P0C5S8 (POLG_HAVSJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Genome polyprotein Cleaved into the following 2 chains: Protein VP1 Alternative name(s): P1D Virion protein 1 Protein 2A Short name=P2A
Organism	Simian hepatitis A virus genotype VI (isolate JM55) (SHAV) (Simian hepatitis A virus (isolate Macaca/Indonesia/JM55/1985))
Taxonomic identifier	470594 [NCBI]
Taxonomic lineage	Viruses › ssRNA viruses › ssRNA positive-strand viruses, no DNA stage › Picornavirales › Picornaviridae › Hepatovirus › Hepatitis A virus › Simian hepatitis A virus
Virus host	Callithrix [TaxID: 9481] Cercopithecus hamlyni (Owl-faced monkey) (Hamlyn's monkey) [TaxID: 9536] Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) [TaxID: 9534] Macaca (macaques) [TaxID: 9539] Pan troglodytes (Chimpanzee) [TaxID: 9598]

Protein attributes

Sequence length	56 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The C-terminal domain of VP1-2A, protein 2A, acts as an assembly signal that allows multimerization of VP1-2A and formation of pentamers of VP1-VP2-VP3 trimers. It is proteolytically removed from the precursor by a host protease and does not seem to be found in mature particles By similarity.
Subcellular location	Protein VP1: Virion. Host cytoplasm Potential.
Post-translational modification	Specific enzymatic cleavages by the viral protease in vivo yield a variety of precursors and mature proteins. Polyprotein processing intermediates are produced, such as VP1-2A precursor. The assembly signal 2A is removed from VP1-2A by a host protease By similarity.
Sequence similarities	Belongs to the picornaviridae polyprotein family.

Ontologies

Keywords
Biological process	Host-virus interaction Viral attachment to host cell Virus entry into host cell
Cellular component	Host cytoplasm Virion
Molecular function	Capsid protein
Gene Ontology (GO)
Biological_process	viral attachment to host cell Inferred from electronic annotation. Source: UniProtKB-KW viral entry into host cell Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	host cell cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell viral capsid Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 5	›5	Protein VP1 Potential		PRO_0000314779
	Chain	6 – ›56	›51	Protein 2A Potential		PRO_0000310691
Sites
	Site	6 – 7	2	Cleavage; by host Potential
	Site	6	1	Important for VP1 folding and capsid assembly By similarity
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	56	1

Sequences

	Sequence		Length	Mass (Da)
	P0C5S8 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: C693DB4D101EF285	FASTA	56	6,485
	10 20 30 40 50 ETMLDRIASG DLESSVDDPR SAEDKRFESH IEQGKPYKEL RMEVGKQTLK YAQEEL

References

[1]

"Genetic relatedness of hepatitis A virus strains recovered from different geographical regions." Robertson B.H., Jansen R.W., Khanna B., Totsuka A., Nainan O.V., Siegl G., Widell A., Margolis H.S., Isomura S., Ito K., Ishizu T., Moritsugu Y., Lemon S.M. J. Gen. Virol. 73:1365-1377(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	L07731 Genomic RNA. No translation available.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR024354. Hepatitis_A_VP1-2A. [Graphical view]
Pfam	PF12944. DUF3840. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

POLG_HAVSJ

Accession

Primary (citable) accession number: P0C5S8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	November 13, 2007
Last modified:	January 9, 2013
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program