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Protein

Alsin

Gene

Als2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May act as a GTPase regulator (By similarity). Controls survival and growth of spinal motoneurons.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiR-RNO-8876198. RAB GEFs exchange GTP for GDP on RABs.

Names & Taxonomyi

Protein namesi
Recommended name:
Alsin
Alternative name(s):
Amyotrophic lateral sclerosis 2 protein homolog
Gene namesi
Name:Als2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi1310372. Als2.

Subcellular locationi

GO - Cellular componenti

  • axon Source: RGD
  • centrosome Source: Ensembl
  • cytoplasm Source: UniProtKB
  • cytosol Source: UniProtKB
  • dendrite Source: UniProtKB
  • dendritic spine Source: Ensembl
  • early endosome Source: UniProtKB
  • growth cone Source: UniProtKB
  • intracellular membrane-bounded organelle Source: RGD
  • lamellipodium Source: Ensembl
  • membrane Source: UniProtKB
  • neuronal cell body Source: RGD
  • neuron projection Source: RGD
  • postsynaptic density Source: Ensembl
  • protein complex Source: UniProtKB
  • ruffle Source: Ensembl
  • vesicle Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003060851 – 1651AlsinAdd BLAST1651

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei459PhosphoserineBy similarity1
Modified residuei460PhosphoserineBy similarity1
Modified residuei477PhosphoserineCombined sources1
Modified residuei486PhosphoserineCombined sources1
Modified residuei504PhosphothreonineCombined sources1
Modified residuei527N6-acetyllysineBy similarity1
Modified residuei1329PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP0C5Y8.
PRIDEiP0C5Y8.

PTM databases

iPTMnetiP0C5Y8.
PhosphoSitePlusiP0C5Y8.

Expressioni

Gene expression databases

ExpressionAtlasiP0C5Y8. baseline and differential.
GenevisibleiP0C5Y8. RN.

Interactioni

Subunit structurei

Forms a heteromeric complex with ALS2CL. Interacts with ALS2CL (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036116.

Structurei

3D structure databases

ProteinModelPortaliP0C5Y8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati59 – 108RCC1 1Add BLAST50
Repeati109 – 167RCC1 2Add BLAST59
Repeati169 – 218RCC1 3Add BLAST50
Repeati519 – 570RCC1 4Add BLAST52
Repeati572 – 621RCC1 5Add BLAST50
Domaini684 – 879DHPROSITE-ProRule annotationAdd BLAST196
Domaini895 – 1001PHAdd BLAST107
Repeati1043 – 1065MORN 1Add BLAST23
Repeati1066 – 1088MORN 2Add BLAST23
Repeati1094 – 1116MORN 3Add BLAST23
Repeati1117 – 1139MORN 4Add BLAST23
Repeati1145 – 1167MORN 5Add BLAST23
Repeati1169 – 1191MORN 6Add BLAST23
Repeati1192 – 1214MORN 7Add BLAST23
Repeati1215 – 1238MORN 8Add BLAST24
Domaini1507 – 1651VPS9PROSITE-ProRule annotationAdd BLAST145

