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Protein

Disintegrin VLO5B

Gene
N/A
Organism
Macrovipera lebetina obtusa (Levant blunt-nosed viper) (Vipera lebetina obtusa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Poor inhibitor of platelet aggregation. The disintegrin inhibits the adhesion of the alpha-4/beta-1 (ITGA4/ITGB1) integrin to VCAM-1. Inhibition on alpha-2b/beta-3 (ITGA2B/ITGB3) is low.1 Publication

Miscellaneous

Does not inhibit alpha-1/beta-1 (ITGA1/ITGB1), alpha-2/beta-1 (ITGA2/ITGB1) and alpha-6/beta-1 (ITGA6/ITGB1).1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionCell adhesion impairing toxin, Hemostasis impairing toxin, Platelet aggregation inhibiting toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin VLO5B
OrganismiMacrovipera lebetina obtusa (Levant blunt-nosed viper) (Vipera lebetina obtusa)
Taxonomic identifieri209528 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeViperinaeMacrovipera

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003190251 – 69Disintegrin VLO5BAdd BLAST69

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi7 ↔ 30
Disulfide bondi8Interchain (with C-7 in VLO5A)
Disulfide bondi13Interchain (with C-12 in VLO5A)
Disulfide bondi21 ↔ 27
Disulfide bondi26 ↔ 51
Disulfide bondi39 ↔ 58

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Heterodimer with VLO5A; disulfide-linked.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP0C6B0.
SMRiP0C6B0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 66DisintegrinAdd BLAST66

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi43 – 45Cell attachment site; atypical (MLD)3

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG005487.

Family and domain databases

Gene3Di4.10.70.10. 1 hit.
InterProiView protein in InterPro
IPR018358. Disintegrin_CS.
IPR001762. Disintegrin_dom.
IPR036436. Disintegrin_dom_sf.
PfamiView protein in Pfam
PF00200. Disintegrin. 1 hit.
PRINTSiPR00289. DISINTEGRIN.
SMARTiView protein in SMART
SM00050. DISIN. 1 hit.
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiView protein in PROSITE
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C6B0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSANPCCDP ITCKPRRGEH CVSGPCCRNC KFLNPGTICK RTMLDGLNDY
60
CTGVTSDCPR NPWKSEEED
Length:69
Mass (Da):7,670
Last modified:February 26, 2008 - v1
Checksum:iC28B1DB048FD2B07
GO

Similar proteinsi

Entry informationi

Entry nameiDID5B_MACLO
AccessioniPrimary (citable) accession number: P0C6B0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: November 22, 2017
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families