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Protein

Mastermind-like domain-containing protein 1

Gene

Mamld1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ (By similarity). Required for testosterone production.By similarity1 Publication

GO - Biological processi

  • male gonad development Source: Ensembl
  • regulation of transcription by RNA polymerase II Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-MMU-2197563 NOTCH2 intracellular domain regulates transcription
R-MMU-350054 Notch-HLH transcription pathway
R-MMU-8941856 RUNX3 regulates NOTCH signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Mastermind-like domain-containing protein 1
Gene namesi
Name:Mamld1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:3045303 Mamld1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003174301 – 803Mastermind-like domain-containing protein 1Add BLAST803

Proteomic databases

PaxDbiP0C6A2
PRIDEiP0C6A2

PTM databases

iPTMnetiP0C6A2
PhosphoSitePlusiP0C6A2

Expressioni

Gene expression databases

BgeeiENSMUSG00000059401
CleanExiMM_MAMLD1
ExpressionAtlasiP0C6A2 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080737

Structurei

3D structure databases

ProteinModelPortaliP0C6A2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mastermind family.Curated

Phylogenomic databases

eggNOGiENOG410IF3V Eukaryota
ENOG4111FBA LUCA
GeneTreeiENSGT00730000111366
HOVERGENiHBG106752
InParanoidiP0C6A2
KOiK19512
OMAiQEGDNFQ
OrthoDBiEOG091G01SE
TreeFamiTF332922

Sequencei

Sequence statusi: Complete.

P0C6A2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDWKSRLVI ENMLPHFNMV GNRQETRKLQ ESGTSKRRQE GENFHFTGMA
60 70 80 90 100
DGSYPNKIKR PCLEDVTLSM GPGAHPTSLS TEMQMPTLNM NPTSADLGVA
110 120 130 140 150
GQSLLLENNP LDSNVVNSSA MGSPFGVPST ADTGLKGHAV PYYEKNNSMP
160 170 180 190 200
AVDQELQDLL EELTKIQEPS SNDLDLEKIL GSKPEEPLVL HNPQAPLGPP
210 220 230 240 250
AKLPVQMPHM ESLGSSKEFA SSCSQVAGTS LPIMPSSTGM SYSIPSSSKQ
260 270 280 290 300
IVSSSSSTAQ AQVKNQVQNM LPVTMPPLSV PQWHHAHQLK ALAASKQGSA
310 320 330 340 350
TKQGSNRNWS SLPPPGLSPP YLPVPSPHPP PPQPPPPPFS PQNFTASCMS
360 370 380 390 400
SSSLSGSAVQ SSPNALLSSM APSSNASLGP TLPYVPAKLP GLPLNQQPQF
410 420 430 440 450
SPQSSILANL VSSSVKSPQG HLISALPTST PGPSPPYRPE NLSSPGLPQQ
460 470 480 490 500
SFTPQYSLIR SLTPTSNLLS QQQQQQQQQQ QQQQQQQQQQ QQQQHQANSI
510 520 530 540 550
FKPMTSSQQP KTLSMIMQQG LSSSSPEAPE PFTFSNTKPL SHFVSEPSPQ
560 570 580 590 600
KMASMSTHSR QSSLLHYLPQ ATPAHAPSAT ASSTATATLQ LQHHHQQHHH
610 620 630 640 650
QQHHHQQQHH QQQHHQQHHH QQQQHQQQQH QQQQQQQPDQ SSFLLQQIMQ
660 670 680 690 700
QPQRFQRMMA SDSMPALPGQ GCCHRCAWTS TALWLEHQHQ QWNSLTSTHG
710 720 730 740 750
HVPPSNLTHV DKACKLGEAR PPHVSLGRQP PSRQALGSES FLPGSSFAHE
760 770 780 790 800
LARVTSTSSY NTSEAAPWGG WDPKAWRQVP APLLPSCDAA AREAEIRSYG

NDP
Length:803
Mass (Da):87,598
Last modified:February 5, 2008 - v1
Checksum:i7AD9FE05DBE365D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL731843 Genomic DNA No translation available.
CCDSiCCDS57759.1
RefSeqiNP_001074823.2, NM_001081354.2
XP_011245924.1, XM_011247622.2
UniGeneiMm.371730

Genome annotation databases

EnsembliENSMUST00000082088; ENSMUSP00000080737; ENSMUSG00000059401
GeneIDi333639
KEGGimmu:333639
UCSCiuc009tjk.1 mouse

Similar proteinsi

Entry informationi

Entry nameiMAMD1_MOUSE
AccessioniPrimary (citable) accession number: P0C6A2
Secondary accession number(s): B1AW19
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: May 23, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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