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Protein

Iota-conotoxin-like Fi11.8

Gene
N/A
Organism
Conus figulinus (Fig cone)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Iota-conotoxins bind to voltage-gated sodium channels (Nav) and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. Produces general excitatory symptoms (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Iota-conotoxin-like Fi11.8
OrganismiConus figulinus (Fig cone)
Taxonomic identifieri101301 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri2810. Fi11.8.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003140871 – 46Iota-conotoxin-like Fi11.8Add BLAST46

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24-hydroxyprolineBy similarity1
Disulfide bondi5 ↔ 19By similarity
Modified residuei114-hydroxyprolineBy similarity1
Disulfide bondi12 ↔ 22By similarity
Disulfide bondi18 ↔ 27By similarity
Disulfide bondi21 ↔ 38By similarity
Modified residuei294-hydroxyprolineBy similarity1
Modified residuei336'-bromotryptophanBy similarity1
Modified residuei44D-phenylalanineBy similarity1

Keywords - PTMi

Bromination, D-amino acid, Disulfide bond, Hydroxylation

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

ProteinModelPortaliP0C611.
SMRiP0C611.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is XI (C-C-CC-CC-C-C).

Sequence similaritiesi

Belongs to the conotoxin I1 superfamily.Curated

Family and domain databases

InterProiView protein in InterPro
IPR013141. Conotoxin-I_CS.
IPR012624. Toxin_19.
PfamiView protein in Pfam
PF08088. Toxin_19. 1 hit.
PROSITEiView protein in PROSITE
PS60019. I_CONOTOXIN. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C611-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
GPSSCKADEE PCEYHADCCN CCLSGICAPS TNWILPGCST SSFFKI
Length:46
Mass (Da):4,877
Last modified:January 15, 2008 - v1
Checksum:i32C2902A2C6BAC55
GO

Similar proteinsi

Entry informationi

Entry nameiCI1B8_CONFI
AccessioniPrimary (citable) accession number: P0C611
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: November 22, 2017
This is version 31 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families