P0C6C1 (AN34C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ankyrin repeat domain-containing protein 34C

Gene names

Name:

ANKRD34C

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	530 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the ANKRD34 family. Contains 4 ANK repeats.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	ANK repeat Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 530	530	Ankyrin repeat domain-containing protein 34C		PRO_0000319104
Regions
	Repeat	10 – 39	30	ANK 1
	Repeat	43 – 80	38	ANK 2
	Repeat	84 – 114	31	ANK 3
	Repeat	118 – 147	30	ANK 4
Natural variations
	Natural variant	369	1	P → R. Corresponds to variant rs410400 [ dbSNP | Ensembl ].		VAR_038953
	Natural variant	427	1	P → H. Corresponds to variant rs449340 [ dbSNP | Ensembl ].		VAR_038954
	Natural variant	442	1	L → I. Corresponds to variant rs422777 [ dbSNP | Ensembl ].		VAR_038955

Sequences

	Sequence		Length	Mass (Da)
	P0C6C1 [UniParc]. Last modified February 26, 2008. Version 1. Checksum: CF3686BB8F68F04E	FASTA	530	57,653
	10 20 30 40 50 60 MMDDDTELRT DGNSLLKAVW LGRLRLTRLL LEGGAYINES NDKGETALMV ACITKHVDQQ 70 80 90 100 110 120 SISKSKMVKY LLDNRADPNI QDKSGKTALI HACIRRAGGE VVSLLLENGA DPSLEDRTGA 130 140 150 160 170 180 SALVYAINAD DKDALKHLLD ACKAKGKEVI IITTDKSSSG TKTTKQYLNV PPSPKVEDRH 190 200 210 220 230 240 SPPLCASPSD IELKALGLDS PLTEKEDDFF SLQAGHPSSC NTSKAVNEPG SPTRKVSNLK 250 260 270 280 290 300 RARLPQLKRL QSEPWGLIAP SVLAASTRQD ETHGASTDNE VIKSISDISF PKRGPLSRTN 310 320 330 340 350 360 SIDSKDPTLF HTVTEQVLKI PVSSAPASWK AAYEKGQAPH PRLARRGTLP VDQEKCGMGP 370 380 390 400 410 420 SGPSALKEPA SLKWLENDLY DLDIQPGPDP PNSISLESGK GPLDRKKLNS SHLSLFHGSR 430 440 450 460 470 480 ESLDTVPSTS PSSARRRPPH LLERRGSGTL LLDRISHTRP GFLPPLNVNL NPPIPDIRSS 490 500 510 520 530 SKPSCSLASG LKSMVPVAPS SPKRVDLRSK KKLLRRHSMQ IEQMKQLSDF

References

[1]

"Analysis of the DNA sequence and duplication history of human chromosome 15." Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C. Nature 440:671-675(2006) [PubMed: 16572171] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC011797 Genomic DNA. No translation available.
IPI	IPI00741635.
UniGene	Hs.531231.
3D structure databases
ProteinModelPortal	P0C6C1.
SMR	P0C6C1. Positions 12-141.
ModBase	Search...
PTM databases
PhosphoSite	P0C6C1.
Polymorphism databases
DMDM	182705275.
Proteomic databases
PRIDE	P0C6C1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000421388; ENSP00000401089; ENSG00000235711.
UCSC	uc002bes.1. human.
Organism-specific databases
GeneCards	GC15P079585.
HGNC	HGNC:33888. ANKRD34C.
neXtProt	NX_P0C6C1.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG13980.
GeneTree	ENSGT00390000012355.
HOGENOM	HBG444529.
HOVERGEN	HBG100441.
OMA	SLLKAVW.
OrthoDB	EOG42FSHR.
PhylomeDB	P0C6C1.
Gene expression databases
Bgee	P0C6C1.
CleanEx	HS_ANKRD34C.
Genevestigator	P0C6C1.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit.
Pfam	PF12796. Ank_2. 1 hit. [Graphical view]
SMART	SM00248. ANK. 4 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AN34C_HUMAN

Accession

Primary (citable) accession number: P0C6C1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	February 26, 2008
Last modified:	January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.