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P0C6D7

- ALDH_VIBCH

UniProt

P0C6D7 - ALDH_VIBCH

Protein

Aldehyde dehydrogenase

Gene

aldA

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (26 Feb 2008)
      Previous versions | rss
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    Functioni

    May be involved in V.cholerae virulence, as its expression is under the control of ToxR, a transcriptional activator of several genes associated with virulence.

    Catalytic activityi

    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei262 – 2621By similarity
    Active sitei301 – 3011By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi240 – 2456NADBy similarity

    GO - Molecular functioni

    1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

    GO - Biological processi

    1. ethanol catabolic process Source: UniProtKB-UniPathway
    2. pathogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Virulence

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    UniPathwayiUPA00780; UER00768.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aldehyde dehydrogenase (EC:1.2.1.3)
    Gene namesi
    Name:aldA
    Ordered Locus Names:VC_0819
    OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
    Taxonomic identifieri243277 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000000584: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 506506Aldehyde dehydrogenasePRO_0000056465Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243277.VC0819.

    Structurei

    3D structure databases

    ProteinModelPortaliP0C6D7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG1012.
    OMAiMACWKMA.
    OrthoDBiEOG6BS8QW.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0C6D7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIYPIPNSET STVHFKDVYD NYIGGQWMKP HSGEYFSNTS PVNGLVFCRV    50
    ARSSSQDVEL ALDAAHNALE SWSTTSAVER SNILLRIADR IESNLETLAI 100
    VESWDNGKPI RETLAADLPL TIDHFRYFAA CIRSQEGAAS ELDSRTLTYH 150
    LPEPIGVVGQ IIPWNFPLLM AAWKLAPALA AGCTVVLKPA EQTPVSILFL 200
    MEIIGDLIPA GVINVVNGFG SEAGNALATS QRIDKLAFTG STEIGNHILK 250
    CAADNLIPST IELGGKSPNI YFPDIFSHED QYLDKCIEGA LLAFFNQGEV 300
    CTCPSRILVH ESIYEKFIAK IIERVALIKQ GNPLDTETQI GAQVSKEQYD 350
    KILGYIQIGK DEGAELIFGG HPNNQENYLS GGYYIKPTLF FGHNQMHIFQ 400
    EEIFGPVIAI TKFKDEIEAL HLANDTVYGL GAGVWTRDIN IAHRMAKNIK 450
    AGRVWVNCYH AYPAHAAFGG YKKSGIGRET HKLTLSHYQN IKNVLISHEI 500
    HPLGLF 506
    Length:506
    Mass (Da):55,885
    Last modified:February 26, 2008 - v1
    Checksum:i69E7F561D6CFED07
    GO

    Sequence cautioni

    The sequence AAF93982.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M60658 Unassigned DNA. Translation: AAA03051.1.
    AF034434 Genomic DNA. Translation: AAC12273.1.
    AE003852 Genomic DNA. Translation: AAF93982.1. Different initiation.
    PIRiA82276.
    T09437.

    Genome annotation databases

    EnsemblBacteriaiAAF93982; AAF93982; VC_0819.
    PATRICi20080743. VBIVibCho83274_0780.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M60658 Unassigned DNA. Translation: AAA03051.1 .
    AF034434 Genomic DNA. Translation: AAC12273.1 .
    AE003852 Genomic DNA. Translation: AAF93982.1 . Different initiation.
    PIRi A82276.
    T09437.

    3D structure databases

    ProteinModelPortali P0C6D7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243277.VC0819.

    Protocols and materials databases

    DNASUi 2614486.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF93982 ; AAF93982 ; VC_0819 .
    PATRICi 20080743. VBIVibCho83274_0780.

    Phylogenomic databases

    eggNOGi COG1012.
    OMAi MACWKMA.
    OrthoDBi EOG6BS8QW.

    Enzyme and pathway databases

    UniPathwayi UPA00780 ; UER00768 .

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of the Vibrio cholerae gene encoding aldehyde dehydrogenase is under control of ToxR, the cholera toxin transcriptional activator."
      Parsot C.R., Mekalanos J.J.
      J. Bacteriol. 173:2842-2851(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: KP8.56.
    2. "A Vibrio cholerae pathogenicity island associated with epidemic and pandemic strains."
      Karaolis D.K.R., Johnson J.A., Bailey C.C., Boedeker E.C., Kaper J.B., Reeves P.R.
      Proc. Natl. Acad. Sci. U.S.A. 95:3134-3139(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 39315 / El Tor Inaba N16961.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 39315 / El Tor Inaba N16961.

    Entry informationi

    Entry nameiALDH_VIBCH
    AccessioniPrimary (citable) accession number: P0C6D7
    Secondary accession number(s): P23240, Q9KTS0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3