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Protein

Putative protein N-methyltransferase FAM86B2

Gene

FAM86B2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei139 – 1391S-adenosyl-L-methionine; via amide nitrogenBy similarity
Binding sitei228 – 2281S-adenosyl-L-methionine; via amide nitrogenBy similarity
Binding sitei247 – 2471S-adenosyl-L-methionine; via carbonyl oxygenBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Putative protein N-methyltransferase FAM86B2Curated (EC:2.1.1.-By similarity)
Gene namesi
Name:FAM86B2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:32222. FAM86B2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671860.

Polymorphism and mutation databases

BioMutaiFAM86B2.
DMDMi160010887.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330Putative protein N-methyltransferase FAM86B2PRO_0000307639Add
BLAST

Proteomic databases

MaxQBiP0C5J1.
PaxDbiP0C5J1.
PRIDEiP0C5J1.
TopDownProteomicsiP0C5J1.

PTM databases

PhosphoSiteiP0C5J1.

Expressioni

Gene expression databases

BgeeiP0C5J1.
CleanExiHS_FAM86B2.
ExpressionAtlasiP0C5J1. baseline and differential.

Organism-specific databases

HPAiHPA041610.

Interactioni

Subunit structurei

Interacts with EEF2KMT.1 Publication

Protein-protein interaction databases

BioGridi575703. 16 interactions.
STRINGi9606.ENSP00000262365.

Structurei

3D structure databases

ProteinModelPortaliP0C5J1.
SMRiP0C5J1. Positions 139-297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni165 – 1673S-adenosyl-L-methionine bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2497. Eukaryota.
ENOG410ZQK4. LUCA.
GeneTreeiENSGT00510000047003.
HOGENOMiHOG000067842.
HOVERGENiHBG059594.
InParanoidiP0C5J1.
OMAiVIFLEWE.
PhylomeDBiP0C5J1.
TreeFamiTF326304.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR029426. FAM86.
IPR019410. Methyltransf_16.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF14904. FAM86. 1 hit.
PF10294. Methyltransf_16. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C5J1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPEENAGTE LLLQGFERRF LAVRTLRSFP WQSLEAKLRD SSDSELLRDI
60 70 80 90 100
LQKTVRHPVC VKHPPSVKYA WCFLSELIKK HEAVHTEPLD KLYEVLAETL
110 120 130 140 150
MAKESTQGHR SYLLSSGGSV TLSKSTAIIS HGTTGLVTWD AALYLAEWAI
160 170 180 190 200
ENPAAFINRT VLELGSGAGL TGLAICKMCR PRAYIFSDPH SRILEQLRGN
210 220 230 240 250
VLLNGLSLEA DITGNLDSPR VTVAQLDWDV AMVHQLSAFQ PDVVIAADVL
260 270 280 290 300
YCPEAIVSLV GVLQRLAACR EHKRAPEVYV AFTVRNPETC QLFTTELGRD
310 320 330
GIRWEAEAHH DQKLFPYGEH LEMAMLNLTL
Length:330
Mass (Da):36,771
Last modified:October 23, 2007 - v1
Checksum:i666286D16B038099
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti43 – 431D → Y.
Corresponds to variant rs2684093 [ dbSNP | Ensembl ].
VAR_036617
Natural varianti285 – 2851R → S.
Corresponds to variant rs7817085 [ dbSNP | Ensembl ].
VAR_036618

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087203 Genomic DNA. No translation available.
CCDSiCCDS59092.1.
RefSeqiNP_001131082.1. NM_001137610.1.
UniGeneiHs.458413.

Genome annotation databases

EnsembliENST00000262365; ENSP00000262365; ENSG00000145002.
GeneIDi653333.
KEGGihsa:653333.
UCSCiuc003wvt.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087203 Genomic DNA. No translation available.
CCDSiCCDS59092.1.
RefSeqiNP_001131082.1. NM_001137610.1.
UniGeneiHs.458413.

3D structure databases

ProteinModelPortaliP0C5J1.
SMRiP0C5J1. Positions 139-297.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi575703. 16 interactions.
STRINGi9606.ENSP00000262365.

PTM databases

PhosphoSiteiP0C5J1.

Polymorphism and mutation databases

BioMutaiFAM86B2.
DMDMi160010887.

Proteomic databases

MaxQBiP0C5J1.
PaxDbiP0C5J1.
PRIDEiP0C5J1.
TopDownProteomicsiP0C5J1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262365; ENSP00000262365; ENSG00000145002.
GeneIDi653333.
KEGGihsa:653333.
UCSCiuc003wvt.5. human.

Organism-specific databases

CTDi653333.
GeneCardsiFAM86B2.
HGNCiHGNC:32222. FAM86B2.
HPAiHPA041610.
MIMi616123. gene.
neXtProtiNX_P0C5J1.
PharmGKBiPA142671860.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2497. Eukaryota.
ENOG410ZQK4. LUCA.
GeneTreeiENSGT00510000047003.
HOGENOMiHOG000067842.
HOVERGENiHBG059594.
InParanoidiP0C5J1.
OMAiVIFLEWE.
PhylomeDBiP0C5J1.
TreeFamiTF326304.

Miscellaneous databases

GenomeRNAii653333.
NextBioi123112.
PROiP0C5J1.
SOURCEiSearch...

Gene expression databases

BgeeiP0C5J1.
CleanExiHS_FAM86B2.
ExpressionAtlasiP0C5J1. baseline and differential.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR029426. FAM86.
IPR019410. Methyltransf_16.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF14904. FAM86. 1 hit.
PF10294. Methyltransf_16. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity."
    Cloutier P., Lavallee-Adam M., Faubert D., Blanchette M., Coulombe B.
    PLoS Genet. 9:E1003210-E1003210(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH EEF2KMT.

Entry informationi

Entry nameiF86B2_HUMAN
AccessioniPrimary (citable) accession number: P0C5J1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: May 11, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.