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Protein

Pre T-cell antigen receptor alpha

Gene

Ptcra

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) regulates early T-cell development.By similarity

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Pre T-cell antigen receptor alpha
Short name:
pT-alpha
Short name:
pTa
Alternative name(s):
pT-alpha-TCR
Gene namesi
Name:Ptcra
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi621388. Ptcra.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 155139ExtracellularSequence analysisAdd
BLAST
Transmembranei156 – 17621HelicalSequence analysisAdd
BLAST
Topological domaini177 – 19923CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Chaini17 – 199183Pre T-cell antigen receptor alphaPRO_0000319110Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi47 ↔ 107By similarity
Glycosylationi67 – 671N-linked (GlcNAc...)Sequence analysis
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence analysis
Disulfide bondi136 – 136Interchain (with TCRB)By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP0C6B3.

Expressioni

Tissue specificityi

Found in CD45+ but not in the CD45- fetal liver cells.1 Publication

Gene expression databases

BgeeiENSRNOG00000042581.
ExpressionAtlasiP0C6B3. baseline.

Interactioni

Subunit structurei

Heterodimer with TCRB; disulfide linked. This heterodimer assembles with CD3 proteins into a signaling-competent pre-T-cell receptor complex. Interacts with RHBDD1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000059713.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi161 – 1644Poly-Leu

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXJS. Eukaryota.
ENOG41114MB. LUCA.
GeneTreeiENSGT00390000007712.
HOGENOMiHOG000204058.
HOVERGENiHBG108303.
InParanoidiP0C6B3.
KOiK06056.
PhylomeDBiP0C6B3.

Family and domain databases

InterProiIPR007110. Ig-like_dom.
IPR027834. PTCRA.
[Graphical view]
PfamiPF15028. PTCRA. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C6B3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARTWLLLFL GLRCQALPSG IAGTPFPSLA PPVTLLVDGR RHTLVVCLVL
60 70 80 90 100
DAAPPGLDSL VWFSGGNGSA LDAFTYGPSP APDGTWTSLG QLSLSSEELE
110 120 130 140 150
AWEPLVCHTR PAAGGLNRST HPLQLSGEEA STDRTCPQET LRGTQRQVLR
160 170 180 190
LSVLRLLLFK LLLLDVFLTC SRLCVLAGQH LLPPPSSKQA PASTHQSWT
Length:199
Mass (Da):21,340
Last modified:February 26, 2008 - v1
Checksum:i3014693F238A4067
GO

Sequence cautioni

The sequence EDM18861 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473987 Genomic DNA. Translation: EDM18861.1. Sequence problems.
AF182508 mRNA. Translation: AAG16904.1.
RefSeqiXP_001065627.1. XM_001065627.3.
XP_003750700.1. XM_003750652.3.
UniGeneiRn.92370.

Genome annotation databases

EnsembliENSRNOT00000067894; ENSRNOP00000059713; ENSRNOG00000042581.
GeneIDi116462.
KEGGirno:116462.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473987 Genomic DNA. Translation: EDM18861.1. Sequence problems.
AF182508 mRNA. Translation: AAG16904.1.
RefSeqiXP_001065627.1. XM_001065627.3.
XP_003750700.1. XM_003750652.3.
UniGeneiRn.92370.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000059713.

Proteomic databases

PaxDbiP0C6B3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000067894; ENSRNOP00000059713; ENSRNOG00000042581.
GeneIDi116462.
KEGGirno:116462.

Organism-specific databases

CTDi171558.
RGDi621388. Ptcra.

Phylogenomic databases

eggNOGiENOG410IXJS. Eukaryota.
ENOG41114MB. LUCA.
GeneTreeiENSGT00390000007712.
HOGENOMiHOG000204058.
HOVERGENiHBG108303.
InParanoidiP0C6B3.
KOiK06056.
PhylomeDBiP0C6B3.

Miscellaneous databases

PROiP0C6B3.

Gene expression databases

BgeeiENSRNOG00000042581.
ExpressionAtlasiP0C6B3. baseline.

Family and domain databases

InterProiIPR007110. Ig-like_dom.
IPR027834. PTCRA.
[Graphical view]
PfamiPF15028. PTCRA. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPTCRA_RAT
AccessioniPrimary (citable) accession number: P0C6B3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: September 7, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.