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Protein

Acid tolerance regulatory protein ActR

Gene

actR

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Member of the two-component regulatory system ActS/ActR acting in acid tolerance. These data implicate that a two-component sensor may be involved in pH sensing and/or response (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation, Two-component regulatory system

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Acid tolerance regulatory protein ActR
Gene namesi
Name:actR
Ordered Locus Names:R00065
ORF Names:SMc02584
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000001976 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000809921 – 194Acid tolerance regulatory protein ActRAdd BLAST194

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei734-aspartylphosphatePROSITE-ProRule annotation1

Post-translational modificationi

Phosphorylated by ActS.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi266834.SMc02584.

Structurei

3D structure databases

ProteinModelPortaliP0C5S3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 138Response regulatoryPROSITE-ProRule annotationAdd BLAST115

Sequence similaritiesi

Contains 1 response regulatory domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108UYB. Bacteria.
COG4567. LUCA.
HOGENOMiHOG000034817.
KOiK15012.
OMAiAIRQRRD.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR009057. Homeodomain-like.
IPR002197. HTH_Fis.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF02954. HTH_8. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C5S3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIEKSMPAQN THAADADLIG PDKSLLIVDD DTAFLRRLAR AMEARGFAVE
60 70 80 90 100
IAESVAEGIA KAKTRPPKHA VIDLRLSDGS GLDVIEAIRG RRDDTRMIVL
110 120 130 140 150
TGYGNIATAV NAVKLGALDY LAKPADADDI LAALIQRPGE RVEPPENPMS
160 170 180 190
ADRVRWEHIQ RVYEMCERNV SETARRLNMH RRTLQRILAK RAPK
Length:194
Mass (Da):21,513
Last modified:November 13, 2007 - v1
Checksum:i4C6B8B00649419C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591688 Genomic DNA. Translation: CAC41452.1.
RefSeqiNP_384171.1. NC_003047.1.
WP_010968328.1. NC_003047.1.

Genome annotation databases

EnsemblBacteriaiCAC41452; CAC41452; SMc02584.
GeneIDi1231690.
KEGGisme:SMc02584.
PATRICi23629283. VBISinMel96828_1419.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591688 Genomic DNA. Translation: CAC41452.1.
RefSeqiNP_384171.1. NC_003047.1.
WP_010968328.1. NC_003047.1.

3D structure databases

ProteinModelPortaliP0C5S3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266834.SMc02584.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC41452; CAC41452; SMc02584.
GeneIDi1231690.
KEGGisme:SMc02584.
PATRICi23629283. VBISinMel96828_1419.

Phylogenomic databases

eggNOGiENOG4108UYB. Bacteria.
COG4567. LUCA.
HOGENOMiHOG000034817.
KOiK15012.
OMAiAIRQRRD.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR009057. Homeodomain-like.
IPR002197. HTH_Fis.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF02954. HTH_8. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACTR_RHIME
AccessioniPrimary (citable) accession number: P0C5S3
Secondary accession number(s): Q52913
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: November 2, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.