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Protein

B9 domain-containing protein 1

Gene

B9d1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity).By similarity

GO - Molecular functioni

  1. hedgehog receptor activity Source: UniProtKB

GO - Biological processi

  1. cilium assembly Source: UniProtKB
  2. cilium morphogenesis Source: UniProtKB
  3. smoothened signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
B9 domain-containing protein 1
Alternative name(s):
Endothelial precursor cells protein B9
Gene namesi
Name:B9d1
Synonyms:Eppb9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 10

Organism-specific databases

RGDi1305522. B9d1.

Subcellular locationi

Cytoplasmcytoskeletoncilium basal body By similarity
Note: Localizes at the transition zone, a region between the basal body and the ciliary axoneme.By similarity

GO - Cellular componenti

  1. centrosome Source: UniProtKB
  2. ciliary basal body Source: UniProtKB
  3. ciliary transition zone Source: UniProtKB
  4. cytoplasm Source: UniProtKB-KW
  5. TCTN-B9D complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 204204B9 domain-containing protein 1PRO_0000307669Add
BLAST

Proteomic databases

PaxDbiP0C5J2.

Expressioni

Gene expression databases

ExpressionAtlasiP0C5J2. baseline.
GenevestigatoriP0C5J2.

Interactioni

Subunit structurei

Part of the tectonic-like complex (also named B9 complex).By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 127119B9PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the B9D family.Curated
Contains 1 B9 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG271150.
GeneTreeiENSGT00530000063756.
HOGENOMiHOG000038832.
HOVERGENiHBG104431.
InParanoidiP0C5J2.
KOiK16744.
OMAiNPSGWPQ.
OrthoDBiEOG78D7M7.
PhylomeDBiP0C5J2.

Family and domain databases

InterProiIPR010796. B9_dom.
[Graphical view]
PfamiPF07162. B9-C2. 1 hit.
[Graphical view]
PROSITEiPS51381. B9. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C5J2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAASPSVFL LMVNGQVESA QFPEYDDLYC KYCFVYGQDW APTAGLEEGI
60 70 80 90 100
SQIASKSQDV RQALVWNFPI DVTFKSTNPY GWPQIVLSVY GPDVFGNDVV
110 120 130 140 150
RGYGAVHVPF SPGRHKRTIP MFVPESTSTL QKFTSWFMGR RPEYTDPKVV
160 170 180 190 200
AQGEGREVTR VRSQGFVTLL FNVVTKDMKK LGYDTGPVDT QGVLSPSLPQ

GNPQ
Length:204
Mass (Da):22,655
Last modified:October 23, 2007 - v1
Checksum:i144D2EA35B002C58
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AW915603 mRNA. No translation available.
RefSeqiNP_001099256.1. NM_001105786.1.
XP_003750891.1. XM_003750843.3.
UniGeneiRn.3741.

Genome annotation databases

EnsembliENSRNOT00000003402; ENSRNOP00000003402; ENSRNOG00000002462.
ENSRNOT00000075073; ENSRNOP00000065889; ENSRNOG00000047790.
GeneIDi100911746.
287383.
KEGGirno:100911746.
rno:287383.
UCSCiRGD:1305522. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AW915603 mRNA. No translation available.
RefSeqiNP_001099256.1. NM_001105786.1.
XP_003750891.1. XM_003750843.3.
UniGeneiRn.3741.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiP0C5J2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003402; ENSRNOP00000003402; ENSRNOG00000002462.
ENSRNOT00000075073; ENSRNOP00000065889; ENSRNOG00000047790.
GeneIDi100911746.
287383.
KEGGirno:100911746.
rno:287383.
UCSCiRGD:1305522. rat.

Organism-specific databases

CTDi27077.
RGDi1305522. B9d1.

Phylogenomic databases

eggNOGiNOG271150.
GeneTreeiENSGT00530000063756.
HOGENOMiHOG000038832.
HOVERGENiHBG104431.
InParanoidiP0C5J2.
KOiK16744.
OMAiNPSGWPQ.
OrthoDBiEOG78D7M7.
PhylomeDBiP0C5J2.

Miscellaneous databases

NextBioi626001.
PROiP0C5J2.

Gene expression databases

ExpressionAtlasiP0C5J2. baseline.
GenevestigatoriP0C5J2.

Family and domain databases

InterProiIPR010796. B9_dom.
[Graphical view]
PfamiPF07162. B9-C2. 1 hit.
[Graphical view]
PROSITEiPS51381. B9. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Rat genome project: generation of a rat EST (REST) catalog & rat gene index."
    Lee N.H., Glodek A., Chandra I., Mason T.M., Quackenbush J., Kerlavage A.R., Adams M.D.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiB9D1_RAT
AccessioniPrimary (citable) accession number: P0C5J2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: January 7, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.