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Protein

Olfactory receptor 4Q2

Gene

OR4Q2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4Q2
Alternative name(s):
olfactory receptor OR14-21
Gene namesi
Name:OR4Q2
Synonyms:OR4Q2P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000196383.5
HGNCiHGNC:15359 OR4Q2
neXtProtiNX_P0C623

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26ExtracellularSequence analysisAdd BLAST26
Transmembranei27 – 47Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini48 – 61CytoplasmicSequence analysisAdd BLAST14
Transmembranei62 – 84Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini85 – 98ExtracellularSequence analysisAdd BLAST14
Transmembranei99 – 119Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini120 – 142CytoplasmicSequence analysisAdd BLAST23
Transmembranei143 – 163Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini164 – 194ExtracellularSequence analysisAdd BLAST31
Transmembranei195 – 215Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini216 – 234CytoplasmicSequence analysisAdd BLAST19
Transmembranei235 – 255Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini256 – 266ExtracellularSequence analysisAdd BLAST11
Transmembranei267 – 287Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini288 – 307CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi166215772

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003146641 – 307Olfactory receptor 4Q2Add BLAST307

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi98 ↔ 179PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP0C623
ProteomicsDBi52317

Structurei

3D structure databases

ProteinModelPortaliP0C623
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00920000148993
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiP0C623
PhylomeDBiP0C623

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0C623-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKNQTEVMR EFFLSGFSQT PSIEAGLFVL FLFFYMSIWV GNVLIMVTVA
60 70 80 90 100
SDKYLNSSPM YFLLGNLSFL DLCYSTVTTP KLLADFFNHE KLISYDQCIV
110 120 130 140 150
QLFFLHFVGA AEMFLLTVMA YDRYVAICRP LHYTTVMSRG LCCVLVAASW
160 170 180 190 200
MGGFVHSTVQ TILTVHLPFC GPNQVTFFCD VPPVIKLACA DTFVIELLMV
210 220 230 240 250
SNSGLISTIS FVVLISSYTT ILVKIRSKEG RRKALSTCAS HLMVVTLFFG
260 270 280 290 300
PCIFIYARPF STFSVDKMVS VLYNVITPML NPLIYTLRNK EVKSAMQKLW

VKIITFQ
Length:307
Mass (Da):34,733
Last modified:March 28, 2018 - v2
Checksum:i8107915E64D5E0B5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti176T → EN in AF399446 (PubMed:12213199).Curated1

Polymorphismi

A single nucleotide insertion at position Cys-180 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL359218 Genomic DNA No translation available.
AF399446 Genomic DNA No translation available.
BK004624 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000622436; ENSP00000484287; ENSG00000196383

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR4Q2_HUMAN
AccessioniPrimary (citable) accession number: P0C623
Secondary accession number(s): A0A087X1L2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 28, 2018
Last modified: June 20, 2018
This is version 71 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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