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P0C601

- ODO1_STAAU

UniProt

P0C601 - ODO1_STAAU

Protein

2-oxoglutarate dehydrogenase E1 component

Gene

odhA

Organism
Staphylococcus aureus
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.By similarity

    Catalytic activityi

    2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

    Cofactori

    Thiamine pyrophosphate.By similarity

    GO - Molecular functioni

    1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
    2. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Thiamine pyrophosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-oxoglutarate dehydrogenase E1 component (EC:1.2.4.2)
    Alternative name(s):
    Alpha-ketoglutarate dehydrogenase
    Gene namesi
    Name:odhA
    OrganismiStaphylococcus aureus
    Taxonomic identifieri1280 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 9329322-oxoglutarate dehydrogenase E1 componentPRO_0000224241Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP0C601.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.40.50.970. 2 hits.
    HAMAPiMF_01169. SucA_OdhA.
    InterProiIPR011603. 2oxoglutarate_DH_E1.
    IPR023784. 2oxoglutarate_DH_E1_bac.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view]
    PANTHERiPTHR23152. PTHR23152. 1 hit.
    PfamiPF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTiSM00861. Transket_pyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 2 hits.
    TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P0C601-1 [UniParc]FASTAAdd to Basket

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    MTNERKEVSE APVNFGANLG LMLDLYDDFL QDPSSVPEDL QVLFSIIKND    50
    DSIVPALKST SSQNSDGTIK RVMRLIDNIR QYGHLKADIY PVNPPKRKHV 100
    PKLEIEDFDL DQQTLEGISA GIVSDHFADI YDNAYEAILR MEKRYKGPIA 150
    FEYTHINNNT ERGWLKRRIE TPYKVTLNNN EKRALFKQLA YVEGFEKYLH 200
    KNFVGAKRFS IEGVDALVPM LQRTITIAAK EGIKNIQIGM AHRGRLNVLT 250
    HVLEKPYEMM ISEFMHTDPM KFLPEDGSLQ LTAGWTGDVK YHLGGIKTTD 300
    SYGTMQRIAL ANNPSHLEIV APVVEGRTRA AQDDTQRAGA PTTDHHKAMP 350
    IIIHGDAAYP GQGINFETMN LGNLKGYSTG GSLHIITNNR IGFTTEPIDA 400
    RSTTYSTDVA KGYDVPIFHV NADDVEATIE AIDIAMEFRK EFHKDVVIDL 450
    VGYRRFGHNE MDEPSITNPV PYQNIRKHDS VEYVFGKKLV NEGVISEDEM 500
    HSFIEQVQKE LRQAHDKINK ADKMDNPDME KPAELALPLQ ADEQSFTFDH 550
    LKEINDALLT YPDGFNILKK LNKVLEKRHE PFNKEDGLVD WAQAEQLAFA 600
    TILQDGTPIR LTGQDSERGT FSHRHAVLHD EQTGETYTPL HHVPDQKATF 650
    DIHNSPLSEA AVVGFEYGYN VENKKSFNIW EAQYGDFANM SQMIFDNFLF 700
    SSRSKWGERS GLTLFLPHAY EGQGPEHSSA RLERFLQLAA ENNCTVVNLS 750
    SSSNYFHLLR AQAASLDSEQ MRPLVVMSPK SLLRNKTVAK PIDEFTSGGF 800
    EPILTESYQA DKVTKVILAT GKMFIDLKEA LAKNPDESVL LVAIERLYPF 850
    PEEEIEALLA QLPKLEEVSW VQEEPKNQGA WLYVYPYVKV LVADKYDLSY 900
    HGRIQRAAPA EGDGEIHKLV QNKIIENALK NN 932
    Length:932
    Mass (Da):105,383
    Last modified:January 15, 2008 - v1
    Checksum:iC744C1868AE20A38
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti46 – 6722Missing in strain: SMH8997, LLA, LLE, SMH10501, SMH11888, SMH12248, SMH14017, SMH17487, SMH17608, SMH18000, SMH18034 and SMH18037.
    Add
    BLAST
    Natural varianti534 – 5341E → D in strain: 23, 3700, 3759, LIM1, LIM2 and LIM3.
    Natural varianti864 – 8641K → N in strain: 23, 3700, 3759, LIM1, LIM2 and LIM3.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ564531 Genomic DNA. Translation: CAD92198.1.
    AJ564532 Genomic DNA. Translation: CAD92199.1.
    AJ564533 Genomic DNA. Translation: CAD92200.1.
    AJ564534 Genomic DNA. Translation: CAD92201.1.
    AJ564535 Genomic DNA. Translation: CAD92202.1.
    AJ564536 Genomic DNA. Translation: CAD92203.1.
    AJ564537 Genomic DNA. Translation: CAD92204.1.
    AJ564538 Genomic DNA. Translation: CAD92205.1.
    AJ564539 Genomic DNA. Translation: CAD92206.1.
    AJ564540 Genomic DNA. Translation: CAD92207.1.
    AJ564541 Genomic DNA. Translation: CAD92208.1.
    AJ564542 Genomic DNA. Translation: CAD92209.1.
    AJ564543 Genomic DNA. Translation: CAD92210.1.
    AJ564544 Genomic DNA. Translation: CAD92211.1.
    AJ564545 Genomic DNA. Translation: CAD92212.1.
    AJ564546 Genomic DNA. Translation: CAD92213.1.
    AJ564547 Genomic DNA. Translation: CAD92214.1.
    AJ564548 Genomic DNA. Translation: CAD92215.1.
    AJ564549 Genomic DNA. Translation: CAD92216.1.
    AJ564550 Genomic DNA. Translation: CAD92217.1.
    AJ564551 Genomic DNA. Translation: CAD92218.1.
    AJ564552 Genomic DNA. Translation: CAD92219.1.
    AJ564553 Genomic DNA. Translation: CAD92220.1.
    AJ564554 Genomic DNA. Translation: CAD92221.1.
    AJ564555 Genomic DNA. Translation: CAD92222.1.
    AJ564556 Genomic DNA. Translation: CAD92223.1.
    AJ564557 Genomic DNA. Translation: CAD92224.1.
    AJ564558 Genomic DNA. Translation: CAD92225.1.
    AJ564559 Genomic DNA. Translation: CAD92226.1.
    AJ564560 Genomic DNA. Translation: CAD92227.1.
    AJ564561 Genomic DNA. Translation: CAD92228.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ564531 Genomic DNA. Translation: CAD92198.1 .
    AJ564532 Genomic DNA. Translation: CAD92199.1 .
    AJ564533 Genomic DNA. Translation: CAD92200.1 .
    AJ564534 Genomic DNA. Translation: CAD92201.1 .
    AJ564535 Genomic DNA. Translation: CAD92202.1 .
    AJ564536 Genomic DNA. Translation: CAD92203.1 .
    AJ564537 Genomic DNA. Translation: CAD92204.1 .
    AJ564538 Genomic DNA. Translation: CAD92205.1 .
    AJ564539 Genomic DNA. Translation: CAD92206.1 .
    AJ564540 Genomic DNA. Translation: CAD92207.1 .
    AJ564541 Genomic DNA. Translation: CAD92208.1 .
    AJ564542 Genomic DNA. Translation: CAD92209.1 .
    AJ564543 Genomic DNA. Translation: CAD92210.1 .
    AJ564544 Genomic DNA. Translation: CAD92211.1 .
    AJ564545 Genomic DNA. Translation: CAD92212.1 .
    AJ564546 Genomic DNA. Translation: CAD92213.1 .
    AJ564547 Genomic DNA. Translation: CAD92214.1 .
    AJ564548 Genomic DNA. Translation: CAD92215.1 .
    AJ564549 Genomic DNA. Translation: CAD92216.1 .
    AJ564550 Genomic DNA. Translation: CAD92217.1 .
    AJ564551 Genomic DNA. Translation: CAD92218.1 .
    AJ564552 Genomic DNA. Translation: CAD92219.1 .
    AJ564553 Genomic DNA. Translation: CAD92220.1 .
    AJ564554 Genomic DNA. Translation: CAD92221.1 .
    AJ564555 Genomic DNA. Translation: CAD92222.1 .
    AJ564556 Genomic DNA. Translation: CAD92223.1 .
    AJ564557 Genomic DNA. Translation: CAD92224.1 .
    AJ564558 Genomic DNA. Translation: CAD92225.1 .
    AJ564559 Genomic DNA. Translation: CAD92226.1 .
    AJ564560 Genomic DNA. Translation: CAD92227.1 .
    AJ564561 Genomic DNA. Translation: CAD92228.1 .

