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P0C601

- ODO1_STAAU

UniProt

P0C601 - ODO1_STAAU

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Protein

2-oxoglutarate dehydrogenase E1 component

Gene
odhA
Organism
Staphylococcus aureus
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.UniRule annotation

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotation

Cofactori

Thiamine pyrophosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 component (EC:1.2.4.2)
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:odhA
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9329322-oxoglutarate dehydrogenase E1 componentUniRule annotationPRO_0000224241Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP0C601.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01169. SucA_OdhA.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C601-1 [UniParc]FASTAAdd to Basket

« Hide

MTNERKEVSE APVNFGANLG LMLDLYDDFL QDPSSVPEDL QVLFSIIKND    50
DSIVPALKST SSQNSDGTIK RVMRLIDNIR QYGHLKADIY PVNPPKRKHV 100
PKLEIEDFDL DQQTLEGISA GIVSDHFADI YDNAYEAILR MEKRYKGPIA 150
FEYTHINNNT ERGWLKRRIE TPYKVTLNNN EKRALFKQLA YVEGFEKYLH 200
KNFVGAKRFS IEGVDALVPM LQRTITIAAK EGIKNIQIGM AHRGRLNVLT 250
HVLEKPYEMM ISEFMHTDPM KFLPEDGSLQ LTAGWTGDVK YHLGGIKTTD 300
SYGTMQRIAL ANNPSHLEIV APVVEGRTRA AQDDTQRAGA PTTDHHKAMP 350
IIIHGDAAYP GQGINFETMN LGNLKGYSTG GSLHIITNNR IGFTTEPIDA 400
RSTTYSTDVA KGYDVPIFHV NADDVEATIE AIDIAMEFRK EFHKDVVIDL 450
VGYRRFGHNE MDEPSITNPV PYQNIRKHDS VEYVFGKKLV NEGVISEDEM 500
HSFIEQVQKE LRQAHDKINK ADKMDNPDME KPAELALPLQ ADEQSFTFDH 550
LKEINDALLT YPDGFNILKK LNKVLEKRHE PFNKEDGLVD WAQAEQLAFA 600
TILQDGTPIR LTGQDSERGT FSHRHAVLHD EQTGETYTPL HHVPDQKATF 650
DIHNSPLSEA AVVGFEYGYN VENKKSFNIW EAQYGDFANM SQMIFDNFLF 700
SSRSKWGERS GLTLFLPHAY EGQGPEHSSA RLERFLQLAA ENNCTVVNLS 750
SSSNYFHLLR AQAASLDSEQ MRPLVVMSPK SLLRNKTVAK PIDEFTSGGF 800
EPILTESYQA DKVTKVILAT GKMFIDLKEA LAKNPDESVL LVAIERLYPF 850
PEEEIEALLA QLPKLEEVSW VQEEPKNQGA WLYVYPYVKV LVADKYDLSY 900
HGRIQRAAPA EGDGEIHKLV QNKIIENALK NN 932
Length:932
Mass (Da):105,383
Last modified:January 15, 2008 - v1
Checksum:iC744C1868AE20A38
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti46 – 6722Missing in strain: SMH8997, LLA, LLE, SMH10501, SMH11888, SMH12248, SMH14017, SMH17487, SMH17608, SMH18000, SMH18034 and SMH18037.
Add
BLAST
Natural varianti534 – 5341E → D in strain: 23, 3700, 3759, LIM1, LIM2 and LIM3.
Natural varianti864 – 8641K → N in strain: 23, 3700, 3759, LIM1, LIM2 and LIM3.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ564531 Genomic DNA. Translation: CAD92198.1.
AJ564532 Genomic DNA. Translation: CAD92199.1.
AJ564533 Genomic DNA. Translation: CAD92200.1.
AJ564534 Genomic DNA. Translation: CAD92201.1.
AJ564535 Genomic DNA. Translation: CAD92202.1.
AJ564536 Genomic DNA. Translation: CAD92203.1.
AJ564537 Genomic DNA. Translation: CAD92204.1.
AJ564538 Genomic DNA. Translation: CAD92205.1.
AJ564539 Genomic DNA. Translation: CAD92206.1.
AJ564540 Genomic DNA. Translation: CAD92207.1.
AJ564541 Genomic DNA. Translation: CAD92208.1.
AJ564542 Genomic DNA. Translation: CAD92209.1.
AJ564543 Genomic DNA. Translation: CAD92210.1.
AJ564544 Genomic DNA. Translation: CAD92211.1.
AJ564545 Genomic DNA. Translation: CAD92212.1.
AJ564546 Genomic DNA. Translation: CAD92213.1.
