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P0C6D7 (ALDH_VIBCH) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aldehyde dehydrogenase

EC=1.2.1.3
Gene names
Name:aldA
Ordered Locus Names:VC_0819
OrganismVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) [Reference proteome] [HAMAP]
Taxonomic identifier243277 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length506 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

May be involved in V.cholerae virulence, as its expression is under the control of ToxR, a transcriptional activator of several genes associated with virulence.

Catalytic activity

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathway

Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Sequence caution

The sequence AAF93982.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processVirulence
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processethanol catabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

pathogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionaldehyde dehydrogenase (NAD) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 506506Aldehyde dehydrogenase
PRO_0000056465

Regions

Nucleotide binding240 – 2456NAD By similarity

Sites

Active site2621 By similarity
Active site3011 By similarity

Sequences

Sequence LengthMass (Da)Tools
P0C6D7 [UniParc].

Last modified February 26, 2008. Version 1.
Checksum: 69E7F561D6CFED07

FASTA50655,885
        10         20         30         40         50         60 
MIYPIPNSET STVHFKDVYD NYIGGQWMKP HSGEYFSNTS PVNGLVFCRV ARSSSQDVEL 

        70         80         90        100        110        120 
ALDAAHNALE SWSTTSAVER SNILLRIADR IESNLETLAI VESWDNGKPI RETLAADLPL 

       130        140        150        160        170        180 
TIDHFRYFAA CIRSQEGAAS ELDSRTLTYH LPEPIGVVGQ IIPWNFPLLM AAWKLAPALA 

       190        200        210        220        230        240 
AGCTVVLKPA EQTPVSILFL MEIIGDLIPA GVINVVNGFG SEAGNALATS QRIDKLAFTG 

       250        260        270        280        290        300 
STEIGNHILK CAADNLIPST IELGGKSPNI YFPDIFSHED QYLDKCIEGA LLAFFNQGEV 

       310        320        330        340        350        360 
CTCPSRILVH ESIYEKFIAK IIERVALIKQ GNPLDTETQI GAQVSKEQYD KILGYIQIGK 

       370        380        390        400        410        420 
DEGAELIFGG HPNNQENYLS GGYYIKPTLF FGHNQMHIFQ EEIFGPVIAI TKFKDEIEAL 

       430        440        450        460        470        480 
HLANDTVYGL GAGVWTRDIN IAHRMAKNIK AGRVWVNCYH AYPAHAAFGG YKKSGIGRET 

       490        500 
HKLTLSHYQN IKNVLISHEI HPLGLF 

« Hide

References

« Hide 'large scale' references
[1]"Expression of the Vibrio cholerae gene encoding aldehyde dehydrogenase is under control of ToxR, the cholera toxin transcriptional activator."
Parsot C.R., Mekalanos J.J.
J. Bacteriol. 173:2842-2851(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: KP8.56.
[2]"A Vibrio cholerae pathogenicity island associated with epidemic and pandemic strains."
Karaolis D.K.R., Johnson J.A., Bailey C.C., Boedeker E.C., Kaper J.B., Reeves P.R.
Proc. Natl. Acad. Sci. U.S.A. 95:3134-3139(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 39315 / El Tor Inaba N16961.
[3]"DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae."
Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R., Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D., Vamathevan J.J., Bass S. expand/collapse author list , Qin H., Dragoi I., Sellers P., McDonald L.A., Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L., Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.
Nature 406:477-483(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 39315 / El Tor Inaba N16961.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M60658 Unassigned DNA. Translation: AAA03051.1.
AF034434 Genomic DNA. Translation: AAC12273.1.
AE003852 Genomic DNA. Translation: AAF93982.1. Different initiation.
PIRA82276.
T09437.

3D structure databases

ProteinModelPortalP0C6D7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243277.VC0819.

Protocols and materials databases

DNASU2614486.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF93982; AAF93982; VC_0819.
PATRIC20080743. VBIVibCho83274_0780.

Phylogenomic databases

eggNOGCOG1012.
OMAMACWKMA.
OrthoDBEOG6BS8QW.

Enzyme and pathway databases

UniPathwayUPA00780; UER00768.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. SSF53720. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALDH_VIBCH
AccessionPrimary (citable) accession number: P0C6D7
Secondary accession number(s): P23240, Q9KTS0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: June 11, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways