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Protein

2-oxoglutarate dehydrogenase E1 component

Gene

odhA

Organism
Staphylococcus aureus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 component (EC:1.2.4.2)
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:odhA
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9329322-oxoglutarate dehydrogenase E1 componentPRO_0000224241Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi158878.SAV1413.

Structurei

3D structure databases

ProteinModelPortaliP0C601.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01169. SucA_OdhA.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C601-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNERKEVSE APVNFGANLG LMLDLYDDFL QDPSSVPEDL QVLFSIIKND
60 70 80 90 100
DSIVPALKST SSQNSDGTIK RVMRLIDNIR QYGHLKADIY PVNPPKRKHV
110 120 130 140 150
PKLEIEDFDL DQQTLEGISA GIVSDHFADI YDNAYEAILR MEKRYKGPIA
160 170 180 190 200
FEYTHINNNT ERGWLKRRIE TPYKVTLNNN EKRALFKQLA YVEGFEKYLH
210 220 230 240 250
KNFVGAKRFS IEGVDALVPM LQRTITIAAK EGIKNIQIGM AHRGRLNVLT
260 270 280 290 300
HVLEKPYEMM ISEFMHTDPM KFLPEDGSLQ LTAGWTGDVK YHLGGIKTTD
310 320 330 340 350
SYGTMQRIAL ANNPSHLEIV APVVEGRTRA AQDDTQRAGA PTTDHHKAMP
360 370 380 390 400
IIIHGDAAYP GQGINFETMN LGNLKGYSTG GSLHIITNNR IGFTTEPIDA
410 420 430 440 450
RSTTYSTDVA KGYDVPIFHV NADDVEATIE AIDIAMEFRK EFHKDVVIDL
460 470 480 490 500
VGYRRFGHNE MDEPSITNPV PYQNIRKHDS VEYVFGKKLV NEGVISEDEM
510 520 530 540 550
HSFIEQVQKE LRQAHDKINK ADKMDNPDME KPAELALPLQ ADEQSFTFDH
560 570 580 590 600
LKEINDALLT YPDGFNILKK LNKVLEKRHE PFNKEDGLVD WAQAEQLAFA
610 620 630 640 650
TILQDGTPIR LTGQDSERGT FSHRHAVLHD EQTGETYTPL HHVPDQKATF
660 670 680 690 700
DIHNSPLSEA AVVGFEYGYN VENKKSFNIW EAQYGDFANM SQMIFDNFLF
710 720 730 740 750
SSRSKWGERS GLTLFLPHAY EGQGPEHSSA RLERFLQLAA ENNCTVVNLS
760 770 780 790 800
SSSNYFHLLR AQAASLDSEQ MRPLVVMSPK SLLRNKTVAK PIDEFTSGGF
810 820 830 840 850
EPILTESYQA DKVTKVILAT GKMFIDLKEA LAKNPDESVL LVAIERLYPF
860 870 880 890 900
PEEEIEALLA QLPKLEEVSW VQEEPKNQGA WLYVYPYVKV LVADKYDLSY
910 920 930
HGRIQRAAPA EGDGEIHKLV QNKIIENALK NN
Length:932
Mass (Da):105,383
Last modified:January 15, 2008 - v1
Checksum:iC744C1868AE20A38
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti46 – 6722Missing in strain: SMH8997, LLA, LLE, SMH10501, SMH11888, SMH12248, SMH14017, SMH17487, SMH17608, SMH18000, SMH18034 and SMH18037.
Add
BLAST
Natural varianti534 – 5341E → D in strain: 23, 3700, 3759, LIM1, LIM2 and LIM3.
Natural varianti864 – 8641K → N in strain: 23, 3700, 3759, LIM1, LIM2 and LIM3.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ564531 Genomic DNA. Translation: CAD92198.1.
AJ564532 Genomic DNA. Translation: CAD92199.1.
AJ564533 Genomic DNA. Translation: CAD92200.1.
AJ564534 Genomic DNA. Translation: CAD92201.1.
AJ564535 Genomic DNA. Translation: CAD92202.1.
AJ564536 Genomic DNA. Translation: CAD92203.1.
AJ564537 Genomic DNA. Translation: CAD92204.1.
AJ564538 Genomic DNA. Translation: CAD92205.1.
AJ564539 Genomic DNA. Translation: CAD92206.1.
AJ564540 Genomic DNA. Translation: CAD92207.1.
AJ564541 Genomic DNA. Translation: CAD92208.1.
AJ564542 Genomic DNA. Translation: CAD92209.1.
AJ564543 Genomic DNA. Translation: CAD92210.1.
AJ564544 Genomic DNA. Translation: CAD92211.1.
AJ564545 Genomic DNA. Translation: CAD92212.1.
AJ564546 Genomic DNA. Translation: CAD92213.1.
