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Protein

B9 domain-containing protein 2

Gene

B9d2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation

Enzyme and pathway databases

ReactomeiR-RNO-141444. Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
R-RNO-2467813. Separation of Sister Chromatids.
R-RNO-2500257. Resolution of Sister Chromatid Cohesion.
R-RNO-5620912. Anchoring of the basal body to the plasma membrane.
R-RNO-5663220. RHO GTPases Activate Formins.
R-RNO-68877. Mitotic Prometaphase.

Names & Taxonomyi

Protein namesi
Recommended name:
B9 domain-containing protein 2
Gene namesi
Name:B9d2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1566122. B9d2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003076761 – 175B9 domain-containing protein 2Add BLAST175

Proteomic databases

PaxDbiP0C5J3.

Expressioni

Gene expression databases

BgeeiENSRNOG00000028753.

Interactioni

Subunit structurei

Part of the tectonic-like complex (also named B9 complex). Interacts with TUBG1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028029.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 118B9PROSITE-ProRule annotationAdd BLAST117

Sequence similaritiesi

Belongs to the B9D family.Curated

Phylogenomic databases

eggNOGiKOG4028. Eukaryota.
ENOG410ZQAW. LUCA.
GeneTreeiENSGT00530000063756.
HOGENOMiHOG000257718.
HOVERGENiHBG107102.
InParanoidiP0C5J3.
KOiK16745.
OMAiQVWHQDS.
OrthoDBiEOG091G0BGX.
PhylomeDBiP0C5J3.

Family and domain databases

InterProiView protein in InterPro
IPR010796. B9_dom.
PANTHERiPTHR12968. PTHR12968. 1 hit.
PfamiView protein in Pfam
PF07162. B9-C2. 1 hit.
PROSITEiView protein in PROSITE
PS51381. B9. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C5J3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEVHVIGQI IGATGFSEGS LFCKWGIHTG AAWKLLSGVR EGQTQVDTPQ
60 70 80 90 100
TGDMAYWSHP IDLHFATKGL QGWPRLHLQV WSQDSFGRCQ LAGYGFCHVP
110 120 130 140 150
SSPGTHQLDC PTWRPLGSWR EQLARAFVGG GPQLLHADTI YSGADRYRLH
160 170
TAAGGTVHLG IGLLLRHFDR YGVEC
Length:175
Mass (Da):19,208
Last modified:October 23, 2007 - v1
Checksum:i82AF5748A70DFE50
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AI227900 mRNA. No translation available.
RefSeqiNP_001100964.1. NM_001107494.1.
XP_006228500.1. XM_006228438.3.
UniGeneiRn.22197.

Genome annotation databases

EnsembliENSRNOT00000028029; ENSRNOP00000028029; ENSRNOG00000028753.
GeneIDi308443.
KEGGirno:308443.
UCSCiRGD:1566122. rat.

Similar proteinsi

Entry informationi

Entry nameiB9D2_RAT
AccessioniPrimary (citable) accession number: P0C5J3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: September 27, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families