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Protein

Ferric uptake regulation protein

Gene

fur

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Fur acts as a repressor, employing Fe2+ as a cofactor to bind the operator of the iron transport operon.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi33ZincBy similarity1
Metal bindingi81ZincBy similarity1
Metal bindingi87IronBy similarity1
Metal bindingi89IronBy similarity1
Metal bindingi90ZincBy similarity1
Metal bindingi93ZincBy similarity1
Metal bindingi96ZincBy similarity1
Metal bindingi101ZincBy similarity1
Metal bindingi108IronBy similarity1
Metal bindingi125IronBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandIron, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciVCHO:VC2106-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferric uptake regulation protein
Short name:
Ferric uptake regulator
Gene namesi
Name:fur
Ordered Locus Names:VC_2106
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000000584 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • protein-DNA complex Source: CollecTF

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000955851 – 150Ferric uptake regulation proteinAdd BLAST150

Expressioni

Gene expression databases

CollecTFiEXPREG_000008b0.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi243277.VC2106.

Structurei

Secondary structure

1150
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 10Combined sources7
Helixi17 – 26Combined sources10
Helixi29 – 31Combined sources3
Beta strandi32 – 35Combined sources4
Helixi36 – 45Combined sources10
Helixi52 – 64Combined sources13
Beta strandi67 – 72Combined sources6
Helixi74 – 76Combined sources3
Beta strandi78 – 82Combined sources5
Beta strandi89 – 93Combined sources5
Turni94 – 96Combined sources3
Beta strandi99 – 102Combined sources4
Helixi105 – 117Combined sources13
Beta strandi121 – 132Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2W57X-ray2.60A/B1-150[»]
ProteinModelPortaliP0C6C8.
SMRiP0C6C8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0C6C8.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 84DNA-bindingBy similarityAdd BLAST84
Regioni85 – 143DimerizationBy similarityAdd BLAST59

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi86 – 90His-rich5

Sequence similaritiesi

Belongs to the Fur family.Curated

Phylogenomic databases

eggNOGiENOG41090R7. Bacteria.
COG0735. LUCA.
KOiK03711.
OMAiGHGAPTY.

Family and domain databases

CDDicd07153. Fur_like. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR002481. FUR.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF01475. FUR. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C6C8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDNNQALKD AGLKVTLPRL KILEVLQQPE CQHISAEELY KKLIDLGEEI
60 70 80 90 100
GLATVYRVLN QFDDAGIVTR HHFEGGKSVF ELSTQHHHDH LVCLDCGEVI
110 120 130 140 150
EFSDDVIEQR QKEIAAKYNV QLTNHSLYLY GKCGSDGSCK DNPNAHKPKK
Length:150
Mass (Da):16,912
Last modified:February 26, 2008 - v1
Checksum:iE03CDE8990F465FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF95252.1.
PIRiA82118.
RefSeqiNP_231738.1. NC_002505.1.
WP_001282826.1. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF95252; AAF95252; VC_2106.
GeneIDi2613362.
KEGGivch:VC2106.
PATRICifig|243277.26.peg.2012.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiFUR_VIBCH
AccessioniPrimary (citable) accession number: P0C6C8
Secondary accession number(s): P33087, Q9KQ94
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: June 7, 2017
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families