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Protein

Aldehyde dehydrogenase

Gene

aldA

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May be involved in V.cholerae virulence, as its expression is under the control of ToxR, a transcriptional activator of several genes associated with virulence.

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathway:iethanol degradation

This protein is involved in step 2 of the subpathway that synthesizes acetate from ethanol.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Aldehyde dehydrogenase (aldA)
This subpathway is part of the pathway ethanol degradation, which is itself part of Alcohol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetate from ethanol, the pathway ethanol degradation and in Alcohol metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei262 – 2621By similarity
Active sitei301 – 3011By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi240 – 2456NADBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Virulence

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00780; UER00768.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase (EC:1.2.1.3)
Gene namesi
Name:aldA
Ordered Locus Names:VC_0819
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000584 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 506506Aldehyde dehydrogenasePRO_0000056465Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243277.VC0819.

Structurei

3D structure databases

ProteinModelPortaliP0C6D7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG1012.
OMAiIMQYASK.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C6D7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIYPIPNSET STVHFKDVYD NYIGGQWMKP HSGEYFSNTS PVNGLVFCRV
60 70 80 90 100
ARSSSQDVEL ALDAAHNALE SWSTTSAVER SNILLRIADR IESNLETLAI
110 120 130 140 150
VESWDNGKPI RETLAADLPL TIDHFRYFAA CIRSQEGAAS ELDSRTLTYH
160 170 180 190 200
LPEPIGVVGQ IIPWNFPLLM AAWKLAPALA AGCTVVLKPA EQTPVSILFL
210 220 230 240 250
MEIIGDLIPA GVINVVNGFG SEAGNALATS QRIDKLAFTG STEIGNHILK
260 270 280 290 300
CAADNLIPST IELGGKSPNI YFPDIFSHED QYLDKCIEGA LLAFFNQGEV
310 320 330 340 350
CTCPSRILVH ESIYEKFIAK IIERVALIKQ GNPLDTETQI GAQVSKEQYD
360 370 380 390 400
KILGYIQIGK DEGAELIFGG HPNNQENYLS GGYYIKPTLF FGHNQMHIFQ
410 420 430 440 450
EEIFGPVIAI TKFKDEIEAL HLANDTVYGL GAGVWTRDIN IAHRMAKNIK
460 470 480 490 500
AGRVWVNCYH AYPAHAAFGG YKKSGIGRET HKLTLSHYQN IKNVLISHEI

HPLGLF
Length:506
Mass (Da):55,885
Last modified:February 26, 2008 - v1
Checksum:i69E7F561D6CFED07
GO

Sequence cautioni

The sequence AAF93982.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60658 Unassigned DNA. Translation: AAA03051.1.
AF034434 Genomic DNA. Translation: AAC12273.1.
AE003852 Genomic DNA. Translation: AAF93982.1. Different initiation.
PIRiA82276.
T09437.

Genome annotation databases

EnsemblBacteriaiAAF93982; AAF93982; VC_0819.
PATRICi20080743. VBIVibCho83274_0780.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60658 Unassigned DNA. Translation: AAA03051.1.
AF034434 Genomic DNA. Translation: AAC12273.1.
AE003852 Genomic DNA. Translation: AAF93982.1. Different initiation.
PIRiA82276.
T09437.

3D structure databases

ProteinModelPortaliP0C6D7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243277.VC0819.

Protocols and materials databases

DNASUi2614486.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF93982; AAF93982; VC_0819.
PATRICi20080743. VBIVibCho83274_0780.

Phylogenomic databases

eggNOGiCOG1012.
OMAiIMQYASK.
OrthoDBiEOG6BS8QW.

Enzyme and pathway databases

UniPathwayiUPA00780; UER00768.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of the Vibrio cholerae gene encoding aldehyde dehydrogenase is under control of ToxR, the cholera toxin transcriptional activator."
    Parsot C.R., Mekalanos J.J.
    J. Bacteriol. 173:2842-2851(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: KP8.56.
  2. "A Vibrio cholerae pathogenicity island associated with epidemic and pandemic strains."
    Karaolis D.K.R., Johnson J.A., Bailey C.C., Boedeker E.C., Kaper J.B., Reeves P.R.
    Proc. Natl. Acad. Sci. U.S.A. 95:3134-3139(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 39315 / El Tor Inaba N16961.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39315 / El Tor Inaba N16961.

Entry informationi

Entry nameiALDH_VIBCH
AccessioniPrimary (citable) accession number: P0C6D7
Secondary accession number(s): P23240, Q9KTS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: July 22, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.