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P0C5S8

- POLG_HAVSJ

UniProt

P0C5S8 - POLG_HAVSJ

Protein

Genome polyprotein

Gene
N/A
Organism
Simian hepatitis A virus genotype VI (isolate JM55) (SHAV) (Simian hepatitis A virus (isolate Macaca/Indonesia/JM55/1985))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    The C-terminal domain of VP1-2A, protein 2A, acts as an assembly signal that allows multimerization of VP1-2A and formation of pentamers of VP1-VP2-VP3 trimers. It is proteolytically removed from the precursor by a host protease and does not seem to be found in mature particles By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei6 – 72Cleavage; by hostSequence Analysis
    Sitei6 – 61Important for VP1 folding and capsid assemblyBy similarity

    GO - Biological processi

    1. suppression by virus of host gene expression Source: UniProtKB-KW
    2. viral entry into host cell Source: UniProtKB-KW
    3. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Biological processi

    Eukaryotic host gene expression shutoff by virus, Eukaryotic host translation shutoff by virus, Host gene expression shutoff by virus, Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Genome polyprotein
    Cleaved into the following 2 chains:
    Alternative name(s):
    P1D
    Virion protein 1
    Protein 2A
    Short name:
    P2A
    OrganismiSimian hepatitis A virus genotype VI (isolate JM55) (SHAV) (Simian hepatitis A virus (isolate Macaca/Indonesia/JM55/1985))
    Taxonomic identifieri470594 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stagePicornaviralesPicornaviridaeHepatovirus
    Virus hostiCallithrix [TaxID: 9481]
    Cercopithecus hamlyni (Owl-faced monkey) (Hamlyn's monkey) [TaxID: 9536]
    Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) [TaxID: 9534]
    Macaca (macaques) [TaxID: 9539]
    Pan troglodytes (Chimpanzee) [TaxID: 9598]

    Subcellular locationi

    GO - Cellular componenti

    1. host cell cytoplasm Source: UniProtKB-SubCell
    2. viral capsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid protein, Host cytoplasm, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 5›5Protein VP1Sequence AnalysisPRO_0000314779
    Chaini6 – ›56›51Protein 2ASequence AnalysisPRO_0000310691Add
    BLAST

    Post-translational modificationi

    Specific enzymatic cleavages by the viral protease in vivo yield a variety of precursors and mature proteins. Polyprotein processing intermediates are produced, such as VP1-2A precursor. The assembly signal 2A is removed from VP1-2A by a host protease By similarity.By similarity

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the picornaviridae polyprotein family.Curated

    Family and domain databases

    InterProiIPR024354. Hepatitis_A_VP1-2A.
    [Graphical view]
    PfamiPF12944. DUF3840. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0C5S8-1 [UniParc]FASTAAdd to Basket

    « Hide

    ETMLDRIASG DLESSVDDPR SAEDKRFESH IEQGKPYKEL RMEVGKQTLK   50
    YAQEEL 56
    Length:56
    Mass (Da):6,485
    Last modified:November 13, 2007 - v1
    Checksum:iC693DB4D101EF285
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Non-terminal residuei56 – 561

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L07731 Genomic RNA. No translation available.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L07731 Genomic RNA. No translation available.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR024354. Hepatitis_A_VP1-2A.
    [Graphical view ]
    Pfami PF12944. DUF3840. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genetic relatedness of hepatitis A virus strains recovered from different geographical regions."
      Robertson B.H., Jansen R.W., Khanna B., Totsuka A., Nainan O.V., Siegl G., Widell A., Margolis H.S., Isomura S., Ito K., Ishizu T., Moritsugu Y., Lemon S.M.
      J. Gen. Virol. 73:1365-1377(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiPOLG_HAVSJ
    AccessioniPrimary (citable) accession number: P0C5S8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 22 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The need for an intact eIF4G factor for the initiation of translation results in an inability to shut off host protein synthesis by a mechanism similar to that of other picornaviruses.By similarity

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3