OR4A8

Functionⁱ

Odorant receptor.Curated

GO - Molecular functionⁱ

G-protein coupled receptor activity Source: UniProtKB-KW
olfactory receptor activity Source: InterPro
transmembrane signaling receptor activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

detection of chemical stimulus involved in sensory perception Source: GO_Central
G-protein coupled receptor signaling pathway Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer
Biological process	Olfaction, Sensory transduction

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381753. Olfactory Signaling Pathway.

Reactomeⁱ

R-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Olfactory receptor 4A8 Alternative name(s): Olfactory receptor OR11-110
Gene namesⁱ	Name:OR4A8 Synonyms:OR4A8P
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Unplaced

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15165. OR4A8.
neXtProtⁱ	NX_P0C604.

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 24	ExtracellularSequence analysisAdd BLAST	24
Transmembraneⁱ	25 – 45	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	46 – 57	CytoplasmicSequence analysisAdd BLAST	12
Transmembraneⁱ	58 – 80	Helical; Name=2Sequence analysisAdd BLAST	23
Topological domainⁱ	81 – 95	ExtracellularSequence analysisAdd BLAST	15
Transmembraneⁱ	96 – 116	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	117 – 139	CytoplasmicSequence analysisAdd BLAST	23
Transmembraneⁱ	140 – 160	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	161 – 193	ExtracellularSequence analysisAdd BLAST	33
Transmembraneⁱ	194 – 214	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	215 – 235	CytoplasmicSequence analysisAdd BLAST	21
Transmembraneⁱ	236 – 256	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	257 – 266	ExtracellularSequence analysis	10
Transmembraneⁱ	267 – 287	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	288 – 315	CytoplasmicSequence analysisAdd BLAST	28

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Polymorphism and mutation databases

DMDMⁱ	166215770.

DMDMⁱ

166215770.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000314021	1 – 315	Olfactory receptor 4A8Add BLAST		315

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	6	N-linked (GlcNAc...) asparagineSequence analysis		1
Disulfide bondⁱ	95 ↔ 177	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	P0C604.
PRIDEⁱ	P0C604.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P0C604.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENⁱ	HBG017625.
InParanoidⁱ	P0C604.
PhylomeDBⁱ	P0C604.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13853. 7tm_4. 1 hit.
PRINTSⁱ	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITEⁱ	View protein in PROSITE PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

P0C604-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRQNNNITEF VLLGFSQYPD VQNALFVMFL LIYIVTMVGN LLIVVSIIAS 
        60         70         80         90        100
PFLGSPVYFF LACLSFIDAV YSTTISPVLI VDLLCDKKTI SFPACMGQLF 
       110        120        130        140        150
IEHLFGDTDV FLLVVMAYDR YVATCKPLRY LTIMNRQVCI LLLVVAVTGG 
       160        170        180        190        200
FLHSVFQILV VYSLPFCGPN VIYHFFCNIY PLLDLECTDT YFVGLAVVFN 
       210        220        230        240        250
GGAICMVIFT LLLISYGVIL NSLKTYSPEG RHKAPFICSS HFIMVILFFV 
       260        270        280        290        300
PCIFLYVRPV SNFPIDKFLT VFYSVITPKL NPFIYMLRNS EMRNAIENLL 
       310 
GYQSGKTGFR CSKLN

Length:315

Mass (Da):35,621

Last modified:January 15, 2008 - v1

Checksum:ⁱC92E10A7A3665F1D

GO

Polymorphismⁱ

A stop codon in the gene coding for this protein at position Arg-136 is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in African-Americans than in non-Africans.1 Publication

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF546448 Genomic DNA. No translation available. AC087377 Genomic DNA. No translation available. BK004702 Genomic DNA. No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AF546448 Genomic DNA. No translation available.
AC087377 Genomic DNA. No translation available.
BK004702 Genomic DNA. No translation available.

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P0C604	UPI0008F4D249 UPI0007DBEC86 UPI0006C99B94 Q8HZL4 Q8HZL3	Gorilla gorilla gorilla (Western lowland gorilla) Pan troglodytes (Chimpanzee) Pan paniscus (Pygmy chimpanzee) (Bonobo)	315	UniRef90_P0C604	Cluster: Olfactory receptor 4A8	6

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P0C604	UPI0008F4D249 UPI0006C99B94 UPI0007DBEC86 Q8HZL4 Q8HZL3 UPI00057B3D3C UPI0003C80CCE A0A1U8C7Q5 A0A1U7Q323 UPI0003F08A28 +352	Gorilla gorilla gorilla (Western lowland gorilla) Pan paniscus (Pygmy chimpanzee) (Bonobo) Pan troglodytes (Chimpanzee) Camelus bactrianus (Bactrian camel) Vicugna pacos (Alpaca) (Lama pacos) Mesocricetus auratus (Golden hamster) Elephantulus edwardii (Cape long-eared elephant shrew) Echinops telfairi (Lesser hedgehog tenrec) Enhydra lutris kenyoni Ailuropoda melanoleuca (Giant panda) And more	315	UniRef50_P0C604	Cluster: Olfactory receptor 4A8	363

Cross-referencesⁱ

Web resourcesⁱ

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF546448 Genomic DNA. No translation available. AC087377 Genomic DNA. No translation available. BK004702 Genomic DNA. No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AF546448 Genomic DNA. No translation available.
AC087377 Genomic DNA. No translation available.
BK004702 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortalⁱ	P0C604.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

Polymorphism and mutation databases

DMDMⁱ	166215770.

DMDMⁱ

166215770.

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	P0C604.
PRIDEⁱ	P0C604.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Organism-specific databases

GeneCardsⁱ	OR4A8.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15165. OR4A8.
neXtProtⁱ	NX_P0C604.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

HOVERGENⁱ	HBG017625.
InParanoidⁱ	P0C604.
PhylomeDBⁱ	P0C604.

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381753. Olfactory Signaling Pathway.

Reactomeⁱ

R-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P0C604.

PROⁱ

PR:P0C604.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13853. 7tm_4. 1 hit.
PRINTSⁱ	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITEⁱ	View protein in PROSITE PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	OR4A8_HUMAN
Accessionⁱ	P0C604Primary (citable) accession number: P0C604
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
	Last sequence update:	January 15, 2008
	Last modified:	January 31, 2018
	This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P0C604 (OR4A8_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Olfactory receptor 4A8

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein family/group databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