Sequence similaritiesi

Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
Contains 8 MORN repeats.Curated
Contains 1 PH domain.Curated
Contains 5 RCC1 repeats.PROSITE-ProRule annotation
Contains 1 VPS9 domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0231. Eukaryota.
KOG1426. Eukaryota.
COG4642. LUCA.
GeneTreeiENSGT00730000110297.
HOGENOMiHOG000033908.
HOVERGENiHBG037320.
InParanoidiP0C5Y8.
KOiK04575.
OMAiDSYTEYC.
OrthoDBiEOG091G00CU.
PhylomeDBiP0C5Y8.
TreeFamiTF331793.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.130.10.30. 2 hits.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR003409. MORN.
IPR011993. PH_dom-like.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
IPR003123. VPS9.
[Graphical view]
PfamiPF02493. MORN. 8 hits.
PF00415. RCC1. 4 hits.
PF00621. RhoGEF. 1 hit.
PF02204. VPS9. 1 hit.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SMARTiSM00698. MORN. 8 hits.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF50985. SSF50985. 2 hits.
PROSITEiPS50010. DH_2. 1 hit.
PS00626. RCC1_2. 2 hits.
PS50012. RCC1_3. 4 hits.
PS51205. VPS9. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C5Y8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSKKKSSAE AEGSKERGLV HVWQAGSFSL TPERLPGWGG KTVLQAALGV
60 70 80 90 100
KHGVLLTEDG EVYSFGTLPW KSEAAEICPS SPLLESALVG HHVVTVATGS
110 120 130 140 150
FHSGAVTESG VVYMWGENAA GQCAVANQQY VSEPSPVSIS DSETSPLLAV
160 170 180 190 200
RILQLACGEE HTLALSISRE IWAWGTGCQL GLITTTFPVT KPQKVEHLAG
210 220 230 240 250
RVVLQVACGA FHSLALVQCL PPQDLKPVPE RCNQCSQLLI TMTDKEDHVI
260 270 280 290 300
ISDSHCCPLG VTLSESQAEK HASTVTSPHP ETLDGQGEVF ENTVAEAELN
310 320 330 340 350
MGSDQTTSGS AISAQQNIVG MAEVSSARTA PSYPDTQTVT AYLQKLSEHS
360 370 380 390 400
VKENHEREEK LPQVQPLVEE AVPDLHSPPT TSTSALNSLV VSCASAVGVR
410 420 430 440 450
VAATYEAGAL SLKKVMNFYS TAPCEPGAPS GTASTGPESL KDLREEQVKQ
460 470 480 490 500
ESLQGKKSSS LMDIREEESE GGSRRLSLPG LLSQVSPRLL RKAARVKTRT
510 520 530 540 550
VVLTPTYSGE ADALLPSLRT EVWTWGKGKE GQLGHGDVLP RLQPLCVKCL
560 570 580 590 600
DGKEVIHLEA GGSHSLALTA KSQVYSWGSN TFGQLGHSEF PTTVPRLSKV
610 620 630 640 650
SSESGVWSVA AGHGYSLFLV DTEDFQPGLY YSGRQDRAEG DTLPENPSGT
660 670 680 690 700
TTPVLLSCSK LGYISRVTAG KDSYLALVDK NIMGYIASLH ELATTERRFY
710 720 730 740 750
SKLSEIKSQI LRPLLSLEHL GTVTTVQLLQ EVASRFSKLC YLIGQHGASL
760 770 780 790 800
SSYLQGMKEA RNLVIMKHSS LFLDSYTEYC TSVSNFLVMG GSQLLAKPAI
810 820 830 840 850
DFLNKNQELL QDLSEVNDEN TQLMEILNAL FFLPIRRLHN YAKVLLKLAT
860 870 880 890 900
CFEVTSPEYQ KLQDSSSCYE SLALHLGKKR KEAEYTLSFW KTFPGKMTDS
910 920 930 940 950
LRKPERRLLC ESSNRALSLQ HAGRFSVNWF ILFNDALVHA QFSTHHVFPL
960 970 980 990 1000
ATLWAEPLSE ETGGVNGLKI TTPEEQFTLI SSTPQEKTKW LRAISQAVDQ
1010 1020 1030 1040 1050
ALRGTSDFPL YGGSSTVQRQ EPPISRSAKY TFYKDTRLKD ATYDGRWLSG
1060 1070 1080 1090 1100
KPHGRGVLKW PDGKVYSGTF RNGLEDGYGE YRIPNKALNK EDHYVGHWKE
1110 1120 1130 1140 1150
GKMCGQGVYS YASGEVFEGC FQDNMRHGHG LLRSGKLTSS SPSMFIGQWV
1160 1170 1180 1190 1200
MDKKAGYGVF DDITRGEKYM GMWQDDACQG NGVVVTQFGL YYEGNFHLNK
1210 1220 1230 1240 1250
MMGNGVLLSE DDTIYEGEFS DDWTLCGKGT LTMPNGDYIE GYFSGEWGSG
1260 1270 1280 1290 1300
IKITGTYFKP SLYESDKDRP KAFRKLGNLA VAADEKWRAV FDECWRQLGC
1310 1320 1330 1340 1350
ESPGQGEVWK AWDNIAVALT TNRRQHKDSP EILSRSQTQT LESLEYIPQH
1360 1370 1380 1390 1400
VGAFSVEKYD DIKKYLIKAC DTPLHPLGRL VETLVAVYRM TYVGVGANRR
1410 1420 1430 1440 1450
LLQEAVKEIK SYLKRIFQLV RFLFPELPEE GSTVPLSAPL PTGRRSFCTG
1460 1470 1480 1490 1500
KSDSRSESPE PGYVVTSSGL LLPVLLPRLY PPLFMLYALD NDREEDIYWE
1510 1520 1530 1540 1550
CVLRLNKQPD IALLGFLGVQ RKFWPATLSI LGESKKVLPS TKDACFASAV
1560 1570 1580 1590 1600
ECLQQISTTF TPSDKLKVIQ QTFEEISQSV LASLQEDFLW SMDDLFPVFL
1610 1620 1630 1640 1650
YVVLRARIRN LGSEVHLIED LMDPYLQHGE QGIMFTTLKA CYYQIQREKL

