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Protein

Histone H2A-Bbd type 2/3

Gene

H2AFB2

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo. They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase. They associate with spliceosome components and are required for mRNA splicing. May participate in spermatogenesis.7 Publications

GO - Molecular functioni

GO - Biological processi

  • chromatin silencing Source: GO_Central
  • mRNA processing Source: UniProtKB
  • nucleosome assembly Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

mRNA processing

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2A-Bbd type 2/3
Alternative name(s):
H2A Barr body-deficient
Short name:
H2A.Bbd
Gene namesi
Name:H2AFB2
AND
Name:H2AFB3
Synonyms:H2ABBD, H2AFB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:18298. H2AFB2.
HGNC:14455. H2AFB3.

Subcellular locationi

GO - Cellular componenti

  • nuclear chromatin Source: GO_Central
  • nuclear nucleosome Source: UniProtKB
  • nucleus Source: UniProtKB
  • transcriptionally active chromatin Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29101.

Polymorphism and mutation databases

DMDMi161784333.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 115115Histone H2A-Bbd type 2/3PRO_0000055321Add
BLAST

Proteomic databases

PaxDbiP0C5Z0.
PeptideAtlasiP0C5Z0.
PRIDEiP0C5Z0.

PTM databases

iPTMnetiP0C5Z0.
PhosphoSiteiP0C5Z0.

Expressioni

Tissue specificityi

Present in mature sperm.1 Publication

Gene expression databases

BgeeiENSG00000185978.
CleanExiHS_H2AFB2.
HS_H2AFB3.
GenevisibleiP0C5Z0. HS.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. May be incorporated into a proportion of nucleosomes, replacing one or more H2A molecules.

Protein-protein interaction databases

BioGridi123748. 1 interaction.
MINTiMINT-6630756.
STRINGi9606.ENSP00000358452.

Structurei

3D structure databases

ProteinModelPortaliP0C5Z0.
SMRiP0C5Z0. Positions 25-109.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni87 – 11529Docking domainAdd
BLAST

Domaini

The docking domain is responsible for the weaker heterodimerization with H2B.1 Publication

Sequence similaritiesi

Belongs to the histone H2A family.Curated

Phylogenomic databases

eggNOGiKOG1756. Eukaryota.
COG5262. LUCA.
GeneTreeiENSGT00840000129729.
HOGENOMiHOG000234652.
HOVERGENiHBG009342.
InParanoidiP0C5Z0.
KOiK11251.
OMAiDMAVHNN.
OrthoDBiEOG091G15D9.
PhylomeDBiP0C5Z0.
TreeFamiTF300137.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR002119. Histone_H2A.
[Graphical view]
PRINTSiPR00620. HISTONEH2A.
SMARTiSM00414. H2A. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C5Z0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRRRRRRGS SGAGGRGRTC SRTVRAELSF SVSQVERSLR EGHYAQRLSR
60 70 80 90 100
TAPVYLAAVI EYLTAKVLEL AGNEAQNSGE RNITPLLLDM VVHNDRLLST
110
LFNTTTISQV APGED
Length:115
Mass (Da):12,713
Last modified:December 4, 2007 - v1
Checksum:iF7CA7588C2F57451
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF254576 mRNA. Translation: AAL01652.1.
BX276110 Genomic DNA. Translation: CAH71440.1.
BX682237 Genomic DNA. Translation: CAI41332.1.
CH471172 Genomic DNA. Translation: EAW72649.1.
BC101409 mRNA. Translation: AAI01410.1.
BC101415 mRNA. Translation: AAI01416.1.
BC101417 mRNA. Translation: AAI01418.1.
BC101418 mRNA. Translation: AAI01419.1.
BC130510 mRNA. Translation: AAI30511.1.
BC130512 mRNA. Translation: AAI30513.1.
BC134365 mRNA. Translation: AAI34366.1.
CCDSiCCDS35461.1.
CCDS35464.1.
RefSeqiNP_001017991.1. NM_001017991.2.
NP_542451.1. NM_080720.1.
UniGeneiHs.534498.
Hs.632841.

Genome annotation databases

EnsembliENST00000354514; ENSP00000346509; ENSG00000277858.
ENST00000615853; ENSP00000482564; ENSG00000277745.
GeneIDi474381.
83740.
KEGGihsa:474381.
hsa:83740.
UCSCiuc004fnh.5. human.

Cross-referencesi

Web resourcesi

Wikipedia

Histone H2A entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF254576 mRNA. Translation: AAL01652.1.
BX276110 Genomic DNA. Translation: CAH71440.1.
BX682237 Genomic DNA. Translation: CAI41332.1.
CH471172 Genomic DNA. Translation: EAW72649.1.
BC101409 mRNA. Translation: AAI01410.1.
BC101415 mRNA. Translation: AAI01416.1.
BC101417 mRNA. Translation: AAI01418.1.
BC101418 mRNA. Translation: AAI01419.1.
BC130510 mRNA. Translation: AAI30511.1.
BC130512 mRNA. Translation: AAI30513.1.
BC134365 mRNA. Translation: AAI34366.1.
CCDSiCCDS35461.1.
CCDS35464.1.
RefSeqiNP_001017991.1. NM_001017991.2.
NP_542451.1. NM_080720.1.
UniGeneiHs.534498.
Hs.632841.

3D structure databases

ProteinModelPortaliP0C5Z0.
SMRiP0C5Z0. Positions 25-109.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123748. 1 interaction.
MINTiMINT-6630756.
STRINGi9606.ENSP00000358452.

PTM databases

iPTMnetiP0C5Z0.
PhosphoSiteiP0C5Z0.

Polymorphism and mutation databases

DMDMi161784333.

Proteomic databases

PaxDbiP0C5Z0.
PeptideAtlasiP0C5Z0.
PRIDEiP0C5Z0.

Protocols and materials databases

DNASUi474381.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354514; ENSP00000346509; ENSG00000277858.
ENST00000615853; ENSP00000482564; ENSG00000277745.
GeneIDi474381.
83740.
KEGGihsa:474381.
hsa:83740.
UCSCiuc004fnh.5. human.

Organism-specific databases

CTDi474381.
83740.
GeneCardsiH2AFB2.
H2AFB3.
HGNCiHGNC:18298. H2AFB2.
HGNC:14455. H2AFB3.
MIMi300445. gene.
neXtProtiNX_P0C5Z0.
PharmGKBiPA29101.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1756. Eukaryota.
COG5262. LUCA.
GeneTreeiENSGT00840000129729.
HOGENOMiHOG000234652.
HOVERGENiHBG009342.
InParanoidiP0C5Z0.
KOiK11251.
OMAiDMAVHNN.
OrthoDBiEOG091G15D9.
PhylomeDBiP0C5Z0.
TreeFamiTF300137.

Miscellaneous databases

GeneWikiiH2AFB2.
H2AFB3.
PROiP0C5Z0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185978.
CleanExiHS_H2AFB2.
HS_H2AFB3.
GenevisibleiP0C5Z0. HS.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR002119. Histone_H2A.
[Graphical view]
PRINTSiPR00620. HISTONEH2A.
SMARTiSM00414. H2A. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiH2AB2_HUMAN
AccessioniPrimary (citable) accession number: P0C5Z0
Secondary accession number(s): A1L4E4
, P98176, Q5TZB2, Q6FG78, Q96PR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: September 7, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

In contrast to other H2A histones, it does not contain the conserved residues that are the target of post-translational modifications.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.