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Protein

Phosphorelay protein LuxU

Gene

luxU

Organism
Vibrio harveyi (Beneckea harveyi)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Phosphorelay protein which receives sensory signals from LuxN and LuxP and transmits them to LuxO, at low cell density. LuxN and LuxP transfer a phosphoryl group to LuxU on His-58 and this phosphoryl group is further transferred to LuxO. At high cell density, as LuxU could function to establish an equilibrium between the aspartyl-phosphate of LuxN and the aspartyl-phosphate of LuxO, LuxU transfers phosphate from LuxO to LuxN (and probably LuxP) and finally phosphate is drained from the system.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Two-component regulatory system

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphorelay protein LuxU
Gene namesi
Name:luxU
OrganismiVibrio harveyi (Beneckea harveyi)
Taxonomic identifieri669 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi58H → A: Constitutive luminescence. 1 Publication1
Mutagenesisi103H → A: No effect. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002201411 – 114Phosphorelay protein LuxUAdd BLAST114

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei58PhosphohistidinePROSITE-ProRule annotation1 Publication1

Keywords - PTMi

Phosphoprotein

PTM databases

iPTMnetiP0C5S4.

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

STRINGi338187.VIBHAR_02958.

Structurei

Secondary structure

1114
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni4 – 9Combined sources6
Helixi10 – 14Combined sources5
Helixi16 – 40Combined sources25
Turni41 – 44Combined sources4
Helixi47 – 57Combined sources11
Helixi59 – 67Combined sources9
Turni68 – 70Combined sources3
Helixi71 – 82Combined sources12
Helixi84 – 88Combined sources5
Turni90 – 92Combined sources3
Turni94 – 99Combined sources6
Helixi100 – 112Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Y6DNMR-A1-114[»]
DisProtiDP00292.
ProteinModelPortaliP0C5S4.
SMRiP0C5S4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0C5S4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 114HPtPROSITE-ProRule annotationAdd BLAST96

Sequence similaritiesi

Contains 1 HPt domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di1.20.120.160. 1 hit.
InterProiIPR008207. Sig_transdc_His_kin_Hpt_dom.
[Graphical view]
PfamiPF01627. Hpt. 1 hit.
[Graphical view]
SUPFAMiSSF47226. SSF47226. 1 hit.
PROSITEiPS50894. HPT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C5S4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTDVLNQQK IEELSAEIGS DNVPVLLDIF LGEMDSYIGT LTELQGSEQL
60 70 80 90 100
LYLKEISHAL KSSAASFGAD RLCERAIAID KKAKANQLQE QGMETSEMLA
110
LLHITRDAYR SWTN
Length:114
Mass (Da):12,689
Last modified:November 13, 2007 - v1
Checksum:iE61DFCE6CB2C8D98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26221 Genomic DNA. Translation: AAD12737.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26221 Genomic DNA. Translation: AAD12737.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Y6DNMR-A1-114[»]
DisProtiDP00292.
ProteinModelPortaliP0C5S4.
SMRiP0C5S4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi338187.VIBHAR_02958.

PTM databases

iPTMnetiP0C5S4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP0C5S4.

Family and domain databases

Gene3Di1.20.120.160. 1 hit.
InterProiIPR008207. Sig_transdc_His_kin_Hpt_dom.
[Graphical view]
PfamiPF01627. Hpt. 1 hit.
[Graphical view]
SUPFAMiSSF47226. SSF47226. 1 hit.
PROSITEiPS50894. HPT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLUXU_VIBHA
AccessioniPrimary (citable) accession number: P0C5S4
Secondary accession number(s): Q9ZBB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: November 30, 2016
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.