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Protein

Histone H2A-Bbd type 2/3

Gene

H2AFB2

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo. They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase. They associate with spliceosome components and are required for mRNA splicing. May participate in spermatogenesis.7 Publications

Miscellaneous

In contrast to other H2A histones, it does not contain the conserved residues that are the target of post-translational modifications.

GO - Molecular functioni

GO - Biological processi

  • chromatin silencing Source: GO_Central
  • mRNA processing Source: UniProtKB
  • nucleosome assembly Source: UniProtKB

Keywordsi

Molecular functionDNA-binding
Biological processmRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2A-Bbd type 2/3
Alternative name(s):
H2A Barr body-deficient
Short name:
H2A.Bbd
Gene namesi
Name:H2AFB2
AND
Name:H2AFB3
Synonyms:H2ABBD, H2AFB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000277745.1.
HostDB:ENSG00000277858.1.
HGNCiHGNC:18298. H2AFB2.
HGNC:14455. H2AFB3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29101.

Polymorphism and mutation databases

DMDMi161784333.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000553211 – 115Histone H2A-Bbd type 2/3Add BLAST115

Proteomic databases

PaxDbiP0C5Z0.
PeptideAtlasiP0C5Z0.
PRIDEiP0C5Z0.

PTM databases

iPTMnetiP0C5Z0.
PhosphoSitePlusiP0C5Z0.

Expressioni

Tissue specificityi

Present in mature sperm.1 Publication

Gene expression databases

BgeeiENSG00000277745.
CleanExiHS_H2AFB2.
HS_H2AFB3.
GenevisibleiP0C5Z0. HS.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. May be incorporated into a proportion of nucleosomes, replacing one or more H2A molecules.

Binary interactionsi

WithEntry#Exp.IntActNotes
HIST1H2BNU3KQK04EBI-13318575,EBI-12142839

GO - Molecular functioni

Protein-protein interaction databases

BioGridi123748. 1 interactor.
IntActiP0C5Z0. 2 interactors.
MINTiMINT-6630756.
STRINGi9606.ENSP00000358452.

Structurei

3D structure databases

ProteinModelPortaliP0C5Z0.
SMRiP0C5Z0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni87 – 115Docking domainAdd BLAST29

Domaini

The docking domain is responsible for the weaker heterodimerization with H2B.1 Publication

Sequence similaritiesi

Belongs to the histone H2A family.Curated

Phylogenomic databases

eggNOGiKOG1756. Eukaryota.
COG5262. LUCA.
GeneTreeiENSGT00760000118934.
HOGENOMiHOG000234652.
HOVERGENiHBG009342.
InParanoidiP0C5Z0.
KOiK11251.
OMAiDMAVHNN.
OrthoDBiEOG091G15D9.
PhylomeDBiP0C5Z0.
TreeFamiTF300137.

Family and domain databases

InterProiView protein in InterPro
IPR009072. Histone-fold.
IPR002119. Histone_H2A.
PRINTSiPR00620. HISTONEH2A.
SMARTiView protein in SMART
SM00414. H2A. 1 hit.
SUPFAMiSSF47113. SSF47113. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C5Z0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRRRRRRGS SGAGGRGRTC SRTVRAELSF SVSQVERSLR EGHYAQRLSR
60 70 80 90 100
TAPVYLAAVI EYLTAKVLEL AGNEAQNSGE RNITPLLLDM VVHNDRLLST
110
LFNTTTISQV APGED
Length:115
Mass (Da):12,713
Last modified:December 4, 2007 - v1
Checksum:iF7CA7588C2F57451
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF254576 mRNA. Translation: AAL01652.1.
BX276110 Genomic DNA. No translation available.
BX682237 Genomic DNA. No translation available.
CH471172 Genomic DNA. Translation: EAW72649.1.
BC101409 mRNA. Translation: AAI01410.1.
BC101415 mRNA. Translation: AAI01416.1.
BC101417 mRNA. Translation: AAI01418.1.
BC101418 mRNA. Translation: AAI01419.1.
BC130510 mRNA. Translation: AAI30511.1.
BC130512 mRNA. Translation: AAI30513.1.
BC134365 mRNA. Translation: AAI34366.1.
CCDSiCCDS35461.1.
CCDS35464.1.
RefSeqiNP_001017991.1. NM_001017991.2.
NP_542451.1. NM_080720.1.
UniGeneiHs.534498.
Hs.632841.

Genome annotation databases

EnsembliENST00000354514; ENSP00000346509; ENSG00000277858.
ENST00000615853; ENSP00000482564; ENSG00000277745.
GeneIDi474381.
83740.
KEGGihsa:474381.
hsa:83740.
UCSCiuc004fnh.5. human.

Similar proteinsi

Entry informationi

Entry nameiH2AB2_HUMAN
AccessioniPrimary (citable) accession number: P0C5Z0
Secondary accession number(s): A1L4E4
, P98176, Q5TZB2, Q6FG78, Q96PR7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: October 25, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families