N
Length:1,651
Mass (Da):182,448
Last modified:December 4, 2007 - v1
Checksum:i039F9225DFAFA1FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03068212 Genomic DNA. No translation available.
BK005190 mRNA. Translation: DAA05671.1.
RefSeqiNP_001013431.1. NM_001013413.1.
XP_006245063.1. XM_006245001.3.
UniGeneiRn.219733.

Genome annotation databases

EnsembliENSRNOT00000035209; ENSRNOP00000036116; ENSRNOG00000023280.
ENSRNOT00000088729; ENSRNOP00000072428; ENSRNOG00000023280.
GeneIDi363235.
KEGGirno:363235.
UCSCiRGD:1310372. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03068212 Genomic DNA. No translation available.
BK005190 mRNA. Translation: DAA05671.1.
RefSeqiNP_001013431.1. NM_001013413.1.
XP_006245063.1. XM_006245001.3.
UniGeneiRn.219733.

3D structure databases

ProteinModelPortaliP0C5Y8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036116.

PTM databases

iPTMnetiP0C5Y8.
PhosphoSitePlusiP0C5Y8.

Proteomic databases

PaxDbiP0C5Y8.
PRIDEiP0C5Y8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000035209; ENSRNOP00000036116; ENSRNOG00000023280.
ENSRNOT00000088729; ENSRNOP00000072428; ENSRNOG00000023280.
GeneIDi363235.
KEGGirno:363235.
UCSCiRGD:1310372. rat.

Organism-specific databases

CTDi57679.
RGDi1310372. Als2.

Phylogenomic databases

eggNOGiKOG0231. Eukaryota.
KOG1426. Eukaryota.
COG4642. LUCA.
GeneTreeiENSGT00730000110297.
HOGENOMiHOG000033908.
HOVERGENiHBG037320.
InParanoidiP0C5Y8.
KOiK04575.
OMAiDSYTEYC.
OrthoDBiEOG091G00CU.
PhylomeDBiP0C5Y8.
TreeFamiTF331793.

Enzyme and pathway databases

ReactomeiR-RNO-8876198. RAB GEFs exchange GTP for GDP on RABs.

Miscellaneous databases

PROiP0C5Y8.

Gene expression databases

ExpressionAtlasiP0C5Y8. baseline and differential.
GenevisibleiP0C5Y8. RN.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.130.10.30. 2 hits.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR003409. MORN.
IPR011993. PH_dom-like.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
IPR003123. VPS9.
[Graphical view]
PfamiPF02493. MORN. 8 hits.
PF00415. RCC1. 4 hits.
PF00621. RhoGEF. 1 hit.
PF02204. VPS9. 1 hit.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SMARTiSM00698. MORN. 8 hits.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF50985. SSF50985. 2 hits.
PROSITEiPS50010. DH_2. 1 hit.
PS00626. RCC1_2. 2 hits.
PS50012. RCC1_3. 4 hits.
PS51205. VPS9. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALS2_RAT
AccessioniPrimary (citable) accession number: P0C5Y8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: November 30, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.