P0C6D7 (ALDH_VIBCH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aldehyde dehydrogenase
EC=1.2.1.3

Gene names

Name:	aldA
Ordered Locus Names:	VC_0819

Organism

Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) [Reference proteome] [HAMAP]

Taxonomic identifier

243277 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio › Vibrio cholerae › Vibrio cholerae O1 › Vibrio cholerae O1 biovar El Tor

Protein attributes

Sequence length	506 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	May be involved in V.cholerae virulence, as its expression is under the control of ToxR, a transcriptional activator of several genes associated with virulence.
Catalytic activity	An aldehyde + NAD+ + H2O = a carboxylate + NADH.
Pathway	Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.
Sequence caution	The sequence AAF93982.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Virulence
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ethanol catabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aldehyde dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 506	506	Aldehyde dehydrogenase		PRO_0000056465
Regions
	Nucleotide binding	240 – 245	6	NAD By similarity
Sites
	Active site	262	1	By similarity
	Active site	301	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0C6D7 [UniParc]. Last modified February 26, 2008. Version 1. Checksum: 69E7F561D6CFED07	FASTA	506	55,885
	10 20 30 40 50 60 MIYPIPNSET STVHFKDVYD NYIGGQWMKP HSGEYFSNTS PVNGLVFCRV ARSSSQDVEL 70 80 90 100 110 120 ALDAAHNALE SWSTTSAVER SNILLRIADR IESNLETLAI VESWDNGKPI RETLAADLPL 130 140 150 160 170 180 TIDHFRYFAA CIRSQEGAAS ELDSRTLTYH LPEPIGVVGQ IIPWNFPLLM AAWKLAPALA 190 200 210 220 230 240 AGCTVVLKPA EQTPVSILFL MEIIGDLIPA GVINVVNGFG SEAGNALATS QRIDKLAFTG 250 260 270 280 290 300 STEIGNHILK CAADNLIPST IELGGKSPNI YFPDIFSHED QYLDKCIEGA LLAFFNQGEV 310 320 330 340 350 360 CTCPSRILVH ESIYEKFIAK IIERVALIKQ GNPLDTETQI GAQVSKEQYD KILGYIQIGK 370 380 390 400 410 420 DEGAELIFGG HPNNQENYLS GGYYIKPTLF FGHNQMHIFQ EEIFGPVIAI TKFKDEIEAL 430 440 450 460 470 480 HLANDTVYGL GAGVWTRDIN IAHRMAKNIK AGRVWVNCYH AYPAHAAFGG YKKSGIGRET 490 500 HKLTLSHYQN IKNVLISHEI HPLGLF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression of the Vibrio cholerae gene encoding aldehyde dehydrogenase is under control of ToxR, the cholera toxin transcriptional activator." Parsot C.R., Mekalanos J.J. J. Bacteriol. 173:2842-2851(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: KP8.56.
[2]	"A Vibrio cholerae pathogenicity island associated with epidemic and pandemic strains." Karaolis D.K.R., Johnson J.A., Bailey C.C., Boedeker E.C., Kaper J.B., Reeves P.R. Proc. Natl. Acad. Sci. U.S.A. 95:3134-3139(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 39315 / El Tor Inaba N16961.
[3]	"DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae." Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R., Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D., Vamathevan J.J., Bass S. , Qin H., Dragoi I., Sellers P., McDonald L.A., Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L., Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M. Nature 406:477-483(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 39315 / El Tor Inaba N16961.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M60658 Unassigned DNA. Translation: AAA03051.1. AF034434 Genomic DNA. Translation: AAC12273.1. AE003852 Genomic DNA. Translation: AAF93982.1. Different initiation.
PIR	A82276. T09437.
RefSeq	NP_230467.1. NC_002505.1.
3D structure databases
ProteinModelPortal	P0C6D7.
ModBase	Search...
Protein-protein interaction databases
STRING	243277.VC0819.
Protocols and materials databases
DNASU	2614486.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAF93982; AAF93982; VC_0819.
GeneID	2614486.
KEGG	vch:VC0819.
PATRIC	20080743. VBIVibCho83274_0780.
Phylogenomic databases
eggNOG	COG1012.
KO	K00128.
OMA	IERDRAY.
ProtClustDB	CLSK793797.
Enzyme and pathway databases
UniPathway	UPA00780; UER00768.
Family and domain databases
Gene3D	3.40.309.10. 1 hit. 3.40.605.10. 1 hit.
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. [Graphical view]
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALDH_VIBCH

Accession

Primary (citable) accession number: P0C6D7
Secondary accession number(s): P23240, Q9KTS0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	February 26, 2008
Last modified:	May 1, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program