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P0C5J2

- B9D1_RAT

UniProt

P0C5J2 - B9D1_RAT

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Protein

B9 domain-containing protein 1

Gene

B9d1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity).By similarity

GO - Molecular functioni

  1. hedgehog receptor activity Source: UniProtKB

GO - Biological processi

  1. cilium assembly Source: UniProtKB
  2. cilium morphogenesis Source: UniProtKB
  3. smoothened signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
B9 domain-containing protein 1
Alternative name(s):
Endothelial precursor cells protein B9
Gene namesi
Name:B9d1
Synonyms:Eppb9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 10

Organism-specific databases

RGDi1305522. B9d1.

Subcellular locationi

Cytoplasmcytoskeletoncilium basal body By similarity
Note: Localizes at the transition zone, a region between the basal body and the ciliary axoneme.By similarity

GO - Cellular componenti

  1. centrosome Source: UniProtKB
  2. ciliary basal body Source: UniProtKB
  3. ciliary transition zone Source: UniProtKB
  4. cytoplasm Source: UniProtKB-KW
  5. TCTN-B9D complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 204204B9 domain-containing protein 1PRO_0000307669Add
BLAST

Proteomic databases

PaxDbiP0C5J2.

Expressioni

Gene expression databases

ExpressionAtlasiP0C5J2. baseline.
GenevestigatoriP0C5J2.

Interactioni

Subunit structurei

Part of the tectonic-like complex (also named B9 complex).By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 127119B9PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the B9D family.Curated
Contains 1 B9 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG271150.
GeneTreeiENSGT00530000063756.
HOGENOMiHOG000038832.
HOVERGENiHBG104431.
InParanoidiP0C5J2.
KOiK16744.
OMAiWPQLVVS.
OrthoDBiEOG78D7M7.
PhylomeDBiP0C5J2.

Family and domain databases

InterProiIPR010796. B9_dom.
[Graphical view]
PfamiPF07162. B9-C2. 1 hit.
[Graphical view]
PROSITEiPS51381. B9. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C5J2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAASPSVFL LMVNGQVESA QFPEYDDLYC KYCFVYGQDW APTAGLEEGI
60 70 80 90 100
SQIASKSQDV RQALVWNFPI DVTFKSTNPY GWPQIVLSVY GPDVFGNDVV
110 120 130 140 150
RGYGAVHVPF SPGRHKRTIP MFVPESTSTL QKFTSWFMGR RPEYTDPKVV
160 170 180 190 200
AQGEGREVTR VRSQGFVTLL FNVVTKDMKK LGYDTGPVDT QGVLSPSLPQ

GNPQ
Length:204
Mass (Da):22,655
Last modified:October 23, 2007 - v1
Checksum:i144D2EA35B002C58
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AW915603 mRNA. No translation available.
RefSeqiNP_001099256.1. NM_001105786.1.
XP_003750891.1. XM_003750843.3.
UniGeneiRn.3741.

Genome annotation databases

EnsembliENSRNOT00000003402; ENSRNOP00000003402; ENSRNOG00000002462.
ENSRNOT00000075073; ENSRNOP00000065889; ENSRNOG00000047790.
GeneIDi100911746.
287383.
KEGGirno:100911746.
rno:287383.
UCSCiRGD:1305522. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AW915603 mRNA. No translation available.
RefSeqi NP_001099256.1. NM_001105786.1.
XP_003750891.1. XM_003750843.3.
UniGenei Rn.3741.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi P0C5J2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000003402 ; ENSRNOP00000003402 ; ENSRNOG00000002462 .
ENSRNOT00000075073 ; ENSRNOP00000065889 ; ENSRNOG00000047790 .
GeneIDi 100911746.
287383.
KEGGi rno:100911746.
rno:287383.
UCSCi RGD:1305522. rat.

Organism-specific databases

CTDi 27077.
RGDi 1305522. B9d1.

Phylogenomic databases

eggNOGi NOG271150.
GeneTreei ENSGT00530000063756.
HOGENOMi HOG000038832.
HOVERGENi HBG104431.
InParanoidi P0C5J2.
KOi K16744.
OMAi WPQLVVS.
OrthoDBi EOG78D7M7.
PhylomeDBi P0C5J2.

Miscellaneous databases

NextBioi 626001.
PROi P0C5J2.

Gene expression databases

ExpressionAtlasi P0C5J2. baseline.
Genevestigatori P0C5J2.

Family and domain databases

InterProi IPR010796. B9_dom.
[Graphical view ]
Pfami PF07162. B9-C2. 1 hit.
[Graphical view ]
PROSITEi PS51381. B9. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Rat genome project: generation of a rat EST (REST) catalog & rat gene index."
    Lee N.H., Glodek A., Chandra I., Mason T.M., Quackenbush J., Kerlavage A.R., Adams M.D.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiB9D1_RAT
AccessioniPrimary (citable) accession number: P0C5J2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: October 29, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3