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Protein

Uncharacterized serine/threonine-protein kinase SBK3

Gene

Sbk3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei72ATPPROSITE-ProRule annotation1
Active sitei163Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi49 – 57ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized serine/threonine-protein kinase SBK3 (EC:2.7.11.1)
Alternative name(s):
SH3-binding domain kinase family member 3
Sugen kinase 110
Gene namesi
Name:Sbk3
Synonyms:Gm1078, Sgk110
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2685924. Sbk3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003082631 – 361Uncharacterized serine/threonine-protein kinase SBK3Add BLAST361

Proteomic databases

PaxDbiP0C5K0.
PRIDEiP0C5K0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000085272.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000122507.

Structurei

3D structure databases

ProteinModelPortaliP0C5K0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 309Protein kinasePROSITE-ProRule annotationAdd BLAST267

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi189 – 278Pro-richAdd BLAST90
Compositional biasi329 – 332Poly-Glu4

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1345. Eukaryota.
ENOG41112JR. LUCA.
GeneTreeiENSGT00680000099954.
HOGENOMiHOG000063666.
HOVERGENiHBG108481.
InParanoidiP0C5K0.
KOiK08858.
OMAiGRCVSAH.
OrthoDBiEOG091G0QNH.
TreeFamiTF326736.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P0C5K0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERRVLETTE DGDTEEDTAM ALQRLVELTA SRVTSVRSLC VQYRLIRKLG
60 70 80 90 100
SGSYGRVLLA QPRQGGQTVA LKLLRRDSVL RTTFLREFCV GRCVSSHPGL
110 120 130 140 150
LQTLGRPLQT PRYFAFAQEF APCGDLSGML QEKGLPELMV KRIVAQLAGA
160 170 180 190 200
LDFLHGRGLV HADVKPDNVL VFDPDCNRVA LGDLGLTRPE GSPTPAPPVP
210 220 230 240 250
LPTAPPELCL LLPPNTLPLR PAVDSWALGV LLFCAATACF PWDVALAPDP
260 270 280 290 300
EFEAFAGWMT TKPQPPRPPA PWDQFAPPAL TLLQGLLDLD PETRSPPLAV
310 320 330 340 350
FDVLGDNWGL QGSGEGSGSL GVIPYKDGEE EEGGSSLEEW TDEEEDEIKD
360
SGGMEADNRA S
Length:361
Mass (Da):39,117
Last modified:December 11, 2013 - v2
Checksum:i282A8AEC143E3949
GO
Isoform 2 (identifier: P0C5K0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: Missing.

Note: No experimental confirmation available.
Show »
Length:342
Mass (Da):36,937
Checksum:i70067C557546DC76
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0535071 – 19Missing in isoform 2. CuratedAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC157563 Genomic DNA. No translation available.
CCDSiCCDS57475.1. [P0C5K0-2]
RefSeqiNP_001186970.1. NM_001200041.1. [P0C5K0-2]
XP_006540196.1. XM_006540133.3. [P0C5K0-1]
XP_006540197.1. XM_006540134.3. [P0C5K0-2]
XP_006540198.1. XM_006540135.3. [P0C5K0-2]
XP_006540200.1. XM_006540137.3. [P0C5K0-2]
UniGeneiMm.297828.

Genome annotation databases

EnsembliENSMUST00000133272; ENSMUSP00000120654; ENSMUSG00000085272. [P0C5K0-1]
ENSMUST00000144863; ENSMUSP00000122507; ENSMUSG00000085272. [P0C5K0-2]
GeneIDi381835.
KEGGimmu:381835.
UCSCiuc009ezb.1. mouse. [P0C5K0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC157563 Genomic DNA. No translation available.
CCDSiCCDS57475.1. [P0C5K0-2]
RefSeqiNP_001186970.1. NM_001200041.1. [P0C5K0-2]
XP_006540196.1. XM_006540133.3. [P0C5K0-1]
XP_006540197.1. XM_006540134.3. [P0C5K0-2]
XP_006540198.1. XM_006540135.3. [P0C5K0-2]
XP_006540200.1. XM_006540137.3. [P0C5K0-2]
UniGeneiMm.297828.

3D structure databases

ProteinModelPortaliP0C5K0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000122507.

Proteomic databases

PaxDbiP0C5K0.
PRIDEiP0C5K0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000133272; ENSMUSP00000120654; ENSMUSG00000085272. [P0C5K0-1]
ENSMUST00000144863; ENSMUSP00000122507; ENSMUSG00000085272. [P0C5K0-2]
GeneIDi381835.
KEGGimmu:381835.
UCSCiuc009ezb.1. mouse. [P0C5K0-1]

Organism-specific databases

CTDi100130827.
MGIiMGI:2685924. Sbk3.

Phylogenomic databases

eggNOGiKOG1345. Eukaryota.
ENOG41112JR. LUCA.
GeneTreeiENSGT00680000099954.
HOGENOMiHOG000063666.
HOVERGENiHBG108481.
InParanoidiP0C5K0.
KOiK08858.
OMAiGRCVSAH.
OrthoDBiEOG091G0QNH.
TreeFamiTF326736.

Miscellaneous databases

PROiP0C5K0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000085272.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSBK3_MOUSE
AccessioniPrimary (citable) accession number: P0C5K0
Secondary accession number(s): D3Z5J0, E9QLM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: December 11, 2013
Last modified: November 2, 2016
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.