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Protein

Probable G-protein coupled receptor 25

Gene

Gpr25

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 25
Gene namesi
Name:Gpr25
Synonyms:Gm1300
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2686146. Gpr25.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43ExtracellularSequence analysisAdd BLAST43
Transmembranei44 – 64Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini65 – 76CytoplasmicSequence analysisAdd BLAST12
Transmembranei77 – 97Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini98 – 113ExtracellularSequence analysisAdd BLAST16
Transmembranei114 – 134Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini135 – 155CytoplasmicSequence analysisAdd BLAST21
Transmembranei156 – 176Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini177 – 200ExtracellularSequence analysisAdd BLAST24
Transmembranei201 – 221Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini222 – 239CytoplasmicSequence analysisAdd BLAST18
Transmembranei240 – 260Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini261 – 284ExtracellularSequence analysisAdd BLAST24
Transmembranei285 – 307Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini308 – 358CytoplasmicSequence analysisAdd BLAST51

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003070931 – 358Probable G-protein coupled receptor 25Add BLAST358

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi112 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP0C5I1.
PRIDEiP0C5I1.

PTM databases

PhosphoSitePlusiP0C5I1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000052759.
GenevisibleiP0C5I1. MM.

Structurei

3D structure databases

ProteinModelPortaliP0C5I1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJV0. Eukaryota.
ENOG4111HMZ. LUCA.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000112789.
HOVERGENiHBG051803.
InParanoidiP0C5I1.
KOiK08405.
OMAiAATRCAG.
OrthoDBiEOG091G0MQK.
PhylomeDBiP0C5I1.
TreeFamiTF330024.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C5I1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSTEPWSPS WGTLSWDYSG SGSLDQVELC PAWNLPYGHA IIPALYLAAF
60 70 80 90 100
AVGLPGNAFV VWLLSRQRGP RRLVDTFVLH LAAADLGFVL TLPLWAAAEA
110 120 130 140 150
RGGLWPFGDG LCKVSSFALA VTRCAGALLL AGMSVDRYLA VGRPLSARPL
160 170 180 190 200
RSARCVRAVC GAAWAAAFLA GLPALLYRGL QPSLDGVGSQ CAEEPWEALQ
210 220 230 240 250
GVGLLLLLLT FALPLAVTLI CYWRVSRRLP RVGRARSNSL RIIFTVESVF
260 270 280 290 300
VGCWLPFGVL RSLFHLARLQ ALPLPCSLLL ALRWGLTVTT CLAFVNSSAN
310 320 330 340 350
PVIYLLLDRS FRARARFGLC ARAGRQVRRI SSASSLSRDD SSVFRGRSPK

VNSASATW
Length:358
Mass (Da):38,754
Last modified:October 2, 2007 - v1
Checksum:i2A7F7D925F4A3E73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124550 Genomic DNA. No translation available.
CCDSiCCDS48381.1.
RefSeqiNP_001094986.1. NM_001101516.1.
UniGeneiMm.40367.

Genome annotation databases

EnsembliENSMUST00000086395; ENSMUSP00000083583; ENSMUSG00000052759.
GeneIDi383563.
KEGGimmu:383563.
UCSCiuc011wsy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124550 Genomic DNA. No translation available.
CCDSiCCDS48381.1.
RefSeqiNP_001094986.1. NM_001101516.1.
UniGeneiMm.40367.

3D structure databases

ProteinModelPortaliP0C5I1.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP0C5I1.

Proteomic databases

PaxDbiP0C5I1.
PRIDEiP0C5I1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000086395; ENSMUSP00000083583; ENSMUSG00000052759.
GeneIDi383563.
KEGGimmu:383563.
UCSCiuc011wsy.1. mouse.

Organism-specific databases

CTDi2848.
MGIiMGI:2686146. Gpr25.

Phylogenomic databases

eggNOGiENOG410IJV0. Eukaryota.
ENOG4111HMZ. LUCA.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000112789.
HOVERGENiHBG051803.
InParanoidiP0C5I1.
KOiK08405.
OMAiAATRCAG.
OrthoDBiEOG091G0MQK.
PhylomeDBiP0C5I1.
TreeFamiTF330024.

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.

Miscellaneous databases

PROiP0C5I1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000052759.
GenevisibleiP0C5I1. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR25_MOUSE
AccessioniPrimary (citable) accession number: P0C5I1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: November 2, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.