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Protein

Beta-crystallin S

Gene

Crygs

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Crystallins are the dominant structural components of the vertebrate eye lens.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Eye lens protein

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-crystallin S
Alternative name(s):
Gamma-S-crystallin
Gamma-crystallin S
Gene namesi
Name:Crygs
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi1587483. Crygs.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 178177Beta-crystallin SPRO_0000304973Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP0C5E9.
PRIDEiP0C5E9.

Expressioni

Gene expression databases

BgeeiENSRNOG00000038355.
GenevisibleiP0C5E9. RN.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000055204.

Structurei

3D structure databases

ProteinModelPortaliP0C5E9.
SMRiP0C5E9. Positions 2-178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 4439Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd
BLAST
Domaini45 – 8743Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd
BLAST
Domaini94 – 13441Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd
BLAST
Domaini135 – 17743Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 54N-terminal arm
Regioni88 – 936Connecting peptide

Domaini

Has a two-domain beta-structure, folded into four very similar Greek key motifs.

Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.Curated
Contains 4 beta/gamma crystallin 'Greek key' domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IEJ7. Eukaryota.
ENOG4111EVU. LUCA.
GeneTreeiENSGT00760000118812.
HOGENOMiHOG000234389.
HOVERGENiHBG003364.
InParanoidiP0C5E9.
OMAiSIMEEWH.
OrthoDBiEOG091G0L2P.
PhylomeDBiP0C5E9.

Family and domain databases

InterProiIPR001064. Beta/gamma_crystallin.
IPR011024. G_crystallin-rel.
[Graphical view]
PfamiPF00030. Crystall. 2 hits.
[Graphical view]
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiSM00247. XTALbg. 2 hits.
[Graphical view]
SUPFAMiSSF49695. SSF49695. 1 hit.
PROSITEiPS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C5E9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKTGAKISF YEDRNFQGRR YDCDCDCVDF RSYLSRCNSI RVEGGTWAVY
60 70 80 90 100
ERPNFSGHMY ILPQGEYPEY QRWMGLNDRL GSCRAVHLSS GGQYKIQIFE
110 120 130 140 150
KGDFSGQMYE TTEDCPSTME RFHLREIHSC KVLEGTWIFY ELPSYHGRQY
160 170
LLDKKEYRKP VDWGAASPAV QSFRRIVE
Length:178
Mass (Da):20,942
Last modified:October 2, 2007 - v1
Checksum:i6D53173F98C25E00
GO

Sequence databases

RefSeqiNP_001103023.1. NM_001109553.1.
UniGeneiRn.198271.

Genome annotation databases

EnsembliENSRNOT00000058402; ENSRNOP00000055204; ENSRNOG00000038355.
GeneIDi689897.
KEGGirno:689897.
UCSCiRGD:1587483. rat.

Cross-referencesi

Sequence databases

RefSeqiNP_001103023.1. NM_001109553.1.
UniGeneiRn.198271.

3D structure databases

ProteinModelPortaliP0C5E9.
SMRiP0C5E9. Positions 2-178.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000055204.

Proteomic databases

PaxDbiP0C5E9.
PRIDEiP0C5E9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000058402; ENSRNOP00000055204; ENSRNOG00000038355.
GeneIDi689897.
KEGGirno:689897.
UCSCiRGD:1587483. rat.

Organism-specific databases

CTDi1427.
RGDi1587483. Crygs.

Phylogenomic databases

eggNOGiENOG410IEJ7. Eukaryota.
ENOG4111EVU. LUCA.
GeneTreeiENSGT00760000118812.
HOGENOMiHOG000234389.
HOVERGENiHBG003364.
InParanoidiP0C5E9.
OMAiSIMEEWH.
OrthoDBiEOG091G0L2P.
PhylomeDBiP0C5E9.

Miscellaneous databases

PROiP0C5E9.

Gene expression databases

BgeeiENSRNOG00000038355.
GenevisibleiP0C5E9. RN.

Family and domain databases

InterProiIPR001064. Beta/gamma_crystallin.
IPR011024. G_crystallin-rel.
[Graphical view]
PfamiPF00030. Crystall. 2 hits.
[Graphical view]
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiSM00247. XTALbg. 2 hits.
[Graphical view]
SUPFAMiSSF49695. SSF49695. 1 hit.
PROSITEiPS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRBS_RAT
AccessioniPrimary (citable) accession number: P0C5E9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: September 7, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.