Reviewed, UniProtKB/Swiss-Prot P0C6D7 (ALDH_VIBCH)

Names and origin

Protein names

Recommended name:
    Aldehyde dehydrogenase
    EC=1.2.1.3

Gene names

Name:	aldA
Ordered Locus Names:	VC_0819

Organism

Vibrio cholerae [Complete proteome] [HAMAP]

Taxonomic identifier

666 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	506 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	May be involved in V.cholerae virulence, as its expression is under the control of toxR, a transcriptional activator of several genes associated with virulence.
Catalytic activity	An aldehyde + NAD+ + H2O = an acid + NADH.
Pathway	Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Biological process	Virulence
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	aldehyde dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 506	506	Aldehyde dehydrogenase		PRO_0000056465
Regions
	Nucleotide binding	240 – 245	6	NAD By similarity
Sites
	Active site	262	1	By similarity
	Active site	301	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0C6D7-1 [UniParc]. Last modified February 26, 2008. Version 1. Checksum: 69E7F561D6CFED07	FASTA	506	55,885
	10 20 30 40 50 60 MIYPIPNSET STVHFKDVYD NYIGGQWMKP HSGEYFSNTS PVNGLVFCRV ARSSSQDVEL 70 80 90 100 110 120 ALDAAHNALE SWSTTSAVER SNILLRIADR IESNLETLAI VESWDNGKPI RETLAADLPL 130 140 150 160 170 180 TIDHFRYFAA CIRSQEGAAS ELDSRTLTYH LPEPIGVVGQ IIPWNFPLLM AAWKLAPALA 190 200 210 220 230 240 AGCTVVLKPA EQTPVSILFL MEIIGDLIPA GVINVVNGFG SEAGNALATS QRIDKLAFTG 250 260 270 280 290 300 STEIGNHILK CAADNLIPST IELGGKSPNI YFPDIFSHED QYLDKCIEGA LLAFFNQGEV 310 320 330 340 350 360 CTCPSRILVH ESIYEKFIAK IIERVALIKQ GNPLDTETQI GAQVSKEQYD KILGYIQIGK 370 380 390 400 410 420 DEGAELIFGG HPNNQENYLS GGYYIKPTLF FGHNQMHIFQ EEIFGPVIAI TKFKDEIEAL 430 440 450 460 470 480 HLANDTVYGL GAGVWTRDIN IAHRMAKNIK AGRVWVNCYH AYPAHAAFGG YKKSGIGRET 490 500 HKLTLSHYQN IKNVLISHEI HPLGLF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression of the Vibrio cholerae gene encoding aldehyde dehydrogenase is under control of ToxR, the cholera toxin transcriptional activator." Parsot C.R., Mekalanos J.J. J. Bacteriol. 173:2842-2851(1991) [PubMed: 1902210] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: KP8.56.
[2]	"A Vibrio cholerae pathogenicity island associated with epidemic and pandemic strains." Karaolis D.K.R., Johnson J.A., Bailey C.C., Boedeker E.C., Kaper J.B., Reeves P.R. Proc. Natl. Acad. Sci. U.S.A. 95:3134-3139(1998) [PubMed: 9501228] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 39315 / El Tor Inaba N16961 / Serotype O1.
[3]	"DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae." Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R., Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D., Vamathevan J.J., Bass S. , Qin H., Dragoi I., Sellers P., McDonald L.A., Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L., Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M. Nature 406:477-483(2000) [PubMed: 10952301] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 39315 / El Tor Inaba N16961 / Serotype O1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M60658 Unassigned DNA. Translation: AAA03051.1. AF034434 Genomic DNA. Translation: AAC12273.1. AE003852 Genomic DNA. Translation: AAF93982.1. Different initiation.
PIR	A82276. T09437.
RefSeq	NP_230467.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2614486.
GenomeReviews	Gene locus VC_0819 in contig AE003852_GR.
KEGG	vch:VC0819.
TIGR	VC_0819.
Phylogenomic databases
HOGENOM	HBG752218.
Enzyme and pathway databases
BRENDA	1.2.1.3. 19019.
Family and domain databases
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALDH_VIBCH

Accession

Primary (citable) accession number: P0C6D7
Secondary accession number(s): P23240, Q9KTS0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	February 26, 2008
Last modified:	December 15, 2009
This is version 13 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)