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Protein

GATA-type zinc finger protein 1

Gene

ZGLP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional repressor that plays a central role in somatic cells of the gonad and is required for germ cell development. Able to repress GATA transcription factor function (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri206 – 230GATA-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
GATA-type zinc finger protein 1
Alternative name(s):
GATA-like protein 1
Short name:
GLP-1
Gene namesi
Name:ZGLP1
Synonyms:GLP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:37245. ZGLP1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi100125288.
OpenTargetsiENSG00000220201.
PharmGKBiPA165394820.

Polymorphism and mutation databases

BioMutaiZGLP1.
DMDMi166990464.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003175571 – 271GATA-type zinc finger protein 1Add BLAST271

Proteomic databases

PaxDbiP0C6A0.
PeptideAtlasiP0C6A0.
PRIDEiP0C6A0.

PTM databases

iPTMnetiP0C6A0.
PhosphoSitePlusiP0C6A0.

Expressioni

Gene expression databases

BgeeiENSG00000220201.
ExpressionAtlasiP0C6A0. baseline and differential.
GenevisibleiP0C6A0. HS.

Organism-specific databases

HPAiHPA049855.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000384434.

Structurei

3D structure databases

ProteinModelPortaliP0C6A0.
SMRiP0C6A0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri206 – 230GATA-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1601. Eukaryota.
COG5641. LUCA.
GeneTreeiENSGT00470000042444.
HOGENOMiHOG000074114.
HOVERGENiHBG107952.
InParanoidiP0C6A0.
OMAiVQPKRLC.
OrthoDBiEOG091G0O9L.
PhylomeDBiP0C6A0.

Family and domain databases

Gene3Di3.30.50.10. 1 hit.
InterProiView protein in InterPro
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
PfamiView protein in Pfam
PF00320. GATA. 1 hit.
PRINTSiPR00619. GATAZNFINGER.
SMARTiView protein in SMART
SM00401. ZnF_GATA. 1 hit.
PROSITEiView protein in PROSITE
PS50114. GATA_ZN_FINGER_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C6A0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEPQVGCVA CPRVHKEPAQ VGTPWPAKPR SHPRKRDPTA LLPRSLWPAC
60 70 80 90 100
QESVTALCFL QETVERLGQS PAQDTPVLGP CWDPMALGTQ GRLLLDRDSK
110 120 130 140 150
DTQTRISQKG RRLQPPGTPS APPQRRPRKQ LNPCRGTERV DPGFEGVTLK
160 170 180 190 200
FQIKPDSSLQ IIPTYSLPCS SRSQESPADA VGGPAAHPGG TEAHSAGSEA
210 220 230 240 250
LEPRRCASCR TQRTPLWRDA EDGTPLCNAC GIRYKKYGTR CSSCWLVPRK
260 270
NVQPKRLCGR CGVSLDPIQE G
Length:271
Mass (Da):29,628
Last modified:February 5, 2008 - v1
Checksum:i7F15849AA6E74732
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096830 mRNA. No translation available.
AC011511 Genomic DNA. No translation available.
BC044225 mRNA. No translation available.
CCDSiCCDS45959.1.
RefSeqiNP_001096637.1. NM_001103167.1.
UniGeneiHs.709296.

Genome annotation databases

EnsembliENST00000403903; ENSP00000384434; ENSG00000220201.
GeneIDi100125288.
KEGGihsa:100125288.
UCSCiuc002mnw.5. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiZGLP1_HUMAN
AccessioniPrimary (citable) accession number: P0C6A0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: March 15, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot