Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P0C5G6

- HAL_HALCG

UniProt

P0C5G6 - HAL_HALCG

Protein

Halcurin

Gene
N/A
Organism
Halcurias carlgreni (Sea anemone)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Is potently lethal to crabs, although it showed neither lethal activity in mice nor hemolytic activity. May bind to the sodium channel (Nav), thereby delaying its inactivation during signal transduction.1 Publication

    GO - Biological processi

    1. regulation of signal transduction Source: InterPro

    Keywords - Molecular functioni

    Ion channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Halcurin
    OrganismiHalcurias carlgreni (Sea anemone)
    Taxonomic identifieri462315 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaEndocoelantheaeHalcuriidaeHalcurias

    Subcellular locationi

    Secreted 1 Publication. Nematocyst 1 Publication

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. nematocyst Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nematocyst, Secreted

    Pathology & Biotechi

    Toxic dosei

    LD50 is 5.8 µg/kg against crabs.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Peptidei1 – 4747HalcurinPRO_0000305120Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi3 ↔ 43By similarity
    Disulfide bondi5 ↔ 33By similarity
    Disulfide bondi26 ↔ 44By similarity

    Keywords - PTMi

    Disulfide bond

    Structurei

    3D structure databases

    ProteinModelPortaliP0C5G6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di2.20.20.10. 1 hit.
    InterProiIPR000693. Anenome_toxin.
    IPR023355. Myo_neuro_toxin.
    [Graphical view]
    PfamiPF00706. Toxin_4. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001905. Anenome_toxin. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P0C5G6-1 [UniParc]FASTAAdd to Basket

    « Hide

    VACRCESDGP DVRSATFTGT VDLWNCNTGW HKCIATYTAV ASCCKKD      47
    Length:47
    Mass (Da):5,086
    Last modified:October 2, 2007 - v1
    Checksum:iB8B008C5C89716F7
    GO

    Mass spectrometryi

    Molecular mass is 5074 Da from positions 1 - 41. Determined by MALDI. 1 Publication

    Cross-referencesi

    3D structure databases

    ProteinModelPortali P0C5G6.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.20.20.10. 1 hit.
    InterProi IPR000693. Anenome_toxin.
    IPR023355. Myo_neuro_toxin.
    [Graphical view ]
    Pfami PF00706. Toxin_4. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001905. Anenome_toxin. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Halcurin, a polypeptide toxin from the sea anemone Halcurias sp., with a structural resemblance to type 1 and 2 toxins."
      Ishida M., Yokoyama A., Shimakura K., Nagashima Y., Shiomi K.
      Toxicon 35:537-544(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, LETHAL DOSE, MASS SPECTROMETRY.

    Entry informationi

    Entry nameiHAL_HALCG
    AccessioniPrimary (citable) accession number: P0C5G6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 23 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Caution

    This toxin probably comes from Halcurias carlgreni, although the identification is not definitive.Curated

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3