 250
WTVGDWKGYN SLCCNIKCKP ITIVTPKAVP GAVVITKAGI GAGLKCYNNV 300
FLKHIIDLVV PGTNLGWGVW RIAKVQSKDD VATSGNVLVD DPEDRLDPCY 350
FGNDGPFATK FKFQLLANSF DDEVKGAIVQ GVVHVNTAIC DVVKDILGLP 400
WFVKKLGSLV TVMWDQFVAG VQSMKICTLK VVQLAKALSC ATMSVVKGVI 450
TLVAEVPEIF KRLFYTLTSA LKSLCTSSCD ALVVAGKSFA KIGDYVLLPS 500
ALVRLVSSKV KGKAQSGIKQ LQFATVVLGD THKVESDRVE FSSVNLKMVD 550
EEFPLNPVGH TVAVGNQAFF CSDGLYRFMA DRDLVITSPI FKPELELEPI 600
FECDAIPGFP KVAASNVAEL CVKVDTLLFN YDKIYKKYST IIKGDRCYIQ 650
CTHTFKAPSY YFDDDEFVEL CTKYYKLPDF DAFYNAVHAA TDMDQFCALC 700
TSGFEVFIPR VPDCPPILND IDGGSIWTSF ILSVRSATDF IKTLKIDLGL 750
NGVVVFVTKK FRKAGALLQK LYNAFLDTVT SFIKVAGVAF KYCATCVPKI 800
VINGCYHTVT RLFAKDLQIP TEDGVADFNT FNHCVFPVNP TRIETDSLEL 850
EEVDFVEPGV DGKLVILDDY SFYSDGTNYY PSDGKGVVAS CFKKKGGGVV 900
TISDEVQVRT IDPVYKVRLE YEFEDETLVK VCEKAIGTKL KVTGDWSNLL 950
ETLEKAMDVV RQHLDVPDYF VYDEEGGTDL NLTIMVSQWP LSSDSEDDFK 1000
AVDDEPNANT DETVDTFAED VAETQNVQQD VTQDEVEAVC DLVVKATEEG 1050
PIEHEELSED QKEVQQALAF IEDKPVVVKP DVFAFSYASY GGLKVLNQSS 1100
NNCWVSSALV QLQLTGLLDS DEMQLFNAGR VSPMVKRCYE SQRAIFGSLG 1150
DVSACLESLL KDRDGMSITC TIDCGCGPGV RVYENAIFRF TPLKTAFPMG 1200
RCLICSKTLM HTITQMKGTG IFCRDATALD VDTLVVKPLC AAVYVGAQDG 1250
GHYLTNMYDA NMAVDGHGRH PIKFNTINTL CYKDVDWEVS NGSCDVKPFL 1300
TYKNIEFYQG ELSALLSVNH DFVVNAANEQ LSHGGGIAKA LDDLTKGELQ 1350
VLSNQYVSRN GSIKVGSGVL IKCKEHSILN VVGPRKGKHA AELLTKAYTF 1400
VFKQKGVPLM PLLSVGIFKV PITESLAAFL ACVGDRVCKC FCYTDKERLA 1450
IQNFVTSFQT EQPVEPLPVI QEVKGVQLEK PVPDVKVENP CEPFRIEGDA 1500
KFYDLTPSMV QSLQVTRLVS FTNSDLCLGS FVRDCDGYVQ GSLGGAIANY 1550
KKSNPVLPAG NCVTLKCDGF ISFTFVILPK EGDTNYEKNF NRAIAKFLKL 1600
KGSLLVVVED SSVFNKISHA SVAGYVAKPA LVDTLFEAKP VQVVVTQDQR 1650
SFHTVELSTS QTYGQQLGDC VVEDKKVTNL KPVSKDKVVS VVPNVDWDKH 1700
YGFVDAGIFH TLDHTMFVFD NNVVNGKRVL RTSDNNCWIN AVCLQLQFAN 1750
AKFKPKGLQQ LWESYCTGDV AMFVHWLYWI TGVEKGEPSD AENTLNIISR 1800
FLKPQGSVEM LRATSTTCDG TCSTKRVVST PVVNASVLKV GLDDGNCVHG 1850
LPLVDRVVSV NGTVIITNVG DTPGKPVVAT ENLLLDGVSY TVFQDSTTGV 1900
GHYTVFDKEA KLMFDGDVLK PCDLNVSPVT SVVVCNNKKI VVQDPVKRVE 1950
LDASKFLDTM NVASEKFFTF GDFVSRNIIV LIVYLFSLLA ICFRALKKRD 2000
MKVMAGVPER TGIILKRSVK YNYKALKFFF RLKFQYIKVF LKFSLVLYTL 2050
YALMFMFIRF TPVGTPICKR YTDGYANSTF DKNDYCGNVL CKICLYGYEE 2100
LSDFTHTRVI WQHLKDPLIG NILPLFYLVF LIIFGGFFVR IGITYFIMQY 2150
INAAGVALGY QDNVWLLHLL PFNSMGNIIV VAFIVTRILL FLKHVLFGCD 2200
