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Protein

Vibriobactin-specific isochorismatase

Gene

vibB

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the biosynthesis of the catechol siderophore vibriobactin. Vibriobactin is a chelating compound involved in transporting iron from the bacterial environment into the cell cytoplasm.

Catalytic activityi

Isochorismate + H2O = (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate.

Cofactori

pantetheine 4'-phosphateBy similarityNote: Binds 1 phosphopantetheine covalently.By similarity

Pathwayi: vibriobactin biosynthesis

This protein is involved in the pathway vibriobactin biosynthesis, which is part of Siderophore biosynthesis.
View all proteins of this organism that are known to be involved in the pathway vibriobactin biosynthesis and in Siderophore biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciMetaCyc:VC0771-MONOMER
VCHO:VC0771-MONOMER
UniPathwayiUPA00022

Names & Taxonomyi

Protein namesi
Recommended name:
Vibriobactin-specific isochorismatase (EC:3.3.2.1)
Alternative name(s):
2,3 dihydro-2,3 dihydroxybenzoate synthase
Isochorismate lyase-ArCP
Gene namesi
Name:vibB
Ordered Locus Names:VC_0771
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000000584 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002018271 – 293Vibriobactin-specific isochorismataseAdd BLAST293

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei248O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi243277.VC0771

Structurei

Secondary structure

1293
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni26 – 28Combined sources3
Beta strandi29 – 34Combined sources6
Helixi38 – 41Combined sources4
Helixi51 – 68Combined sources18
Beta strandi72 – 76Combined sources5
Helixi83 – 86Combined sources4
Helixi89 – 93Combined sources5
Helixi105 – 107Combined sources3
Beta strandi113 – 117Combined sources5
Beta strandi120 – 122Combined sources3
Turni123 – 126Combined sources4
Helixi129 – 136Combined sources8
Beta strandi140 – 146Combined sources7
Turni148 – 150Combined sources3
Helixi151 – 161Combined sources11
Beta strandi165 – 174Combined sources10
Helixi178 – 191Combined sources14
Beta strandi194 – 196Combined sources3
Helixi198 – 205Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3TB4X-ray1.35A1-215[»]
3TG2X-ray1.10A1-215[»]
ProteinModelPortaliP0C6D3
SMRiP0C6D3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini211 – 287CarrierPROSITE-ProRule annotationAdd BLAST77

Sequence similaritiesi

Belongs to the isochorismatase family.Curated

Phylogenomic databases

eggNOGiENOG4105WQI Bacteria
COG1535 LUCA
COG3433 LUCA
KOiK01252
OMAiRDIKPFF

Family and domain databases

Gene3Di1.10.1200.10, 1 hit
3.40.50.850, 1 hit
InterProiView protein in InterPro
IPR036736 ACP-like_sf
IPR016291 Isochorismatase
IPR000868 Isochorismatase-like
IPR036380 Isochorismatase-like_sf
IPR009081 PP-bd_ACP
PANTHERiPTHR43540:SF3 PTHR43540:SF3, 1 hit
PfamiView protein in Pfam
PF00857 Isochorismatase, 1 hit
PF00550 PP-binding, 1 hit
PIRSFiPIRSF001111 Isochorismatase, 1 hit
PRINTSiPR01398 ISCHRISMTASE
SUPFAMiSSF47336 SSF47336, 1 hit
SSF52499 SSF52499, 1 hit
PROSITEiView protein in PROSITE
PS50075 CARRIER, 1 hit

Sequencei

Sequence statusi: Complete.

P0C6D3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIPKIASYP LPVSLPTNKV DWRIDASRAV LLIHDMQEYF VHYFDSQAEP
60 70 80 90 100
IPSLIKHIQQ LKAHAKQAGI PVVYTAQPAN QDPAERALLS DFWGPGLSEE
110 120 130 140 150
TAIIAPLAPE SGDVQLTKWR YSAFKKSPLL DWLRETGRDQ LIITGVYAHI
160 170 180 190 200
GILSTALDAF MFDIQPFVIG DGVADFSLSD HEFSLRYISG RTGAVKSTQQ
210 220 230 240 250
ACLEIAAQHS KLTGLSLRTM QHDVAAALNL SVDEVDVQEN LLFLGLDSIR
260 270 280 290
AIQLLEKWKA QGADISFAQL MEHVTLQQWW QTIQANLHQP CSA
Length:293
Mass (Da):32,553
Last modified:February 26, 2008 - v1
Checksum:iA64283991E17A3F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52150 Genomic DNA Translation: AAC45926.1
AE003852 Genomic DNA Translation: AAF93936.1
PIRiG82282
RefSeqiNP_230420.1, NC_002505.1
WP_000997093.1, NC_002505.1

Genome annotation databases

EnsemblBacteriaiAAF93936; AAF93936; VC_0771
GeneIDi2615314
KEGGivch:VC0771
PATRICifig|243277.26.peg.735

Similar proteinsi

Entry informationi

Entry nameiVIBB_VIBCH
AccessioniPrimary (citable) accession number: P0C6D3
Secondary accession number(s): O07900, Q9JQ11
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: April 25, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health