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Genome polyprotein

Simian hepatitis A virus genotype VI (isolate JM55) (SHAV) (Simian hepatitis A virus (isolate Macaca/Indonesia/JM55/1985))
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi


The C-terminal domain of VP1-2A, protein 2A, acts as an assembly signal that allows multimerization of VP1-2A and formation of pentamers of VP1-VP2-VP3 trimers. It is proteolytically removed from the precursor by a host protease and does not seem to be found in mature particles (By similarity).By similarity


The need for an intact eIF4G factor for the initiation of translation results in an inability to shut off host protein synthesis by a mechanism similar to that of other picornaviruses.By similarity


Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei6Important for VP1 folding and capsid assemblyBy similarity1

GO - Biological processi


Biological processEukaryotic host gene expression shutoff by virus, Eukaryotic host translation shutoff by virus, Host gene expression shutoff by virus, Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Genome polyprotein
Cleaved into the following 2 chains:
Alternative name(s):
Virion protein 1
Protein 2A
Short name:
OrganismiSimian hepatitis A virus genotype VI (isolate JM55) (SHAV) (Simian hepatitis A virus (isolate Macaca/Indonesia/JM55/1985))
Taxonomic identifieri470594 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stagePicornaviralesPicornaviridaeHepatovirus
Virus hostiCallithrix [TaxID: 9481]
Cercopithecus hamlyni (Owl-faced monkey) (Hamlyn's monkey) [TaxID: 9536]
Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) [TaxID: 9534]
Macaca (macaques) [TaxID: 9539]
Pan troglodytes (Chimpanzee) [TaxID: 9598]

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Host cytoplasm, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000314779‹1 – 5Protein VP1Sequence analysis›5
ChainiPRO_00003106916 – ›56Protein 2ASequence analysisAdd BLAST›51

Post-translational modificationi

Specific enzymatic cleavages by the viral protease in vivo yield a variety of precursors and mature proteins. Polyprotein processing intermediates are produced, such as VP1-2A precursor. The assembly signal 2A is removed from VP1-2A by a host protease (By similarity).By similarity


Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei6 – 7Cleavage; by hostSequence analysis2

Family & Domainsi

Sequence similaritiesi

Belongs to the picornaviridae polyprotein family.Curated


Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C5S8-1 [UniParc]FASTAAdd to basket

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Mass (Da):6,485
Last modified:November 13, 2007 - v1

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei561

Sequence databases

Select the link destinations:
Links Updated
L07731 Genomic RNA. No translation available.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPOLG_HAVSJ
AccessioniPrimary (citable) accession number: P0C5S8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: September 7, 2016
This is version 27 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program



  1. SIMILARITY comments
    Index of protein domains and families