P0C601 (ODO1_STAAU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2-oxoglutarate dehydrogenase E1 component
EC=1.2.4.2

Alternative name(s):
Alpha-ketoglutarate dehydrogenase

Gene names

Name:

odhA

Organism

Staphylococcus aureus

Taxonomic identifier

1280 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus

Protein attributes

Sequence length	932 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. HAMAP-Rule MF_01169
Catalytic activity	2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2. HAMAP-Rule MF_01169
Cofactor	Thiamine pyrophosphate By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the alpha-ketoglutarate dehydrogenase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	Thiamine pyrophosphate
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: HAMAP tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity Inferred from electronic annotation. Source: HAMAP thiamine pyrophosphate binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 932	932	2-oxoglutarate dehydrogenase E1 component HAMAP-Rule MF_01169		PRO_0000224241
Natural variations
	Natural variant	46 – 67	22	Missing in strain: SMH8997, LLA, LLE, SMH10501, SMH11888, SMH12248, SMH14017, SMH17487, SMH17608, SMH18000, SMH18034 and SMH18037.
	Natural variant	534	1	E → D in strain: 23, 3700, 3759, LIM1, LIM2 and LIM3.
	Natural variant	864	1	K → N in strain: 23, 3700, 3759, LIM1, LIM2 and LIM3.

Sequences

	Sequence		Length	Mass (Da)
	P0C601 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: C744C1868AE20A38	FASTA	932	105,383
	10 20 30 40 50 60 MTNERKEVSE APVNFGANLG LMLDLYDDFL QDPSSVPEDL QVLFSIIKND DSIVPALKST 70 80 90 100 110 120 SSQNSDGTIK RVMRLIDNIR QYGHLKADIY PVNPPKRKHV PKLEIEDFDL DQQTLEGISA 130 140 150 160 170 180 GIVSDHFADI YDNAYEAILR MEKRYKGPIA FEYTHINNNT ERGWLKRRIE TPYKVTLNNN 190 200 210 220 230 240 EKRALFKQLA YVEGFEKYLH KNFVGAKRFS IEGVDALVPM LQRTITIAAK EGIKNIQIGM 250 260 270 280 290 300 AHRGRLNVLT HVLEKPYEMM ISEFMHTDPM KFLPEDGSLQ LTAGWTGDVK YHLGGIKTTD 310 320 330 340 350 360 SYGTMQRIAL ANNPSHLEIV APVVEGRTRA AQDDTQRAGA PTTDHHKAMP IIIHGDAAYP 370 380 390 400 410 420 GQGINFETMN LGNLKGYSTG GSLHIITNNR IGFTTEPIDA RSTTYSTDVA KGYDVPIFHV 430 440 450 460 470 480 NADDVEATIE AIDIAMEFRK EFHKDVVIDL VGYRRFGHNE MDEPSITNPV PYQNIRKHDS 490 500 510 520 530 540 VEYVFGKKLV NEGVISEDEM HSFIEQVQKE LRQAHDKINK ADKMDNPDME KPAELALPLQ 550 560 570 580 590 600 ADEQSFTFDH LKEINDALLT YPDGFNILKK LNKVLEKRHE PFNKEDGLVD WAQAEQLAFA 610 620 630 640 650 660 TILQDGTPIR LTGQDSERGT FSHRHAVLHD EQTGETYTPL HHVPDQKATF DIHNSPLSEA 670 680 690 700 710 720 AVVGFEYGYN VENKKSFNIW EAQYGDFANM SQMIFDNFLF SSRSKWGERS GLTLFLPHAY 730 740 750 760 770 780 EGQGPEHSSA RLERFLQLAA ENNCTVVNLS SSSNYFHLLR AQAASLDSEQ MRPLVVMSPK 790 800 810 820 830 840 SLLRNKTVAK PIDEFTSGGF EPILTESYQA DKVTKVILAT GKMFIDLKEA LAKNPDESVL 850 860 870 880 890 900 LVAIERLYPF PEEEIEALLA QLPKLEEVSW VQEEPKNQGA WLYVYPYVKV LVADKYDLSY 910 920 930 HGRIQRAAPA EGDGEIHKLV QNKIIENALK NN

