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Protein

Probable G-protein coupled receptor 52

Gene

Gpr52

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Orphan receptor.

GO - Molecular functioni

GO - Biological processi

  • locomotory behavior Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 52
Gene namesi
Name:Gpr52
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:3643278. Gpr52.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4444ExtracellularSequence analysisAdd
BLAST
Transmembranei45 – 6521Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini66 – 8116CytoplasmicSequence analysisAdd
BLAST
Transmembranei82 – 10221Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini103 – 11513ExtracellularSequence analysisAdd
BLAST
Transmembranei116 – 13621Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini137 – 15923CytoplasmicSequence analysisAdd
BLAST
Transmembranei160 – 18021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini181 – 20525ExtracellularSequence analysisAdd
BLAST
Transmembranei206 – 22621Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini227 – 26539CytoplasmicSequence analysisAdd
BLAST
Transmembranei266 – 28621Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini287 – 29610ExtracellularSequence analysis
Transmembranei297 – 31721Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini318 – 36144CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 361361Probable G-protein coupled receptor 52PRO_0000307680Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...)Sequence analysis
Glycosylationi13 – 131N-linked (GlcNAc...)Sequence analysis
Glycosylationi20 – 201N-linked (GlcNAc...)Sequence analysis
Disulfide bondi114 ↔ 193PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP0C5J4.
PRIDEiP0C5J4.

Structurei

3D structure databases

ProteinModelPortaliP0C5J4.
SMRiP0C5J4. Positions 45-331.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG051801.
InParanoidiP0C5J4.
KOiK08407.
PhylomeDBiP0C5J4.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C5J4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNESRWTEWR ILNMSSSIVN VSEHHSCPLG FGHYSVEDVC IFETVVIVLL
60 70 80 90 100
TFLIISGNLT VIFVFHCAPL LHHYTTSYFI QTMAYADLLV GVTCLVPTLS
110 120 130 140 150
LLHYSTGVHE SLTCQVFGYI ISVLKSVSMA CLACISVDRY LAITKPLSYN
160 170 180 190 200
QLVTPCRLRI CIIMIWIYSC LIFLPSFFGW GKPGYHGDIF EWCATSWLTS
210 220 230 240 250
AYFTCFIVCL LYAPAALVVC FTYFHIFKIC RQHTKEINDR RARFPSHEVE
260 270 280 290 300
ASREAGHSPD RRYAMVLFRI TSVFYMLWLP YIIYFLLESS RVLDNPTLSF
310 320 330 340 350
LTTWLAISNS FCNCVIYSLS NSVFRLGLRR LSETMCTSCV CAKDQEAQDP
360
KPRRRANSCS I
Length:361
Mass (Da):41,343
Last modified:October 23, 2007 - v1
Checksum:i150F8A395B63290B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC117787 Genomic DNA. No translation available.
RefSeqiNP_001139802.1. NM_001146330.1.
UniGeneiMm.478780.

Genome annotation databases

GeneIDi620246.
KEGGimmu:620246.
UCSCiuc011wum.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC117787 Genomic DNA. No translation available.
RefSeqiNP_001139802.1. NM_001146330.1.
UniGeneiMm.478780.

3D structure databases

ProteinModelPortaliP0C5J4.
SMRiP0C5J4. Positions 45-331.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

MaxQBiP0C5J4.
PRIDEiP0C5J4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi620246.
KEGGimmu:620246.
UCSCiuc011wum.1. mouse.

Organism-specific databases

CTDi9293.
MGIiMGI:3643278. Gpr52.

Phylogenomic databases

HOVERGENiHBG051801.
InParanoidiP0C5J4.
KOiK08407.
PhylomeDBiP0C5J4.

Miscellaneous databases

PROiP0C5J4.
SOURCEiSearch...

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiGPR52_MOUSE
AccessioniPrimary (citable) accession number: P0C5J4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: June 8, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.