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P0C601 (ODO1_STAAU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2-oxoglutarate dehydrogenase E1 component

EC=1.2.4.2
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene names
Name:odhA
OrganismStaphylococcus aureus
Taxonomic identifier1280 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length932 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. HAMAP-Rule MF_01169

Catalytic activity

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2. HAMAP-Rule MF_01169

Cofactor

Thiamine pyrophosphate By similarity. HAMAP-Rule MF_01169

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01169

Sequence similarities

Belongs to the alpha-ketoglutarate dehydrogenase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9329322-oxoglutarate dehydrogenase E1 component HAMAP-Rule MF_01169
PRO_0000224241

Natural variations

Natural variant46 – 6722Missing in strain: SMH8997, LLA, LLE, SMH10501, SMH11888, SMH12248, SMH14017, SMH17487, SMH17608, SMH18000, SMH18034 and SMH18037.
Natural variant5341E → D in strain: 23, 3700, 3759, LIM1, LIM2 and LIM3.
Natural variant8641K → N in strain: 23, 3700, 3759, LIM1, LIM2 and LIM3.

Sequences

Sequence LengthMass (Da)Tools
P0C601 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: C744C1868AE20A38

FASTA932105,383
        10         20         30         40         50         60 
MTNERKEVSE APVNFGANLG LMLDLYDDFL QDPSSVPEDL QVLFSIIKND DSIVPALKST 

        70         80         90        100        110        120 
SSQNSDGTIK RVMRLIDNIR QYGHLKADIY PVNPPKRKHV PKLEIEDFDL DQQTLEGISA 

       130        140        150        160        170        180 
GIVSDHFADI YDNAYEAILR MEKRYKGPIA FEYTHINNNT ERGWLKRRIE TPYKVTLNNN 

       190        200        210        220        230        240 
EKRALFKQLA YVEGFEKYLH KNFVGAKRFS IEGVDALVPM LQRTITIAAK EGIKNIQIGM 

       250        260        270        280        290        300 
AHRGRLNVLT HVLEKPYEMM ISEFMHTDPM KFLPEDGSLQ LTAGWTGDVK YHLGGIKTTD 

       310        320        330        340        350        360 
SYGTMQRIAL ANNPSHLEIV APVVEGRTRA AQDDTQRAGA PTTDHHKAMP IIIHGDAAYP 

       370        380        390        400        410        420 
GQGINFETMN LGNLKGYSTG GSLHIITNNR IGFTTEPIDA RSTTYSTDVA KGYDVPIFHV 

       430        440        450        460        470        480 
NADDVEATIE AIDIAMEFRK EFHKDVVIDL VGYRRFGHNE MDEPSITNPV PYQNIRKHDS 

       490        500        510        520        530        540 
VEYVFGKKLV NEGVISEDEM HSFIEQVQKE LRQAHDKINK ADKMDNPDME KPAELALPLQ 

       550        560        570        580        590        600 
ADEQSFTFDH LKEINDALLT YPDGFNILKK LNKVLEKRHE PFNKEDGLVD WAQAEQLAFA 

       610        620        630        640        650        660 
TILQDGTPIR LTGQDSERGT FSHRHAVLHD EQTGETYTPL HHVPDQKATF DIHNSPLSEA 

       670        680        690        700        710        720 
AVVGFEYGYN VENKKSFNIW EAQYGDFANM SQMIFDNFLF SSRSKWGERS GLTLFLPHAY 

       730        740        750        760        770        780 
EGQGPEHSSA RLERFLQLAA ENNCTVVNLS SSSNYFHLLR AQAASLDSEQ MRPLVVMSPK 

       790        800        810        820        830        840 
SLLRNKTVAK PIDEFTSGGF EPILTESYQA DKVTKVILAT GKMFIDLKEA LAKNPDESVL 

       850        860        870        880        890        900 
LVAIERLYPF PEEEIEALLA QLPKLEEVSW VQEEPKNQGA WLYVYPYVKV LVADKYDLSY 

       910        920        930 
HGRIQRAAPA EGDGEIHKLV QNKIIENALK NN 

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References

[1]"Genetic analysis of seventeen genes in Staphylococcus aureus with reduced susceptibility to vancomycin (VRSA) and hetero-VRSA (hVRSA)."
Wootton M., Avison M.B., Bennett P.M., Howe R.A., MacGowan A.P., Walsh T.R.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: FranceDuf, Glasgow3700, Glasgow3759, LIM1, LIM2, LIM3, LiverpoolAG, LLA, LLE, Michigan, New Jersey, Norway1018, PC1, PC3, Slovenia6096, SMH10501, SMH11888, SMH12248, SMH14017, SMH17487, SMH17608, SMH18000, SMH18034, SMH18037, SMH2, SMH8997, Southampton23, St. Luke, Sweden307 and Sweden309.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ564531 Genomic DNA. Translation: CAD92198.1.
AJ564532 Genomic DNA. Translation: CAD92199.1.
AJ564533 Genomic DNA. Translation: CAD92200.1.
AJ564534 Genomic DNA. Translation: CAD92201.1.
AJ564535 Genomic DNA. Translation: CAD92202.1.
AJ564536 Genomic DNA. Translation: CAD92203.1.
AJ564537 Genomic DNA. Translation: CAD92204.1.
AJ564538 Genomic DNA. Translation: CAD92205.1.
AJ564539 Genomic DNA. Translation: CAD92206.1.
AJ564540 Genomic DNA. Translation: CAD92207.1.
AJ564541 Genomic DNA. Translation: CAD92208.1.
AJ564542 Genomic DNA. Translation: CAD92209.1.
AJ564543 Genomic DNA. Translation: CAD92210.1.
AJ564544 Genomic DNA. Translation: CAD92211.1.
AJ564545 Genomic DNA. Translation: CAD92212.1.
AJ564546 Genomic DNA. Translation: CAD92213.1.
AJ564547 Genomic DNA. Translation: CAD92214.1.
AJ564548 Genomic DNA. Translation: CAD92215.1.
AJ564549 Genomic DNA. Translation: CAD92216.1.
AJ564550 Genomic DNA. Translation: CAD92217.1.
AJ564551 Genomic DNA. Translation: CAD92218.1.
AJ564552 Genomic DNA. Translation: CAD92219.1.
AJ564553 Genomic DNA. Translation: CAD92220.1.
AJ564554 Genomic DNA. Translation: CAD92221.1.
AJ564555 Genomic DNA. Translation: CAD92222.1.
AJ564556 Genomic DNA. Translation: CAD92223.1.
AJ564557 Genomic DNA. Translation: CAD92224.1.
AJ564558 Genomic DNA. Translation: CAD92225.1.
AJ564559 Genomic DNA. Translation: CAD92226.1.
AJ564560 Genomic DNA. Translation: CAD92227.1.
AJ564561 Genomic DNA. Translation: CAD92228.1.

3D structure databases

ProteinModelPortalP0C601.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

HAMAPMF_01169. SucA_OdhA.
InterProIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERPTHR23152. PTHR23152. 1 hit.
PfamPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
TIGRFAMsTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetSearch...

Entry information

Entry nameODO1_STAAU
AccessionPrimary (citable) accession number: P0C601
Secondary accession number(s): Q7ASB7 expand/collapse secondary AC list , Q7WRM3, Q7WRN1, Q7WRX0, Q7WZ40
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: February 19, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families