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Protein

UBX domain-containing protein 2B

Gene

Ubxn2b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
UBX domain-containing protein 2B
Alternative name(s):
NSFL1 cofactor p37
p97 cofactor p37
Gene namesi
Name:Ubxn2b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1308557. Ubxn2b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 331330UBX domain-containing protein 2BPRO_0000315230Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei56 – 561PhosphoserineBy similarity
Modified residuei59 – 591PhosphothreonineBy similarity
Modified residuei66 – 661PhosphoserineBy similarity
Modified residuei231 – 2311PhosphoserineBy similarity
Modified residuei234 – 2341PhosphoserineCombined sources
Modified residuei235 – 2351PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP0C627.
PRIDEiP0C627.

PTM databases

iPTMnetiP0C627.
PhosphoSiteiP0C627.

Expressioni

Tissue specificityi

Present at high level in brain. Also present in liver, kidney, spleen, testis, lung and heart (at protein level).1 Publication

Gene expression databases

GenevisibleiP0C627. RN.

Interactioni

Subunit structurei

Interacts with VCP. Does not bind ubiquitin.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi260285. 1 interaction.
STRINGi10116.ENSRNOP00000012551.

Structurei

3D structure databases

ProteinModelPortaliP0C627.
SMRiP0C627. Positions 140-232, 246-330.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini141 – 20666SEPPROSITE-ProRule annotationAdd
BLAST
Domaini252 – 32978UBXPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the NSFL1C family.Curated
Contains 1 SEP domain.PROSITE-ProRule annotation
Contains 1 UBX domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2086. Eukaryota.
ENOG410YGXU. LUCA.
GeneTreeiENSGT00520000055567.
HOGENOMiHOG000159961.
HOVERGENiHBG054517.
InParanoidiP0C627.
OMAiELYEDEM.
OrthoDBiEOG7ZKSBB.
PhylomeDBiP0C627.
TreeFamiTF312973.

Family and domain databases

InterProiIPR012989. SEP_domain.
IPR029071. Ubiquitin-rel_dom.
IPR001012. UBX_dom.
[Graphical view]
PfamiPF08059. SEP. 1 hit.
PF00789. UBX. 1 hit.
[Graphical view]
SMARTiSM00553. SEP. 1 hit.
SM00166. UBX. 1 hit.
[Graphical view]
SUPFAMiSSF102848. SSF102848. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS51399. SEP. 1 hit.
PS50033. UBX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C627-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGGGAEPE EQERRSSRPR PPSARDLQLA LAELYEDEMK CKSSKPDRST
60 70 80 90 100
ATAFKSPRTP PLRLYSGDQE YGGLHIAQPP TGKIVNELFK EAREHGAVPL
110 120 130 140 150
NEATRSSSDD KAKSFTGGGY RLGSSFYKRS EYIYGENQLQ DVQILLRLWS
160 170 180 190 200
NGFSLDDGEL RPYSDPTNAQ FLESVKRGEI PLELQRLVHG SQVSLDMEDH
210 220 230 240 250
QDQEYIKPRL RFKAFSGEGQ KLGSLTPEIV STPSSPEEED KSILNAAVLI
260 270 280 290 300
DDSVPTTKIQ IRLADGSRLI QRFNSTHRIL DVRDFIVQSR PEFATTDFIL
310 320 330
VTSFPSKELT DESVTLQDAD ILNTVILQQL K
Length:331
Mass (Da):37,075
Last modified:January 15, 2008 - v1
Checksum:i208726A4A562FC35
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03041043 Genomic DNA. No translation available.
RefSeqiNP_001101375.1. NM_001107905.1.
XP_006237899.1. XM_006237837.2.
UniGeneiRn.213813.

Genome annotation databases

EnsembliENSRNOT00000012551; ENSRNOP00000012551; ENSRNOG00000009137.
GeneIDi312965.
KEGGirno:312965.
UCSCiRGD:1308557. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03041043 Genomic DNA. No translation available.
RefSeqiNP_001101375.1. NM_001107905.1.
XP_006237899.1. XM_006237837.2.
UniGeneiRn.213813.

3D structure databases

ProteinModelPortaliP0C627.
SMRiP0C627. Positions 140-232, 246-330.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi260285. 1 interaction.
STRINGi10116.ENSRNOP00000012551.

PTM databases

iPTMnetiP0C627.
PhosphoSiteiP0C627.

Proteomic databases

PaxDbiP0C627.
PRIDEiP0C627.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000012551; ENSRNOP00000012551; ENSRNOG00000009137.
GeneIDi312965.
KEGGirno:312965.
UCSCiRGD:1308557. rat.

Organism-specific databases

CTDi137886.
RGDi1308557. Ubxn2b.

Phylogenomic databases

eggNOGiKOG2086. Eukaryota.
ENOG410YGXU. LUCA.
GeneTreeiENSGT00520000055567.
HOGENOMiHOG000159961.
HOVERGENiHBG054517.
InParanoidiP0C627.
OMAiELYEDEM.
OrthoDBiEOG7ZKSBB.
PhylomeDBiP0C627.
TreeFamiTF312973.

Miscellaneous databases

PROiP0C627.

Gene expression databases

GenevisibleiP0C627. RN.

Family and domain databases

InterProiIPR012989. SEP_domain.
IPR029071. Ubiquitin-rel_dom.
IPR001012. UBX_dom.
[Graphical view]
PfamiPF08059. SEP. 1 hit.
PF00789. UBX. 1 hit.
[Graphical view]
SMARTiSM00553. SEP. 1 hit.
SM00166. UBX. 1 hit.
[Graphical view]
SUPFAMiSSF102848. SSF102848. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS51399. SEP. 1 hit.
PS50033. UBX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "p37 is a p97 adaptor required for Golgi and ER biogenesis in interphase and at the end of mitosis."
    Uchiyama K., Totsukawa G., Puhka M., Kaneko Y., Jokitalo E., Dreveny I., Beuron F., Zhang X., Freemont P., Kondo H.
    Dev. Cell 11:803-816(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH VCP.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-234 AND SER-235, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiUBX2B_RAT
AccessioniPrimary (citable) accession number: P0C627
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: July 6, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.