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P0C6D0

- FNR_VIBCH

UniProt

P0C6D0 - FNR_VIBCH

Protein

Fumarate and nitrate reduction regulatory protein

Gene

fnr

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (26 Feb 2008)
      Previous versions | rss
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    Functioni

    Global transcription factor that controls the expression of over 100 target genes in response to anoxia. It facilitates the adaptation to anaerobic growth conditions by regulating the expression of gene products that are involved in anaerobic energy metabolism. When the terminal electron acceptor, O2, is no longer available, it represses the synthesis of enzymes involved in aerobic respiration and increases the synthesis of enzymes required for anaerobic respiration By similarity.By similarity

    Cofactori

    Binds 1 4Fe-4S cluster per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi20 – 201Iron-sulfur (4Fe-4S)Sequence Analysis
    Metal bindingi23 – 231Iron-sulfur (4Fe-4S)Sequence Analysis
    Metal bindingi29 – 291Iron-sulfur (4Fe-4S)Sequence Analysis
    Metal bindingi122 – 1221Iron-sulfur (4Fe-4S)Sequence Analysis

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi200 – 21920H-T-H motifPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    2. DNA binding Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW
    4. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    4Fe-4S, DNA-binding, Iron, Iron-sulfur, Metal-binding

    Enzyme and pathway databases

    BioCyciVCHO:VC1434-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fumarate and nitrate reduction regulatory protein
    Gene namesi
    Name:fnr
    Ordered Locus Names:VC_1434
    OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
    Taxonomic identifieri243277 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000000584: Chromosome 1

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 250250Fumarate and nitrate reduction regulatory proteinPRO_0000100170Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi243277.VC1434.

    Structurei

    3D structure databases

    ProteinModelPortaliP0C6D0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini164 – 23774HTH crp-typePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni23 – 3210Essential for the oxygen-regulated activityBy similarity
    Regioni50 – 534Activating region 2ASequence Analysis
    Regioni63 – 642Activating region 3ASequence Analysis
    Regioni74 – 785Activating region 1ASequence Analysis
    Regioni84 – 841Activating region 3BSequence Analysis
    Regioni88 – 903Activating region 3CSequence Analysis
    Regioni115 – 1151Activating region 3DSequence Analysis
    Regioni119 – 1246Activating region 1BSequence Analysis
    Regioni126 – 1272Activating region 2BSequence Analysis
    Regioni130 – 1312Activating region 2CSequence Analysis
    Regioni143 – 16220DimerizationSequence AnalysisAdd
    BLAST
    Regioni184 – 19411Activating region 1CSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
    Contains 1 HTH crp-type DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0664.
    KOiK01420.
    OMAiFSANQFR.
    OrthoDBiEOG6RVFWF.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    2.60.120.10. 1 hit.
    InterProiIPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR012318. HTH_CRP_2.
    IPR014710. RmlC-like_jellyroll.
    IPR001808. Tscrpt_reg_HTH_Crp.
    IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 1 hit.
    PF00325. Crp. 1 hit.
    [Graphical view]
    PRINTSiPR00034. HTHCRP.
    SMARTiSM00100. cNMP. 1 hit.
    SM00419. HTH_CRP. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
    PS00042. HTH_CRP_1. 1 hit.
    PS51063. HTH_CRP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0C6D0-1 [UniParc]FASTAAdd to Basket

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    MISEKPAAKR IQSGGCAIHC QDCSISQLCI PFTLNESELD QLDQIIERKK    50
    PIQKGQELFK AGDELRSLYA IRSGTIKSYT ITEQGDEQIT AFHLAGDLVG 100
    FDAITGDQHP SFAQALETSM VCEIPYEILD DLSGKMPKLR QQIMRLMSNE 150
    IKGDQEMILL LSKKNAEERL AAFLYNLSTR FSQRGFSPRE FRLTMTRGDI 200
    GNYLGLTVET ISRLLGRFQK SEILSVKGKY ITILNHAELM ELAGVSKESK 250
    Length:250
    Mass (Da):28,071
    Last modified:February 26, 2008 - v1
    Checksum:iA3E3ED036BBBC490
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE003852 Genomic DNA. Translation: AAF94591.1.
    PIRiF82199.
    RefSeqiNP_231077.1. NC_002505.1.

    Genome annotation databases

    EnsemblBacteriaiAAF94591; AAF94591; VC_1434.
    GeneIDi2614066.
    KEGGivch:VC1434.
    PATRICi20081930. VBIVibCho83274_1364.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE003852 Genomic DNA. Translation: AAF94591.1 .
    PIRi F82199.
    RefSeqi NP_231077.1. NC_002505.1.

    3D structure databases

    ProteinModelPortali P0C6D0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243277.VC1434.

    Protocols and materials databases

    DNASUi 2614066.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF94591 ; AAF94591 ; VC_1434 .
    GeneIDi 2614066.
    KEGGi vch:VC1434.
    PATRICi 20081930. VBIVibCho83274_1364.

    Phylogenomic databases

    eggNOGi COG0664.
    KOi K01420.
    OMAi FSANQFR.
    OrthoDBi EOG6RVFWF.

    Enzyme and pathway databases

    BioCyci VCHO:VC1434-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    2.60.120.10. 1 hit.
    InterProi IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR012318. HTH_CRP_2.
    IPR014710. RmlC-like_jellyroll.
    IPR001808. Tscrpt_reg_HTH_Crp.
    IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 1 hit.
    PF00325. Crp. 1 hit.
    [Graphical view ]
    PRINTSi PR00034. HTHCRP.
    SMARTi SM00100. cNMP. 1 hit.
    SM00419. HTH_CRP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
    PS00042. HTH_CRP_1. 1 hit.
    PS51063. HTH_CRP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 39315 / El Tor Inaba N16961.

    Entry informationi

    Entry nameiFNR_VIBCH
    AccessioniPrimary (citable) accession number: P0C6D0
    Secondary accession number(s): Q9KS27
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3