Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P0C6D0 (FNR_VIBCH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fumarate and nitrate reduction regulatory protein
Gene names
Name:fnr
Ordered Locus Names:VC_1434
OrganismVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) [Reference proteome] [HAMAP]
Taxonomic identifier243277 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length250 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Global transcription factor that controls the expression of over 100 target genes in response to anoxia. It facilitates the adaptation to anaerobic growth conditions by regulating the expression of gene products that are involved in anaerobic energy metabolism. When the terminal electron acceptor, O2, is no longer available, it represses the synthesis of enzymes involved in aerobic respiration and increases the synthesis of enzymes required for anaerobic respiration By similarity.

Cofactor

Binds 1 4Fe-4S cluster per subunit By similarity.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm Probable.

Sequence similarities

Contains 1 cyclic nucleotide-binding domain.

Contains 1 HTH crp-type DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 250250Fumarate and nitrate reduction regulatory protein
PRO_0000100170

Regions

Domain164 – 23774HTH crp-type
DNA binding200 – 21920H-T-H motif Potential
Region23 – 3210Essential for the oxygen-regulated activity By similarity
Region50 – 534Activating region 2A Potential
Region63 – 642Activating region 3A Potential
Region74 – 785Activating region 1A Potential
Region841Activating region 3B Potential
Region88 – 903Activating region 3C Potential
Region1151Activating region 3D Potential
Region119 – 1246Activating region 1B Potential
Region126 – 1272Activating region 2B Potential
Region130 – 1312Activating region 2C Potential
Region143 – 16220Dimerization Potential
Region184 – 19411Activating region 1C Potential

Sites

Metal binding201Iron-sulfur (4Fe-4S) Potential
Metal binding231Iron-sulfur (4Fe-4S) Potential
Metal binding291Iron-sulfur (4Fe-4S) Potential
Metal binding1221Iron-sulfur (4Fe-4S) Potential

Sequences

Sequence LengthMass (Da)Tools
P0C6D0 [UniParc].

Last modified February 26, 2008. Version 1.
Checksum: A3E3ED036BBBC490

FASTA25028,071
        10         20         30         40         50         60 
MISEKPAAKR IQSGGCAIHC QDCSISQLCI PFTLNESELD QLDQIIERKK PIQKGQELFK 

        70         80         90        100        110        120 
AGDELRSLYA IRSGTIKSYT ITEQGDEQIT AFHLAGDLVG FDAITGDQHP SFAQALETSM 

       130        140        150        160        170        180 
VCEIPYEILD DLSGKMPKLR QQIMRLMSNE IKGDQEMILL LSKKNAEERL AAFLYNLSTR 

       190        200        210        220        230        240 
FSQRGFSPRE FRLTMTRGDI GNYLGLTVET ISRLLGRFQK SEILSVKGKY ITILNHAELM 

       250 
ELAGVSKESK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE003852 Genomic DNA. Translation: AAF94591.1.
PIRF82199.
RefSeqNP_231077.1. NC_002505.1.

3D structure databases

ProteinModelPortalP0C6D0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243277.VC1434.

Protocols and materials databases

DNASU2614066.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF94591; AAF94591; VC_1434.
GeneID2614066.
KEGGvch:VC1434.
PATRIC20081930. VBIVibCho83274_1364.

Phylogenomic databases

eggNOGCOG0664.
KOK01420.
OMAAIRTGFF.
OrthoDBEOG6RVFWF.
ProtClustDBPRK11161.

Enzyme and pathway databases

BioCycVCHO:VC1434-MONOMER.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00027. cNMP_binding. 1 hit.
PF00325. Crp. 1 hit.
[Graphical view]
PRINTSPR00034. HTHCRP.
SMARTSM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view]
SUPFAMSSF51206. SSF51206. 1 hit.
PROSITEPS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFNR_VIBCH
AccessionPrimary (citable) accession number: P0C6D0
Secondary accession number(s): Q9KS27
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: February 19, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families