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P0C5S8

- POLG_HAVSJ

UniProt

P0C5S8 - POLG_HAVSJ

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Protein

Genome polyprotein

Gene
N/A
Organism
Simian hepatitis A virus genotype VI (isolate JM55) (SHAV) (Simian hepatitis A virus (isolate Macaca/Indonesia/JM55/1985))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The C-terminal domain of VP1-2A, protein 2A, acts as an assembly signal that allows multimerization of VP1-2A and formation of pentamers of VP1-VP2-VP3 trimers. It is proteolytically removed from the precursor by a host protease and does not seem to be found in mature particles By similarity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei6 – 72Cleavage; by hostSequence Analysis
Sitei6 – 61Important for VP1 folding and capsid assemblyBy similarity

GO - Biological processi

  1. suppression by virus of host gene expression Source: UniProtKB-KW
  2. viral entry into host cell Source: UniProtKB-KW
  3. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Eukaryotic host gene expression shutoff by virus, Eukaryotic host translation shutoff by virus, Host gene expression shutoff by virus, Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Genome polyprotein
Cleaved into the following 2 chains:
Alternative name(s):
P1D
Virion protein 1
Protein 2A
Short name:
P2A
OrganismiSimian hepatitis A virus genotype VI (isolate JM55) (SHAV) (Simian hepatitis A virus (isolate Macaca/Indonesia/JM55/1985))
Taxonomic identifieri470594 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stagePicornaviralesPicornaviridaeHepatovirus
Virus hostiCallithrix [TaxID: 9481]
Cercopithecus hamlyni (Owl-faced monkey) (Hamlyn's monkey) [TaxID: 9536]
Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) [TaxID: 9534]
Macaca (macaques) [TaxID: 9539]
Pan troglodytes (Chimpanzee) [TaxID: 9598]

Subcellular locationi

GO - Cellular componenti

  1. host cell cytoplasm Source: UniProtKB-KW
  2. viral capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Host cytoplasm, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 5›5Protein VP1Sequence AnalysisPRO_0000314779
Chaini6 – ›56›51Protein 2ASequence AnalysisPRO_0000310691Add
BLAST

Post-translational modificationi

Specific enzymatic cleavages by the viral protease in vivo yield a variety of precursors and mature proteins. Polyprotein processing intermediates are produced, such as VP1-2A precursor. The assembly signal 2A is removed from VP1-2A by a host protease By similarity.By similarity

Family & Domainsi

Sequence similaritiesi

Belongs to the picornaviridae polyprotein family.Curated

Family and domain databases

InterProiIPR024354. Hepatitis_A_VP1-2A.
[Graphical view]
PfamiPF12944. DUF3840. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C5S8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
ETMLDRIASG DLESSVDDPR SAEDKRFESH IEQGKPYKEL RMEVGKQTLK

YAQEEL
Length:56
Mass (Da):6,485
Last modified:November 13, 2007 - v1
Checksum:iC693DB4D101EF285
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei56 – 561

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L07731 Genomic RNA. No translation available.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L07731 Genomic RNA. No translation available.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR024354. Hepatitis_A_VP1-2A.
[Graphical view ]
Pfami PF12944. DUF3840. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genetic relatedness of hepatitis A virus strains recovered from different geographical regions."
    Robertson B.H., Jansen R.W., Khanna B., Totsuka A., Nainan O.V., Siegl G., Widell A., Margolis H.S., Isomura S., Ito K., Ishizu T., Moritsugu Y., Lemon S.M.
    J. Gen. Virol. 73:1365-1377(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiPOLG_HAVSJ
AccessioniPrimary (citable) accession number: P0C5S8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: October 29, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

The need for an intact eIF4G factor for the initiation of translation results in an inability to shut off host protein synthesis by a mechanism similar to that of other picornaviruses.By similarity

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3