ID   ZGLP1_HUMAN             Reviewed;         271 AA.
AC   P0C6A0;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   27-MAR-2024, entry version 115.
DE   RecName: Full=GATA-type zinc finger protein 1 {ECO:0000305};
DE   AltName: Full=GATA-like protein 1 {ECO:0000250|UniProtKB:Q1WG82};
DE            Short=GLP-1 {ECO:0000250|UniProtKB:Q1WG82};
GN   Name=ZGLP1 {ECO:0000312|HGNC:HGNC:37245};
GN   Synonyms=GLP1 {ECO:0000250|UniProtKB:Q1WG82};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Fetal brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Transcriptional regulator that plays a key role in germ cell
CC       development. Determines the oogenic fate by activating key genes for
CC       the oogenic program and meiotic prophase entry. Acts downstream of bone
CC       morphogenetic protein (BMP) by regulating expression of genes required
CC       for the oogenic programs, which are repressed by Polycomb activities in
CC       sexually uncommitted germ cells. Regulates expression of STRA8, a
CC       central downstream effector for the meiotic program. Acts independently
CC       of retinoic acid (RA). In males, not required for germ-cell sex
CC       determination, but required to allow the spermatogonia to efficiently
CC       accomplish the meiotic prophase. {ECO:0000250|UniProtKB:Q1WG82}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q1WG82}.
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DR   EMBL; AK096830; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AC011511; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC044225; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS45959.1; -.
DR   RefSeq; NP_001096637.1; NM_001103167.1.
DR   AlphaFoldDB; P0C6A0; -.
DR   STRING; 9606.ENSP00000384434; -.
DR   iPTMnet; P0C6A0; -.
DR   PhosphoSitePlus; P0C6A0; -.
DR   BioMuta; ZGLP1; -.
DR   DMDM; 166990464; -.
DR   MassIVE; P0C6A0; -.
DR   PaxDb; 9606-ENSP00000384434; -.
DR   PeptideAtlas; P0C6A0; -.
DR   ProteomicsDB; 52325; -.
DR   Antibodypedia; 42858; 103 antibodies from 20 providers.
DR   DNASU; 100125288; -.
DR   Ensembl; ENST00000403903.7; ENSP00000384434.4; ENSG00000220201.8.
DR   GeneID; 100125288; -.
DR   KEGG; hsa:100125288; -.
DR   UCSC; uc002mnw.5; human.
DR   AGR; HGNC:37245; -.
DR   CTD; 100125288; -.
DR   DisGeNET; 100125288; -.
DR   GeneCards; ZGLP1; -.
DR   HGNC; HGNC:37245; ZGLP1.
DR   HPA; ENSG00000220201; Low tissue specificity.
DR   MIM; 611639; gene.
DR   neXtProt; NX_P0C6A0; -.
DR   PharmGKB; PA165394820; -.
DR   VEuPathDB; HostDB:ENSG00000220201; -.
DR   eggNOG; KOG1601; Eukaryota.
DR   InParanoid; P0C6A0; -.
DR   OMA; ALGPCWE; -.
DR   OrthoDB; 3616433at2759; -.
DR   PhylomeDB; P0C6A0; -.
DR   PathwayCommons; P0C6A0; -.
DR   SignaLink; P0C6A0; -.
DR   BioGRID-ORCS; 100125288; 21 hits in 1177 CRISPR screens.
DR   ChiTaRS; ZGLP1; human.
DR   GenomeRNAi; 100125288; -.
DR   Pharos; P0C6A0; Tdark.
DR   PRO; PR:P0C6A0; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; P0C6A0; Protein.
DR   Bgee; ENSG00000220201; Expressed in primordial germ cell in gonad and 94 other cell types or tissues.
DR   ExpressionAtlas; P0C6A0; baseline and differential.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProt.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISS:ARUK-UCL.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0048599; P:oocyte development; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
DR   CDD; cd00202; ZnF_GATA; 1.
DR   Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR   InterPro; IPR000679; Znf_GATA.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   PANTHER; PTHR47341; GATA-TYPE ZINC FINGER PROTEIN 1; 1.
DR   PANTHER; PTHR47341:SF1; GATA-TYPE ZINC FINGER PROTEIN 1; 1.
DR   Pfam; PF00320; GATA; 1.
DR   PRINTS; PR00619; GATAZNFINGER.
DR   SMART; SM00401; ZnF_GATA; 1.
DR   SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR   PROSITE; PS50114; GATA_ZN_FINGER_2; 1.
DR   Genevisible; P0C6A0; HS.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; Differentiation; DNA-binding;
KW   Metal-binding; Nucleus; Oogenesis; Reference proteome; Repressor;
KW   Spermatogenesis; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..271
FT                   /note="GATA-type zinc finger protein 1"
FT                   /id="PRO_0000317557"
FT   ZN_FING         206..230
FT                   /note="GATA-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT   REGION          18..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          96..141
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          170..199
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   271 AA;  29628 MW;  7F15849AA6E74732 CRC64;
     MTEPQVGCVA CPRVHKEPAQ VGTPWPAKPR SHPRKRDPTA LLPRSLWPAC QESVTALCFL
     QETVERLGQS PAQDTPVLGP CWDPMALGTQ GRLLLDRDSK DTQTRISQKG RRLQPPGTPS
     APPQRRPRKQ LNPCRGTERV DPGFEGVTLK FQIKPDSSLQ IIPTYSLPCS SRSQESPADA
     VGGPAAHPGG TEAHSAGSEA LEPRRCASCR TQRTPLWRDA EDGTPLCNAC GIRYKKYGTR
     CSSCWLVPRK NVQPKRLCGR CGVSLDPIQE G
//