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P0C5S8 (POLG_HAVSJ) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length56 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

The C-terminal domain of VP1-2A, protein 2A, acts as an assembly signal that allows multimerization of VP1-2A and formation of pentamers of VP1-VP2-VP3 trimers. It is proteolytically removed from the precursor by a host protease and does not seem to be found in mature particles By similarity.

Subcellular location

Protein VP1: Virion. Host cytoplasm Potential.

Post-translational modification

Specific enzymatic cleavages by the viral protease in vivo yield a variety of precursors and mature proteins. Polyprotein processing intermediates are produced, such as VP1-2A precursor. The assembly signal 2A is removed from VP1-2A by a host protease By similarity.

Miscellaneous

The need for an intact eIF4G factor for the initiation of translation results in an inability to shut off host protein synthesis by a mechanism similar to that of other picornaviruses By similarity.

Sequence similarities

Belongs to the picornaviridae polyprotein family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 5›5Protein VP1 Potential
PRO_0000314779
Chain6 – ›56›51Protein 2A Potential
PRO_0000310691

Sites

Site6 – 72Cleavage; by host Potential
Site61Important for VP1 folding and capsid assembly By similarity

Experimental info

Non-terminal residue11
Non-terminal residue561

Sequences

Sequence LengthMass (Da)Tools
P0C5S8 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: C693DB4D101EF285

FASTA566,485
        10         20         30         40         50 
ETMLDRIASG DLESSVDDPR SAEDKRFESH IEQGKPYKEL RMEVGKQTLK YAQEEL 

« Hide

References

[1]"Genetic relatedness of hepatitis A virus strains recovered from different geographical regions."
Robertson B.H., Jansen R.W., Khanna B., Totsuka A., Nainan O.V., Siegl G., Widell A., Margolis H.S., Isomura S., Ito K., Ishizu T., Moritsugu Y., Lemon S.M.
J. Gen. Virol. 73:1365-1377(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L07731 Genomic RNA. No translation available.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR024354. Hepatitis_A_VP1-2A.
[Graphical view]
PfamPF12944. DUF3840. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePOLG_HAVSJ
AccessionPrimary (citable) accession number: P0C5S8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: July 9, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families