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Protein

Olfactory receptor 4Q2

Gene

OR4Q2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-31469-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4Q2
Alternative name(s):
olfactory receptor OR14-21
Gene namesi
Name:OR4Q2
Synonyms:OR4Q2P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:15359. OR4Q2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26ExtracellularSequence analysisAdd BLAST26
Transmembranei27 – 47Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini48 – 61CytoplasmicSequence analysisAdd BLAST14
Transmembranei62 – 84Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini85 – 98ExtracellularSequence analysisAdd BLAST14
Transmembranei99 – 119Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini120 – 142CytoplasmicSequence analysisAdd BLAST23
Transmembranei143 – 163Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini164 – 195ExtracellularSequence analysisAdd BLAST32
Transmembranei196 – 216Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini217 – 235CytoplasmicSequence analysisAdd BLAST19
Transmembranei236 – 256Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini257 – 267ExtracellularSequence analysisAdd BLAST11
Transmembranei268 – 288Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini289 – 310CytoplasmicSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi166215772.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003146641 – 313Olfactory receptor 4Q2Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi98 ↔ 180PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP0C623.

Structurei

3D structure databases

ProteinModelPortaliP0C623.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiP0C623.
PhylomeDBiP0C623.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C623-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKNQTEVMR EFFLSGFSQT PSIEAGLFVL FLFFYMSIWV GNVLIMVTVA
60 70 80 90 100
SDKYLNSSPM YFLLGNLSFL DLCYSTVTTP KLLADFFNHE KLISYDQCIV
110 120 130 140 150
QLFFLHFVGA AEMFLLTVMA YDRYVAICRP LHYTTVMSRG LCCVLVAASW
160 170 180 190 200
MGGFVHSTVQ TILTVHLPFC GPNQVENFFC DVPPVIKLAC ADTFVIELLM
210 220 230 240 250
VSNSGLISTI SFVVLISSYT TILVKIRSKE GRRKALSTCA SHLMVVTLFF
260 270 280 290 300
GPCIFIYARP FSTFSVDKMV SVLYNVITPM LNPLIYTLRN KEVKSAMQKL
310
WVRNGLTWKK QET
Length:313
Mass (Da):35,487
Last modified:January 15, 2008 - v1
Checksum:iD91DF0129E481C83
GO

Polymorphismi

A single nucleotide insertion at position Cys-180 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF399446 Genomic DNA. No translation available.
BK004624 Genomic DNA. No translation available.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF399446 Genomic DNA. No translation available.
BK004624 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliP0C623.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

DMDMi166215772.

Proteomic databases

PRIDEiP0C623.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiOR4Q2.
HGNCiHGNC:15359. OR4Q2.
neXtProtiNX_P0C623.
GenAtlasiSearch...

Phylogenomic databases

HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiP0C623.
PhylomeDBiP0C623.

Enzyme and pathway databases

BioCyciZFISH:G66-31469-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

PROiP0C623.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR4Q2_HUMAN
AccessioniPrimary (citable) accession number: P0C623
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: November 2, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.