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Protein

Phosphorelay protein LuxU

Gene

luxU

Organism
Vibrio harveyi (Beneckea harveyi)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Phosphorelay protein which receives sensory signals from LuxN and LuxP and transmits them to LuxO, at low cell density. LuxN and LuxP transfer a phosphoryl group to LuxU on His-58 and this phosphoryl group is further transferred to LuxO. At high cell density, as LuxU could function to establish an equilibrium between the aspartyl-phosphate of LuxN and the aspartyl-phosphate of LuxO, LuxU transfers phosphate from LuxO to LuxN (and probably LuxP) and finally phosphate is drained from the system.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Two-component regulatory system

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphorelay protein LuxU
Gene namesi
Name:luxU
OrganismiVibrio harveyi (Beneckea harveyi)
Taxonomic identifieri669 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi58 – 581H → A: Constitutive luminescence. 1 Publication
Mutagenesisi103 – 1031H → A: No effect. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 114114Phosphorelay protein LuxUPRO_0000220141Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei58 – 581PhosphohistidinePROSITE-ProRule annotation1 Publication

Keywords - PTMi

Phosphoprotein

PTM databases

iPTMnetiP0C5S4.

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

STRINGi338187.VIBHAR_02958.

Structurei

Secondary structure

1
114
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni4 – 96Combined sources
Helixi10 – 145Combined sources
Helixi16 – 4025Combined sources
Turni41 – 444Combined sources
Helixi47 – 5711Combined sources
Helixi59 – 679Combined sources
Turni68 – 703Combined sources
Helixi71 – 8212Combined sources
Helixi84 – 885Combined sources
Turni90 – 923Combined sources
Turni94 – 996Combined sources
Helixi100 – 11213Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Y6DNMR-A1-114[»]
DisProtiDP00292.
ProteinModelPortaliP0C5S4.
SMRiP0C5S4. Positions 1-114.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0C5S4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 11496HPtPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HPt domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di1.20.120.160. 1 hit.
InterProiIPR008207. Sig_transdc_His_kin_Hpt_dom.
[Graphical view]
PfamiPF01627. Hpt. 1 hit.
[Graphical view]
SUPFAMiSSF47226. SSF47226. 1 hit.
PROSITEiPS50894. HPT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C5S4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTDVLNQQK IEELSAEIGS DNVPVLLDIF LGEMDSYIGT LTELQGSEQL
60 70 80 90 100
LYLKEISHAL KSSAASFGAD RLCERAIAID KKAKANQLQE QGMETSEMLA
110
LLHITRDAYR SWTN
Length:114
Mass (Da):12,689
Last modified:November 13, 2007 - v1
Checksum:iE61DFCE6CB2C8D98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26221 Genomic DNA. Translation: AAD12737.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26221 Genomic DNA. Translation: AAD12737.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Y6DNMR-A1-114[»]
DisProtiDP00292.
ProteinModelPortaliP0C5S4.
SMRiP0C5S4. Positions 1-114.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi338187.VIBHAR_02958.

PTM databases

iPTMnetiP0C5S4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP0C5S4.

Family and domain databases

Gene3Di1.20.120.160. 1 hit.
InterProiIPR008207. Sig_transdc_His_kin_Hpt_dom.
[Graphical view]
PfamiPF01627. Hpt. 1 hit.
[Graphical view]
SUPFAMiSSF47226. SSF47226. 1 hit.
PROSITEiPS50894. HPT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLUXU_VIBHA
AccessioniPrimary (citable) accession number: P0C5S4
Secondary accession number(s): Q9ZBB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: May 11, 2016
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.