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Protein

Probable G-protein coupled receptor 52

Gene

Gpr52

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Orphan receptor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 52
Gene namesi
Name:Gpr52
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:3643278. Gpr52.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 44ExtracellularSequence analysisAdd BLAST44
Transmembranei45 – 65Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini66 – 81CytoplasmicSequence analysisAdd BLAST16
Transmembranei82 – 102Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini103 – 115ExtracellularSequence analysisAdd BLAST13
Transmembranei116 – 136Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini137 – 159CytoplasmicSequence analysisAdd BLAST23
Transmembranei160 – 180Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini181 – 205ExtracellularSequence analysisAdd BLAST25
Transmembranei206 – 226Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini227 – 265CytoplasmicSequence analysisAdd BLAST39
Transmembranei266 – 286Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini287 – 296ExtracellularSequence analysis10
Transmembranei297 – 317Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini318 – 361CytoplasmicSequence analysisAdd BLAST44

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003076801 – 361Probable G-protein coupled receptor 52Add BLAST361

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...)Sequence analysis1
Glycosylationi13N-linked (GlcNAc...)Sequence analysis1
Glycosylationi20N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi114 ↔ 193PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP0C5J4.

Structurei

3D structure databases

ProteinModelPortaliP0C5J4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG051801.
InParanoidiP0C5J4.
KOiK08407.
PhylomeDBiP0C5J4.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C5J4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNESRWTEWR ILNMSSSIVN VSEHHSCPLG FGHYSVEDVC IFETVVIVLL
60 70 80 90 100
TFLIISGNLT VIFVFHCAPL LHHYTTSYFI QTMAYADLLV GVTCLVPTLS
110 120 130 140 150
LLHYSTGVHE SLTCQVFGYI ISVLKSVSMA CLACISVDRY LAITKPLSYN
160 170 180 190 200
QLVTPCRLRI CIIMIWIYSC LIFLPSFFGW GKPGYHGDIF EWCATSWLTS
210 220 230 240 250
AYFTCFIVCL LYAPAALVVC FTYFHIFKIC RQHTKEINDR RARFPSHEVE
260 270 280 290 300
ASREAGHSPD RRYAMVLFRI TSVFYMLWLP YIIYFLLESS RVLDNPTLSF
310 320 330 340 350
LTTWLAISNS FCNCVIYSLS NSVFRLGLRR LSETMCTSCV CAKDQEAQDP
360
KPRRRANSCS I
Length:361
Mass (Da):41,343
Last modified:October 23, 2007 - v1
Checksum:i150F8A395B63290B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC117787 Genomic DNA. No translation available.
RefSeqiNP_001139802.1. NM_001146330.1.
XP_017177375.1. XM_017321886.1.
XP_017177377.1. XM_017321888.1.
UniGeneiMm.478780.

Genome annotation databases

GeneIDi620246.
KEGGimmu:620246.
UCSCiuc011wum.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC117787 Genomic DNA. No translation available.
RefSeqiNP_001139802.1. NM_001146330.1.
XP_017177375.1. XM_017321886.1.
XP_017177377.1. XM_017321888.1.
UniGeneiMm.478780.

3D structure databases

ProteinModelPortaliP0C5J4.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PRIDEiP0C5J4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi620246.
KEGGimmu:620246.
UCSCiuc011wum.1. mouse.

Organism-specific databases

CTDi9293.
MGIiMGI:3643278. Gpr52.

Phylogenomic databases

HOVERGENiHBG051801.
InParanoidiP0C5J4.
KOiK08407.
PhylomeDBiP0C5J4.

Miscellaneous databases

PROiP0C5J4.
SOURCEiSearch...

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR52_MOUSE
AccessioniPrimary (citable) accession number: P0C5J4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: November 2, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.