Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Putative tetraspanin-19

Gene

TSPAN19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein uncertaini

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Putative tetraspanin-19
Short name:
Tspan-19
Gene namesi
Name:TSPAN19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000231738.10.
HGNCiHGNC:31886. TSPAN19.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Transmembranei59 – 79HelicalSequence analysisAdd BLAST21
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000231738.
PharmGKBiPA142670689.

Polymorphism and mutation databases

BioMutaiTSPAN19.
DMDMi166991177.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003172541 – 248Putative tetraspanin-19Add BLAST248

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi158N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP0C672.
PeptideAtlasiP0C672.
PRIDEiP0C672.

PTM databases

iPTMnetiP0C672.
PhosphoSitePlusiP0C672.

Expressioni

Gene expression databases

BgeeiENSG00000231738.
CleanExiHS_TSPAN19.
ExpressionAtlasiP0C672. baseline and differential.

Organism-specific databases

HPAiHPA057066.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000433816.

Structurei

3D structure databases

ProteinModelPortaliP0C672.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00880000137858.
HOGENOMiHOG000154694.
InParanoidiP0C672.
KOiK17358.
OMAiAGDANNM.
OrthoDBiEOG091G11NU.
PhylomeDBiP0C672.
TreeFamiTF316345.

Family and domain databases

Gene3Di1.10.1450.10. 1 hit.
InterProiView protein in InterPro
IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2_sf.
PfamiView protein in Pfam
PF00335. Tetraspannin. 1 hit.
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C672-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRNNKTIII KYFLNLINGA FLVLGLLFMG FGAWLLLDRN NFLTAFDENN
60 70 80 90 100
HFIVPISQIL IGMGSSTVLF CLLGYIGIHN EIRWLLIVYA VLITWTFAVQ
110 120 130 140 150
VVLSAFIITK KEEVQQLWHD KIDFVISEYG SKDKPEDITK WTILNALQKT
160 170 180 190 200
LQCCGQHNYT DWIKNKNKEN SGQVPCSCTK STLRKWFCDE PLNATYLEGC
210 220 230 240
ENKISAWYNV NVLTLIGINF GLLTSEVFQV SLTVCFFKNI KNIIHAEM
Length:248
Mass (Da):28,460
Last modified:February 5, 2008 - v1
Checksum:iE15FE8E971987382
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025418 Genomic DNA. No translation available.
CCDSiCCDS44949.1.
RefSeqiNP_001094387.1. NM_001100917.1.
XP_005268726.1. XM_005268669.4.
XP_016874351.1. XM_017018862.1.
UniGeneiHs.156962.

Genome annotation databases

EnsembliENST00000532498; ENSP00000433816; ENSG00000231738.
GeneIDi144448.
KEGGihsa:144448.
UCSCiuc009zsj.4. human.

Similar proteinsi

Entry informationi

Entry nameiTSN19_HUMAN
AccessioniPrimary (citable) accession number: P0C672
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: November 22, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families