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Protein

Immunoglobulin superfamily member 11

Gene

Igsf11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion, Growth regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin superfamily member 11
Short name:
IgSF11
Alternative name(s):
Brain and testis-specific immunoglobulin superfamily protein
Short name:
Bt-IGSF
Gene namesi
Name:Igsf11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2388477. Igsf11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 240218ExtracellularSequence analysisAdd
BLAST
Transmembranei241 – 26121HelicalSequence analysisAdd
BLAST
Topological domaini262 – 428167CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 428406Immunoglobulin superfamily member 11PRO_0000317371Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi44 ↔ 120PROSITE-ProRule annotation
Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence analysis
Disulfide bondi165 ↔ 215PROSITE-ProRule annotation

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP0C673.
PaxDbiP0C673.
PeptideAtlasiP0C673.
PRIDEiP0C673.

PTM databases

iPTMnetiP0C673.
PhosphoSiteiP0C673.

Expressioni

Tissue specificityi

Highly expressed in testis and detected in kidney and adrenal gland. In brain, expressed in commissure fibers of the corpus callosum and pyramidal cell layers of the dentate gyrus and hippocampus where it is probably expressed by both neurons and glial cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000022790.
CleanExiMM_IGSF11.
ExpressionAtlasiP0C673. baseline and differential.
GenevisibleiP0C673. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023478.

Structurei

3D structure databases

ProteinModelPortaliP0C673.
SMRiP0C673. Positions 32-235.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 136114Ig-like V-typeAdd
BLAST
Domaini144 – 23491Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJM9. Eukaryota.
ENOG410Y8CN. LUCA.
GeneTreeiENSGT00760000119145.
HOGENOMiHOG000111222.
HOVERGENiHBG107996.
InParanoidiP0C673.
KOiK06791.
OMAiQHTHSYT.
OrthoDBiEOG091G05PI.
PhylomeDBiP0C673.
TreeFamiTF330875.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C673-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRRRSAPAS WLLVSLLGVA TSLEVSESPG SVQVARGQTA VLPCAFSTSA
60 70 80 90 100
ALLNLNVIWM VIPLSNANQP EQVILYQGGQ MFDGALRFHG RVGFTGTMPA
110 120 130 140 150
TNVSIFINNT QLSDTGTYQC LVNNLPDRGG RNIGVTGLTV LVPPSAPQCQ
160 170 180 190 200
IQGSQDLGSD VILLCSSEEG IPRPTYLWEK LDNTLKLPPT ATQDQVQGTV
210 220 230 240 250
TIRNISALSS GLYQCVASNA IGTSTCLLDL QVISPQPRSV GVIAGAVGTG
260 270 280 290 300
AVLIVICLAL ISGAFFYWRS KNKEEEEEEI PNEIREDDLP PKCSSAKAFH
310 320 330 340 350
TEISSSENNT LTSSNTYNSR YWNNNPKPHR NTESFNHFSD LRQSFSGNAV
360 370 380 390 400
IPSIYANGNH LVLGPHKTLV VTANRGSSPQ VLPRNNGSVS RKPWPQHTHS
410 420
YTVSQMTLER IGAVPVMVPA QSRAGSLV
Length:428
Mass (Da):46,067
Last modified:February 5, 2008 - v1
Checksum:i64A45D8C6A0258CE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti349 – 3491A → P in BAC07547 (PubMed:12207903).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB079880 mRNA. Translation: BAC07547.1.
BC057555 mRNA. Translation: AAH57555.1.
CCDSiCCDS28175.1.
RefSeqiNP_733548.2. NM_170599.2.
UniGeneiMm.245564.

Genome annotation databases

EnsembliENSMUST00000023478; ENSMUSP00000023478; ENSMUSG00000022790.
GeneIDi207683.
KEGGimmu:207683.
UCSCiuc007zfp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB079880 mRNA. Translation: BAC07547.1.
BC057555 mRNA. Translation: AAH57555.1.
CCDSiCCDS28175.1.
RefSeqiNP_733548.2. NM_170599.2.
UniGeneiMm.245564.

3D structure databases

ProteinModelPortaliP0C673.
SMRiP0C673. Positions 32-235.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023478.

PTM databases

iPTMnetiP0C673.
PhosphoSiteiP0C673.

Proteomic databases

MaxQBiP0C673.
PaxDbiP0C673.
PeptideAtlasiP0C673.
PRIDEiP0C673.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023478; ENSMUSP00000023478; ENSMUSG00000022790.
GeneIDi207683.
KEGGimmu:207683.
UCSCiuc007zfp.1. mouse.

Organism-specific databases

CTDi152404.
MGIiMGI:2388477. Igsf11.

Phylogenomic databases

eggNOGiENOG410IJM9. Eukaryota.
ENOG410Y8CN. LUCA.
GeneTreeiENSGT00760000119145.
HOGENOMiHOG000111222.
HOVERGENiHBG107996.
InParanoidiP0C673.
KOiK06791.
OMAiQHTHSYT.
OrthoDBiEOG091G05PI.
PhylomeDBiP0C673.
TreeFamiTF330875.

Miscellaneous databases

PROiP0C673.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022790.
CleanExiMM_IGSF11.
ExpressionAtlasiP0C673. baseline and differential.
GenevisibleiP0C673. MM.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIGS11_MOUSE
AccessioniPrimary (citable) accession number: P0C673
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 7, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.