AJ564547 Genomic DNA. Translation: CAD92214.1.
AJ564548 Genomic DNA. Translation: CAD92215.1.
AJ564549 Genomic DNA. Translation: CAD92216.1.
AJ564550 Genomic DNA. Translation: CAD92217.1.
AJ564551 Genomic DNA. Translation: CAD92218.1.
AJ564552 Genomic DNA. Translation: CAD92219.1.
AJ564553 Genomic DNA. Translation: CAD92220.1.
AJ564554 Genomic DNA. Translation: CAD92221.1.
AJ564555 Genomic DNA. Translation: CAD92222.1.
AJ564556 Genomic DNA. Translation: CAD92223.1.
AJ564557 Genomic DNA. Translation: CAD92224.1.
AJ564558 Genomic DNA. Translation: CAD92225.1.
AJ564559 Genomic DNA. Translation: CAD92226.1.
AJ564560 Genomic DNA. Translation: CAD92227.1.
AJ564561 Genomic DNA. Translation: CAD92228.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ564531 Genomic DNA. Translation: CAD92198.1.
AJ564532 Genomic DNA. Translation: CAD92199.1.
AJ564533 Genomic DNA. Translation: CAD92200.1.
AJ564534 Genomic DNA. Translation: CAD92201.1.
AJ564535 Genomic DNA. Translation: CAD92202.1.
AJ564536 Genomic DNA. Translation: CAD92203.1.
AJ564537 Genomic DNA. Translation: CAD92204.1.
AJ564538 Genomic DNA. Translation: CAD92205.1.
AJ564539 Genomic DNA. Translation: CAD92206.1.
AJ564540 Genomic DNA. Translation: CAD92207.1.
AJ564541 Genomic DNA. Translation: CAD92208.1.
AJ564542 Genomic DNA. Translation: CAD92209.1.
AJ564543 Genomic DNA. Translation: CAD92210.1.
AJ564544 Genomic DNA. Translation: CAD92211.1.
AJ564545 Genomic DNA. Translation: CAD92212.1.
AJ564546 Genomic DNA. Translation: CAD92213.1.
AJ564547 Genomic DNA. Translation: CAD92214.1.
AJ564548 Genomic DNA. Translation: CAD92215.1.
AJ564549 Genomic DNA. Translation: CAD92216.1.
AJ564550 Genomic DNA. Translation: CAD92217.1.
AJ564551 Genomic DNA. Translation: CAD92218.1.
AJ564552 Genomic DNA. Translation: CAD92219.1.
AJ564553 Genomic DNA. Translation: CAD92220.1.
AJ564554 Genomic DNA. Translation: CAD92221.1.
AJ564555 Genomic DNA. Translation: CAD92222.1.
AJ564556 Genomic DNA. Translation: CAD92223.1.
AJ564557 Genomic DNA. Translation: CAD92224.1.
AJ564558 Genomic DNA. Translation: CAD92225.1.
AJ564559 Genomic DNA. Translation: CAD92226.1.
AJ564560 Genomic DNA. Translation: CAD92227.1.
AJ564561 Genomic DNA. Translation: CAD92228.1.

3D structure databases

ProteinModelPortaliP0C601.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi158878.SAV1413.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01169. SucA_OdhA.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genetic analysis of seventeen genes in Staphylococcus aureus with reduced susceptibility to vancomycin (VRSA) and hetero-VRSA (hVRSA)."
    Wootton M., Avison M.B., Bennett P.M., Howe R.A., MacGowan A.P., Walsh T.R.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: FranceDuf, Glasgow3700, Glasgow3759, LIM1, LIM2, LIM3, LiverpoolAG, LLA, LLE, Michigan, New Jersey, Norway1018, PC1, PC3, Slovenia6096, SMH10501, SMH11888, SMH12248, SMH14017, SMH17487, SMH17608, SMH18000, SMH18034, SMH18037, SMH2, SMH8997, Southampton23, St. Luke, Sweden307 and Sweden309.

Entry informationi

Entry nameiODO1_STAAU
AccessioniPrimary (citable) accession number: P0C601
Secondary accession number(s): Q7ASB7
, Q7WRM3, Q7WRN1, Q7WRX0, Q7WZ40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: June 24, 2015
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.