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Protein

Halcurin

Gene
N/A
Organism
Halcurias carlgreni (Sea anemone)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Is potently lethal to crabs, although it showed neither lethal activity in mice nor hemolytic activity. May bind to the sodium channel (Nav), thereby delaying its inactivation during signal transduction.1 Publication

GO - Biological processi

  1. regulation of signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Halcurin
OrganismiHalcurias carlgreni (Sea anemone)
Taxonomic identifieri462315 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaEndocoelantheaeHalcuriidaeHalcurias

Subcellular locationi

Secreted 1 Publication. Nematocyst 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. nematocyst Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nematocyst, Secreted

Pathology & Biotechi

Toxic dosei

LD50 is 5.8 µg/kg against crabs.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 4747HalcurinPRO_0000305120Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi3 ↔ 43By similarity
Disulfide bondi5 ↔ 33By similarity
Disulfide bondi26 ↔ 44By similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliP0C5G6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di2.20.20.10. 1 hit.
InterProiIPR000693. Anenome_toxin.
IPR023355. Myo_neuro_toxin.
[Graphical view]
PfamiPF00706. Toxin_4. 1 hit.
[Graphical view]
PIRSFiPIRSF001905. Anenome_toxin. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C5G6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40 
VACRCESDGP DVRSATFTGT VDLWNCNTGW HKCIATYTAV ASCCKKD
Length:47
Mass (Da):5,086
Last modified:October 2, 2007 - v1
Checksum:iB8B008C5C89716F7
GO

Mass spectrometryi

Molecular mass is 5074 Da from positions 1 - 41. Determined by MALDI. 1 Publication

Cross-referencesi

3D structure databases

ProteinModelPortaliP0C5G6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.20.20.10. 1 hit.
InterProiIPR000693. Anenome_toxin.
IPR023355. Myo_neuro_toxin.
[Graphical view]
PfamiPF00706. Toxin_4. 1 hit.
[Graphical view]
PIRSFiPIRSF001905. Anenome_toxin. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Halcurin, a polypeptide toxin from the sea anemone Halcurias sp., with a structural resemblance to type 1 and 2 toxins."
    Ishida M., Yokoyama A., Shimakura K., Nagashima Y., Shiomi K.
    Toxicon 35:537-544(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, LETHAL DOSE, MASS SPECTROMETRY.

Entry informationi

Entry nameiHAL_HALCG
AccessioniPrimary (citable) accession number: P0C5G6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: January 7, 2015
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Caution

This toxin probably comes from Halcurias carlgreni, although the identification is not definitive.Curated

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.