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P0C6A0

- ZGLP1_HUMAN

UniProt

P0C6A0 - ZGLP1_HUMAN

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Protein
GATA-type zinc finger protein 1
Gene
ZGLP1, GLP1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Transcriptional repressor that plays a central role in somatic cells of the gonad and is required for germ cell development. Able to repress GATA transcription factor function By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri206 – 23025GATA-type
Add
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  3. oocyte development Source: Ensembl
  4. spermatogenesis Source: Ensembl
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
GATA-type zinc finger protein 1
Alternative name(s):
GATA-like protein 1
Short name:
GLP-1
Gene namesi
Name:ZGLP1
Synonyms:GLP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:37245. ZGLP1.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165394820.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271GATA-type zinc finger protein 1
PRO_0000317557Add
BLAST

Proteomic databases

PaxDbiP0C6A0.
PRIDEiP0C6A0.

PTM databases

PhosphoSiteiP0C6A0.

Expressioni

Gene expression databases

BgeeiP0C6A0.
GenevestigatoriP0C6A0.

Organism-specific databases

HPAiHPA049855.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000384434.

Structurei

3D structure databases

ProteinModelPortaliP0C6A0.
SMRiP0C6A0. Positions 203-240.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG279053.
HOGENOMiHOG000074114.
HOVERGENiHBG107952.
InParanoidiP0C6A0.
OMAiVQPKRLC.
OrthoDBiEOG78D7P1.
PhylomeDBiP0C6A0.

Family and domain databases

Gene3Di3.30.50.10. 1 hit.
InterProiIPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00320. GATA. 1 hit.
[Graphical view]
PRINTSiPR00619. GATAZNFINGER.
SMARTiSM00401. ZnF_GATA. 1 hit.
[Graphical view]
PROSITEiPS50114. GATA_ZN_FINGER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C6A0-1 [UniParc]FASTAAdd to Basket

« Hide

MTEPQVGCVA CPRVHKEPAQ VGTPWPAKPR SHPRKRDPTA LLPRSLWPAC    50
QESVTALCFL QETVERLGQS PAQDTPVLGP CWDPMALGTQ GRLLLDRDSK 100
DTQTRISQKG RRLQPPGTPS APPQRRPRKQ LNPCRGTERV DPGFEGVTLK 150
FQIKPDSSLQ IIPTYSLPCS SRSQESPADA VGGPAAHPGG TEAHSAGSEA 200
LEPRRCASCR TQRTPLWRDA EDGTPLCNAC GIRYKKYGTR CSSCWLVPRK 250
NVQPKRLCGR CGVSLDPIQE G 271
Length:271
Mass (Da):29,628
Last modified:February 5, 2008 - v1
Checksum:i7F15849AA6E74732
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK096830 mRNA. No translation available.
AC011511 Genomic DNA. No translation available.
BC044225 mRNA. No translation available.
CCDSiCCDS45959.1.
RefSeqiNP_001096637.1. NM_001103167.1.
UniGeneiHs.709296.

Genome annotation databases

EnsembliENST00000403903; ENSP00000384434; ENSG00000220201.
GeneIDi100125288.
KEGGihsa:100125288.
UCSCiuc002mnw.4. human.

Polymorphism databases

DMDMi166990464.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK096830 mRNA. No translation available.
AC011511 Genomic DNA. No translation available.
BC044225 mRNA. No translation available.
CCDSi CCDS45959.1.
RefSeqi NP_001096637.1. NM_001103167.1.
UniGenei Hs.709296.

3D structure databases

ProteinModelPortali P0C6A0.
SMRi P0C6A0. Positions 203-240.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000384434.

PTM databases

PhosphoSitei P0C6A0.

Polymorphism databases

DMDMi 166990464.

Proteomic databases

PaxDbi P0C6A0.
PRIDEi P0C6A0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000403903 ; ENSP00000384434 ; ENSG00000220201 .
GeneIDi 100125288.
KEGGi hsa:100125288.
UCSCi uc002mnw.4. human.

Organism-specific databases

CTDi 100125288.
GeneCardsi GC19M010415.
HGNCi HGNC:37245. ZGLP1.
HPAi HPA049855.
MIMi 611639. gene.
neXtProti NX_P0C6A0.
PharmGKBi PA165394820.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG279053.
HOGENOMi HOG000074114.
HOVERGENi HBG107952.
InParanoidi P0C6A0.
OMAi VQPKRLC.
OrthoDBi EOG78D7P1.
PhylomeDBi P0C6A0.

Miscellaneous databases

NextBioi 136391.
PROi P0C6A0.
SOURCEi Search...

Gene expression databases

Bgeei P0C6A0.
Genevestigatori P0C6A0.

Family and domain databases

Gene3Di 3.30.50.10. 1 hit.
InterProi IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00320. GATA. 1 hit.
[Graphical view ]
PRINTSi PR00619. GATAZNFINGER.
SMARTi SM00401. ZnF_GATA. 1 hit.
[Graphical view ]
PROSITEi PS50114. GATA_ZN_FINGER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal brain.

Entry informationi

Entry nameiZGLP1_HUMAN
AccessioniPrimary (citable) accession number: P0C6A0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: July 9, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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