KPSCIACSKS AKLTRVPLQT ILQGVTKSFY VNANGGKKFC KKHNFFCVDC 2250
DSYGYGCTFI NDVIAPELSN VTKLNVIPTG PATIIIDKVE FSNGFYYLYS 2300
GSTFWKYNFD ITEAKYACKD VLKNCNILTD FVVFNNSGSN VTQVKNACVY 2350
FSQLLCKPIK LVDSALLASL NVDFSANLHK AFVEVLSNSF GKDLSNCSNM 2400
NECRESLGLS DVPEEEFSAA VSEAHRYDVL ISDVSFNNLI VSYAKPEEKL 2450
AVHDIANCMR VGAKVVNHNV LTKDNVPVVW LAKDFIALSE EARKYIVRTT 2500
KTKGINFMLT FNDRRMHLTI PTISVANKKG AGLPSLFTRL YSFFWHLCVL 2550
IVVLFVATSL LDFSAQVTSD TQYDFKYIEN GVLKVFEKPL DCVHNAFVNF 2600
NEWHNAKFGS IPTNSRRCPI VVGTSDEVRY IPGVPAGVFL YGKSLIFAMS 2650
TIFGTSGLCF DDRGLTDPDS CIFNSACTTL SGIGGRNVYC YREGVVDNAK 2700
LYSSLLPHSY YRLMDGNHIV LPEIITRGFG IRTIKTQAMT YCRTGECIDS 2750
QAGVCVGLDR FFVYSKTPGS DYVCGTGFFS LLFNVIGMFS NSIPVTVMSG 2800
QILLNCVVAF TAVMACFAFT KFKRLFGDMS FGVLSVGLCT VVNNLSYVVT 2850
QNSIGMLAYA TLYFLCTKGV RYSWVWHVGF AISYCFLAPW WVVLAYLICA 2900
LLEFLPNLFK LKVSTQLFEG DKFVGSFESA ASGTFVLDMH SYQKLANSIS 2950
TEKLKQYCAS YNRYKYYSGS ASEADYRLAC FAHLAKAMSD FANDHMDKLY 3000
TPPTVSYNST LQAGLRKMAQ PSGIVEGCIV RVSYGNLTLN GLWLGDTVIC 3050
PRHVIASNTT NVIDYDHAMS LVRLHNFSIS SGNMFLGVIS ASMRGTLLHI 3100
KVNQSNVNTP NYTYKVLKPG DSFNILACYD GSAAGVYGVN MRTNYTIRGS 3150
FISGACGSPG YNINNGVVEF CYMHHLELGS GCHVGSDMDG TMYGKYEDQP 3200
TLQIEGASNL VTENVCSWLY GALINGDRWW LSSVSVGVDT YNEWALRNGM 3250
TALKNVDCFS LLVAKTGVDV GRLLASIQKL HGNFGGKSIL GCTSLCDEFT 3300
LSEVVKQMYG VTLQSGKVSR AFRNASIVCC LLFLFLSEML NHSKLFWINP 3350
GYITPVFLAI IVASSALMLL VKHKLLFLQL YLLPSLCIVS GYNIFKDYHF 3400
YTYMLEEFDY KVPFGGFNVT GVLNISLCCF VMGLHTFRFL QTPNKIFSYV 3450
VAVLTVLYTY YYSTDVLGLI LTSMSGFTNY WFIGTATYKL ATYVLPHTSL 3500
LDSFDAIKAV VFLYLLLGYC NCVYYGSLYW INRFCKLTLG CYEFKVSAAE 3550
FKYMVANGLR APTGVFDALI LSLKLIGVGG RKTIKISSVQ SKLTDLKCTN 3600
VVLLGCLSNM NIAANSREWA YCVDLHNKIN LCNDAEAAQE MLLALLAFFL 3650
SKNSAFGVDE LLDSYFNDSS VLQSVAATYV NLPSYLAYET ARQSYEDALA 3700
NGSPPQLVKQ LRHAMNVAKS EFDREASTQR KLDRMAEQAA SQMYKEARAV 3750
NRKSKVVSAM HSLLFGMLRR LDMSSVDTIL SLAKDGVVPL SIIPAVSATK 3800
LNIVVSDIES YSKIQREGCV HYAGVIWSVV DIKDNDGKPV HAKEVVTSNV 3850
ESLAWPLFLN CERIIKLQNN EIIPSKIKQR PIKAEGEGVV ADGNALYSNE 3900
GGRTFMYAFI SDKPDLKVVK WEFDGGSNAI ELEPPCKFLV EAPSGPVVKY 3950
LYFVRNLNNL RRGAVLGFIG ATVRLQAGKQ TEQATNSSLL TLCAFAVDPP 4000
KTYLDAVKSG HRPVGNCVKM LANGSGNGQA ITNGVEASTN QDSYGGASVC 4050
LYCRAHVEHP DMDGFCKLRG KYVQVPLGTL DPIRFVLENT VCKVCGCWQA 4100
NGCTCDRAVI QSVDSGYLNE CGALVQLD 4128

