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Protein

Cerebral dopamine neurotrophic factor

Gene

Cdnf

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra.1 Publication

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Cerebral dopamine neurotrophic factor
Alternative name(s):
ARMET-like protein 1
Arginine-rich protein mutated in early stage tumors-like 1
Conserved dopamine neurotrophic factor
Gene namesi
Name:Cdnf
Synonyms:Armetl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi1307600. Cdnf.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 187163Cerebral dopamine neurotrophic factorPRO_0000306860Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi37 ↔ 124By similarity
Disulfide bondi40 ↔ 113By similarity
Disulfide bondi71 ↔ 82By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP0C5I0.
PRIDEiP0C5I0.

Expressioni

Gene expression databases

BgeeiENSRNOG00000026493.
GenevisibleiP0C5I0. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030751.

Family & Domainsi

Sequence similaritiesi

Belongs to the ARMET family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4154. Eukaryota.
ENOG4111QMZ. LUCA.
GeneTreeiENSGT00390000007160.
HOGENOMiHOG000264245.
InParanoidiP0C5I0.
OMAiCLDVKGK.
OrthoDBiEOG091G0P3O.
PhylomeDBiP0C5I0.
TreeFamiTF314252.

Family and domain databases

InterProiIPR019345. Armet_prot.
[Graphical view]
PfamiPF10208. Armet. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C5I0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRCTSPAALV TFCAGLWISN HVLAQGLEAG VRSRADCEVC KEFLNRFYNS
60 70 80 90 100
LLTRGIDFSV DTIEEELISF CADTKGKENR LCYYLGATKD SATKILGEVT
110 120 130 140 150
RPMSVHMPTV KICEKLKKMD SQICELKYEK KLDLESVDLW KMRVAELKQI
160 170 180
LHSWGEECRA CAEKHDYVNL IKELAPKYVE TRPQTEL
Length:187
Mass (Da):21,361
Last modified:October 2, 2007 - v1
Checksum:iC04217BD6E48F8E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03104971 Genomic DNA. No translation available.
AABR03106335 Genomic DNA. No translation available.
AABR03107130 Genomic DNA. No translation available.
RefSeqiNP_001032632.1. NM_001037543.1.
UniGeneiRn.144150.

Genome annotation databases

EnsembliENSRNOT00000036299; ENSRNOP00000030751; ENSRNOG00000026493.
GeneIDi361276.
KEGGirno:361276.
UCSCiRGD:1307600. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03104971 Genomic DNA. No translation available.
AABR03106335 Genomic DNA. No translation available.
AABR03107130 Genomic DNA. No translation available.
RefSeqiNP_001032632.1. NM_001037543.1.
UniGeneiRn.144150.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030751.

Proteomic databases

PaxDbiP0C5I0.
PRIDEiP0C5I0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000036299; ENSRNOP00000030751; ENSRNOG00000026493.
GeneIDi361276.
KEGGirno:361276.
UCSCiRGD:1307600. rat.

Organism-specific databases

CTDi441549.
RGDi1307600. Cdnf.

Phylogenomic databases

eggNOGiKOG4154. Eukaryota.
ENOG4111QMZ. LUCA.
GeneTreeiENSGT00390000007160.
HOGENOMiHOG000264245.
InParanoidiP0C5I0.
OMAiCLDVKGK.
OrthoDBiEOG091G0P3O.
PhylomeDBiP0C5I0.
TreeFamiTF314252.

Miscellaneous databases

PROiP0C5I0.

Gene expression databases

BgeeiENSRNOG00000026493.
GenevisibleiP0C5I0. RN.

Family and domain databases

InterProiIPR019345. Armet_prot.
[Graphical view]
PfamiPF10208. Armet. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDNF_RAT
AccessioniPrimary (citable) accession number: P0C5I0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: September 7, 2016
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.