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Protein

Delta-halcutoxin-Hcg1a

Gene
N/A
Organism
Halcurias carlgreni (Sea anemone)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Is potently lethal to crabs, although it showed neither lethal activity in mice nor hemolytic activity. May bind to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal transduction.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-halcutoxin-Hcg1a1 Publication
Short name:
Delta-HCTX-Hcg1a1 Publication
Alternative name(s):
Halcurin1 Publication
OrganismiHalcurias carlgreni (Sea anemone)
Taxonomic identifieri462315 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaEndocoelantheaeHalcuriidaeHalcurias

Subcellular locationi

  • Secreted 1 Publication
  • Nematocyst 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nematocyst, Secreted

Pathology & Biotechi

Toxic dosei

LD50 is 5.8 µg/kg against crabs.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 4747Delta-halcutoxin-Hcg1a1 PublicationPRO_0000305120Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi3 ↔ 43By similarity
Disulfide bondi5 ↔ 33By similarity
Disulfide bondi26 ↔ 44By similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliP0C5G6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di2.20.20.10. 1 hit.
InterProiIPR000693. Anenome_toxin.
IPR023355. Myo_neuro_toxin.
[Graphical view]
PfamiPF00706. Toxin_4. 1 hit.
[Graphical view]
PIRSFiPIRSF001905. Anenome_toxin. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C5G6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
VACRCESDGP DVRSATFTGT VDLWNCNTGW HKCIATYTAV ASCCKKD
Length:47
Mass (Da):5,086
Last modified:October 2, 2007 - v1
Checksum:iB8B008C5C89716F7
GO

Mass spectrometryi

Molecular mass is 5074 Da from positions 1 - 41. Determined by MALDI. 1 Publication

Cross-referencesi

3D structure databases

ProteinModelPortaliP0C5G6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.20.20.10. 1 hit.
InterProiIPR000693. Anenome_toxin.
IPR023355. Myo_neuro_toxin.
[Graphical view]
PfamiPF00706. Toxin_4. 1 hit.
[Graphical view]
PIRSFiPIRSF001905. Anenome_toxin. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNA2H_HALCG
AccessioniPrimary (citable) accession number: P0C5G6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: December 9, 2015
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Caution

This toxin probably comes from Halcurias carlgreni, although the identification is not definitive.Curated

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.