Note: Produced by conventional translation.

Length:4,128
Mass (Da):456,581
Last modified:June 10, 2008 - v1
Checksum:i550324DCD9D1820F
GO
Isoform Replicase polyprotein 1ab (identifier: P0C6W0-1) [UniParc]FASTAAdd to Basket

Also known as: pp1ab

The sequence of this isoform can be found in the external entry P0C6W0.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Produced by -1 ribosomal frameshifting at the 1a-1b genes boundary.

Length:6,793
Mass (Da):757,262
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ648858 Genomic RNA. No translation available.

Keywords - Coding sequence diversityi

Ribosomal frameshifting

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ648858 Genomic RNA. No translation available.

3D structure databases

ProteinModelPortali P0C6F6.
SMRi P0C6F6. Positions 3013-3311, 3871-3975, 3982-4107.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR002589. Macro_dom.
IPR014828. NSP7.
IPR014829. NSP8.
IPR014822. NSP9.
IPR008740. Peptidase_C30.
IPR013016. Peptidase_C30/C16.
IPR018995. RNA_synth_NSP10_coronavirus.
IPR009003. Trypsin-like_Pept_dom.
IPR014827. Viral_protease.
[Graphical view ]
Pfami PF01661. Macro. 1 hit.
PF09401. NSP10. 1 hit.
PF08716. nsp7. 1 hit.
PF08717. nsp8. 1 hit.
PF08710. nsp9. 1 hit.
PF05409. Peptidase_C30. 1 hit.
PF08715. Viral_protease. 2 hits.
[Graphical view ]
SUPFAMi SSF101816. SSF101816. 1 hit.
SSF144246. SSF144246. 1 hit.
SSF50494. SSF50494. 1 hit.
PROSITEi PS51442. M_PRO. 1 hit.
PS51154. MACRO. 1 hit.
PS51124. PEPTIDASE_C16. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiR1A_BC512
AccessioniPrimary (citable) accession number: P0C6F6
Secondary accession number(s): Q0Q467
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: May 14, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

Bat coronavirus 512/2005 is highly similar to porcine epidemic diarrhea virus (PEDV).

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi