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P0C6D7

- ALDH_VIBCH

UniProt

P0C6D7 - ALDH_VIBCH

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Protein

Aldehyde dehydrogenase

Gene

aldA

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

May be involved in V.cholerae virulence, as its expression is under the control of ToxR, a transcriptional activator of several genes associated with virulence.

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei262 – 2621By similarity
Active sitei301 – 3011By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi240 – 2456NADBy similarity

GO - Molecular functioni

  1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

GO - Biological processi

  1. ethanol catabolic process Source: UniProtKB-UniPathway
  2. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Virulence

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00780; UER00768.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase (EC:1.2.1.3)
Gene namesi
Name:aldA
Ordered Locus Names:VC_0819
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000584: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 506506Aldehyde dehydrogenasePRO_0000056465Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243277.VC0819.

Structurei

3D structure databases

ProteinModelPortaliP0C6D7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG1012.
OMAiMACWKMA.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C6D7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIYPIPNSET STVHFKDVYD NYIGGQWMKP HSGEYFSNTS PVNGLVFCRV
60 70 80 90 100
ARSSSQDVEL ALDAAHNALE SWSTTSAVER SNILLRIADR IESNLETLAI
110 120 130 140 150
VESWDNGKPI RETLAADLPL TIDHFRYFAA CIRSQEGAAS ELDSRTLTYH
160 170 180 190 200
LPEPIGVVGQ IIPWNFPLLM AAWKLAPALA AGCTVVLKPA EQTPVSILFL
210 220 230 240 250
MEIIGDLIPA GVINVVNGFG SEAGNALATS QRIDKLAFTG STEIGNHILK
260 270 280 290 300
CAADNLIPST IELGGKSPNI YFPDIFSHED QYLDKCIEGA LLAFFNQGEV
310 320 330 340 350
CTCPSRILVH ESIYEKFIAK IIERVALIKQ GNPLDTETQI GAQVSKEQYD
360 370 380 390 400
KILGYIQIGK DEGAELIFGG HPNNQENYLS GGYYIKPTLF FGHNQMHIFQ
410 420 430 440 450
EEIFGPVIAI TKFKDEIEAL HLANDTVYGL GAGVWTRDIN IAHRMAKNIK
460 470 480 490 500
AGRVWVNCYH AYPAHAAFGG YKKSGIGRET HKLTLSHYQN IKNVLISHEI

HPLGLF
Length:506
Mass (Da):55,885
Last modified:February 26, 2008 - v1
Checksum:i69E7F561D6CFED07
GO

Sequence cautioni

The sequence AAF93982.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60658 Unassigned DNA. Translation: AAA03051.1.
AF034434 Genomic DNA. Translation: AAC12273.1.
AE003852 Genomic DNA. Translation: AAF93982.1. Different initiation.
PIRiA82276.
T09437.

Genome annotation databases

EnsemblBacteriaiAAF93982; AAF93982; VC_0819.
PATRICi20080743. VBIVibCho83274_0780.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60658 Unassigned DNA. Translation: AAA03051.1 .
AF034434 Genomic DNA. Translation: AAC12273.1 .
AE003852 Genomic DNA. Translation: AAF93982.1 . Different initiation.
PIRi A82276.
T09437.

3D structure databases

ProteinModelPortali P0C6D7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243277.VC0819.

Protocols and materials databases

DNASUi 2614486.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF93982 ; AAF93982 ; VC_0819 .
PATRICi 20080743. VBIVibCho83274_0780.

Phylogenomic databases

eggNOGi COG1012.
OMAi MACWKMA.
OrthoDBi EOG6BS8QW.

Enzyme and pathway databases

UniPathwayi UPA00780 ; UER00768 .

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of the Vibrio cholerae gene encoding aldehyde dehydrogenase is under control of ToxR, the cholera toxin transcriptional activator."
    Parsot C.R., Mekalanos J.J.
    J. Bacteriol. 173:2842-2851(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: KP8.56.
  2. "A Vibrio cholerae pathogenicity island associated with epidemic and pandemic strains."
    Karaolis D.K.R., Johnson J.A., Bailey C.C., Boedeker E.C., Kaper J.B., Reeves P.R.
    Proc. Natl. Acad. Sci. U.S.A. 95:3134-3139(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 39315 / El Tor Inaba N16961.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39315 / El Tor Inaba N16961.

Entry informationi

Entry nameiALDH_VIBCH
AccessioniPrimary (citable) accession number: P0C6D7
Secondary accession number(s): P23240, Q9KTS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: October 1, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3