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P0C5G6 (HAL_HALCG) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Halcurin
OrganismHalcurias carlgreni (Sea anemone)
Taxonomic identifier462315 [NCBI]
Taxonomic lineageEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaEndocoelantheaeHalcuriidaeHalcurias

Protein attributes

Sequence length47 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Is potently lethal to crabs, although it showed neither lethal activity in mice nor hemolytic activity. May bind to the sodium channel (Nav), thereby delaying its inactivation during signal transduction. Ref.1

Subcellular location

Secreted. Nematocyst Probable Ref.1.

Toxic dose

LD50 is 5.8 µg/kg against crabs. Ref.1

Sequence similarities

Belongs to the sea anemone sodium channel inhibitory toxin family. Type II subfamily.

Caution

This toxin probably comes from Halcurias carlgreni, although the identification is not definitive.

Mass spectrometry

Molecular mass is 5074 Da from positions 1 - 41. Determined by MALDI. Ref.1

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Peptide1 – 4747Halcurin
PRO_0000305120

Amino acid modifications

Disulfide bond3 ↔ 43 By similarity
Disulfide bond5 ↔ 33 By similarity
Disulfide bond26 ↔ 44 By similarity

Sequences

Sequence LengthMass (Da)Tools
P0C5G6 [UniParc].

Last modified October 2, 2007. Version 1.
Checksum: B8B008C5C89716F7

FASTA475,086
        10         20         30         40 
VACRCESDGP DVRSATFTGT VDLWNCNTGW HKCIATYTAV ASCCKKD 

« Hide

References

[1]"Halcurin, a polypeptide toxin from the sea anemone Halcurias sp., with a structural resemblance to type 1 and 2 toxins."
Ishida M., Yokoyama A., Shimakura K., Nagashima Y., Shiomi K.
Toxicon 35:537-544(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, LETHAL DOSE, MASS SPECTROMETRY.

Cross-references

3D structure databases

ProteinModelPortalP0C5G6.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.20.20.10. 1 hit.
InterProIPR000693. Anenome_toxin.
IPR023355. Myo_neuro_toxin.
[Graphical view]
PfamPF00706. Toxin_4. 1 hit.
[Graphical view]
PIRSFPIRSF001905. Anenome_toxin. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHAL_HALCG
AccessionPrimary (citable) accession number: P0C5G6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: October 16, 2013
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families