P0C625 (HBEAG_HBVA3) Reviewed, UniProtKB/Swiss-Prot
Last modified
September 21, 2011.
Version 16.
History...
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: External core antigen Alternative name(s): HBeAg Precore protein p25 | ||
| Gene names |
| ||
| Organism | Hepatitis B virus genotype A2 subtype adw2 (strain Rutter 1979) (HBV-A) [Complete proteome] | ||
| Taxonomic identifier | 480116 [NCBI] | ||
| Taxonomic lineage | Viruses › Retro-transcribing viruses › Hepadnaviridae › Orthohepadnavirus | ||
| Virus host | Pan troglodytes (Chimpanzee) [TaxID: 9598] Homo sapiens (Human) [TaxID: 9606] |
Protein attributes
| Sequence length | 214 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | May regulate immune response to the intracellular capsid in acting as a T cell tolerogen, by having an immunoregulatory effect which prevents destruction of infected cells by cytotoxic T cells. This immune regulation may predispose to chronicity during perinatal infections and prevent severe liver injury during adult infections By similarity. |
| Subunit structure | Homodimerizes. |
| Subcellular location | |
| Post-translational modification | Phosphorylated. Cleaved by host furin By similarity. |
| Sequence similarities | Belongs to the orthohepadnavirus precore antigen family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Host-virus interaction Viral immunoevasion |
| Cellular component | Host nucleus Secreted |
| Coding sequence diversity | Alternative initiation |
| Domain | Repeat Signal |
| PTM | Disulfide bond |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | evasion by virus of host immune response Inferred from electronic annotation. Source: UniProtKB-KW pathogenesisInferred from electronic annotation. Source: InterPro |
| Cellular component | host cell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | structural molecule activity Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative initiation. [Align] [Select] | ||||||
| Isoform External core antigen (identifier: P0C625-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform Capsid protein (identifier: P03148-1) The sequence of this isoform can be found in the external entry P03148. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 19 | 19 | Potential | ||||||
| Chain | 20 – 185 | 166 | External core antigen | PRO_0000315013 | |||||
| Propeptide | 186 – 214 | 29 | By similarity | PRO_0000314869 | |||||
Regions | |||||||||
| Repeat | 186 – 192 | 7 | 1; half-length | ||||||
| Repeat | 193 – 200 | 8 | 2 | ||||||
| Repeat | 201 – 208 | 8 | 3 | ||||||
| Region | 186 – 208 | 23 | 3 X 8 AA repeats of S-P-R-R-R-R-S-[PQ] | ||||||
Sites | |||||||||
| Site | 185 – 186 | 2 | Cleavage; by host By similarity | ||||||
Amino acid modifications | |||||||||
| Disulfide bond | 77 | Interchain By similarity | |||||||
| Disulfide bond | 90 | Interchain By similarity | |||||||
Natural variations | |||||||||
| Natural variant | 122 | 1 | V → M. | ||||||
| Natural variant | 126 | 1 | I → L Frequent mutation in chronic HBV carriers. Ref.4 | ||||||
| Natural variant | 198 | 1 | R → P. | ||||||
Sequences
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References
| [1] | "The nucleotide sequence of the hepatitis B viral genome and the identification of the major viral genes." Valenzuela P., Quiroga M., Zaldivar J., Gray P., Rutter W.J. (In) Field B.N., Jaenisch R., Fox C.F. (eds.); Animal virus genetics, pp.57-70, Academic Press, New York (1980) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "Proteaselike sequence in hepatitis B virus core antigen is not required for e antigen generation and may not be part of an aspartic acid-type protease." Nassal M., Galle P.R., Schaller H. J. Virol. 63:2598-2604(1989) [PubMed: 2657101] [Abstract] Cited for: CLEAVAGE BY HOST. |
| [3] | "Transport of hepatitis B virus precore protein into the nucleus after cleavage of its signal peptide." Ou J.H., Yeh C.T., Yen T.S. J. Virol. 63:5238-5243(1989) [PubMed: 2585603] [Abstract] Cited for: SUBCELLULAR LOCATION. |
| [4] | "Subtype-independent immature secretion and subtype-dependent replication deficiency of a highly frequent, naturally occurring mutation of human hepatitis B virus core antigen." Yuan T.T., Tai P.C., Shih C. J. Virol. 73:10122-10128(1999) [PubMed: 10559327] [Abstract] Cited for: VARIANT LEU-126. |
Web resources
| HepSEQ Hepatitis virus B database |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X02763 Genomic DNA. No translation available. |
3D structure databases | |
| ProteinModelPortal | P0C625. |
| SMR | P0C625. Positions 30-172. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Family and domain databases | |
| InterPro | IPR013195. Hepatitis_B_virus_capsid_N. IPR002006. Viral_capsid_core_Hepatitis. [Graphical view] |
| Pfam | PF08290. Hep_core_N. 1 hit. PF00906. Hepatitis_core. 1 hit. [Graphical view] |
| ProDom | PD000874. Vir_capsid_Znf-put_N_Hepatitis. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SUPFAM | SSF47852. Viral_capsid_core_Hepatitis. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | HBEAG_HBVA3 | ||||||||
| Accession | Primary (citable) accession number: P0C625 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Viral Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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