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P0C6A0

- ZGLP1_HUMAN

UniProt

P0C6A0 - ZGLP1_HUMAN

Protein

GATA-type zinc finger protein 1

Gene

ZGLP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Transcriptional repressor that plays a central role in somatic cells of the gonad and is required for germ cell development. Able to repress GATA transcription factor function By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri206 – 23025GATA-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    3. oocyte development Source: Ensembl
    4. spermatogenesis Source: Ensembl
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GATA-type zinc finger protein 1
    Alternative name(s):
    GATA-like protein 1
    Short name:
    GLP-1
    Gene namesi
    Name:ZGLP1
    Synonyms:GLP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:37245. ZGLP1.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165394820.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 271271GATA-type zinc finger protein 1PRO_0000317557Add
    BLAST

    Proteomic databases

    PaxDbiP0C6A0.
    PRIDEiP0C6A0.

    PTM databases

    PhosphoSiteiP0C6A0.

    Expressioni

    Gene expression databases

    BgeeiP0C6A0.
    GenevestigatoriP0C6A0.

    Organism-specific databases

    HPAiHPA049855.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000384434.

    Structurei

    3D structure databases

    ProteinModelPortaliP0C6A0.
    SMRiP0C6A0. Positions 203-240.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 GATA-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri206 – 23025GATA-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG279053.
    HOGENOMiHOG000074114.
    HOVERGENiHBG107952.
    InParanoidiP0C6A0.
    OMAiVQPKRLC.
    OrthoDBiEOG78D7P1.
    PhylomeDBiP0C6A0.

    Family and domain databases

    Gene3Di3.30.50.10. 1 hit.
    InterProiIPR000679. Znf_GATA.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF00320. GATA. 1 hit.
    [Graphical view]
    PRINTSiPR00619. GATAZNFINGER.
    SMARTiSM00401. ZnF_GATA. 1 hit.
    [Graphical view]
    PROSITEiPS50114. GATA_ZN_FINGER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0C6A0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTEPQVGCVA CPRVHKEPAQ VGTPWPAKPR SHPRKRDPTA LLPRSLWPAC    50
    QESVTALCFL QETVERLGQS PAQDTPVLGP CWDPMALGTQ GRLLLDRDSK 100
    DTQTRISQKG RRLQPPGTPS APPQRRPRKQ LNPCRGTERV DPGFEGVTLK 150
    FQIKPDSSLQ IIPTYSLPCS SRSQESPADA VGGPAAHPGG TEAHSAGSEA 200
    LEPRRCASCR TQRTPLWRDA EDGTPLCNAC GIRYKKYGTR CSSCWLVPRK 250
    NVQPKRLCGR CGVSLDPIQE G 271
    Length:271
    Mass (Da):29,628
    Last modified:February 5, 2008 - v1
    Checksum:i7F15849AA6E74732
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK096830 mRNA. No translation available.
    AC011511 Genomic DNA. No translation available.
    BC044225 mRNA. No translation available.
    CCDSiCCDS45959.1.
    RefSeqiNP_001096637.1. NM_001103167.1.
    UniGeneiHs.709296.

    Genome annotation databases

    EnsembliENST00000403903; ENSP00000384434; ENSG00000220201.
    GeneIDi100125288.
    KEGGihsa:100125288.
    UCSCiuc002mnw.4. human.

    Polymorphism databases

    DMDMi166990464.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK096830 mRNA. No translation available.
    AC011511 Genomic DNA. No translation available.
    BC044225 mRNA. No translation available.
    CCDSi CCDS45959.1.
    RefSeqi NP_001096637.1. NM_001103167.1.
    UniGenei Hs.709296.

    3D structure databases

    ProteinModelPortali P0C6A0.
    SMRi P0C6A0. Positions 203-240.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000384434.

    PTM databases

    PhosphoSitei P0C6A0.

    Polymorphism databases

    DMDMi 166990464.

    Proteomic databases

    PaxDbi P0C6A0.
    PRIDEi P0C6A0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000403903 ; ENSP00000384434 ; ENSG00000220201 .
    GeneIDi 100125288.
    KEGGi hsa:100125288.
    UCSCi uc002mnw.4. human.

    Organism-specific databases

    CTDi 100125288.
    GeneCardsi GC19M010415.
    HGNCi HGNC:37245. ZGLP1.
    HPAi HPA049855.
    MIMi 611639. gene.
    neXtProti NX_P0C6A0.
    PharmGKBi PA165394820.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG279053.
    HOGENOMi HOG000074114.
    HOVERGENi HBG107952.
    InParanoidi P0C6A0.
    OMAi VQPKRLC.
    OrthoDBi EOG78D7P1.
    PhylomeDBi P0C6A0.

    Miscellaneous databases

    NextBioi 136391.
    PROi P0C6A0.
    SOURCEi Search...

    Gene expression databases

    Bgeei P0C6A0.
    Genevestigatori P0C6A0.

    Family and domain databases

    Gene3Di 3.30.50.10. 1 hit.
    InterProi IPR000679. Znf_GATA.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF00320. GATA. 1 hit.
    [Graphical view ]
    PRINTSi PR00619. GATAZNFINGER.
    SMARTi SM00401. ZnF_GATA. 1 hit.
    [Graphical view ]
    PROSITEi PS50114. GATA_ZN_FINGER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Fetal brain.

    Entry informationi

    Entry nameiZGLP1_HUMAN
    AccessioniPrimary (citable) accession number: P0C6A0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3