AJ564547 Genomic DNA. Translation: CAD92214.1.
AJ564548 Genomic DNA. Translation: CAD92215.1.
AJ564549 Genomic DNA. Translation: CAD92216.1.
AJ564550 Genomic DNA. Translation: CAD92217.1.
AJ564551 Genomic DNA. Translation: CAD92218.1.
AJ564552 Genomic DNA. Translation: CAD92219.1.
AJ564553 Genomic DNA. Translation: CAD92220.1.
AJ564554 Genomic DNA. Translation: CAD92221.1.
AJ564555 Genomic DNA. Translation: CAD92222.1.
AJ564556 Genomic DNA. Translation: CAD92223.1.
AJ564557 Genomic DNA. Translation: CAD92224.1.
AJ564558 Genomic DNA. Translation: CAD92225.1.
AJ564559 Genomic DNA. Translation: CAD92226.1.
AJ564560 Genomic DNA. Translation: CAD92227.1.
AJ564561 Genomic DNA. Translation: CAD92228.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ564531 Genomic DNA. Translation: CAD92198.1 .
AJ564532 Genomic DNA. Translation: CAD92199.1 .
AJ564533 Genomic DNA. Translation: CAD92200.1 .
AJ564534 Genomic DNA. Translation: CAD92201.1 .
AJ564535 Genomic DNA. Translation: CAD92202.1 .
AJ564536 Genomic DNA. Translation: CAD92203.1 .
AJ564537 Genomic DNA. Translation: CAD92204.1 .
AJ564538 Genomic DNA. Translation: CAD92205.1 .
AJ564539 Genomic DNA. Translation: CAD92206.1 .
AJ564540 Genomic DNA. Translation: CAD92207.1 .
AJ564541 Genomic DNA. Translation: CAD92208.1 .
AJ564542 Genomic DNA. Translation: CAD92209.1 .
AJ564543 Genomic DNA. Translation: CAD92210.1 .
AJ564544 Genomic DNA. Translation: CAD92211.1 .
AJ564545 Genomic DNA. Translation: CAD92212.1 .
AJ564546 Genomic DNA. Translation: CAD92213.1 .
AJ564547 Genomic DNA. Translation: CAD92214.1 .
AJ564548 Genomic DNA. Translation: CAD92215.1 .
AJ564549 Genomic DNA. Translation: CAD92216.1 .
AJ564550 Genomic DNA. Translation: CAD92217.1 .
AJ564551 Genomic DNA. Translation: CAD92218.1 .
AJ564552 Genomic DNA. Translation: CAD92219.1 .
AJ564553 Genomic DNA. Translation: CAD92220.1 .
AJ564554 Genomic DNA. Translation: CAD92221.1 .
AJ564555 Genomic DNA. Translation: CAD92222.1 .
AJ564556 Genomic DNA. Translation: CAD92223.1 .
AJ564557 Genomic DNA. Translation: CAD92224.1 .
AJ564558 Genomic DNA. Translation: CAD92225.1 .
AJ564559 Genomic DNA. Translation: CAD92226.1 .
AJ564560 Genomic DNA. Translation: CAD92227.1 .
AJ564561 Genomic DNA. Translation: CAD92228.1 .

3D structure databases

ProteinModelPortali P0C601.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
HAMAPi MF_01169. SucA_OdhA.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genetic analysis of seventeen genes in Staphylococcus aureus with reduced susceptibility to vancomycin (VRSA) and hetero-VRSA (hVRSA)."
    Wootton M., Avison M.B., Bennett P.M., Howe R.A., MacGowan A.P., Walsh T.R.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: FranceDuf, Glasgow3700, Glasgow3759, LIM1, LIM2, LIM3, LiverpoolAG, LLA, LLE, Michigan, New Jersey, Norway1018, PC1, PC3, Slovenia6096, SMH10501, SMH11888, SMH12248, SMH14017, SMH17487, SMH17608, SMH18000, SMH18034, SMH18037, SMH2, SMH8997, Southampton23, St. Luke, Sweden307 and Sweden309.

Entry informationi

Entry nameiODO1_STAAU
AccessioniPrimary (citable) accession number: P0C601
Secondary accession number(s): Q7ASB7
, Q7WRM3, Q7WRN1, Q7WRX0, Q7WZ40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: June 11, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi