P0C5J2 (B9D1_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
B9 domain-containing protein 1

Alternative name(s):
Endothelial precursor cells protein B9

Gene names

Name:	B9d1
Synonyms:	Eppb9

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	204 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling By similarity.
Subunit structure	Part of the tectonic-like complex (also named B9 complex) By similarity.
Subcellular location	Cytoplasm › cytoskeleton › cilium basal body By similarity. Note: Localizes at the transition zone, a region between the basal body and the ciliary axoneme By similarity.
Sequence similarities	Belongs to the B9D family. Contains 1 B9 domain.

Ontologies

Keywords
Biological process	Cilium biogenesis/degradation
Cellular component	Cell projection Cytoplasm Cytoskeleton
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cilium assembly Inferred from sequence or structural similarity. Source: UniProtKB smoothened signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	TCTN-B9D complex Inferred from sequence or structural similarity. Source: UniProtKB centrosome Inferred from sequence or structural similarity. Source: UniProtKB cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW microtubule basal body Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	hedgehog receptor activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 204	204	B9 domain-containing protein 1		PRO_0000307669
Regions
	Domain	9 – 127	119	B9

Sequences

	Sequence		Length	Mass (Da)
	P0C5J2 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: 144D2EA35B002C58	FASTA	204	22,655
	10 20 30 40 50 60 MAAASPSVFL LMVNGQVESA QFPEYDDLYC KYCFVYGQDW APTAGLEEGI SQIASKSQDV 70 80 90 100 110 120 RQALVWNFPI DVTFKSTNPY GWPQIVLSVY GPDVFGNDVV RGYGAVHVPF SPGRHKRTIP 130 140 150 160 170 180 MFVPESTSTL QKFTSWFMGR RPEYTDPKVV AQGEGREVTR VRSQGFVTLL FNVVTKDMKK 190 200 LGYDTGPVDT QGVLSPSLPQ GNPQ

References

[1]	"Rat genome project: generation of a rat EST (REST) catalog & rat gene index." Lee N.H., Glodek A., Chandra I., Mason T.M., Quackenbush J., Kerlavage A.R., Adams M.D. Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AW915603 mRNA. No translation available.
IPI	IPI00369541.
RefSeq	NP_001099256.1. NM_001105786.1. XP_003750891.1. XM_003750843.1.
UniGene	Rn.3741.
3D structure databases
ModBase	Search...
Proteomic databases
PaxDb	P0C5J2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000003402; ENSRNOP00000003402; ENSRNOG00000002462. ENSRNOT00000075073; ENSRNOP00000065889; ENSRNOG00000047790.
GeneID	100911746. 287383.
KEGG	rno:100911746. rno:287383.
UCSC	RGD:1305522. rat.
Organism-specific databases
CTD	27077.
RGD	1305522. B9d1.
Phylogenomic databases
eggNOG	NOG271150.
GeneTree	ENSGT00530000063756.
HOGENOM	HOG000038832.
HOVERGEN	HBG104431.
InParanoid	P0C5J2.
KO	K16744.
OMA	NPSGWPQ.
OrthoDB	EOG4001KC.
Gene expression databases
ArrayExpress	P0C5J2.
Genevestigator	P0C5J2.
Family and domain databases
InterPro	IPR010796. B9_dom. [Graphical view]
Pfam	PF07162. B9-C2. 1 hit. [Graphical view]
PROSITE	PS51381. B9. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	626001.

Entry information

Entry name

B9D1_RAT

Accession

Primary (citable) accession number: P0C5J2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	October 23, 2007
Last modified:	April 3, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program