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Protein

Immunoglobulin superfamily member 6

Gene

Igsf6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin superfamily member 6
Short name:
IgSF6
Gene namesi
Name:Igsf6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1891393. Igsf6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 152125ExtracellularSequence analysisAdd
BLAST
Transmembranei153 – 17321HelicalSequence analysisAdd
BLAST
Topological domaini174 – 23764CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Chaini28 – 237210Immunoglobulin superfamily member 6PRO_0000320138Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi51 ↔ 118PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP0C6B7.
PaxDbiP0C6B7.
PRIDEiP0C6B7.

Expressioni

Tissue specificityi

Ubiquitous with higher expression in immune tissue.1 Publication

Gene expression databases

BgeeiP0C6B7.
CleanExiMM_IGSF6.
GenevisibleiP0C6B7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039059.

Structurei

3D structure databases

ProteinModelPortaliP0C6B7.
SMRiP0C6B7. Positions 31-145.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 134105Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IUPA. Eukaryota.
ENOG410Z30T. LUCA.
GeneTreeiENSGT00390000014131.
HOGENOMiHOG000113019.
HOVERGENiHBG098510.
InParanoidiP0C6B7.
OMAiKDNTYEN.
OrthoDBiEOG7Z69DZ.
PhylomeDBiP0C6B7.
TreeFamiTF335767.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C6B7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPVSARRSR LRPEISLILF QVGMVGACTV YVLQPGYLEV DYGSDAVTME
60 70 80 90 100
CNFSTVGCPP VPPKSLWFRC GTHQPEALCL DGCRNEADKF TVKETLDPDQ
110 120 130 140 150
VFLTVNRLSP NDSAIYICGI AFPNELSPSA KHVGKGTTLV VRERLFSKEV
160 170 180 190 200
RSFLIVLLAL LSVYITGVCV TFIVLFKSKS NGPRSRETKG SKKKSARRIF
210 220 230
QEIAQELYHK RYVETSHLPE QEGTDENRKA LPNPGRA
Length:237
Mass (Da):26,354
Last modified:February 26, 2008 - v1
Checksum:i838097E701C73FC0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278574 Genomic DNA. Translation: CAC20696.1.
AJ278575 mRNA. Translation: CAC20697.1.
CCDSiCCDS21801.1.
RefSeqiNP_109616.1. NM_030691.1.
UniGeneiMm.160384.

Genome annotation databases

EnsembliENSMUST00000047194; ENSMUSP00000039059; ENSMUSG00000035004.
GeneIDi80719.
KEGGimmu:80719.
UCSCiuc009jnm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278574 Genomic DNA. Translation: CAC20696.1.
AJ278575 mRNA. Translation: CAC20697.1.
CCDSiCCDS21801.1.
RefSeqiNP_109616.1. NM_030691.1.
UniGeneiMm.160384.

3D structure databases

ProteinModelPortaliP0C6B7.
SMRiP0C6B7. Positions 31-145.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039059.

Proteomic databases

MaxQBiP0C6B7.
PaxDbiP0C6B7.
PRIDEiP0C6B7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047194; ENSMUSP00000039059; ENSMUSG00000035004.
GeneIDi80719.
KEGGimmu:80719.
UCSCiuc009jnm.1. mouse.

Organism-specific databases

CTDi10261.
MGIiMGI:1891393. Igsf6.

Phylogenomic databases

eggNOGiENOG410IUPA. Eukaryota.
ENOG410Z30T. LUCA.
GeneTreeiENSGT00390000014131.
HOGENOMiHOG000113019.
HOVERGENiHBG098510.
InParanoidiP0C6B7.
OMAiKDNTYEN.
OrthoDBiEOG7Z69DZ.
PhylomeDBiP0C6B7.
TreeFamiTF335767.

Miscellaneous databases

NextBioi350075.
PROiP0C6B7.
SOURCEiSearch...

Gene expression databases

BgeeiP0C6B7.
CleanExiMM_IGSF6.
GenevisibleiP0C6B7. MM.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The mouse and human IGSF6 (DORA) genes map to the inflammatory bowel disease 1 locus and are embedded in an intron of a gene of unknown function."
    Bates E.E.M., Kissenpfennig A., Peronne C., Mattei M.-G., Fossiez F., Malissen B., Lebecque S.
    Immunogenetics 52:112-120(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.

Entry informationi

Entry nameiIGSF6_MOUSE
AccessioniPrimary (citable) accession number: P0C6B7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: May 11, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This gene is coded entirely within the intron of Mettl9 which is transcribed in the opposite strand of the DNA.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.