References

[1]

"Genetic analysis of seventeen genes in Staphylococcus aureus with reduced susceptibility to vancomycin (VRSA) and hetero-VRSA (hVRSA)." Wootton M., Avison M.B., Bennett P.M., Howe R.A., MacGowan A.P., Walsh T.R. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: FranceDuf, Glasgow3700, Glasgow3759, LIM1, LIM2, LIM3, LiverpoolAG, LLA, LLE, Michigan, New Jersey, Norway1018, PC1, PC3, Slovenia6096, SMH10501, SMH11888, SMH12248, SMH14017, SMH17487, SMH17608, SMH18000, SMH18034, SMH18037, SMH2, SMH8997, Southampton23, St. Luke, Sweden307 and Sweden309.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ564531 Genomic DNA. Translation: CAD92198.1. AJ564532 Genomic DNA. Translation: CAD92199.1. AJ564533 Genomic DNA. Translation: CAD92200.1. AJ564534 Genomic DNA. Translation: CAD92201.1. AJ564535 Genomic DNA. Translation: CAD92202.1. AJ564536 Genomic DNA. Translation: CAD92203.1. AJ564537 Genomic DNA. Translation: CAD92204.1. AJ564538 Genomic DNA. Translation: CAD92205.1. AJ564539 Genomic DNA. Translation: CAD92206.1. AJ564540 Genomic DNA. Translation: CAD92207.1. AJ564541 Genomic DNA. Translation: CAD92208.1. AJ564542 Genomic DNA. Translation: CAD92209.1. AJ564543 Genomic DNA. Translation: CAD92210.1. AJ564544 Genomic DNA. Translation: CAD92211.1. AJ564545 Genomic DNA. Translation: CAD92212.1. AJ564546 Genomic DNA. Translation: CAD92213.1. AJ564547 Genomic DNA. Translation: CAD92214.1. AJ564548 Genomic DNA. Translation: CAD92215.1. AJ564549 Genomic DNA. Translation: CAD92216.1. AJ564550 Genomic DNA. Translation: CAD92217.1. AJ564551 Genomic DNA. Translation: CAD92218.1. AJ564552 Genomic DNA. Translation: CAD92219.1. AJ564553 Genomic DNA. Translation: CAD92220.1. AJ564554 Genomic DNA. Translation: CAD92221.1. AJ564555 Genomic DNA. Translation: CAD92222.1. AJ564556 Genomic DNA. Translation: CAD92223.1. AJ564557 Genomic DNA. Translation: CAD92224.1. AJ564558 Genomic DNA. Translation: CAD92225.1. AJ564559 Genomic DNA. Translation: CAD92226.1. AJ564560 Genomic DNA. Translation: CAD92227.1. AJ564561 Genomic DNA. Translation: CAD92228.1.
3D structure databases
ProteinModelPortal	P0C601.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
HAMAP	MF_01169. SucA_OdhA.
InterPro	IPR011603. 2oxoglutarate_DH_E1. IPR023784. 2oxoglutarate_DH_E1_bac. IPR001017. DH_E1. IPR005475. Transketolase-like_Pyr-bd. [Graphical view]
PANTHER	PTHR23152. PTHR23152. 1 hit.
Pfam	PF00676. E1_dh. 1 hit. PF02779. Transket_pyr. 1 hit. [Graphical view]
PIRSF	PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
TIGRFAMs	TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ODO1_STAAU

Accession

Primary (citable) accession number: P0C601
Secondary accession number(s): Q7ASB7 , Q7WRM3, Q7WRN1, Q7WRX0, Q7WZ40

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 15, 2008
Last modified:	April 3, 2013
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program