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Protein

Toluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component

Gene

todA

Organism
Pseudomonas putida (Arthrobacter siderocapsulatus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Part of the electron transfer component of toluene 1,2-dioxygenase, transfers electrons from ferredoxin (TodB) to NADH.

Catalytic activityi

Reduced ferredoxin + NAD+ = oxidized ferredoxin + NADH.

Cofactori

Pathwayi: toluene degradation

This protein is involved in the pathway toluene degradation, which is part of Xenobiotic degradation.
View all proteins of this organism that are known to be involved in the pathway toluene degradation and in Xenobiotic degradation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi4 – 3532FADSequence analysisAdd
BLAST
Nucleotide bindingi145 – 17329NADSequence analysisAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

UniPathwayiUPA00273.

Names & Taxonomyi

Protein namesi
Recommended name:
Toluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component (EC:1.18.1.3)
Gene namesi
Name:todA
OrganismiPseudomonas putida (Arthrobacter siderocapsulatus)
Taxonomic identifieri303 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 409408Toluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase componentPRO_0000167654Add
BLAST

Interactioni

Subunit structurei

This dioxygenase system consists of four proteins: the two subunits of the hydroxylase component (todC1 and todC2), a ferredoxin (TodB) and a ferredoxin reductase (TodA).

Protein-protein interaction databases

STRINGi351746.Pput_2878.

Structurei

3D structure databases

ProteinModelPortaliP0C621.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108EQM. Bacteria.
COG0446. LUCA.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR028202. Reductase_C.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF14759. Reductase_C. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
SSF55424. SSF55424. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C621-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATHVAIIGN GVGGFTTAQA LRAEGFEGRI SLIGDEPHLP YDRPSLSKAV
60 70 80 90 100
LDGSLERPPI LAEADWYGEA RIDMLTGPEV TALDVQTRTI SLDDGTTLSA
110 120 130 140 150
DAIVIATGSR ARTMALPGSQ LPGVVTLRTY GDVQVLRDSW TSATRLLIVG
160 170 180 190 200
GGLIGCEVAT TARKLGLSVT ILEAGDELLV RVLGRRIGAW LRGLLTELGV
210 220 230 240 250
QVELGTGVVG FSGEGQLEQV MASDGRSFVA DSALICVGAE PADQLARQAG
260 270 280 290 300
LACDRGVIVD HCGATLAKGY SPSEMWPVGA AAGGRRSLET YMNAQRQAAA
310 320 330 340 350
VAAAILGKNV SAPQLPVSWT EIAGHRMQMA GDIEGPGDFV SRGMPGSGAA
360 370 380 390 400
LLFRLQERRI QAVVAVDAPR DFALATRLVE ARAAIEPARL ADLSNSMRDF

VRANEGDLT
Length:409
Mass (Da):42,820
Last modified:January 15, 2008 - v1
Checksum:i20451B8A657FB895
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17904 Genomic DNA. No translation available.
PIRiD36516.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17904 Genomic DNA. No translation available.
PIRiD36516.

3D structure databases

ProteinModelPortaliP0C621.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi351746.Pput_2878.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4108EQM. Bacteria.
COG0446. LUCA.

Enzyme and pathway databases

UniPathwayiUPA00273.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR028202. Reductase_C.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF14759. Reductase_C. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
SSF55424. SSF55424. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTODA_PSEPU
AccessioniPrimary (citable) accession number: P0C621
Secondary accession number(s): P13452
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: November 11, 2015
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.