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Protein

Putative tetraspanin-19

Gene

TSPAN19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein uncertaini

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Putative tetraspanin-19
Short name:
Tspan-19
Gene namesi
Name:TSPAN19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:31886. TSPAN19.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621HelicalSequence analysisAdd
BLAST
Transmembranei59 – 7921HelicalSequence analysisAdd
BLAST
Transmembranei87 – 10721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670689.

Polymorphism and mutation databases

BioMutaiTSPAN19.
DMDMi166991177.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 248248Putative tetraspanin-19PRO_0000317254Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Glycosylationi158 – 1581N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP0C672.
PRIDEiP0C672.

PTM databases

iPTMnetiP0C672.
PhosphoSiteiP0C672.

Expressioni

Gene expression databases

BgeeiENSG00000231738.
CleanExiHS_TSPAN19.
ExpressionAtlasiP0C672. baseline and differential.

Organism-specific databases

HPAiHPA057066.

Structurei

3D structure databases

ProteinModelPortaliP0C672.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00740000115750.
HOGENOMiHOG000154694.
InParanoidiP0C672.
KOiK17358.
OMAiTSEVFQV.
OrthoDBiEOG091G11NU.
PhylomeDBiP0C672.
TreeFamiTF316345.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C672-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRNNKTIII KYFLNLINGA FLVLGLLFMG FGAWLLLDRN NFLTAFDENN
60 70 80 90 100
HFIVPISQIL IGMGSSTVLF CLLGYIGIHN EIRWLLIVYA VLITWTFAVQ
110 120 130 140 150
VVLSAFIITK KEEVQQLWHD KIDFVISEYG SKDKPEDITK WTILNALQKT
160 170 180 190 200
LQCCGQHNYT DWIKNKNKEN SGQVPCSCTK STLRKWFCDE PLNATYLEGC
210 220 230 240
ENKISAWYNV NVLTLIGINF GLLTSEVFQV SLTVCFFKNI KNIIHAEM
Length:248
Mass (Da):28,460
Last modified:February 5, 2008 - v1
Checksum:iE15FE8E971987382
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025418 Genomic DNA. No translation available.
CCDSiCCDS44949.1.
RefSeqiNP_001094387.1. NM_001100917.1.
XP_005268726.1. XM_005268669.4.
UniGeneiHs.156962.

Genome annotation databases

EnsembliENST00000532498; ENSP00000433816; ENSG00000231738.
GeneIDi144448.
KEGGihsa:144448.
UCSCiuc009zsj.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025418 Genomic DNA. No translation available.
CCDSiCCDS44949.1.
RefSeqiNP_001094387.1. NM_001100917.1.
XP_005268726.1. XM_005268669.4.
UniGeneiHs.156962.

3D structure databases

ProteinModelPortaliP0C672.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiP0C672.
PhosphoSiteiP0C672.

Polymorphism and mutation databases

BioMutaiTSPAN19.
DMDMi166991177.

Proteomic databases

PaxDbiP0C672.
PRIDEiP0C672.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000532498; ENSP00000433816; ENSG00000231738.
GeneIDi144448.
KEGGihsa:144448.
UCSCiuc009zsj.4. human.

Organism-specific databases

CTDi144448.
GeneCardsiTSPAN19.
HGNCiHGNC:31886. TSPAN19.
HPAiHPA057066.
neXtProtiNX_P0C672.
PharmGKBiPA142670689.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00740000115750.
HOGENOMiHOG000154694.
InParanoidiP0C672.
KOiK17358.
OMAiTSEVFQV.
OrthoDBiEOG091G11NU.
PhylomeDBiP0C672.
TreeFamiTF316345.

Miscellaneous databases

GenomeRNAii144448.

Gene expression databases

BgeeiENSG00000231738.
CleanExiHS_TSPAN19.
ExpressionAtlasiP0C672. baseline and differential.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTSN19_HUMAN
AccessioniPrimary (citable) accession number: P0C672
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 7, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.