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Protein

Mastermind-like domain-containing protein 1

Gene

Mamld1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ (By similarity). Required for testosterone production.By similarity1 Publication

GO - Biological processi

  • male gonad development Source: Ensembl
  • regulation of transcription from RNA polymerase II promoter Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Mastermind-like domain-containing protein 1
Gene namesi
Name:Mamld1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:3045303. Mamld1.

Subcellular locationi

  • Nucleus By similarity

  • Note: Punctate nuclear localization.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 803803Mastermind-like domain-containing protein 1PRO_0000317430Add
BLAST

Proteomic databases

MaxQBiP0C6A2.
PaxDbiP0C6A2.
PRIDEiP0C6A2.

PTM databases

iPTMnetiP0C6A2.
PhosphoSiteiP0C6A2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000059401.
CleanExiMM_MAMLD1.
ExpressionAtlasiP0C6A2. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080737.

Structurei

3D structure databases

ProteinModelPortaliP0C6A2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mastermind family.Curated

Phylogenomic databases

eggNOGiENOG410IF3V. Eukaryota.
ENOG4111FBA. LUCA.
GeneTreeiENSGT00730000111366.
HOVERGENiHBG106752.
InParanoidiP0C6A2.
KOiK19512.
OMAiAFNNAAW.
OrthoDBiEOG091G01SE.
TreeFamiTF332922.

Family and domain databases

InterProiIPR026131. MAMLD1.
[Graphical view]
PANTHERiPTHR15275. PTHR15275. 2 hits.

Sequencei

Sequence statusi: Complete.

P0C6A2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDWKSRLVI ENMLPHFNMV GNRQETRKLQ ESGTSKRRQE GENFHFTGMA
60 70 80 90 100
DGSYPNKIKR PCLEDVTLSM GPGAHPTSLS TEMQMPTLNM NPTSADLGVA
110 120 130 140 150
GQSLLLENNP LDSNVVNSSA MGSPFGVPST ADTGLKGHAV PYYEKNNSMP
160 170 180 190 200
AVDQELQDLL EELTKIQEPS SNDLDLEKIL GSKPEEPLVL HNPQAPLGPP
210 220 230 240 250
AKLPVQMPHM ESLGSSKEFA SSCSQVAGTS LPIMPSSTGM SYSIPSSSKQ
260 270 280 290 300
IVSSSSSTAQ AQVKNQVQNM LPVTMPPLSV PQWHHAHQLK ALAASKQGSA
310 320 330 340 350
TKQGSNRNWS SLPPPGLSPP YLPVPSPHPP PPQPPPPPFS PQNFTASCMS
360 370 380 390 400
SSSLSGSAVQ SSPNALLSSM APSSNASLGP TLPYVPAKLP GLPLNQQPQF
410 420 430 440 450
SPQSSILANL VSSSVKSPQG HLISALPTST PGPSPPYRPE NLSSPGLPQQ
460 470 480 490 500
SFTPQYSLIR SLTPTSNLLS QQQQQQQQQQ QQQQQQQQQQ QQQQHQANSI
510 520 530 540 550
FKPMTSSQQP KTLSMIMQQG LSSSSPEAPE PFTFSNTKPL SHFVSEPSPQ
560 570 580 590 600
KMASMSTHSR QSSLLHYLPQ ATPAHAPSAT ASSTATATLQ LQHHHQQHHH
610 620 630 640 650
QQHHHQQQHH QQQHHQQHHH QQQQHQQQQH QQQQQQQPDQ SSFLLQQIMQ
660 670 680 690 700
QPQRFQRMMA SDSMPALPGQ GCCHRCAWTS TALWLEHQHQ QWNSLTSTHG
710 720 730 740 750
HVPPSNLTHV DKACKLGEAR PPHVSLGRQP PSRQALGSES FLPGSSFAHE
760 770 780 790 800
LARVTSTSSY NTSEAAPWGG WDPKAWRQVP APLLPSCDAA AREAEIRSYG

NDP
Length:803
Mass (Da):87,598
Last modified:February 5, 2008 - v1
Checksum:i7AD9FE05DBE365D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL731843 Genomic DNA. Translation: CAM20183.2.
CCDSiCCDS57759.1.
RefSeqiNP_001074823.2. NM_001081354.2.
XP_006528172.1. XM_006528109.2.
XP_011245924.1. XM_011247622.1.
UniGeneiMm.371730.

Genome annotation databases

EnsembliENSMUST00000082088; ENSMUSP00000080737; ENSMUSG00000059401.
GeneIDi333639.
KEGGimmu:333639.
UCSCiuc009tjk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL731843 Genomic DNA. Translation: CAM20183.2.
CCDSiCCDS57759.1.
RefSeqiNP_001074823.2. NM_001081354.2.
XP_006528172.1. XM_006528109.2.
XP_011245924.1. XM_011247622.1.
UniGeneiMm.371730.

3D structure databases

ProteinModelPortaliP0C6A2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080737.

PTM databases

iPTMnetiP0C6A2.
PhosphoSiteiP0C6A2.

Proteomic databases

MaxQBiP0C6A2.
PaxDbiP0C6A2.
PRIDEiP0C6A2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000082088; ENSMUSP00000080737; ENSMUSG00000059401.
GeneIDi333639.
KEGGimmu:333639.
UCSCiuc009tjk.1. mouse.

Organism-specific databases

CTDi10046.
MGIiMGI:3045303. Mamld1.

Phylogenomic databases

eggNOGiENOG410IF3V. Eukaryota.
ENOG4111FBA. LUCA.
GeneTreeiENSGT00730000111366.
HOVERGENiHBG106752.
InParanoidiP0C6A2.
KOiK19512.
OMAiAFNNAAW.
OrthoDBiEOG091G01SE.
TreeFamiTF332922.

Miscellaneous databases

PROiP0C6A2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000059401.
CleanExiMM_MAMLD1.
ExpressionAtlasiP0C6A2. baseline and differential.

Family and domain databases

InterProiIPR026131. MAMLD1.
[Graphical view]
PANTHERiPTHR15275. PTHR15275. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiMAMD1_MOUSE
AccessioniPrimary (citable) accession number: P0C6A2
Secondary accession number(s): B1AW19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 7, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.