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Protein

UBX domain-containing protein 2B

Gene

Ubxn2b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity. Together with NSFL1C/p47, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
UBX domain-containing protein 2B
Alternative name(s):
NSFL1 cofactor p37
p97 cofactor p37
Gene namesi
Name:Ubxn2b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1308557 Ubxn2b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Golgi apparatus, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003152302 – 331UBX domain-containing protein 2BAdd BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei56PhosphoserineBy similarity1
Modified residuei59PhosphothreonineBy similarity1
Modified residuei66PhosphoserineBy similarity1
Modified residuei231PhosphoserineBy similarity1
Modified residuei234PhosphoserineCombined sources1
Modified residuei235PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP0C627
PRIDEiP0C627

PTM databases

iPTMnetiP0C627
PhosphoSitePlusiP0C627

Expressioni

Tissue specificityi

Present at high level in brain. Also present in liver, kidney, spleen, testis, lung and heart (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000009137
GenevisibleiP0C627 RN

Interactioni

Subunit structurei

Interacts with VCP. Does not bind ubiquitin.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi260285, 1 interactor
STRINGi10116.ENSRNOP00000012551

Structurei

3D structure databases

ProteinModelPortaliP0C627
SMRiP0C627
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini141 – 206SEPPROSITE-ProRule annotationAdd BLAST66
Domaini252 – 329UBXPROSITE-ProRule annotationAdd BLAST78

Sequence similaritiesi

Belongs to the NSFL1C family.Curated

Phylogenomic databases

eggNOGiKOG2086 Eukaryota
ENOG410YGXU LUCA
GeneTreeiENSGT00520000055567
HOGENOMiHOG000159961
HOVERGENiHBG054517
InParanoidiP0C627
OMAiFIIQSRP
OrthoDBiEOG091G0QFZ
PhylomeDBiP0C627
TreeFamiTF312973

Family and domain databases

Gene3Di3.30.420.210, 1 hit
InterProiView protein in InterPro
IPR036241 NSFL1C_SEP_dom_sf
IPR012989 SEP_domain
IPR029071 Ubiquitin-like_domsf
IPR001012 UBX_dom
PfamiView protein in Pfam
PF08059 SEP, 1 hit
PF00789 UBX, 1 hit
SMARTiView protein in SMART
SM00553 SEP, 1 hit
SM00166 UBX, 1 hit
SUPFAMiSSF102848 SSF102848, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS51399 SEP, 1 hit
PS50033 UBX, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C627-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGGGAEPE EQERRSSRPR PPSARDLQLA LAELYEDEMK CKSSKPDRST
60 70 80 90 100
ATAFKSPRTP PLRLYSGDQE YGGLHIAQPP TGKIVNELFK EAREHGAVPL
110 120 130 140 150
NEATRSSSDD KAKSFTGGGY RLGSSFYKRS EYIYGENQLQ DVQILLRLWS
160 170 180 190 200
NGFSLDDGEL RPYSDPTNAQ FLESVKRGEI PLELQRLVHG SQVSLDMEDH
210 220 230 240 250
QDQEYIKPRL RFKAFSGEGQ KLGSLTPEIV STPSSPEEED KSILNAAVLI
260 270 280 290 300
DDSVPTTKIQ IRLADGSRLI QRFNSTHRIL DVRDFIVQSR PEFATTDFIL
310 320 330
VTSFPSKELT DESVTLQDAD ILNTVILQQL K
Length:331
Mass (Da):37,075
Last modified:January 15, 2008 - v1
Checksum:i208726A4A562FC35
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03041043 Genomic DNA No translation available.
RefSeqiNP_001101375.1, NM_001107905.1
XP_006237899.1, XM_006237837.3
UniGeneiRn.213813

Genome annotation databases

EnsembliENSRNOT00000012551; ENSRNOP00000012551; ENSRNOG00000009137
GeneIDi312965
KEGGirno:312965
UCSCiRGD:1308557 rat

Similar proteinsi

Entry informationi

Entry nameiUBX2B_RAT
AccessioniPrimary (citable) accession number: P0C627
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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