Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Delta-halcutoxin-Hcg1a

Gene
N/A
Organism
Halcurias carlgreni (Sea anemone)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Is potently lethal to crabs, although it showed neither lethal activity in mice nor hemolytic activity. May bind to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal transduction.1 Publication

Caution

This toxin probably comes from Halcurias carlgreni, although the identification is not definitive.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-halcutoxin-Hcg1a1 Publication
Short name:
Delta-HCTX-Hcg1a1 Publication
Alternative name(s):
Halcurin1 Publication
OrganismiHalcurias carlgreni (Sea anemone)
Taxonomic identifieri462315 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaEndocoelantheaeHalcuriidaeHalcurias

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nematocyst, Secreted

Pathology & Biotechi

Toxic dosei

LD50 is 5.8 µg/kg against crabs.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00003051201 – 47Delta-halcutoxin-Hcg1a1 PublicationAdd BLAST47

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi3 ↔ 43By similarity
Disulfide bondi5 ↔ 33By similarity
Disulfide bondi26 ↔ 44By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP0C5G6

Structurei

3D structure databases

ProteinModelPortaliP0C5G6
SMRiP0C5G6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di2.20.20.10, 1 hit
InterProiView protein in InterPro
IPR000693 Anenome_toxin
IPR023355 Myo_ane_neurotoxin_sf
PfamiView protein in Pfam
PF00706 Toxin_4, 1 hit
PIRSFiPIRSF001905 Anenome_toxin, 1 hit

Sequencei

Sequence statusi: Complete.

P0C5G6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
VACRCESDGP DVRSATFTGT VDLWNCNTGW HKCIATYTAV ASCCKKD
Length:47
Mass (Da):5,086
Last modified:October 2, 2007 - v1
Checksum:iB8B008C5C89716F7
GO

Mass spectrometryi

Molecular mass is 5074 Da from positions 1 - 41. Determined by MALDI. 1 Publication

Similar proteinsi

Entry informationi

Entry nameiNA2H_HALCG
AccessioniPrimary (citable) accession number: P0C5G6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: May 23, 2018
This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health