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Protein

Olfactory receptor 5AL1

Gene

OR5AL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5AL1
Alternative name(s):
Olfactory receptor OR11-184
Gene namesi
Name:OR5AL1
Synonyms:OR5AL1P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:14844. OR5AL1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4444ExtracellularSequence analysisAdd
BLAST
Transmembranei45 – 6521Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini66 – 738CytoplasmicSequence analysis
Transmembranei74 – 9421Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini95 – 11319ExtracellularSequence analysisAdd
BLAST
Transmembranei114 – 13421Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini135 – 15622CytoplasmicSequence analysisAdd
BLAST
Transmembranei157 – 17721Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini178 – 21942ExtracellularSequence analysisAdd
BLAST
Transmembranei220 – 24021Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini241 – 25212CytoplasmicSequence analysisAdd
BLAST
Transmembranei253 – 27321Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini274 – 28613ExtracellularSequence analysisAdd
BLAST
Transmembranei287 – 30721Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini308 – 32821CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi166215763.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328Olfactory receptor 5AL1PRO_0000314462Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi21 – 211N-linked (GlcNAc...)Sequence analysis
Disulfide bondi113 ↔ 204PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP0C617.

PTM databases

iPTMnetiP0C617.
PhosphoSiteiP0C617.

Structurei

3D structure databases

ProteinModelPortaliP0C617.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG017625.
InParanoidiP0C617.
PhylomeDBiP0C617.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C617-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCALKGFLEE NFYTYSVAKG NHSTVYEFIL LGLTDNAELQ VTLFGIFLVV
60 70 80 90 100
YLASFMGNFG LIMLIQISPQ LHTPMYFFLS HLAFVDFSFT SSVAPNTLVN
110 120 130 140 150
FLCEVKSITF YACAIQVCCF ITFVVCELYL LSIMAYDRYV AICNPLLYVI
160 170 180 190 200
LIPRKCIKLI ASTYVYGFTV GLVQTVATSY LSFCDSNVIN HFYHDDVPLV
210 220 230 240 250
ALACSDTHVK ELMLLIIAGF NTLCSLVIVL ISYGFIFFAI LRIHSAEGRQ
260 270 280 290 300
KAFSTSASHL TSITIFYGTI IFMYPQPKSS HSLNMDKVAS VFNVVVIPTL
310 320
NPLIYSLRNQ EVKNALKRII EKLCLAVK
Length:328
Mass (Da):36,816
Last modified:January 15, 2008 - v1
Checksum:iE35BB33D99A665E2
GO

Polymorphismi

A double nucleotide deletion at position Cys-156 in the gene coding for this protein produces a stop codon which is responsible for functional diversity thus producing a pseudogene.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF399353 Genomic DNA. No translation available.
BK004654 Genomic DNA. No translation available.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF399353 Genomic DNA. No translation available.
BK004654 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliP0C617.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP0C617.
PhosphoSiteiP0C617.

Polymorphism and mutation databases

DMDMi166215763.

Proteomic databases

PRIDEiP0C617.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiOR5AL1.
HGNCiHGNC:14844. OR5AL1.
neXtProtiNX_P0C617.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG017625.
InParanoidiP0C617.
PhylomeDBiP0C617.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

PROiP0C617.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO5AL1_HUMAN
AccessioniPrimary (citable) accession number: P0C617
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: July 6, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.