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Protein

Olfactory receptor 4Q2

Gene

OR4Q2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4Q2
Alternative name(s):
olfactory receptor OR14-21
Gene namesi
Name:OR4Q2
Synonyms:OR4Q2P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:15359. OR4Q2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626ExtracellularSequence analysisAdd
BLAST
Transmembranei27 – 4721Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini48 – 6114CytoplasmicSequence analysisAdd
BLAST
Transmembranei62 – 8423Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini85 – 9814ExtracellularSequence analysisAdd
BLAST
Transmembranei99 – 11921Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini120 – 14223CytoplasmicSequence analysisAdd
BLAST
Transmembranei143 – 16321Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini164 – 19532ExtracellularSequence analysisAdd
BLAST
Transmembranei196 – 21621Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini217 – 23519CytoplasmicSequence analysisAdd
BLAST
Transmembranei236 – 25621Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini257 – 26711ExtracellularSequence analysisAdd
BLAST
Transmembranei268 – 28821Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini289 – 31022CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi166215772.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Olfactory receptor 4Q2PRO_0000314664Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence analysis
Disulfide bondi98 ↔ 180PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP0C623.
PRIDEiP0C623.

Structurei

3D structure databases

ProteinModelPortaliP0C623.
SMRiP0C623. Positions 26-300.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiP0C623.
PhylomeDBiP0C623.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C623-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKNQTEVMR EFFLSGFSQT PSIEAGLFVL FLFFYMSIWV GNVLIMVTVA
60 70 80 90 100
SDKYLNSSPM YFLLGNLSFL DLCYSTVTTP KLLADFFNHE KLISYDQCIV
110 120 130 140 150
QLFFLHFVGA AEMFLLTVMA YDRYVAICRP LHYTTVMSRG LCCVLVAASW
160 170 180 190 200
MGGFVHSTVQ TILTVHLPFC GPNQVENFFC DVPPVIKLAC ADTFVIELLM
210 220 230 240 250
VSNSGLISTI SFVVLISSYT TILVKIRSKE GRRKALSTCA SHLMVVTLFF
260 270 280 290 300
GPCIFIYARP FSTFSVDKMV SVLYNVITPM LNPLIYTLRN KEVKSAMQKL
310
WVRNGLTWKK QET
Length:313
Mass (Da):35,487
Last modified:January 15, 2008 - v1
Checksum:iD91DF0129E481C83
GO

Polymorphismi

A single nucleotide insertion at position Cys-180 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF399446 Genomic DNA. No translation available.
BK004624 Genomic DNA. No translation available.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF399446 Genomic DNA. No translation available.
BK004624 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliP0C623.
SMRiP0C623. Positions 26-300.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

DMDMi166215772.

Proteomic databases

EPDiP0C623.
PRIDEiP0C623.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiOR4Q2.
HGNCiHGNC:15359. OR4Q2.
neXtProtiNX_P0C623.
GenAtlasiSearch...

Phylogenomic databases

HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiP0C623.
PhylomeDBiP0C623.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

PROiP0C623.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-210.
  2. Cited for: IDENTIFICATION.
  3. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
  4. Cited for: POLYMORPHISM.

Entry informationi

Entry nameiOR4Q2_HUMAN
AccessioniPrimary (citable) accession number: P0C623
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: March 16, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.