    3D structure databases

    ProteinModelPortali P0C601.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.50.970. 2 hits.
    HAMAPi MF_01169. SucA_OdhA.
    InterProi IPR011603. 2oxoglutarate_DH_E1.
    IPR023784. 2oxoglutarate_DH_E1_bac.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view ]
    PANTHERi PTHR23152. PTHR23152. 1 hit.
    Pfami PF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTi SM00861. Transket_pyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 2 hits.
    TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genetic analysis of seventeen genes in Staphylococcus aureus with reduced susceptibility to vancomycin (VRSA) and hetero-VRSA (hVRSA)."
      Wootton M., Avison M.B., Bennett P.M., Howe R.A., MacGowan A.P., Walsh T.R.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: FranceDuf, Glasgow3700, Glasgow3759, LIM1, LIM2, LIM3, LiverpoolAG, LLA, LLE, Michigan, New Jersey, Norway1018, PC1, PC3, Slovenia6096, SMH10501, SMH11888, SMH12248, SMH14017, SMH17487, SMH17608, SMH18000, SMH18034, SMH18037, SMH2, SMH8997, Southampton23, St. Luke, Sweden307 and Sweden309.

    Entry informationi

    Entry nameiODO1_STAAU
    AccessioniPrimary (citable) accession number: P0C601
    Secondary accession number(s): Q7ASB7
    , Q7WRM3, Q7WRN1, Q7WRX0, Q7WZ40
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3